Rtecs number : ww2710000 chemical name : Talc (powder), containing no asbestos fibers

TEREPHTHALIC DICHLORIDE

CHEMICAL NAME : Terephthaloyl chloride

CAS REGISTRY NUMBER : 100-20-9

BEILSTEIN REFERENCE NO. : 0607796

REFERENCE : 4-09-00-03318 (Beilstein Handbook Reference)

LAST UPDATED : 199710

DATA ITEMS CITED : 12

MOLECULAR FORMULA : C8-H4-Cl2-O2

MOLECULAR WEIGHT : 203.02

WISWESSER LINE NOTATION : GVR DVG

COMPOUND DESCRIPTOR : Reproductive Effector

SYNONYMS/TRADE NAMES :

* 1,4-Benzenedicarbonyl chloride

* 1,4-Benzenedicarbonyl dichloride

* p-Phenylenedicarbonyl dichloride

* p-Phthaloyl chloride

* p-Phthaloyl dichloride

* Terephthalic acid chloride

* Terephthalic acid dichloride

* Terephthalic dichloride

* Terephthaloyl dichloride

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 2500 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,

Academic Press, Inc., 1969 Volume(issue)/page/year: -,475,1969

TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 700 mg/m3/4H

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - lacrimation

Lungs, Thorax, or Respiration - dyspnea

Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: OTS0533726

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 2140 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity)

Lungs, Thorax, or Respiration - dyspnea

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O

Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-

Volume(issue)/page/year: 49(12),35,1984

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 950 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity)

Lungs, Thorax, or Respiration - dyspnea

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O

Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-

Volume(issue)/page/year: 49(12),35,1984

TYPE OF TEST : LD - Lethal dose

ROUTE OF EXPOSURE : Administration onto the skin

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : >200 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: OTS0533726

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 4168 mg/kg/26W-I

TOXIC EFFECTS :

Liver - other changes

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O

Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-

Volume(issue)/page/year: 49(12),40,1984

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE : 4122 mg/kg

SEX/DURATION : male 26 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic

material,

sperm morphology, motility, and count)

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O

Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-

Volume(issue)/page/year: 49(12),35,1984

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE : 4122 mg/kg

SEX/DURATION : female 26 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O

Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-

Volume(issue)/page/year: 49(12),35,1984

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - X4188

No. of Facilities: 27 (estimated)

No. of Industries: 1

No. of Occupations: 1

No. of Employees: 212 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999

TERGITOL

CHEMICAL NAME : Tergitol 15-S-5

CAS REGISTRY NUMBER : 68131-40-8

LAST UPDATED : 199710

DATA ITEMS CITED : 9

COMPOUND DESCRIPTOR : Primary Irritant

*** HEALTH HAZARD DATA ***

** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Open irritation test

ROUTE OF EXPOSURE : Administration onto the skin

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 500 mg

REACTION SEVERITY : Mild

REFERENCE :

UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury

Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/16/1968

TYPE OF TEST : Standard Draize test

ROUTE OF EXPOSURE : Administration into the eye

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 100 mg

REACTION SEVERITY : Mild

REFERENCE :

UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury

Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/16/1968

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 8570 uL/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury

Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/16/1968

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Administration onto the skin

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 4 mL/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury

Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/16/1968

*** U.S. STANDARDS AND REGULATIONS ***

EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION

FEREAC Federal Register. (U.S. Government Printing Office, Supt. of

Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:

54,7740,1989

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - X9200

No. of Facilities: 5213 (estimated)

No. of Industries: 72

No. of Occupations: 62

No. of Employees: 131650 (estimated)

No. of Female Employees: 41446 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999