Rtecs number : ww2710000 chemical name : Talc (powder), containing no asbestos fibers

TRYPTOPHAN

CHEMICAL NAME : Tryptophan, DL-

CAS REGISTRY NUMBER : 54-12-6

LAST UPDATED : 199709

DATA ITEMS CITED : 6

MOLECULAR FORMULA : C11-H12-N2-O2

MOLECULAR WEIGHT : 204.25

WISWESSER LINE NOTATION : T56 BMJ D1YZVQ -DL

COMPOUND DESCRIPTOR : Tumorigen

Mutagen

* (+-)-Tryptophan

* DL-Tryptophan

* (RS)-Tryptophan

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : >1 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,

Fairview Park, Elmsford, NY 10523) V.1- 1958-

Volume(issue)/page/year:

15,2134,1966

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 844 gm/kg/92W-C

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria

Lungs, Thorax, or Respiration - tumors

Reproductive - Tumorigenic effects - testicular tumors

REFERENCE :

CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut

Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:

39,1207,1979

*** REVIEWS ***

TOXICOLOGY REVIEW

BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New

York,

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - X3905

No. of Facilities: 559 (estimated)

No. of Industries: 3

No. of Occupations: 11

No. of Employees: 6205 (estimated)

No. of Female Employees: 3513 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-human

EPA TSCA Section 8(b) CHEMICAL INVENTORY

TRYPTOPHAN (D-)

CHEMICAL NAME : Tryptophan, D-

CAS REGISTRY NUMBER : 153-94-6

LAST UPDATED : 199803

DATA ITEMS CITED : 3

MOLECULAR FORMULA : C11-H12-N2-O2

MOLECULAR WEIGHT : 204.25

WISWESSER LINE NOTATION : T56 BMJ D1YZVQ -D

SYNONYMS/TRADE NAMES :

* (+)-Tryptophan

* D-Tryptophan

* (R)-Tryptophan

* D-Tryptophane

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 4289 mg/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex)

Lungs, Thorax, or Respiration - dyspnea

Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :

ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1

E.

First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year:

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - X5536

No. of Facilities: 7 (estimated)

No. of Industries: 1

No. of Occupations: 2

No. of Employees: 307 (estimated)

No. of Female Employees: 251 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

TRYPTOPHAN (L-)

CHEMICAL NAME : Tryptophan, L-

CAS REGISTRY NUMBER : 73-22-3

OTHER CAS REGISTRY NOS. : 6912-86-3

80206-30-0

LAST UPDATED : 199904

DATA ITEMS CITED : 30

MOLECULAR FORMULA : C11-H12-N2-O2

MOLECULAR WEIGHT : 204.25

WISWESSER LINE NOTATION : T56 BMJ D1YZVQ -L

COMPOUND DESCRIPTOR : Tumorigen

Drug

Reproductive Effector

Human

SYNONYMS/TRADE NAMES :

* L-Alanine, 3-(1H-indol-3-yl)-

* (S)-alpha-Amino-1H-indole-3-propanoic acid

* alpha'-Amino-3-indolepropionic acid

* (S)-alpha-Aminoindole-3-propionic acid

* 2-Amino-3-indolylpropanoic acid

* EH 121

* Indole-3-alanine

* 1H-Indole-3-alanine, (S)-

* 1H-Indole-3-propanoic acid, alpha-amino-, (S)-

* 3-Indol-3-ylalanine

* 1-beta-3-Indolylalanine

* 3-Indol-3-ylalanine

* NCI-C01729

* Pacitron

* Propionic acid, 2-amino-3-indol-3-yl-

* L-Tryptofan

* L-Trp

* (-)-Tryptophan

* L-Tryptophan

* (S)-Tryptophan

* Tryptophane

* L-Tryptophane

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Human - woman

DOSE/DURATION : 10960 mg/kg/20W-I

TOXIC EFFECTS :

Behavioral - muscle weakness

Lungs, Thorax, or Respiration - chronic pulmonary edema

Blood - eosinophilia

REFERENCE :

BMJOAE British Medical Journal. (British Medical Assoc., BMA House,

Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-

Volume(issue)/page/year:

301,21,1990

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Human - woman

DOSE/DURATION : 2700 mg/kg/13W-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - structural or functional change in

trachea

Lungs, Thorax, or Respiration - acute pulmonary edema

Blood - eosinophilia

REFERENCE :

AIMEAS Annals of Internal Medicine. (American College of Physicians,

4200

Volume(issue)/page/year:

112,301,1990

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Human - woman

DOSE/DURATION : 3276 mg/kg/9W-I

TOXIC EFFECTS :

Behavioral - muscle weakness

Blood - eosinophilia

Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :

AIMEAS Annals of Internal Medicine. (American College of Physicians,

4200

Volume(issue)/page/year:

112,344,1990

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Human - woman

DOSE/DURATION : 9 gm/kg/22W-I

TOXIC EFFECTS :

Behavioral - muscle weakness

Liver - liver function tests impaired

Blood - eosinophilia

REFERENCE :

AIMEAS Annals of Internal Medicine. (American College of Physicians,

4200

Volume(issue)/page/year:

112,957,1990

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Human - man

DOSE/DURATION : 300 mg/kg

TOXIC EFFECTS :

Behavioral - excitement

Behavioral - antianxiety

REFERENCE :

BMJOAE British Medical Journal. (British Medical Assoc., BMA House,

Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-

Volume(issue)/page/year:

2,701,1976

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Human - man

DOSE/DURATION : 857 mg/kg/30D-I

TOXIC EFFECTS :

Blood - eosinophilia

Musculoskeletal - other changes

Skin and Appendages - other glands

REFERENCE :

NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10

Shattuck St., Boston, MA 02115) V.198- 1928-

Volume(issue)/page/year:

322,874,1990

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Human - woman

DOSE/DURATION : 4800 mg/kg/34W-I

TOXIC EFFECTS :

Peripheral Nerve and Sensation - paresthesis

Blood - eosinophilia

Skin and Appendages - other glands

REFERENCE :

NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10

Shattuck St., Boston, MA 02115) V.198- 1928-

Volume(issue)/page/year:

322,874,1990

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Human - woman

DOSE/DURATION : 5400 mg/kg/134W-I

TOXIC EFFECTS :

Blood - eosinophilia

Skin and Appendages - other glands

REFERENCE :

NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10

Shattuck St., Boston, MA 02115) V.198- 1928-

Volume(issue)/page/year:

322,874,1990

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : >16 gm/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - ptosis

Behavioral - coma

Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :

IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho

Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1-

1970-

Volume(issue)/page/year: 11,635,1980

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 1634 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - dyspnea

Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :

ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1

E.

First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year:

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Unreported

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 2553 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,

Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-

Volume(issue)/page/year: 23,884,1973

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 15 gm/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - ptosis

Lungs, Thorax, or Respiration - cyanosis

Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :

IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho

Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1-

1970-

Volume(issue)/page/year: 11,635,1980

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 4800 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity)

Lungs, Thorax, or Respiration - cyanosis

Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :

IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho

Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1-

1970-

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Bird - domestic

DOSE/DURATION : 2410 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,

Japan) Volume(issue)/page/year: -,744,1990

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 72 gm/kg/30D-C

TOXIC EFFECTS :

Liver - changes in liver weight

Kidney, Ureter, Bladder - urine volume increased

Biochemical - Enzyme inhibition, induction, or change in blood or tissue

levels - transaminases

REFERENCE :

IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho

Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1-

1970-

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intravenous

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 30 gm/kg/30D-I

TOXIC EFFECTS :

Blood - changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic - weight loss or decreased weight gain

Related to Chronic Data - changes in testicular weight

REFERENCE :

IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho

Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1-

1970-

Volume(issue)/page/year: 11,666,1980

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 9500 mg/kg/2Y-C

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Reproductive - Tumorigenic effects - uterine tumors

REFERENCE :

VOONAW Voprosy Onkologii. Problems of Oncology. For English

translation,

see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,

1928-37; V.1- 1955- Volume(issue)/page/year: 20(8),75,1974

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Implant

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 80 mg/kg

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, Bladder - tumors

REFERENCE :

CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.

Ireland

Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE : 200 mg/kg

SEX/DURATION : female 18 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - maternal-fetal exchange

REFERENCE :

LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview

Park,

Volume(issue)/page/year:

49,53,1991

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE : 1400 mg/kg

SEX/DURATION : female 15-21 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - delayed effects

REFERENCE :

BRREAP Brain Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1966- Volume(issue)/page/year:

774,265,1997

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 900 mg/kg

SEX/DURATION : female 3 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - ovaries, fallopian tubes

REFERENCE :

BIRSB5 Biology of Reproduction, Supplement. (Champaign, IL) No.1-4,

1969-71(?). Discontinued. For publisher information, see BIREBV.

Volume(issue)/page/year: 20(Suppl 1),133A,1979

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms

TEST SYSTEM : Microorganism - not otherwise specified

DOSE/DURATION : 5 gm/L

REFERENCE :

MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger

Pl.

Volume(issue)/page/year: 121,117,1973

TYPE OF TEST : Mutation test systems - not otherwise specified

TEST SYSTEM : Insect - not otherwise specified Cells - not

otherwise specified

DOSE/DURATION : 80 mmol/L

REFERENCE :

EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,

Switzerland) V.1- 1945- Volume(issue)/page/year: 35,1501,1979

TYPE OF TEST : DNA inhibition

TEST SYSTEM : Human Lymphocyte

DOSE/DURATION : 1 mmol/L

REFERENCE :

PNASA6 Proceedings of the National Academy of Sciences of the United

States

of America. (National Academy of Sciences, Printing & Pub. Office, 2101

Volume(issue)/page/year: 79,1171,1982

TYPE OF TEST : Sister chromatid exchange

TEST SYSTEM : Human Lymphocyte

DOSE/DURATION : 10 mg/L

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

372,75,1996

TYPE OF TEST : DNA inhibition

TEST SYSTEM : Rodent - rat Liver

DOSE/DURATION : 100 umol/L

REFERENCE :

CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut

Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:

45,337,1985

*** REVIEWS ***

TOXICOLOGY REVIEW

BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New

York,

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - X3075

No. of Facilities: 1257 (estimated)

No. of Industries: 6

No. of Occupations: 19

No. of Employees: 24809 (estimated)

No. of Female Employees: 18622 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat

NCITR* National Cancer Institute Carcinogenesis Technical Report Series.

(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.

Volume(issue)/page/year: NCI-TR-71,1978