Rtecs number : ww2710000 chemical name : Talc (powder), containing no asbestos fibers

TUBOCURARINE CHLORIDE

CHEMICAL NAME : Tubocurarine, dichloride, (+)-

CAS REGISTRY NUMBER : 57-94-3

LAST UPDATED : 199707

DATA ITEMS CITED : 13

MOLECULAR FORMULA : C38-H44-N2-O6.2Cl

MOLECULAR WEIGHT : 695.74

WISWESSER LINE NOTATION : T E6 J6 J-6 T6-18-6 B6 A E- E-- T- 2BJ- I& IO QK

B&O

I&K&&T&T&TJ KQ LO1 Q1 Q1 WQ D&O1 I&1 I&1

Mutagen

* Amerizol

* Curarin-haf

* Delacurarine

* Dextrotubocurarine chloride

* d-7',12'-Dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraranium

chloride

* Intocostrin

* Intocostrine T

* d-Paracurarine chloride

* Tubadil

* Tubarine

* Tubocurarine chloride

* Tubocurarine, chloride, hydrochloride, (+)-

* (+)-Tubocurarine chloride

* d-Tubocurarine chloride

* d-Tubocurarine dichloride

* Tubocurarine hydrochloride

* (+)-Tubocurarine hydrochloride

* d-Tubocurarine hydrochloride

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 28 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine.

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-

1903/04-

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 340 ug/kg

TOXIC EFFECTS :

Behavioral - muscle weakness

Lungs, Thorax, or Respiration - respiratory depression

Lungs, Thorax, or Respiration - other changes

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,

Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,117,1975

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 310 ug/kg

TOXIC EFFECTS :

Behavioral - muscle weakness

Lungs, Thorax, or Respiration - respiratory depression

Lungs, Thorax, or Respiration - other changes

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,

Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,117,1975

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intravenous

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 66 ug/kg

TOXIC EFFECTS :

Behavioral - muscle weakness

Lungs, Thorax, or Respiration - respiratory depression

Lungs, Thorax, or Respiration - other changes

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,

Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,117,1975

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 33 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine.

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-

1903/04-

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 420 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

RPTOAN Russian Pharmacology and Toxicology (English Translation).

Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton,

Surrey,

UK) V.30- 1967- Volume(issue)/page/year: 32,74,1969

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 640 ug/kg

TOXIC EFFECTS :

Behavioral - muscle weakness

Lungs, Thorax, or Respiration - respiratory depression

Lungs, Thorax, or Respiration - other changes

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,

Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,117,1975

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intravenous

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 97 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.

(Heymans

1898- Volume(issue)/page/year: 109,191,1957

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 540 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical

Journal.

For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095

Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 24(12),24,1990

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intravenous

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 170 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical

Journal.

Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 24(12),24,1990

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intravenous

SPECIES OBSERVED : Rodent - guinea pig

DOSE/DURATION : 66 ug/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold

Lungs, Thorax, or Respiration - other changes

REFERENCE :

JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co.,

11830

Volume(issue)/page/year: 34,516,1949

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - X5569

No. of Facilities: 34 (estimated)

No. of Industries: 1

No. of Occupations: 3

No. of Employees: 1010 (estimated)

No. of Female Employees: 668 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9; Histidine

reversion-Ames test