Rtecs number : ww2710000 chemical name : Talc (powder), containing no asbestos fibers

TERPINEOL

CHEMICAL NAME : alpha-Terpineol

CAS REGISTRY NUMBER : 98-55-5

OTHER CAS REGISTRY NOS. : 22347-88-2

2438-12-2

BEILSTEIN REFERENCE NO. : 1906604

REFERENCE : 2-06-00-00067 (Beilstein Handbook Reference)

LAST UPDATED : 199806

DATA ITEMS CITED : 8

MOLECULAR FORMULA : C10-H18-O

MOLECULAR WEIGHT : 154.28

WISWESSER LINE NOTATION : L6UTJ A1 DXQ1&1

SYNONYMS/TRADE NAMES :

* 3-Cyclohexene-1-methanol, alpha,alpha,4-trimethyl-

* p-Menth-1-en-8-ol

* 2-(4-Methyl-3-cyclohexenyl)-2-propanol

* PC 593

* Terpenol

* Terpineol 350

* dl-alpha-Terpineol

* Terpineol schlechthin

* alpha,alpha,4-Trimethyl-3-cyclohexene-1-methanol

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 5170 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and

Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)

V.1-36, 1957-1992. For publisher information, see MTPEEI

Volume(issue)/page/year: 31(2),29,1987

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 2830 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co.,

USA,

Volume(issue)/page/year: 33,1669,1985

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 2 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JSICAZ Journal of Scientific and Industrial Research, Section C:

Biological

Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher

information,

see IJEBA6. Volume(issue)/page/year: 21,342,1962

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 7755 mg/kg/30D-I

TOXIC EFFECTS :

Brain and Coverings - other degenerative changes

Liver - other changes

Biochemical - Enzyme inhibition, induction, or change in blood or tissue

levels - dehydrogenases

REFERENCE :

GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and

Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)

V.1-36, 1957-1992. For publisher information, see MTPEEI

Volume(issue)/page/year: 31(2),29,1987

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :

NOHS - National Occupational Hazard Survey (1974)

NOHS Hazard Code - 80268

No. of Facilities: 2241 (estimated)

No. of Industries: 37

No. of Occupations: 47

No. of Employees: 16136 (estimated)

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - 80268

No. of Facilities: 20420 (estimated)

No. of Industries: 125

No. of Occupations: 102

No. of Employees: 328085 (estimated)

No. of Female Employees: 125759 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999

TESTOSTERONE

CHEMICAL NAME : Testosterone

CAS REGISTRY NUMBER : 58-22-0

LAST UPDATED : 199803

DATA ITEMS CITED : 60

MOLECULAR FORMULA : C19-H28-O2

MOLECULAR WEIGHT : 288.47

WISWESSER LINE NOTATION : L E5 B666 OV MUTJ A1 E1 FQ

COMPOUND DESCRIPTOR : Tumorigen

Drug

Reproductive Effector

Human

Hormone

* Androlin

* Androst-4-en-3-one, 17-hydroxy-, (17-beta)-

* Andronaq

* Androst-4-en-17beta-ol-3-one

* delta(sup 4)-Androsten-17(beta)-ol-3-one

* Androst-4-en-3-one, 17-beta-hydroxy-

* Andrusol

* Cristerone T

* Geno-cristaux gremy

* Homosteron

* Homosterone

* 17-beta-Hydroxy-delta(sup 4)-androsten-3-one

* 17-beta-Hydroxyandrost-4-en-3-one

* 17-beta-Hydroxy-4-androsten-3-one

* 7-beta-Hydroxyandrost-4-en-3-one

* Malestrone (amps)

* Mertestate

* Neo-testis

* Oreton-F

* Orquisteron

* Perandren

* Percutacrine androgenique

* Primotest

* Primoteston

* Sustanone

* Synandrol F

* Teslen

* Testiculosterone

* Testobase

* Testopropon

* Testosteroid

* Testosteron

* trans-Testosterone

* Testosterone hydrate

* Testostosterone

* Testoviron schering

* Testoviron T

* Testrone

* Testryl

* Virormone

* Virosterone

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 326 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - other changes

REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine.

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-

1903/04-

Volume(issue)/page/year: 46,116,1941

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Mammal - species unspecified

DOSE/DURATION : >5 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow,

101479,

Russia) History Unknown Volume(issue)/page/year: (2),6,1996

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 6240 mg/kg/52D-C

TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria

Reproductive - Tumorigenic effects - ovarian tumors

REFERENCE :

CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut

Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:

48,2788,1988

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 30 mg/kg/5D-I

TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria

Endocrine - adrenal cortex tumors

Reproductive - Tumorigenic effects - other reproductive system tumors

REFERENCE :

JNCIAM Journal of the National Cancer Institute. (Washington, DC)

V.1-60,

1940-78. For publisher information, see JJIND8.

39,75,1967

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Implant

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 400 mg/kg/50D-C

TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria

Reproductive - Tumorigenic effects - ovarian tumors

REFERENCE :

CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut

Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:

48,2788,1988

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Implant

SPECIES OBSERVED : Human - man

DOSE : 17 mg/kg

SEX/DURATION : male 26 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic

material,

sperm morphology, motility, and count)

Reproductive - Paternal Effects - other effects on male

REFERENCE :

JCEMAZ Journal of Clinical Endocrinology and Metabolism. (Williams &

Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.12- 1952-

Volume(issue)/page/year: 75,1326,1992

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Unreported

SPECIES OBSERVED : Human - woman

DOSE : 34600 ug/kg

SEX/DURATION : female 7-13 week(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :

AMDCA5 AMA Journal of Diseases of Children. (Chicago, IL) V.91-99,

1956-60. For publisher information, see AJDCAI.

Volume(issue)/page/year:

95,9,1958

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE : 100 mg/kg

SEX/DURATION : female 17-20 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :

ECJPAE Endocrinologia Japonica. (Japan Pub. Trading Co., Ltd., POB 5030,

Tokyo International, Tokyo, Japan) V.1- 1954-

Volume(issue)/page/year:

24,77,1977

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE : 64 mg/kg

SEX/DURATION : male 10 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's

gland,

REFERENCE :

JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical

Assoc.,

Volume(issue)/page/year: 71,514,1982

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE : 25 mg/kg

SEX/DURATION : female 17 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - physical

Reproductive - Effects on Newborn - delayed effects

REFERENCE :

DENED7 Developmental Neuroscience (Basel). (S. Karger Pub., Inc., 79

Fifth

Ave., New York, NY 10003) V.1- 1978- Volume(issue)/page/year:

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE : 7 mg/kg

SEX/DURATION : female 10-16 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - abortion

REFERENCE :

JPHYA7 Journal of Physiology. (Cambridge Univ. Press, 32 E. 57th St.,

New

York, NY 10022) V.1- 1878- Volume(issue)/page/year: 164,138,1962

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE : 4 mg/kg

SEX/DURATION : female 9 day(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - parturition

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

REFERENCE :

JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,

Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-

Volume(issue)/page/year: 18,271,1959

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE : 20 mg/kg

SEX/DURATION : female 5 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - pre-implantation mortality (e.g. reduction in

number of implants per female; total number of implants per corpora

lutea)

JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,

Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-

Volume(issue)/page/year: 18,271,1959

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE : 8400 ug/kg

SEX/DURATION : male 21 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic

material,

sperm morphology, motility, and count)

Reproductive - Paternal Effects - testes, epididymis, sperm duct

Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's

gland,

REFERENCE :

ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E,

DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year:

49,145,1965

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE : 1400 ug/kg

SEX/DURATION : female 14 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - other measures of fertility

REFERENCE :

CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022)

V.1-

1970- Volume(issue)/page/year: 5,489,1972

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE : 700 ug/kg

SEX/DURATION : female 14 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - ovaries, fallopian tubes

Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :

CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022)

V.1-

1970- Volume(issue)/page/year: 5,489,1972

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - rat

DOSE : 60 mg/kg

SEX/DURATION : female 3-7 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - pre-implantation mortality (e.g. reduction in

number of implants per female; total number of implants per corpora

lutea)

REFERENCE :

Preston

100,1684,1977

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - rat

DOSE : 8 mg/kg

SEX/DURATION : female 13-20 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - skin and skin

appendages

Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.

Preston

99,1490,1976

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - rat

DOSE : 280 ug/kg

SEX/DURATION : male 14 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct

Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's

gland,

accessory glands

IJEBA6 Indian Journal of Experimental Biology. (Publications &

Information

Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-

Volume(issue)/page/year: 14,86,1976

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Rodent - rat

DOSE : 2500 ug/kg

SEX/DURATION : female 10 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - ovaries, fallopian tubes

REFERENCE :

JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book

Depot,

POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Rodent - rat

DOSE : 4 mg/kg

SEX/DURATION : male 3 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :

85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press,

1965 Volume(issue)/page/year: -,29,1965

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Rodent - rat

DOSE : 8 mg/kg

SEX/DURATION : male 3 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic

material,

sperm morphology, motility, and count)

REFERENCE :

85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press,

1965 Volume(issue)/page/year: -,29,1965

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Implant

SPECIES OBSERVED : Rodent - rat

DOSE : 10440 ug/kg

SEX/DURATION : male 30 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :

CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022)

V.1-

1970- Volume(issue)/page/year: 7,105,1973

ROUTE OF EXPOSURE : Implant

SPECIES OBSERVED : Rodent - rat

DOSE : 27 mg/kg

SEX/DURATION : male 90 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic

material,

sperm morphology, motility, and count)

Reproductive - Paternal Effects - testes, epididymis, sperm duct

Reproductive - Fertility - male fertility index (e.g. # males

impregnating

females per # males exposed to fertile nonpregnant females)

REFERENCE :

BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309

W.

Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year:

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Implant

SPECIES OBSERVED : Rodent - rat

DOSE : 10920 ug/kg

SEX/DURATION : male 91 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's

gland,

accessory glands

BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309

W.

Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year:

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Implant

SPECIES OBSERVED : Rodent - rat

DOSE : 33300 ug/kg

SEX/DURATION : male 15 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - other effects on male

Reproductive - Fertility - pre-implantation mortality (e.g. reduction in

number of implants per female; total number of implants per corpora

lutea)

Reproductive - Fertility - litter size (e.g. # fetuses per litter;

before birth)

REFERENCE :

BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309

W.

Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year:

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intratesticular

SPECIES OBSERVED : Rodent - rat

DOSE : 24 mg/kg

SEX/DURATION : male 30 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct

Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's

gland,

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.

Preston

46,453,1950

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE : 15 gm/kg

SEX/DURATION : female 8-12 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - live birth index (measured after

birth)

4

per # born alive)

TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,

Inc.,

41 E. 11th St., New York, NY 10003) V.1- 1980-

6,361,1986

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 40 mg/kg

SEX/DURATION : female 10 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - uterus, cervix, vagina

Reproductive - Maternal Effects - other effects

REFERENCE :

ECJPAE Endocrinologia Japonica. (Japan Pub. Trading Co., Ltd., POB 5030,

Tokyo International, Tokyo, Japan) V.1- 1954-

Volume(issue)/page/year:

23,327,1976

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 168 mg/kg

SEX/DURATION : female 3 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :

FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave.

S,

Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 20,211,1969

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 10 mg/kg

SEX/DURATION : female 5 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - uterus, cervix, vagina

Reproductive - Fertility - female fertility index (e.g. # females

pregnant

per # sperm positive females; # females pregnant per # females mated)

REFERENCE :

BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309

W.

Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year:

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Rodent - mouse

DOSE : 4524 mg/kg

SEX/DURATION : male 19 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.

Preston

St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Rodent - mouse

DOSE : 9583 ng/kg

SEX/DURATION : female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :

PPHAD4 Pediatric Pharmacology. (New York, NY) V.1-5, 1980-86. For

publisher information, see DPTHDL. Volume(issue)/page/year: 5,157,1985

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Implant

SPECIES OBSERVED : Primate - monkey

DOSE : 1426 ug/kg

SEX/DURATION : male 70 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic

material,

sperm morphology, motility, and count)

REFERENCE :

CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022)

V.1-

1970- Volume(issue)/page/year: 13,583,1976

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rabbit

DOSE : 30 mg/kg

SEX/DURATION : female 1-3 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - pre-implantation mortality (e.g. reduction in

number of implants per female; total number of implants per corpora

lutea)

REFERENCE :

S,

Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 20,211,1969

ROUTE OF EXPOSURE : Unreported

SPECIES OBSERVED : Rodent - rabbit

DOSE : 6 mg/kg

SEX/DURATION : female 1-3 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - pre-implantation mortality (e.g. reduction in

number of implants per female; total number of implants per corpora

lutea)

REFERENCE :

V.1-

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - guinea pig

DOSE : 86 mg/kg

SEX/DURATION : female 18-60 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - endocrine system

Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :

FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave.

S,

Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 19,606,1968

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - hamster

DOSE : 180 mg/kg

SEX/DURATION : female 3-8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - female fertility index (e.g. # females

pregnant

REFERENCE :

STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA

94609)

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Mammal - domestic

DOSE : 13333 ug/kg

SEX/DURATION : female 50 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - behavioral

REFERENCE :

PHBHA4 Physiology and Behavior. (Pergamon Press Inc., Maxwell House,

Fairview Park, Elmsford, NY 10523) V.1- 1966-

Volume(issue)/page/year:

57,185,1995

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Implant

SPECIES OBSERVED : Mammal - domestic

DOSE : 6398 ug/kg

SEX/DURATION : female 30-80 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :

JEEMAF Journal of Embryology and Experimental Morphology. (Essex, UK)

V.1-98, 1953-86. For Publisher information, see DEVPED

Volume(issue)/page/year: 36,87,1976

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Implant

SPECIES OBSERVED : Mammal - domestic

DOSE : 6491 ug/kg

SEX/DURATION : female 13-20 week(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :

JEEMAF Journal of Embryology and Experimental Morphology. (Essex, UK)

V.1-98, 1953-86. For Publisher information, see DEVPED

Volume(issue)/page/year: 36,87,1976

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Implant

SPECIES OBSERVED : Mammal - domestic

DOSE : 18 ug/kg

SEX/DURATION : female 7-14 week(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - mating performance (e.g. # sperm positive

females

per # females mated; # copulations per # estrus cycles)

JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book

Depot,

POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-

** MUTATION DATA **

TYPE OF TEST : Sperm Morphology

ROUTE OF EXPOSURE : Parenteral

TEST SYSTEM : Non-mammalian species

DOSE/DURATION : 12 mg/8W (Intermittent)

REFERENCE :

JEZOAO Journal of Experimental Zoology. (Alan R. Liss, Inc., 41 E. 11th

St., New York, NY 10003) V.1- 1904- Volume(issue)/page/year:

205,403,1978

TYPE OF TEST : DNA inhibition

TEST SYSTEM : Human Lymphocyte

DOSE/DURATION : 50 umol/L

REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine.

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-

1903/04-

Volume(issue)/page/year: 146,401,1974

TYPE OF TEST : DNA inhibition

TEST SYSTEM : Human Kidney

DOSE/DURATION : 100 ug/L

REFERENCE :

CNJGA8 Canadian Journal of Genetics and Cytology. (National Research

Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,

Canada) V.1- 1959- Volume(issue)/page/year: 10,299,1968

TYPE OF TEST : Cytogenetic analysis

TEST SYSTEM : Human Kidney

DOSE/DURATION : 100 ug/L

REFERENCE :

CNJGA8 Canadian Journal of Genetics and Cytology. (National Research

Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,

Canada) V.1- 1959- Volume(issue)/page/year: 10,299,1968

TYPE OF TEST : Unscheduled DNA synthesis

ROUTE OF EXPOSURE : Parenteral

TEST SYSTEM : Rodent - rat

DOSE/DURATION : 10 mg/kg

REFERENCE :

ACHCBO Acta Histochemica et Cytochemica. (Japan Soc. of Histochemistry

and

Cytochemistry, Dept. Anatomy, Faculty of Medicine, Kyoto Univ.,

Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1968-

Volume(issue)/page/year:

18,213,1985

TYPE OF TEST : DNA inhibition

TEST SYSTEM : Rodent - rat Liver

DOSE/DURATION : 100 umol/L

REFERENCE :

CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut

Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:

45,337,1985

TYPE OF TEST : DNA damage

TEST SYSTEM : Rodent - mouse Liver

DOSE/DURATION : 100 umol/L

REFERENCE :

ENZYAS Enzymologia. (The Hague, Netherlands) V.1-43, 1936-72.

Volume(issue)/page/year: 41,183,1971

TYPE OF TEST : Morphological transformation

TEST SYSTEM : Rodent - hamster Embryo

DOSE/DURATION : 5 mg/L

REFERENCE :

CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,

Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-

Volume(issue)/page/year: 11,541,1990

TYPE OF TEST : DNA damage

TEST SYSTEM : Mammal - species unspecified Lymphocyte

DOSE/DURATION : 10 umol/L

REFERENCE :

ENZYAS Enzymologia. (The Hague, Netherlands) V.1-43, 1936-72.

Volume(issue)/page/year: 41,183,1971

TYPE OF TEST : DNA damage

TEST SYSTEM : Mammal - species unspecified Liver

DOSE/DURATION : 1 umol/L

REFERENCE :

ENZYAS Enzymologia. (The Hague, Netherlands) V.1-43, 1936-72.

Volume(issue)/page/year: 41,183,1971

*** REVIEWS ***

IARC Cancer Review:Animal Sufficient Evidence

IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of

Chemicals

to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY

12210)

IARC Cancer Review:Animal Sufficient Evidence

IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of

Chemicals

to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY

12210)

IARC Cancer Review:Human Limited Evidence

IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of

Chemicals

to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY

12210)

TOXICOLOGY REVIEW

PCNAA8 Pediatric Clinics of North America. (W.B. Saunders Co., W.

Washington Sq., Philadelphia, PA 19105) V.1- 1954-

Volume(issue)/page/year: 8,413,1961

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - X9850

No. of Facilities: 57 (estimated)

No. of Industries: 2

No. of Occupations: 2

No. of Employees: 774 (estimated)

No. of Female Employees: 347 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Sperm

morphology-human

EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse

EPA TSCA Section 8(b) CHEMICAL INVENTORY