Rtecs number : ww2710000 chemical name : Talc (powder), containing no asbestos fibers

TETRABROMOPHTHALIC ANHYDRIDE

CHEMICAL NAME : Phthalic anhydride, tetrabromo-

CAS REGISTRY NUMBER : 632-79-1

BEILSTEIN REFERENCE NO. : 0018908

REFERENCE : 5-17-11-00265 (Beilstein Handbook Reference)

LAST UPDATED : 199806

DATA ITEMS CITED : 11

MOLECULAR FORMULA : C8-Br4-O3

MOLECULAR WEIGHT : 463.72

COMPOUND DESCRIPTOR : Mutagen

Primary Irritant

SYNONYMS/TRADE NAMES :

* Bromophthal

* FG 400

* 1,3-Isobenzofurandione, 4,5,6,7-tetrabromo-

* PHT 4

* Saytex RB 49

* Tetrabromophthalic anhydride

* 3,4,5,6-Tetrabromophthalic anhydride

*** HEALTH HAZARD DATA ***

** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Standard Draize test

ROUTE OF EXPOSURE : Administration into the eye

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 100 mg

REACTION SEVERITY : Mild

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: OTS0523271

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : >10 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: OTS0539755

TYPE OF TEST : LC - Lethal concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : >10920 mg/m3/4H

TOXIC EFFECTS :

Behavioral - changes in motor activity (specific assay)

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: OTS0522251

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Administration onto the skin

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : >10 gm/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity)

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: OTS0522251

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Administration onto the skin

SPECIES OBSERVED : Rodent - guinea pig

DOSE/DURATION : >1 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: OTS0521611

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 2 gm/m3/4H/3W-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - changes in lung weight

Gastrointestinal - changes in structure or function of salivary glands

Liver - changes in liver weight

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: OTS0523277

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Administration onto the skin

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 100 gm/kg/4W-I

TOXIC EFFECTS :

Behavioral - ataxia

Nutritional and Gross Metabolic - weight loss or decreased weight gain

Related to Chronic Data - death

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: OTS0523276

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999

TETRABROMOXYLENE

CHEMICAL NAME : m-Xylene, alpha,alpha,alpha',alpha'-tetrabromo-

CAS REGISTRY NUMBER : 36323-28-1

BEILSTEIN REFERENCE NO. : 1954342

REFERENCE : 3-05-00-00839 (Beilstein Handbook Reference)

LAST UPDATED : 199701

DATA ITEMS CITED : 2

MOLECULAR FORMULA : C8-H6-Br4

MOLECULAR WEIGHT : 421.78

WISWESSER LINE NOTATION : EYER CYEE

SYNONYMS/TRADE NAMES :

* Benzene, 1,3-bis(dibromomethyl)-

* 1,3-Bis(dibromomethyl)benzene

* alpha,alpha,alpha',alpha'-Tetrabromo-m-xylene

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intravenous

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 56 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

CSLNX* U.S. Army Armament Research & Development Command, Chemical

Systems

Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD

Volume(issue)/page/year: NX#00642

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY