Rtecs number : ww2710000 chemical name : Talc (powder), containing no asbestos fibers

TRITON X-100

CHEMICAL NAME : Triton X 45

CAS REGISTRY NUMBER : 9002-93-1

LAST UPDATED : 199803

DATA ITEMS CITED : 3

MOLECULAR FORMULA : (C2-H4-O)n.C14-H22-O

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 3800 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

PSTGAW Proceedings of the Scientific Section of the Toilet Goods

Association. (Washington, DC) No.1-48, 1944-67. Discontinued.

Volume(issue)/page/year: 20,16,1953

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999

TRIZMA BASE

CHEMICAL NAME : 1-Propanol, 2,3-dibromo-, phosphate (3:1)

CAS REGISTRY NUMBER : 126-72-7

BEILSTEIN REFERENCE NO. : 1915153

LAST UPDATED : 199904

DATA ITEMS CITED : 78

MOLECULAR FORMULA : C9-H15-Br6-O4-P

MOLECULAR WEIGHT : 697.67

WISWESSER LINE NOTATION : E1YE1OPO&O1YE1EO1YE1E

COMPOUND DESCRIPTOR : Tumorigen

Mutagen

Reproductive Effector

SYNONYMS/TRADE NAMES :

* Anfram 3PB

* APEX 462-5

* Bromkal P 67-6HP

* 2,3-Dibromo-1-propanol phosphate

* (2,3-Dibromopropyl) phosphate

* ES685

* Firemaster T23P

* Firemaster T23P-LV

* Flacavon R

* Flamex T 23P

* Flammex AP

* Flammex LV-T 23P

* Flammex T 23P

* Fyrol HB32

* NCI-C03270

* Phosphoric acid, tris(2,3-dibromopropyl) ester

* RCRA waste number U235

* TDBP

* TDBPP

* Tris-BP

* Tris(dibromopropyl)phosphate

* Tris(2,3-dibromopropyl) phosphate

* Tris(2,3-dibromopropyl) phosphoric acid ester

* Tris-2,3-dibrompropyl ester kyseliny fosforecne

* Tris-(2,3-dibrompropyl)fosfat

* Tris (flame retardant)

* USAF DO-41

* Zetifex ZN

*** HEALTH HAZARD DATA ***

** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Standard Draize test

ROUTE OF EXPOSURE : Administration onto the skin

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 2 mg/24H

REACTION SEVERITY : Severe

REFERENCE :

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,

Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:

-,1137,1986

TYPE OF TEST : Standard Draize test

ROUTE OF EXPOSURE : Administration into the eye

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 500 mg/24H

REACTION SEVERITY : Mild

REFERENCE :

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,

Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:

-,1137,1986

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 810 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity)

Liver - other changes

REFERENCE :

SRTCAC Science Reports of the Research Institutes, Tohoku University,

Series

C: Medicine. (Tohoku University, Research Institute for Tuberculosis and

Volume(issue)/page/year: 36(1-4),10,1989

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 6800 mg/kg

TOXIC EFFECTS :

Behavioral - excitement

REFERENCE :

GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and

Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)

V.1-36, 1957-1992. For publisher information, see MTPEEI

Volume(issue)/page/year: 29(12),53,1985

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 300 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: AD277-689

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Unreported

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 1149 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)

V.61-79, 1978-87. For publisher information, see JNCIEQ.

Volume(issue)/page/year: 66,691,1981

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Administration onto the skin

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : >8 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

FRCHD6 JFF/Fire Retardant Chemistry. (Technomic Pub. Co., Inc., 265 W.

State St., Westport, CN 06880) V.1- 1974- Volume(issue)/page/year:

1,205,1974

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 1400 mg/kg/7D-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in tubules (including acute renal

failure,

acute tubular necrosis)

Kidney, Ureter, Bladder - other changes in urine composition

REFERENCE :

JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,

Baffins

Volume(issue)/page/year: 7,23,1987

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Administration onto the skin

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 29510 mg/kg/13W-I

TOXIC EFFECTS :

Liver - changes in liver weight

Related to Chronic Data - changes in testicular weight

REFERENCE :

JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,

1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-

Volume(issue)/page/year: 3,979,1977

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 1330 mg/kg/76W-C

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria

Kidney, Ureter, Bladder - Kidney tumors

REFERENCE :

NCITR* National Cancer Institute Carcinogenesis Technical Report Series.

(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.

Volume(issue)/page/year: NCI-TR-76,1978

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 39 gm/kg/92W-C

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria

Lungs, Thorax, or Respiration - tumors

Liver - tumors

REFERENCE :

NCITR* National Cancer Institute Carcinogenesis Technical Report Series.

(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.

Volume(issue)/page/year: NCI-TR-76,1978

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Administration onto the skin

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 85 gm/kg/71W-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria

Lungs, Thorax, or Respiration - tumors

Gastrointestinal - tumors

REFERENCE :

CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut

Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:

38,3236,1978

TYPE OF TEST : TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 87 gm/kg/103W-C

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria

Lungs, Thorax, or Respiration - tumors

Liver - tumors

REFERENCE :

NCITR* National Cancer Institute Carcinogenesis Technical Report Series.

(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.

Volume(issue)/page/year: NCI-TR-76,1978

TYPE OF TEST : TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 3600 mg/kg/103W-C

TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria

Kidney, Ureter, Bladder - Kidney tumors

REFERENCE :

NCITR* National Cancer Institute Carcinogenesis Technical Report Series.

(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.

Volume(issue)/page/year: NCI-TR-76,1978

TYPE OF TEST : TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 1800 mg/kg/103W-C

TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria

Kidney, Ureter, Bladder - Kidney tumors

REFERENCE :

NCITR* National Cancer Institute Carcinogenesis Technical Report Series.

(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.

Volume(issue)/page/year: NCI-TR-76,1978

TYPE OF TEST : TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 43 gm/kg/103W-C

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria

Lungs, Thorax, or Respiration - tumors

Liver - tumors

REFERENCE :

NCITR* National Cancer Institute Carcinogenesis Technical Report Series.

(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.

Volume(issue)/page/year: NCI-TR-76,1978

TYPE OF TEST : TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 1820 mg/kg/2Y-C

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, Bladder - tumors

REFERENCE :

FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.

For

publisher information, see FCTOD7. Volume(issue)/page/year: 18,743,1980

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 43680 mg/kg/2Y-C

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, Bladder - tumors

REFERENCE :

FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.

For

TYPE OF TEST : TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 26 gm/kg/52W-I

TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria

Gastrointestinal - colon tumors

Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :

LAINAW Laboratory Investigation. (Williams & Wilkins Co., 428 E. Preston

St., Baltimore, MD 21202) V.1- 1952- Volume(issue)/page/year:

44,74,1981

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE : 1800 mg/kg

SEX/DURATION : female 7-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :

ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic

Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,

Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year:

(98),50,1980

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE : 250 mg/kg

SEX/DURATION : female 6-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - musculoskeletal

system

FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.

For

publisher information, see FCTOD7. Volume(issue)/page/year: 19,67,1981

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE : 450 mg/kg

SEX/DURATION : female 7-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - viability index (e.g., # alive at day

4

per # born alive)

JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of

Toxicological

Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,

Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 4,296,1979

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE : 1800 mg/kg

SEX/DURATION : female 7-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - musculoskeletal

system

REFERENCE :

Toxicological

Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,

Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 8,339,1983

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rat

DOSE : 8510 mg/kg

SEX/DURATION : male 72 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic

material,

sperm morphology, motility, and count)

Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :

JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,

Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.

Discontinued.

Volume(issue)/page/year: 5(2),153,1986

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rat

DOSE : 4260 mg/kg

SEX/DURATION : male 72 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's

gland,

accessory glands

JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,

Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.

Discontinued.

Volume(issue)/page/year: 5(2),153,1986

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms

TEST SYSTEM : Bacteria - Salmonella typhimurium

DOSE/DURATION : 2270 ug/plate

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

57,381,1978

TYPE OF TEST : Mutation in microorganisms

TEST SYSTEM : Bacteria - Salmonella typhimurium

DOSE/DURATION : 110 nmol/plate

REFERENCE :

MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,

Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:

2,287,1987

TYPE OF TEST : Mutation in microorganisms

TEST SYSTEM : Bacteria - Escherichia coli

DOSE/DURATION : 100 ug/plate

REFERENCE :

ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For

publisher information, see EMMUEG. Volume(issue)/page/year: 7(Suppl

5),1,1985

TYPE OF TEST : DNA repair

TEST SYSTEM : Bacteria - Escherichia coli

DOSE/DURATION : 10 ug/plate

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

74,107,1980

TYPE OF TEST : Specific locus test

ROUTE OF EXPOSURE : Oral

TEST SYSTEM : Insect - Drosophila melanogaster

DOSE/DURATION : 250 umol/L

REFERENCE :

CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,

Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-

Volume(issue)/page/year: 15,1197,1994

TYPE OF TEST : Sex chromosome loss and nondisjunction

ROUTE OF EXPOSURE : Unreported

TEST SYSTEM : Insect - Drosophila melanogaster

DOSE/DURATION : 1000 ppm

REFERENCE :

JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest

South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.

Volume(issue)/page/year: 3(1-2),207,1979

TYPE OF TEST : Sex chromosome loss and nondisjunction

ROUTE OF EXPOSURE : Oral

TEST SYSTEM : Insect - Drosophila melanogaster

DOSE/DURATION : 500 ppm

REFERENCE :

ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For

publisher information, see EMMUEG. Volume(issue)/page/year: 1,144,1979

TYPE OF TEST : Heritable translocation test

ROUTE OF EXPOSURE : Oral

TEST SYSTEM : Insect - Drosophila melanogaster

DOSE/DURATION : 1000 ppm/2D (Continuous)

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

57,385,1978

TYPE OF TEST : DNA damage

TEST SYSTEM : Human Cells - not otherwise specified

DOSE/DURATION : 2 mg/L

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

56,89,1977

TYPE OF TEST : Sister chromatid exchange

TEST SYSTEM : Human Embryo

DOSE/DURATION : 69700 ug/L

REFERENCE :

SNSHBT Senshokutai. Chromosome. (Sensyokutai Gakkai, Kaokusai

Kirisutokyo

Daigaku, Mitaka, Tokyo-to, Japan) No.1- 1946- Adopted new

numbering

in 1976. Volume(issue)/page/year: (20),574,1980

TYPE OF TEST : Micronucleus test

ROUTE OF EXPOSURE : Intraperitoneal

TEST SYSTEM : Rodent - rat

DOSE/DURATION : 250 umol/kg

REFERENCE :

CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,

Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-

Volume(issue)/page/year: 15,1197,1994

TYPE OF TEST : Morphological transformation

TEST SYSTEM : Rodent - rat Embryo

DOSE/DURATION : 1270 ng/plate

REFERENCE :

JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,

Baffins

Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-

TYPE OF TEST : DNA damage

ROUTE OF EXPOSURE : Intraperitoneal

TEST SYSTEM : Rodent - rat

DOSE/DURATION : 2500 nmol/L

REFERENCE :

CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.

Ireland

82,195,1992

TYPE OF TEST : DNA damage

TEST SYSTEM : Rodent - rat Liver

DOSE/DURATION : 10 umol/L

REFERENCE :

CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.

Ireland

82,195,1992

TYPE OF TEST : Unscheduled DNA synthesis

TEST SYSTEM : Rodent - rat Liver

DOSE/DURATION : 50 umol/L

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

124,213,1983

TYPE OF TEST : Body fluid assay

TEST SYSTEM : Rodent - rat Bacteria - Salmonella typhimurium

DOSE/DURATION : 500 mg/kg

REFERENCE :

CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For

publisher

information, see JTCTDW. Volume(issue)/page/year: 17,101,1980

TYPE OF TEST : Micronucleus test

ROUTE OF EXPOSURE : Intraperitoneal

TEST SYSTEM : Rodent - mouse

DOSE/DURATION : 1020 mg/kg

REFERENCE :

JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)

V.61-79, 1978-87. For publisher information, see JNCIEQ.

Volume(issue)/page/year: 66,691,1981

TYPE OF TEST : Mutation in microorganisms

TEST SYSTEM : Rodent - mouse Lymphocyte

DOSE/DURATION : 25 mg/L

REFERENCE :

JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest

South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.

Volume(issue)/page/year: 3(1-2),207,1979

TYPE OF TEST : Morphological transformation

TEST SYSTEM : Rodent - mouse Lymphocyte

DOSE/DURATION : 2500 ug/L

REFERENCE :

JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest

South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.

Volume(issue)/page/year: 3(1-2),207,1979

TYPE OF TEST : Body fluid assay

TEST SYSTEM : Rodent - mouse Bacteria - Salmonella typhimurium

DOSE/DURATION : 50 mg/kg

REFERENCE :

JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest

South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.

Volume(issue)/page/year: 3(1-2),207,1979

TYPE OF TEST : Cytogenetic analysis

ROUTE OF EXPOSURE : Intravenous

TEST SYSTEM : Rodent - mouse

DOSE/DURATION : 1500 mg/kg

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

60,329,1979

TYPE OF TEST : Cytogenetic analysis

TEST SYSTEM : Rodent - mouse Lymphocyte

DOSE/DURATION : 10 mg/L

REFERENCE :

JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest

South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.

Volume(issue)/page/year: 3(1-2),207,1979

TYPE OF TEST : Sister chromatid exchange

ROUTE OF EXPOSURE : Intravenous

TEST SYSTEM : Rodent - mouse

DOSE/DURATION : 1500 mg/kg

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

60,329,1979

TYPE OF TEST : Sister chromatid exchange

TEST SYSTEM : Rodent - mouse Lymphocyte

DOSE/DURATION : 5 mg/L

REFERENCE :

JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest

South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.

Volume(issue)/page/year: 3(1-2),207,1979

TYPE OF TEST : Sister chromatid exchange

TEST SYSTEM : Rodent - mouse Lung

DOSE/DURATION : 125 mg/kg

REFERENCE :

JNCIAM Journal of the National Cancer Institute. (Washington, DC)

V.1-60,

1940-78. For publisher information, see JJIND8.

60,1179,1978

TYPE OF TEST : Mutation in mammalian somatic cells

ROUTE OF EXPOSURE : Oral

TEST SYSTEM : Rodent - mouse

DOSE/DURATION : 1200 mg/kg/4D (Continuous)

REFERENCE :

EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41

E.

11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:

TYPE OF TEST : Mutation in mammalian somatic cells

TEST SYSTEM : Rodent - mouse Lymphocyte

DOSE/DURATION : 5 ppm

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

53,160,1978

TYPE OF TEST : Sperm Morphology

ROUTE OF EXPOSURE : Intraperitoneal

TEST SYSTEM : Rodent - mouse

DOSE/DURATION : 4085 mg/kg/5D (Intermittent)

REFERENCE :

JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)

V.61-79, 1978-87. For publisher information, see JNCIEQ.

Volume(issue)/page/year: 66,691,1981

TYPE OF TEST : Micronucleus test

ROUTE OF EXPOSURE : Intraperitoneal

TEST SYSTEM : Rodent - hamster

DOSE/DURATION : 400 mg/kg

REFERENCE :

EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon

Press,

c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591)

25, 1981-89. For publisher information, see EJCAEL

Volume(issue)/page/year:

18,1337,1982

TYPE OF TEST : Mutation in microorganisms

TEST SYSTEM : Rodent - hamster Lung

DOSE/DURATION : 20 umol/L

REFERENCE :

APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)

V.1-59,

56,20,1985

TYPE OF TEST : Morphological transformation

TEST SYSTEM : Rodent - hamster Embryo

DOSE/DURATION : 25 mg/L

REFERENCE :

EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon

Press,

V.17(7)-

Volume(issue)/page/year:

18,1337,1982

TYPE OF TEST : Cytogenetic analysis

TEST SYSTEM : Rodent - hamster Lung

DOSE/DURATION : 100 mg/L

REFERENCE :

AMONDS Applied Methods in Oncology. (Elsevier Science Pub. Co., Inc., 52

Vanderbilt Ave., New York, NY 10017) V.1- 1978-

Volume(issue)/page/year:

3,253,1980

TYPE OF TEST : Sister chromatid exchange

TEST SYSTEM : Rodent - hamster Lung

DOSE/DURATION : 5 mg/L

REFERENCE :

JNCIAM Journal of the National Cancer Institute. (Washington, DC)

V.1-60,

1940-78. For publisher information, see JJIND8.

60,1179,1978

TYPE OF TEST : Mutation in mammalian somatic cells

TEST SYSTEM : Rodent - hamster Lung

DOSE/DURATION : 20 umol/L

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

124,213,1983

TYPE OF TEST : Sister chromatid exchange

ROUTE OF EXPOSURE : Parenteral

TEST SYSTEM : Bird - chicken

DOSE/DURATION : 424 ug/kg

REFERENCE :

47JMAE "Cytogenetic Assays of Environmental Mutagens," Hsu, T.C., ed.,

Totowa, NJ, Allanheld, Osmun & Co., 1982 Volume(issue)/page/year:

-,137,1982

*** REVIEWS ***

IARC Cancer Review:Animal Sufficient Evidence

IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of

Chemicals

to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY

12210)

V.1- 1972- Volume(issue)/page/year: 20,575,1979

IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49

Sheridan Ave., Albany, NY 12210) No.1- 1979-

Volume(issue)/page/year:

7,369,1987

IARC Cancer Review:Group 2A

IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49

Sheridan Ave., Albany, NY 12210) No.1- 1979-

Volume(issue)/page/year:

7,369,1987

TOXICOLOGY REVIEW

ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,

Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 13,74,1977

TOXICOLOGY REVIEW

CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For

publisher

information, see JTCTDW. Volume(issue)/page/year: 17,101,1980

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-FINLAND;Carcinogen JAN 1993

OEL-SWEDEN;Carcinogen JAN 1993

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :

NOHS - National Occupational Hazard Survey (1974)

NOHS Hazard Code - M1916

No. of Facilities: 18 (estimated)

No. of Industries: 2

No. of Occupations: 7

No. of Employees: 206 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat

EPA GENETOX PROGRAM 1988, Positive: D melanogaster-reciprocal

translocation

EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay; Histidine

reversion-Ames test

EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-mouse; D

melanogaster

Sex-linked lethal

EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman;

In

vivo SCE-nonhuman

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999

NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,rat

NCITR* National Cancer Institute Carcinogenesis Technical Report Series.

(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.

Volume(issue)/page/year: NCI-TR-76,1978

NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be

Human Carcinogen