Rtecs number : ww2710000 chemical name : Talc (powder), containing no asbestos fibers

TROPOLONE

CHEMICAL NAME : 2,4,6-Cycloheptatrien-1-one, 2-hydroxy-

CAS REGISTRY NUMBER : 533-75-5

BEILSTEIN REFERENCE NO. : 1904978

REFERENCE : 4-08-00-00159 (Beilstein Handbook Reference)

LAST UPDATED : 199709

DATA ITEMS CITED : 4

MOLECULAR FORMULA : C7-H6-O2

MOLECULAR WEIGHT : 122.13

WISWESSER LINE NOTATION : L7VJ BQ

COMPOUND DESCRIPTOR : Drug

SYNONYMS/TRADE NAMES :

* 2-Hydroxytropone

* Purpurocatechol

* Tropolone

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 190 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold

Behavioral - excitement

Behavioral - rigidity (including catalepsy)

REFERENCE :

TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,

Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 14,217,1979

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 212 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold

Behavioral - excitement

Behavioral - rigidity (including catalepsy)

REFERENCE :

TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,

Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 14,217,1979

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 233 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold

Behavioral - analgesia

Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :

YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai,

2-12-15

Volume(issue)/page/year: 91,550,1971

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intravenous

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 106 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai,

2-12-15

Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-

TRYPAN BLUE

CHEMICAL NAME : 2,7-Naphthalenedisulfonic acid,

3,3'-((3,3'-dimethyl-4,4'-biphenylylene)bis(azo))bis(

5- amino-4-hydroxy-, tetrasodium salt

CAS REGISTRY NUMBER : 72-57-1

LAST UPDATED : 199710

DATA ITEMS CITED : 82

MOLECULAR FORMULA : C34-H28-N6-O14-S4.4Na

MOLECULAR WEIGHT : 964.88

WISWESSER LINE NOTATION : L66J BQ DSWQ HSWQ JZ CNUNR B D- 2 &-NA- 4

COMPOUND DESCRIPTOR : Tumorigen

Drug

Reproductive Effector

SYNONYMS/TRADE NAMES :

* Amanil Sky Blue R

* Amidine Blue 4B

* Azidinblau 3B

* Azidine Blue 3B

* Azurro diretto 3B

* Bencidal Blue 3B

* Benzaminblau 3B

* Benzamine Blue

* Benzamine Blue 3B

* Benzanil Blue 3BN

* Benzanil Blue R

* Benzoblau 3B

* Benzo Blue

* Benzo Blue 3B

* Benzo Blue 3BS

* Bleu diamine

* Bleu diazole N 3B

* Bleu directe 3B

* Bleue diretto 3B

* Bleu trypane N

* Blue 3B

* Blue EMB

* Brasilamina Blue 3B

* Brasilazina Blue 3B

* Centraline Blue 3B

* Chloramiblau 3B

* Chloramine Blue

* Chloramine Blue 3B

* Chlorazol Blue 3B

* Chrome Leather Blue 3B

* C.I. 23850

* C.I. Direct Blue 14

* C.I. Direct Blue 14, tetrasodium salt

* Congoblau 3B

* Congo Blue

* Congo Blue 3B

* Cresotine Blue 3B

* Diaminblau 3B

* Diamineblue

* Diamine Blue 3B

* Dianilblau

* Dianilblau H3G

* Dianil Blue

* Dianil Blue H3G

* Diaphtamine Blue TH

* Diazine Blue 3B

* Diazol Blue 3B

* Diphenyl Blue 3B

* Directblau 3B

* Direct Blue 14

* Direct Blue 3B

* Direct Blue 3BX

* Direct Blue M3B

* Directakol Blue 3BL

* Hispamin Blue 3BX

* Modr Prima 14

* Modr Trypanova

* Naphtamine Blue 3BX

* Naphthaminblau 3BX

* Naphthamine Blue 3BX

* Naphthylamine Blue

* NCI C61289

* Niagara Blue

* Niagara Blue 3B

* Orion Blue 3B

* Paramine Blue 3B

* Parkibleu

* Parkipan

* Pontamine Blue 3BX

* Pyrazol Blue 3B

* Pyrotropblau

* RCRA waste number U236

* Renolblau 3B

* Sodium ditolyldisazobis-8-amino-1-naphthol-3,6-disulfonate

* Sodium ditolyldisazobis-8-amino-1-naphthol-3,6-disulphonate

* Trianol Direct Blue 3B

* Triazolblau 3BX

* Tripan Blue

* Trypanblau

* Trypan Blue

* Trypan Blue BPC

* Trypane Blue

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 6200 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection

Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)

Volume(issue)/page/year: OTS 215154

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 300 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - acute pulmonary edema

REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine.

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-

1903/04-

Volume(issue)/page/year: 31,825,1934

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 300 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - acute pulmonary edema

REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine.

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-

1903/04-

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Intravenous

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 300 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - acute pulmonary edema

REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine.

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-

1903/04-

Volume(issue)/page/year: 31,825,1934

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 350 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - acute pulmonary edema

REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine.

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-

1903/04-

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 267 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NNAPBA Naunyn-Schmiedebergs Archiv fuer Pharmakologie. (Berlin, Ger.)

V.264-271, 1969-71. For publisher information, see NSAPCC.

Volume(issue)/page/year: 267,31,1970

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intravenous

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 328 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

23,537,1972

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 400 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - acute pulmonary edema

REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine.

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-

1903/04-

Volume(issue)/page/year: 31,825,1934

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Intravenous

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 100 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - acute pulmonary edema

REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine.

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-

1903/04-

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - guinea pig

DOSE/DURATION : 250 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - acute pulmonary edema

REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine.

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-

1903/04-

Volume(issue)/page/year: 31,825,1934

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - guinea pig

DOSE/DURATION : 300 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - acute pulmonary edema

REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine.

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-

1903/04-

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 630 mg/kg/43W-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria

Tumorigenic - tumors at site of application

REFERENCE :

BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific

Pub. Ltd., POB 88, Oxford, UK) V.1- 1920- Volume(issue)/page/year:

33,524,1952

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 250 mg/kg/10W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Blood - lymphoma, including Hodgkin's disease

REFERENCE :

CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment

Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-

Volume(issue)/page/year: 5,792,1952

TYPE OF TEST : TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 7500 mg/kg/86W-I

TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria

Liver - tumors

Tumorigenic - tumors at site of application

REFERENCE :

LAINAW Laboratory Investigation. (Williams & Wilkins Co., 428 E. Preston

St., Baltimore, MD 21202) V.1- 1952- Volume(issue)/page/year:

12,1221,1963

TYPE OF TEST : TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 1275 mg/kg/34W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Liver - tumors

Blood - leukemia

REFERENCE :

APHGBP Acta Pathologica (Belgrade). (Belgrade Univerzitet, Institute de

Pathologie, Belgrade, Yugoslavia) V.2/3- 1938-

Volume(issue)/page/year:

33,1,1953

TYPE OF TEST : TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 1300 mg/kg/1Y-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Liver - tumors

Blood - lymphoma, including Hodgkin's disease

REFERENCE :

AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal

Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1-

1925-

Volume(issue)/page/year: 106,326,1982

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 300 mg/kg/6W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Liver - tumors

Blood - lymphoma, including Hodgkin's disease

REFERENCE :

AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal

Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1-

1925-

TYPE OF TEST : TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 620 mg/kg/31W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Liver - tumors

REFERENCE :

GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan)

V.1-75,

1907-84. For publisher information, see JJCREP.

48,573,1957

TYPE OF TEST : TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE : Unreported

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 700 mg/kg/4W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Liver - tumors

REFERENCE :

FZPAAZ Frankfurter Zeitschrift fuer Pathologie. (Munich, Fed. Rep. Ger.)

V.1-77, 1907-67. For publisher information, see VAAZA2.

Volume(issue)/page/year: 75,74,1966

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE : 150 mg/kg

SEX/DURATION : female 7-9 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

Reproductive - Specific Developmental Abnormalities - Central Nervous

System

system

MEXPAG Medicina Experimentalis. (Basel, Switzerland) V.1-11, 1959-64;

V.18-19, 1968-69. For publisher information, see JNMDBO.

Volume(issue)/page/year: 10,201,1964

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rat

DOSE : 40 mg/kg

SEX/DURATION : female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - musculoskeletal

system

(circulatory) system

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development.

(Alan

R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rat

DOSE : 12500 ug/kg

SEX/DURATION : female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

Reproductive - Effects on Embryo or Fetus - fetal death

Reproductive - Specific Developmental Abnormalities - Central Nervous

System

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams

&

Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rat

DOSE : 12500 ug/kg

SEX/DURATION : female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - body wall

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams

&

Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rat

DOSE : 30 mg/kg

SEX/DURATION : female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,

e.g., stunted fetus)

Reproductive - Specific Developmental Abnormalities - Central Nervous

System

Reproductive - Specific Developmental Abnormalities - eye/ear

TJADAB Teratology, The International Journal of Abnormal Development.

(Alan

R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rat

DOSE : 14 mg/kg

SEX/DURATION : female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - eye/ear

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development.

(Alan

R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE : 10 mg/kg

SEX/DURATION : female 7 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - behavioral

REFERENCE :

ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic

Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,

Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year:

(103),75,1985

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE : 50 mg/kg

SEX/DURATION : female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

Reproductive - Specific Developmental Abnormalities - Central Nervous

System

Reproductive - Specific Developmental Abnormalities - eye/ear

JEEMAF Journal of Embryology and Experimental Morphology. (Essex, UK)

V.1-98, 1953-86. For Publisher information, see DEVPED

Volume(issue)/page/year: 11,175,1963

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE : 50 mg/kg

SEX/DURATION : female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - musculoskeletal

system

JEEMAF Journal of Embryology and Experimental Morphology. (Essex, UK)

V.1-98, 1953-86. For Publisher information, see DEVPED

Volume(issue)/page/year: 11,175,1963

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE : 50 mg/kg

SEX/DURATION : female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - cardiovascular

(circulatory) system

REFERENCE :

AJANA2 American Journal of Anatomy. (Alan R. Liss, Inc., 41 E. 11th St.,

New York, NY 10003) V.1-192, 1901-91. Volume(issue)/page/year:

102,65,1958

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intravenous

SPECIES OBSERVED : Rodent - rat

DOSE : 50 mg/kg

SEX/DURATION : female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - litter size (e.g. # fetuses per litter;

measured

Reproductive - Specific Developmental Abnormalities - Central Nervous

System

REFERENCE :

NY

10003) V.1- 1906/08- Volume(issue)/page/year: 159,453,1967

ROUTE OF EXPOSURE : Intravenous

SPECIES OBSERVED : Rodent - rat

DOSE : 15 mg/kg

SEX/DURATION : female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

REFERENCE :

ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York,

NY

10003) V.1- 1906/08- Volume(issue)/page/year: 159,453,1967

ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Rodent - rat

DOSE : 5 mg/kg

SEX/DURATION : female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - cardiovascular

(circulatory) system

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development.

(Alan

R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Rodent - rat

DOSE : 50 mg/kg

SEX/DURATION : female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

REFERENCE :

NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ

08736)

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Rodent - rat

DOSE : 150 mg/kg

SEX/DURATION : female 8-10 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - Central Nervous

System

Reproductive - Specific Developmental Abnormalities - musculoskeletal

REFERENCE :

JOANAY Journal of Anatomy. (Cambridge Univ. Press, 32 E. 57th St., New

York, NY 10022) V.51- 1916- Volume(issue)/page/year: 100,361,1966

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Unreported

SPECIES OBSERVED : Rodent - rat

DOSE : 225 mg/kg

SEX/DURATION : female 7-9 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - Central Nervous

System

system

DMCSAD Developmental Medicine and Child Neurology, Supplement. (William

Heinemann Medical Books Ltd., 23 Bedford Sq., London WC1B 3HT, UK) V.5-

1962- Volume(issue)/page/year: 25,50,1971

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intrauterine

SPECIES OBSERVED : Rodent - rat

DOSE : 2500 ug/kg

SEX/DURATION : female 6 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

REFERENCE :

NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.

(Nippon

Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,

Volume(issue)/page/year:

83,433,1984

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE : 100 mg/kg

SEX/DURATION : female 6 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - other measures of fertility

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development.

(Alan

R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE : 66667 ug/kg

SEX/DURATION : female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - Central Nervous

System

Reproductive - Specific Developmental Abnormalities - eye/ear

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development.

(Alan

Volume(issue)/page/year: 3,371,1970

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE : 66667 ug/kg

SEX/DURATION : female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,

e.g., stunted fetus)

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development.

(Alan

R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE : 1 gm/kg

SEX/DURATION : female 8-12 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

Reproductive - Effects on Newborn - live birth index (measured after

birth)

Reproductive - Effects on Newborn - viability index (e.g., # alive at day

per # born alive)

REFERENCE :

TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,

Inc.,

41 E. 11th St., New York, NY 10003) V.1- 1980-

7,7,1987

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE : 100 mg/kg

SEX/DURATION : female 7 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - other developmental

abnormalities

REFERENCE :

JEZOAO Journal of Experimental Zoology. (Alan R. Liss, Inc., 41 E. 11th

St., New York, NY 10003) V.1- 1904- Volume(issue)/page/year:

171,343,1969

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 25 mg/kg

SEX/DURATION : female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,

e.g., stunted fetus)

Reproductive - Specific Developmental Abnormalities - other developmental

abnormalities

REFERENCE :

NNAPBA Naunyn-Schmiedebergs Archiv fuer Pharmakologie. (Berlin, Ger.)

V.264-271, 1969-71. For publisher information, see NSAPCC.

Volume(issue)/page/year: 267,31,1970

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 160 mg/kg

SEX/DURATION : female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

Reproductive - Fertility - litter size (e.g. # fetuses per litter;

measured

Reproductive - Specific Developmental Abnormalities - musculoskeletal

system

REFERENCE :

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

31,191,1975

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 45 mg/kg

SEX/DURATION : female 6-14 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - Central Nervous

System

Reproductive - Specific Developmental Abnormalities - eye/ear

(including nose and tongue)

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: PB223-160

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 45 mg/kg

SEX/DURATION : female 6-14 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: PB223-160

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rabbit

DOSE : 150 mg/kg

SEX/DURATION : female 1 day(s) pre-mating

female 2-7 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - Central Nervous

System

system

system

ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York,

NY

10003) V.1- 1906/08- Volume(issue)/page/year: 133,513,1959

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rabbit

DOSE : 150 mg/kg

SEX/DURATION : female 1 day(s) pre-mating

female 2-7 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :

ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York,

NY

10003) V.1- 1906/08- Volume(issue)/page/year: 133,513,1959

ROUTE OF EXPOSURE : Intravenous

SPECIES OBSERVED : Mammal - pig

DOSE : 100 mg/kg

SEX/DURATION : female 10 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - cardiovascular

(circulatory) system

Reproductive - Specific Developmental Abnormalities - gastrointestinal

system

JPDSA3 Journal of Pediatric Surgery. (Grune and Stratton, Inc., Journal

Subscription Dept., POB 6280, Duluth, MN 55806) V.1- 1966-

Volume(issue)/page/year: 5,232,1970

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - guinea pig

DOSE : 40 mg/kg

SEX/DURATION : female 11 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,

e.g., stunted fetus)

Reproductive - Fertility - litter size (e.g. # fetuses per litter;

measured

Reproductive - Maternal Effects - parturition

REFERENCE :

ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York,

NY

10003) V.1- 1906/08- Volume(issue)/page/year: 141,173,1961

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - guinea pig

DOSE : 40 mg/kg

SEX/DURATION : female 11 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - craniofacial

(including nose and tongue)

Reproductive - Specific Developmental Abnormalities - musculoskeletal

system

REFERENCE :

ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York,

NY

10003) V.1- 1906/08- Volume(issue)/page/year: 141,173,1961

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - guinea pig

DOSE : 40 mg/kg

SEX/DURATION : female 11 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

REFERENCE :

ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York,

NY

10003) V.1- 1906/08- Volume(issue)/page/year: 136,270,1960

ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Rodent - guinea pig

DOSE : 33 mg/kg

SEX/DURATION : female 11 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

REFERENCE :

ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York,

NY

10003) V.1- 1906/08- Volume(issue)/page/year: 157,617,1967

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - hamster

DOSE : 20 ug/kg

SEX/DURATION : female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetal death

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,

e.g., stunted fetus)

REFERENCE :

LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview

Park,

Volume(issue)/page/year:

8,525,1969

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - hamster

DOSE : 20 ug/kg

SEX/DURATION : female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - Central Nervous

System

Reproductive - Specific Developmental Abnormalities - body wall

REFERENCE :

LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview

Park,

Volume(issue)/page/year:

8,525,1969

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - hamster

DOSE : 130 ug/kg

SEX/DURATION : female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - musculoskeletal

system

REFERENCE :

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-

1903/04-

Volume(issue)/page/year: 130,1168,1969

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - hamster

DOSE : 900 ug/kg

SEX/DURATION : female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - other developmental

abnormalities

REFERENCE :

AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,

11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-

Volume(issue)/page/year: 123,705,1975

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Mammal - species unspecified

DOSE : 25 mg/kg

SEX/DURATION : female 18 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,

e.g., stunted fetus)

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development.

(Alan

R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Mammal - species unspecified

DOSE : 25 mg/kg

SEX/DURATION : female 13 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - craniofacial

(including nose and tongue)

Reproductive - Specific Developmental Abnormalities - body wall

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development.

(Alan

R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Mammal - species unspecified

DOSE : 50 mg/kg

SEX/DURATION : female 13 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - musculoskeletal

system

Reproductive - Specific Developmental Abnormalities - urogenital system

TJADAB Teratology, The International Journal of Abnormal Development.

(Alan

R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms

TEST SYSTEM : Bacteria - Salmonella typhimurium

DOSE/DURATION : 33 ug/plate

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

189,223,1987

TYPE OF TEST : DNA adduct

TEST SYSTEM : Bacteria - Escherichia coli

DOSE/DURATION : 20 umol/L

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

89,95,1981

TYPE OF TEST : Mutation in microorganisms

TEST SYSTEM : Mold - Aspergillus nidulans

DOSE/DURATION : 50 mg/L

REFERENCE :

NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ

08736)

TYPE OF TEST : Unscheduled DNA synthesis

ROUTE OF EXPOSURE : Oral

TEST SYSTEM : Rodent - rat

DOSE/DURATION : 125 mg/kg

REFERENCE :

ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For

publisher information, see EMMUEG. Volume(issue)/page/year: 5,488,1983

TYPE OF TEST : Unscheduled DNA synthesis

TEST SYSTEM : Rodent - rat Liver

DOSE/DURATION : 10 umol/L

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

136,255,1984

TYPE OF TEST : Body fluid assay

TEST SYSTEM : Rodent - rat Bacteria - Salmonella typhimurium

DOSE/DURATION : 500 mg/kg

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

156,131,1985

TYPE OF TEST : Cytogenetic analysis

ROUTE OF EXPOSURE : Intraperitoneal

TEST SYSTEM : Rodent - mouse

DOSE/DURATION : 100 mg/kg

REFERENCE :

CNJGA8 Canadian Journal of Genetics and Cytology. (National Research

Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,

Canada) V.1- 1959- Volume(issue)/page/year: 10,91,1968

TYPE OF TEST : Unscheduled DNA synthesis

TEST SYSTEM : Rodent - hamster Liver

DOSE/DURATION : 100 umol/L

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

136,255,1984

*** REVIEWS ***

IARC Cancer Review:Animal Sufficient Evidence

IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of

Chemicals

to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY

12210)

V.1- 1972- Volume(issue)/page/year: 8,267,1975

IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of

Chemicals

to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY

12210)

V.1- 1972- Volume(issue)/page/year: 8,267,1975

IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49

Sheridan Ave., Albany, NY 12210) No.1- 1979-

Volume(issue)/page/year:

7,56,1987

TOXICOLOGY REVIEW

ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72.

Discontinued. Volume(issue)/page/year: 1,131,1966

TOXICOLOGY REVIEW

CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby

Co.,

11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1960-

TOXICOLOGY REVIEW

ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75.

For

TOXICOLOGY REVIEW

JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial

Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year:

59,1,1961

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :

NOHS - National Occupational Hazard Survey (1974)

NOHS Hazard Code - M2160

No. of Facilities: 62 (estimated)

No. of Industries: 3

No. of Occupations: 11

No. of Employees: 1759 (estimated)

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - M2160

No. of Facilities: 55 (estimated)

No. of Industries: 1

No. of Occupations: 3

No. of Employees: 813 (estimated)

No. of Female Employees: 623 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; B subtilis

rec assay

EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE

FEREAC Federal Register. (U.S. Government Printing Office, Supt. of

Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:

47,26992,82

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999