Rtecs number : ww2710000 chemical name : Talc (powder), containing no asbestos fibers

TYRAMINE

CHEMICAL NAME : Phenol, p-(2-aminoethyl)-

CAS REGISTRY NUMBER : 51-67-2

BEILSTEIN REFERENCE NO. : 1099914

REFERENCE : 4-13-00-01788 (Beilstein Handbook Reference)

LAST UPDATED : 199612

DATA ITEMS CITED : 9

MOLECULAR FORMULA : C8-H11-N-O

MOLECULAR WEIGHT : 137.20

WISWESSER LINE NOTATION : Z2R DQ

COMPOUND DESCRIPTOR : Drug

Mutagen

* p-beta-Aminoethylphenol

* p-Hydroxyphenethylamine

* p-Hydroxy-beta-phenethylamine

* 4-Hydroxyphenethylamine

* alpha-(4-Hydroxyphenyl)-beta-aminoethane

* beta-Hydroxyphenylethylamine

* p-Hydroxyphenylethylamine

* 2-(p-Hydroxyphenyl)ethylamine

* 4-Hydroxyphenylethylamine

* Phenethylamine, p-hydroxy-

* Systogene

* Tenosin-wirkstoff

* Tocosine

* Tyramine

* p-Tyramine

* Tyrosamine

* Uteramine

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 800 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPHYA7 Journal of Physiology. (Cambridge Univ. Press, 32 E. 57th St.,

New

York, NY 10022) V.1- 1878- Volume(issue)/page/year: 76,224,1932

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 225 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed.,

Barnes,

C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intravenous

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 229 mg/kg

TOXIC EFFECTS :

Behavioral - changes in motor activity (specific assay)

REFERENCE :

APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)

V.1-59,

38,474,1976

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Unreported

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 2200 mg/kg

TOXIC EFFECTS :

Autonomic Nervous System - sympathomimetic

REFERENCE :

AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und

Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher

information, see NSAPCC. Volume(issue)/page/year: 153,161,1930

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intracervical

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 30 mg/kg

TOXIC EFFECTS :

Behavioral - changes in motor activity (specific assay)

Behavioral - muscle contraction or spasticity

REFERENCE :

TYKNAQ Tohoku Yakka Daigaku Kenkyu Nempo. Annual Report of the Tohoku

College of Pharmacy. (Tohoku Yakka Daigaku, 4-4-1 Kamatsujima, Sendai,

Japan) No.10- 1963- Volume(issue)/page/year: 27,131,1980

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Mammal - cat

DOSE/DURATION : 30 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."

(Leipzig,

Ger. Dem. Rep.) Volume(issue)/page/year: 4,1412,1935

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intravenous

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 300 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,

Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:

-,691,1986

** MUTATION DATA **

TYPE OF TEST : Cytogenetic analysis

ROUTE OF EXPOSURE : Intraperitoneal

TEST SYSTEM : Rodent - rat

DOSE/DURATION : 686 mg/kg

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

240,281,1990

TYPE OF TEST : Micronucleus test

ROUTE OF EXPOSURE : Intraperitoneal

TEST SYSTEM : Rodent - mouse

DOSE/DURATION : 137 mg/kg

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

240,19,1990

TYRAMINE HYDROCHLORIDE

CHEMICAL NAME : Phenol, p-(2-aminoethyl)-, monohydrochloride

CAS REGISTRY NUMBER : 60-19-5

LAST UPDATED : 199709

DATA ITEMS CITED : 7

MOLECULAR FORMULA : C8-H11-N-O.Cl-H

MOLECULAR WEIGHT : 173.66

WISWESSER LINE NOTATION : Z2R DQ &G

COMPOUND DESCRIPTOR : Drug

Mutagen

* 4-(2-Aminoethyl)phenol hydrochloride

* Phenol, 4-(2-aminoethyl)-, hydrochloride

* Tyramine monochloride

* p-Tryamine hydrochloride

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 710 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

28,227,1974

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intravenous

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 208 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold

Lungs, Thorax, or Respiration - dyspnea

Lungs, Thorax, or Respiration - other changes

REFERENCE :

EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V.,

POB

Volume(issue)/page/year:

9,289,1970

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Unreported

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 2750 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams

&

Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - guinea pig

DOSE/DURATION : 1044 mg/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)

Behavioral - tremor

Behavioral - convulsions or effect on seizure threshold

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams

&

Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms

TEST SYSTEM : Rodent - mouse Lymphocyte

DOSE/DURATION : 1010 umol/L

REFERENCE :

MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,

Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:

3,193,1988

TYPE OF TEST : Mutation in mammalian somatic cells

TEST SYSTEM : Rodent - mouse Lymphocyte

DOSE/DURATION : 2530 umol/L

REFERENCE :

MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,

Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:

3,193,1988

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

TYROSINE (DL-)

CHEMICAL NAME : o-Tyrosine, DL-

CAS REGISTRY NUMBER : 2370-61-8

LAST UPDATED : 197901

DATA ITEMS CITED : 1

MOLECULAR FORMULA : C9-H11-N-O3

MOLECULAR WEIGHT : 181.21

WISWESSER LINE NOTATION : QVYZ1R BQ

SYNONYMS/TRADE NAMES :

* Alanine, 3-(o-hydroxyphenyl)-, DL

* DL-3-(o-Hydroxyphenyl)alanine

* DL-o-Tyrosine

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intravenous

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 320 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

CSLNX* U.S. Army Armament Research & Development Command, Chemical

Systems

Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD

Volume(issue)/page/year: NX#02426

TYROSINE (L-)

CHEMICAL NAME : Tyrosine, L-

CAS REGISTRY NUMBER : 60-18-4

OTHER CAS REGISTRY NOS. : 140-43-2

46209-14-7

LAST UPDATED : 199903

DATA ITEMS CITED : 11

MOLECULAR FORMULA : C9-H11-N-O3

MOLECULAR WEIGHT : 181.21

WISWESSER LINE NOTATION : QVYZ1R DQ

COMPOUND DESCRIPTOR : Mutagen

Reproductive Effector

SYNONYMS/TRADE NAMES :

* (S)-alpha-Amino-4-hydroxybenzenepropanoic acid

* (-)-alpha-Amino-p-hydroxyhydrocinnamic acid

* Benzenepropanoic acid, alpha-amino-4-hydroxy-, (S)-

* L-Phenylalanine, 4-hydroxy-

* Propanoic acid, 2-amino-3-(4-hydroxyphenyl)-, (S)-

* Tyrosine

* L-Tyrosine

* L-p-Tyrosine

* p-Tyrosine

* (S)-Tyrosine

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : >1450 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai,

2-12-15

Volume(issue)/page/year: 97,1117,1977

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 42 gm/kg/2W-C

TOXIC EFFECTS :

Behavioral - food intake (animal)

Biochemical - Metabolism (Intermediary) - amino acids (including renal

excretion)

Related to Chronic Data - death

REFERENCE :

JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike,

Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 95,535,1968

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE : 20750 mg/kg

SEX/DURATION : female 15-19 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - other effects to embryo

REFERENCE :

TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho

University.

(Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,

Japan) V.1- 1954- Volume(issue)/page/year: 30,518,1983

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE : 5 gm/kg

SEX/DURATION : female 11-20 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - behavioral

REFERENCE :

PHBHA4 Physiology and Behavior. (Pergamon Press Inc., Maxwell House,

Fairview Park, Elmsford, NY 10523) V.1- 1966-

Volume(issue)/page/year:

55,607,1994

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE : 3500 mg/kg

SEX/DURATION : female 15-21 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - Central Nervous

System

BRREAP Brain Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1966- Volume(issue)/page/year:

635,96,1994

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 150 mg/kg

SEX/DURATION : female 3 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - ovaries, fallopian tubes

REFERENCE :

BIRSB5 Biology of Reproduction, Supplement. (Champaign, IL) No.1-4,

1969-71(?). Discontinued. For publisher information, see BIREBV.

Volume(issue)/page/year: 20(Suppl 1),133A,1979

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rabbit

DOSE : 3 gm/kg

SEX/DURATION : female 29-31 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :

BINEAA Biologia Neonatorum. (Basel, Switzerland) V.1-14, 1956-69. For

publisher information, see BNEOBV. Volume(issue)/page/year: 12,282,1968

** MUTATION DATA **

TYPE OF TEST : Sister chromatid exchange

TEST SYSTEM : Human Lymphocyte

DOSE/DURATION : 10 mg/L

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

372,75,1996

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :

NOHS - National Occupational Hazard Survey (1974)

NOHS Hazard Code - 81869

No. of Facilities: 133 (estimated)

No. of Industries: 2

No. of Occupations: 4

No. of Employees: 1421 (estimated)

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - 81869

No. of Facilities: 275 (estimated)

No. of Industries: 3

No. of Occupations: 12

No. of Employees: 14731 (estimated)

No. of Female Employees: 12371 (estimated)