Rtecs number : ww2710000 chemical name : Talc (powder), containing no asbestos fibers

TESTOSTERONE PROPIONATE (17,BETA-)

CHEMICAL NAME : Testosterone, propionate

CAS REGISTRY NUMBER : 57-85-2

LAST UPDATED : 199706

DATA ITEMS CITED : 81

MOLECULAR FORMULA : C22-H32-O3

MOLECULAR WEIGHT : 344.54

WISWESSER LINE NOTATION : L E5 B666 OV MUTJ A1 E1 FOV2 -B&AEF

COMPOUND DESCRIPTOR : Tumorigen

Drug

Reproductive Effector

Human

Hormone

* Agovirin

* delta(sup 4)-Androstene-17-beta-propionate-3-one

* Androst-4-en-3-one, 17-(1-oxopropoxy)-(17-beta)-

* Andrusol-P

* Androteston

* Androtest P

* Anertan

* Aquaviron

* Bio-testiculina

* Enarmon

* Homandren

* neo-Hombreol

* Hormoteston

* Masenate

* Nasdol

* Okasa-Mascul

* Orchiol

* Orchistin

* Oreton

* Oreton propionate

* Pantestin

* Propiokan

* Recthormone testosterone

* Synandrol

* Sterandryl

* Synerone

* Telipex

* Testaform

* Testex

* Testodet

* Vulvan

* Testodrin

* Testogen

* Testonique

* Testormol

* Testosteron propionate

* Testosterone-17-beta-propionate

* Testoviron (ampule)

* Testoxyl

* Testrex

* Tostrin

* TP

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 1 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,

Japan) Volume(issue)/page/year: 6,487,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 585 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,

Japan) Volume(issue)/page/year: 6,487,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : >5 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,

Japan) Volume(issue)/page/year: 6,487,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 1350 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,

Japan) Volume(issue)/page/year: 6,487,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 970 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,

Japan) Volume(issue)/page/year: 6,487,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : >5 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,

Japan) Volume(issue)/page/year: 6,487,1982

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 3900 mg/kg/26W-I

TOXIC EFFECTS :

Liver - changes in liver weight

Kidney, Ureter, Bladder - changes in bladder weight

Endocrine - changes in spleen weight

REFERENCE :

KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda

Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-

Volume(issue)/page/year: 7,2786,1973

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 1560 mg/kg/26W-I

TOXIC EFFECTS :

Cardiac - changes in heart weight

Kidney, Ureter, Bladder - changes in bladder weight

Endocrine - changes in thymus weight

REFERENCE :

KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda

Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-

Volume(issue)/page/year: 7,2786,1973

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 10 mg/kg

TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria

Skin and Appendages - tumors

REFERENCE :

JSONDX Journal of Soviet Oncology. (New York, NY) V.1-5, 1980-84.

Volume(issue)/page/year: 5,396,1984

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Implant

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 432 mg/kg/48W-C

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Reproductive - Tumorigenic effects - prostate tumors

REFERENCE :

CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut

Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:

37,1929,1977

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Implant

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 5200 mg/kg/65W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Lungs, Thorax, or Respiration - tumors

Reproductive - Tumorigenic effects - uterine tumors

REFERENCE :

NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ

08736)

V.1- 1869- Volume(issue)/page/year: 192,1303,1961

ROUTE OF EXPOSURE : Implant

SPECIES OBSERVED : Rodent - hamster

DOSE/DURATION : 360 mg/kg

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Musculoskeletal - tumors

Reproductive - Tumorigenic effects - other reproductive system tumors

REFERENCE :

CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut

Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:

25,141,1965

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Human - man

DOSE : 10714 ug/kg

SEX/DURATION : male 30 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic

material,

sperm morphology, motility, and count)

REFERENCE :

CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022)

V.1-

1970- Volume(issue)/page/year: 5,295,1972

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Human - man

DOSE : 4286 ug/kg

SEX/DURATION : male 14 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic

material,

sperm morphology, motility, and count)

REFERENCE :

ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of

Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-

Volume(issue)/page/year: 55,725,1952

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Human - woman

DOSE : 3 mg/kg

SEX/DURATION : female 6 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine.

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-

1903/04-

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Human - man

DOSE : 8570 ug/kg

SEX/DURATION : male 24 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic

material,

sperm morphology, motility, and count)

Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :

JCENA4 Journal of Clinical Endocrinology. (Springfield, IL) V.1-11,

1941-51. For publisher information, see JCEMAZ.

Volume(issue)/page/year:

10,816,1950

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Human - woman

DOSE : 18500 ug/kg

SEX/DURATION : female 31 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - menstrual cycle changes or disorders

Reproductive - Fertility - other measures of fertility

REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine.

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-

1903/04-

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE : 100 mg/kg

SEX/DURATION : female 17-20 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :

ECJPAE Endocrinologia Japonica. (Japan Pub. Trading Co., Ltd., POB 5030,

Tokyo International, Tokyo, Japan) V.1- 1954-

Volume(issue)/page/year:

24,77,1977

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE : 25 mg/kg

SEX/DURATION : female 16-20 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :

ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,

Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-

Volume(issue)/page/year: 36,1069,1986

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rat

DOSE : 4550 mg/kg

SEX/DURATION : male 26 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct

Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's

gland,

accessory glands

KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda

Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-

Volume(issue)/page/year: 7,2786,1973

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rat

DOSE : 4550 mg/kg

SEX/DURATION : female 26 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - ovaries, fallopian tubes

Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :

KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda

Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-

Volume(issue)/page/year: 7,2786,1973

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE : 50 ug/kg

SEX/DURATION : female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - ovaries, fallopian tubes

Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :

JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book

Depot,

POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE : 200 ug/kg

SEX/DURATION : male 20 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :

JOURAA Journal of Urology. (Williams & Wilkins Co., 428 E. Preston St.,

Baltimore, MD 21202) V.1- 1917- Volume(issue)/page/year: 45,780,1941

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE : 7500 ug/kg

SEX/DURATION : female 17 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

Reproductive - Effects on Newborn - delayed effects

REFERENCE :

JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,

Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-

Volume(issue)/page/year: 48,477,1970

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE : 50 ug/kg

SEX/DURATION : female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - other measures of fertility

REFERENCE :

ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E,

DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year:

49,193,1965

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE : 6250 ug/kg

SEX/DURATION : female 15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - skin and skin

appendages

REFERENCE :

AAMMAU Archives d'Anatomie Microscopique et de Morphologie Experimentale.

(SPPIF, B.P.22, F-41353 Vineuil, France) V.36-76, 1947-1987. For

publisher

information, see BSTME2. Volume(issue)/page/year: 66,207,1977

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE : 6250 ug/kg

SEX/DURATION : multigenerations

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced

weight

REFERENCE :

AAMMAU Archives d'Anatomie Microscopique et de Morphologie Experimentale.

(SPPIF, B.P.22, F-41353 Vineuil, France) V.36-76, 1947-1987. For

publisher

information, see BSTME2. Volume(issue)/page/year: 66,207,1977

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE : 50 ug/kg

SEX/DURATION : female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - menstrual cycle changes or disorders

Reproductive - Fertility - mating performance (e.g. # sperm positive

females

per # females mated; # copulations per # estrus cycles)

pregnant

REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine.

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-

1903/04-

Volume(issue)/page/year: 122,88,1966

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - rat

DOSE : 6250 ug/kg

SEX/DURATION : female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - ovaries, fallopian tubes

REFERENCE :

JPHYA7 Journal of Physiology. (Cambridge Univ. Press, 32 E. 57th St.,

New

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - rat

DOSE : 1200 ug/kg

SEX/DURATION : female 9-14 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - litter size (e.g. # fetuses per litter;

measured

before birth)

Reproductive - Specific Developmental Abnormalities - musculoskeletal

system

weight

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,

Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,723,1973

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - rat

DOSE : 3600 ug/kg

SEX/DURATION : female 9-14 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

Reproductive - Effects on Newborn - live birth index (measured after

birth)

Reproductive - Effects on Newborn - weaning or lactation index (e.g., #

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,

Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,723,1973

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - rat

DOSE : 3600 ug/kg

SEX/DURATION : female 9-14 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,

e.g., stunted fetus)

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,

Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,723,1973

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - rat

DOSE : 50 ug/kg

SEX/DURATION : female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - female fertility index (e.g. # females

pregnant

per # sperm positive females; # females pregnant per # females mated)

REFERENCE :

JPHYA7 Journal of Physiology. (Cambridge Univ. Press, 32 E. 57th St.,

New

York, NY 10022) V.1- 1878- Volume(issue)/page/year: 172,393,1964

ROUTE OF EXPOSURE : Intracerebral

SPECIES OBSERVED : Rodent - rat

DOSE : 10 ug/kg

SEX/DURATION : female 77 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - ovaries, fallopian tubes

Reproductive - Maternal Effects - menstrual cycle changes or disorders

Reproductive - Maternal Effects - other effects

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.

Preston

79,1135,1966

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Rodent - rat

DOSE : 15 mg/kg

SEX/DURATION : female 15-20 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - behavioral

REFERENCE :

JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,

Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-

Volume(issue)/page/year: 25,549,1962

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Rodent - rat

DOSE : 250 ug/kg

SEX/DURATION : female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - ovaries, fallopian tubes

Reproductive - Fertility - other measures of fertility

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.

Preston

77,859,1965

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Rodent - rat

DOSE : 500 ug/kg

SEX/DURATION : female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.

Preston

77,859,1965

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Rodent - rat

DOSE : 92 mg/kg

SEX/DURATION : male 23 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - mating performance (e.g. # sperm positive

females

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.

Preston

29,409,1941

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Implant

SPECIES OBSERVED : Rodent - rat

DOSE : 10 ug/kg

SEX/DURATION : female 77 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - ovaries, fallopian tubes

Reproductive - Maternal Effects - uterus, cervix, vagina

Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.

Preston

79,1135,1966

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Implant

SPECIES OBSERVED : Rodent - rat

DOSE : 30 ug/kg

SEX/DURATION : female 77 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - other effects

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.

Preston

79,1135,1966

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Unreported

SPECIES OBSERVED : Rodent - rat

DOSE : 20 mg/kg

SEX/DURATION : male 5 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - mating performance (e.g. # sperm positive

females

REFERENCE :

ANENAG Annales d'Endocrinologie. (Masson Editeur, 120 Blvd.

Saint-Germain,

F-25280 Paris Cedex 06, France) V.1- 1939- Volume(issue)/page/year:

24(Suppl 3),1,1963

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Unreported

SPECIES OBSERVED : Rodent - rat

DOSE : 3500 mg/kg

SEX/DURATION : female 10-16 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - female fertility index (e.g. # females

pregnant

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :

SAKNAH Soobshcheniia Akademii Nauk Gruzinskoi SSR. (V/O Mezhdunarodnaya

Kniga, 113095 Moscow, USSR) V.2- 1941- Volume(issue)/page/year:

64,737,1971

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Multiple routes

SPECIES OBSERVED : Rodent - rat

DOSE : 52500 ug/kg

SEX/DURATION : female 15 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - other effects

REFERENCE :

SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H

St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:

181,770,1973

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 4 mg/kg

SEX/DURATION : male 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct

Reproductive - Fertility - mating performance (e.g. # sperm positive

females

REFERENCE :

DEPBA5 Developmental Psychobiology. (John Wiley & Sons, Inc., 605 Third

Ave., New York, NY 10158) V.1- 1968- Volume(issue)/page/year:

12,231,1979

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 200 mg/kg

SEX/DURATION : female 12 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - skin and skin

appendages

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.

Preston

76,789,1965

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 40 mg/kg

SEX/DURATION : female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - female fertility index (e.g. # females

pregnant

REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine.

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-

1903/04-

Volume(issue)/page/year: 85,673,1954

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 20 mg/kg

SEX/DURATION : female 10 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - other effects

REFERENCE :

ECJPAE Endocrinologia Japonica. (Japan Pub. Trading Co., Ltd., POB 5030,

Tokyo International, Tokyo, Japan) V.1- 1954-

Volume(issue)/page/year:

23,327,1976

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 190 mg/kg

SEX/DURATION : male 35 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's

gland,

REFERENCE :

JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,

Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-

Volume(issue)/page/year: 46,477,1970

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - mouse

DOSE : 15 mg/kg

SEX/DURATION : female 7-12 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - musculoskeletal

system

Reproductive - Specific Developmental Abnormalities - urogenital system

weight

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,

Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,723,1973

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - mouse

DOSE : 15 mg/kg

SEX/DURATION : female 7-12 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - litter size (e.g. # fetuses per litter;

measured

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,

e.g., stunted fetus)

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,

Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,723,1973

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - mouse

DOSE : 240 mg/kg

SEX/DURATION : female 7-12 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - eye/ear

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,

Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,723,1973

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intracerebral

SPECIES OBSERVED : Rodent - mouse

DOSE : 2 mg/kg

SEX/DURATION : female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - ovaries, fallopian tubes

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development.

(Alan

Volume(issue)/page/year: 25,351,1982

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intracerebral

SPECIES OBSERVED : Rodent - mouse

DOSE : 2 mg/kg

SEX/DURATION : male 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic

material,

sperm morphology, motility, and count)

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development.

(Alan

Volume(issue)/page/year: 25,351,1982

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Mammal - dog

DOSE : 30 mg/kg

SEX/DURATION : male 60 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic

material,

sperm morphology, motility, and count)

Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :

JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland

Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year:

27,327,1989

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rabbit

DOSE : 24500 ug/kg

SEX/DURATION : male 49 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic

material,

sperm morphology, motility, and count)

Reproductive - Fertility - male fertility index (e.g. # males

impregnating

females per # males exposed to fertile nonpregnant females)

REFERENCE :

EXCEDS Experimental and Clinical Edocrinology. (Johann Ambrosius Barth

Verlag, Postfach 109, Leipzig DDR-7010, Ger. Dem. Rep.) V.81- 1983-

Volume(issue)/page/year: 81,137,1983

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rabbit

DOSE : 1500 ug/kg

SEX/DURATION : female 27-29 day(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - postpartum

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

Reproductive - Fertility - abortion

REFERENCE :

JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book

Depot,

POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rabbit

DOSE : 10 mg/kg

SEX/DURATION : female 5 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :

ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York,

NY

10003) V.1- 1906/08- Volume(issue)/page/year: 142,469,1962

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rabbit

DOSE : 500 ug/kg

SEX/DURATION : male 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - mating performance (e.g. # sperm positive

females

REFERENCE :

JPHYA7 Journal of Physiology. (Cambridge Univ. Press, 32 E. 57th St.,

New

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - rabbit

DOSE : 15750 ug/kg

SEX/DURATION : male 21 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic

material,

sperm morphology, motility, and count)

REFERENCE :

IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical

Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-

Volume(issue)/page/year: 71,375,1980

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Mammal - pig

DOSE : 142 mg/kg

SEX/DURATION : female 40-77 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

Reproductive - Effects on Newborn - delayed effects

REFERENCE :

ENDKAC Endokrinologie. (Leipzig, Ger. Dem. Rep.) V.1-80, 1928-82. For

publisher information, see EXCEDS. Volume(issue)/page/year: 63,161,1974

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Mammal - pig

DOSE : 140 mg/kg

SEX/DURATION : female 29-35 day(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :

BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309

W.

Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year:

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Mammal - pig

DOSE : 140 mg/kg

SEX/DURATION : female 39-45 day(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :

BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309

W.

Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year:

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - guinea pig

DOSE : 80 mg/kg

SEX/DURATION : female 30-45 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - mating performance (e.g. # sperm positive

females

per # females mated; # copulations per # estrus cycles)

Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :

JCPPAV Journal of Comparative and Physiological Psychology. (Washington,

DC) V.40-96, 1947-82. Volume(issue)/page/year: 57,166,1964

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - guinea pig

DOSE : 150 mg/kg

SEX/DURATION : female 28-58 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - delayed effects

REFERENCE :

HOBEAO Hormones and Behavior. (Academic Press, Inc., 1 E. First St.,

Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 6,139,1975

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - guinea pig

DOSE : 110 mg/kg

SEX/DURATION : female 50 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - other effects

Reproductive - Fertility - male fertility index (e.g. # males

impregnating

females per # males exposed to fertile nonpregnant females)

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.

Preston

72,429,1963

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Rodent - guinea pig

DOSE : 98 mg/kg

SEX/DURATION : female 24-68 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

Reproductive - Effects on Newborn - delayed effects

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.

Preston

St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Mammal - horse, donkey

DOSE : 1575 ug/kg

SEX/DURATION : male 9 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's

gland,

accessory glands

JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309

W.

Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year:

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Mammal - cattle

DOSE : 5500 ug/kg

SEX/DURATION : female 40-60 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :

JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309

W.

Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year:

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Mammal - domestic

DOSE : 693 mg/kg

SEX/DURATION : female 40-60 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - endocrine system

Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :

JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309

W.

Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year:

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Implant

SPECIES OBSERVED : Mammal - domestic

DOSE : 3045 ug/kg

SEX/DURATION : female 40-60 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced

weight

gain)

Reproductive - Effects on Newborn - physical

REFERENCE :

JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309

W.

Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year:

** MUTATION DATA **

TYPE OF TEST : Cytogenetic analysis

ROUTE OF EXPOSURE : Unreported

TEST SYSTEM : Fish - not otherwise specified

DOSE/DURATION : 500 ug

REFERENCE :

BEXBBO Biochemistry and Experimental Biology. (Padua, Italy) V.10-16,

1971/72-80. Suspended. Volume(issue)/page/year: 15,329,1980

TYPE OF TEST : Sperm Morphology

ROUTE OF EXPOSURE : Unreported

TEST SYSTEM : Fish - not otherwise specified

DOSE/DURATION : 500 ug

REFERENCE :

BEXBBO Biochemistry and Experimental Biology. (Padua, Italy) V.10-16,

1971/72-80. Suspended. Volume(issue)/page/year: 15,329,1980

TYPE OF TEST : DNA damage

TEST SYSTEM : Rodent - rat Liver

DOSE/DURATION : 300 umol/L

REFERENCE :

SinJF# Personal Communication from J.F. Sina, Merck Institute for

Therapeutic Research, West Point, PA 19486, Oct. 26, 1982

Volume(issue)/page/year: 26OCT1982

TYPE OF TEST : Sperm Morphology

ROUTE OF EXPOSURE : Subcutaneous

TEST SYSTEM : Rodent - rat

DOSE/DURATION : 10 mg/kg

REFERENCE :

AMTUA3 Acta Medica Turcica. (Dr. Ayhan Okcuoglu, Cocuk Hastalikari

Klinigi,

1948-58;

TYPE OF TEST : Morphological transformation

TEST SYSTEM : Rodent - hamster Embryo

DOSE/DURATION : 1 mg/L

REFERENCE :

CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,

Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-

Volume(issue)/page/year: 16,1329,1995

*** REVIEWS ***

IARC Cancer Review:Animal Sufficient Evidence

IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of

Chemicals

to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY

12210)

TOXICOLOGY REVIEW

CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment

Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-

Volume(issue)/page/year: 40,1825,1977

TOXICOLOGY REVIEW

ACRSAJ Advances in Cancer Research. (Academic Press, Inc., 465 S.

Lincoln

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - X6098

No. of Facilities: 7 (estimated)

No. of Industries: 1

No. of Occupations: 2

No. of Employees: 628 (estimated)

No. of Female Employees: 314 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Sperm

morphology-human

EPA TSCA Section 8(b) CHEMICAL INVENTORY