Rtecs number : ww2710000 chemical name : Talc (powder), containing no asbestos fibers

TETRACHLOROETHENE

CHEMICAL NAME : Ethylene, tetrachloro-

CAS REGISTRY NUMBER : 127-18-4

BEILSTEIN REFERENCE NO. : 1361721

REFERENCE : 4-01-00-00715 (Beilstein Handbook Reference)

LAST UPDATED : 199907

DATA ITEMS CITED : 115

MOLECULAR FORMULA : C2-Cl4

MOLECULAR WEIGHT : 165.82

WISWESSER LINE NOTATION : GYGUYGG

COMPOUND DESCRIPTOR : Agricultural Chemical

Tumorigen

Drug

Mutagen

Human

SYNONYMS/TRADE NAMES :

* Ankilostin

* Antisol 1

* Carbon bichloride

* Carbon dichloride

* Czterochloroetylen

* Didakene

* Dilatin PT

* Dow-per

* ENT 1,860

* Ethene, tetrachloro-

* Ethylene tetrachloride

* Fedal-UN

* NCI-C04580

* PER

* Perchloorethyleen, per

* Perchlor

* Perchloraethylen, per

* Perchlorethylene

* Perchloroethylene

* Perclene

* Perclene D

* Percloroetilene

* Percosolve

* PERK

* Perklone

* RCRA waste number U210

* Tetlen

* Tetracap

* Tetrachlooretheen

* Tetrachloraethen

* Tetrachlorethylene

* Tetrachloroethene

* Tetrachloroethylene

* 1,1,2,2-Tetrachloroethylene

* Tetrachloroethylene

* Tetracloroetene

* Tetraleno

* Tetralex

* Tetravec

* Tetroguer

* Tetropil

*** HEALTH HAZARD DATA ***

** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Standard Draize test

ROUTE OF EXPOSURE : Administration onto the skin

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 810 mg/24H

REACTION SEVERITY : Severe

REFERENCE :

EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris,

France) V.7-9, 1974-76. For publisher information, see TOERD9.

Volume(issue)/page/year: 9,171,1976

TYPE OF TEST : Standard Draize test

ROUTE OF EXPOSURE : Administration onto the skin

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 500 mg/24H

REACTION SEVERITY : Mild

REFERENCE :

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,

Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:

-,108,1986

TYPE OF TEST : Standard Draize test

ROUTE OF EXPOSURE : Administration into the eye

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 162 mg

REACTION SEVERITY : Mild

REFERENCE :

EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris,

France) V.7-9, 1974-76. For publisher information, see TOERD9.

Volume(issue)/page/year: 9,171,1976

TYPE OF TEST : Standard Draize test

ROUTE OF EXPOSURE : Administration into the eye

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 500 mg/24H

REACTION SEVERITY : Mild

REFERENCE :

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,

Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:

-,108,1986

** ACUTE TOXICITY DATA **

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Human

DOSE/DURATION : 96 ppm/7H

TOXIC EFFECTS :

Peripheral Nerve and Sensation - local anesthetic

Sense Organs and Special Senses (Eye) - conjunctive irritation

Behavioral - hallucinations, distorted perceptions

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: PB257-185

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Human - child

DOSE/DURATION : 545 mg/kg

TOXIC EFFECTS :

Behavioral - coma

REFERENCE :

JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270

Madison Ave., New York, NY 10016) V.19- 1982-

Volume(issue)/page/year:

23,103,1985

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Human - man

DOSE/DURATION : 600 ppm/10M

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - conjunctive irritation

Behavioral - general anesthetic

REFERENCE :

AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.

(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.

Volume(issue)/page/year: 5,566,1952

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 2629 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf

Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:

20,364,1959

TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 34200 mg/m3/8H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf

Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:

20,364,1959

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 4678 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,

Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 40,411,1986

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Intratracheal

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 450 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: OTS0520615

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 8100 mg/kg

TOXIC EFFECTS :

Behavioral - general anesthetic

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: PB257-185

TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 5200 ppm/4H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)

V.1-59,

9,303,1953

TYPE OF TEST : LD - Lethal dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : >500 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

CBCCT* "Summary Tables of Biological Tests," National Research Council

Chemical-Biological Coordination Center. (National Academy of Science

Library, 2101 Constitution Ave., NW, Washington, DC 20418)

Volume(issue)/page/year: 4,378,1952

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 65 gm/kg

TOXIC EFFECTS :

Behavioral - sleep

Behavioral - ataxia

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams

&

Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Mammal - dog

DOSE/DURATION : 4 gm/kg

TOXIC EFFECTS :

Behavioral - sleep

Behavioral - somnolence (general depressed activity)

REFERENCE :

AJHYA2 American Journal of Hygiene. (Baltimore, MD) V.1-80, 1921-64.

For

publisher information, see AJEPAS. Volume(issue)/page/year: 9,430,1929

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Mammal - dog

DOSE/DURATION : 2100 mg/kg

TOXIC EFFECTS :

Liver - liver function tests impaired

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

10,119,1967

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Intravenous

SPECIES OBSERVED : Mammal - dog

DOSE/DURATION : 85 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK)

V.2-21,

1929-48. For publisher information, see JPPMAB.

7,205,1934

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Mammal - cat

DOSE/DURATION : 4 gm/kg

TOXIC EFFECTS :

Behavioral - sleep

Behavioral - somnolence (general depressed activity)

REFERENCE :

AJHYA2 American Journal of Hygiene. (Baltimore, MD) V.1-80, 1921-64.

For

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 5 gm/kg

TOXIC EFFECTS :

Behavioral - sleep

Behavioral - somnolence (general depressed activity)

REFERENCE :

AJHYA2 American Journal of Hygiene. (Baltimore, MD) V.1-80, 1921-64.

For

publisher information, see AJEPAS. Volume(issue)/page/year: 9,430,1929

ROUTE OF EXPOSURE : Administration onto the skin

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : >3228 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: AD-A180-198

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 2200 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK)

V.2-21,

1929-48. For publisher information, see JPPMAB.

7,205,1934

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 14 gm/kg/4W-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - other changes in urine composition

REFERENCE :

ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,

Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 59,427,1992

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 36 gm/kg/90D-C

TOXIC EFFECTS :

Nutritional and Gross Metabolic - weight loss or decreased weight gain

Biochemical - Enzyme inhibition, induction, or change in blood or tissue

levels - phosphatases

REFERENCE :

FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,

see TOSCF2 Volume(issue)/page/year: 7,119,1986

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 3 gm/kg/6W-I

TOXIC EFFECTS :

Liver - other changes

Liver - changes in liver weight

Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

78,105,1985

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 1750 ppm/6H/14D-I

TOXIC EFFECTS :

Related to Chronic Data - death

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research

Triangle Park, NC 27709) No.206- Volume(issue)/page/year:

NTP-TR-311,1986

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 19300 mg/m3/24H/94D-C

TOXIC EFFECTS :

Brain and Coverings - recordings from specific areas of CNS

Biochemical - Enzyme inhibition, induction, or change in blood or tissue

levels - true cholinesterase

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O

Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-

Volume(issue)/page/year: 42(8),50,1977

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 200 ppm/4W-C

TOXIC EFFECTS :

Biochemical - Enzyme inhibition, induction, or change in blood or tissue

levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,

etc.)

levels - other oxidoreductases

Biochemical - Enzyme inhibition, induction, or change in blood or tissue

levels - transaminases

REFERENCE :

TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year:

54,207,1990

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 7000 ppm/8H/50D-I

TOXIC EFFECTS :

Liver - hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, Bladder - changes in blood vessels or in circulation of

kidney

REFERENCE :

JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)

V.18-31, 1936-49. For publisher information, see AEHLAU.

Volume(issue)/page/year: 19,323,1937

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 49750 ug/kg/3D-I

TOXIC EFFECTS :

Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

Liver - other changes

REFERENCE :

TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co.,

POB 2155, Princeton, NJ 08540) V.1- 1985- Volume(issue)/page/year:

8,191,1992

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 200 ppm/4H/8W-I

TOXIC EFFECTS :

Liver - fatty liver degeneration

REFERENCE :

APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)

V.1-59,

1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 1750 ppm/6H/14D-I

TOXIC EFFECTS :

Liver - fatty liver degeneration

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research

Triangle Park, NC 27709) No.206- Volume(issue)/page/year:

NTP-TR-311,1986

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 1600 ppm/6H/13W-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in tubules (including acute renal

failure,

Kidney, Ureter, Bladder - other changes

Related to Chronic Data - death

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research

Triangle Park, NC 27709) No.206- Volume(issue)/page/year:

NTP-TR-311,1986

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 2500 ppm/7H/39D-I

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity)

REFERENCE :

AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.

(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.

Volume(issue)/page/year: 5,566,1952

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - guinea pig

DOSE/DURATION : 200 ppm/7H/32W-I

TOXIC EFFECTS :

Liver - changes in liver weight

Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :

AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.

(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.

Volume(issue)/page/year: 5,566,1952

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - gerbil

DOSE/DURATION : 120 ppm/24H/1Y-C

TOXIC EFFECTS :

Brain and Coverings - other degenerative changes

Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :

TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year:

22,343,1984

** TUMORIGENIC DATA **

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 200 ppm/6H/2Y-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria

Blood - leukemia

Reproductive - Tumorigenic effects - testicular tumors

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research

Triangle Park, NC 27709) No.206- Volume(issue)/page/year:

NTP-TR-311,1986

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 195 gm/kg/50W-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria

Liver - tumors

REFERENCE :

NCITR* National Cancer Institute Carcinogenesis Technical Report Series.

(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.

Volume(issue)/page/year: NCI-TR-13,1977

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 100 ppm/6H/2Y-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria

Liver - tumors

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research

Triangle Park, NC 27709) No.206- Volume(issue)/page/year:

NTP-TR-311,1986

TYPE OF TEST : TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 240 gm/kg/62W-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria

Liver - tumors

REFERENCE :

NCITR* National Cancer Institute Carcinogenesis Technical Report Series.

(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.

Volume(issue)/page/year: NCI-TR-13,1977

TYPE OF TEST : TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 200 ppm/6H/2Y-I

TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria

Kidney, Ureter, Bladder - Kidney tumors

Blood - leukemia

REFERENCE :

TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year:

31(Suppl),16,1986

TYPE OF TEST : TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 100 ppm/6H/2Y-I

TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria

Liver - tumors

REFERENCE :

TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year:

31(Suppl),16,1986

** REPRODUCTIVE DATA **

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - rat

DOSE : 1000 ppm/24H

SEX/DURATION : female 14 day(s) pre-mating

female 1-22 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - musculoskeletal

system

APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings.

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802)

Volume(issue)/page/year: 19,A21,1980

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - rat

DOSE : 1000 ppm/24H

SEX/DURATION : female 1-22 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,

e.g., stunted fetus)

REFERENCE :

APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings.

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802)

Volume(issue)/page/year: 19,A21,1980

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - rat

DOSE : 900 ppm/7H

SEX/DURATION : female 7-13 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - live birth index (measured after

birth)

Reproductive - Effects on Newborn - behavioral

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development.

(Alan

R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - rat

DOSE : 300 ppm/7H

SEX/DURATION : female 6-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

32,84,1975

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - mouse

DOSE : 300 ppm/7H

SEX/DURATION : female 6-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,

e.g., stunted fetus)

Reproductive - Specific Developmental Abnormalities - musculoskeletal

system

Reproductive - Specific Developmental Abnormalities - homeostasis

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

32,84,1975

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - mouse

DOSE : 500 ppm/7H

SEX/DURATION : male 5 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic

material,

sperm morphology, motility, and count)

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: PB82-185075

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms

TEST SYSTEM : Bacteria - Salmonella typhimurium

DOSE/DURATION : 50 uL/plate

REFERENCE :

NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.

of

Health, Education, and Welfare, Reports and Memoranda.

TYPE OF TEST : Unscheduled DNA synthesis

TEST SYSTEM : Human Lung

DOSE/DURATION : 100 mg/L

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: PB82-185075

TYPE OF TEST : Morphological transformation

TEST SYSTEM : Rodent - rat Embryo

DOSE/DURATION : 97 umol/L

REFERENCE :

ITCSAF In Vitro. (Rockville, MD) V.1-20, 1965-85. For publisher

information, see ICDBEO. Volume(issue)/page/year: 14,290,1978

TYPE OF TEST : Cytogenetic analysis

ROUTE OF EXPOSURE : Inhalation

TEST SYSTEM : Rodent - rat

DOSE/DURATION : 500 ppm

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: PB82-185075

TYPE OF TEST : DNA damage

ROUTE OF EXPOSURE : Intraperitoneal

TEST SYSTEM : Rodent - mouse

DOSE/DURATION : 4 mmol/kg

REFERENCE :

TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year:

31,31,1986

TYPE OF TEST : Mutation test systems - not otherwise specified

ROUTE OF EXPOSURE : Oral

TEST SYSTEM : Rodent - mouse

DOSE/DURATION : 1 gm/kg

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

343,157,1995

TYPE OF TEST : Host-mediated assay

TEST SYSTEM : Rodent - mouse Bacteria - Salmonella typhimurium

DOSE/DURATION : 100 ppm

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: PB82-185075

TYPE OF TEST : Sperm Morphology

ROUTE OF EXPOSURE : Inhalation

TEST SYSTEM : Rodent - mouse

DOSE/DURATION : 500 ppm

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: PB82-185075

TYPE OF TEST : Sex chromosome loss and nondisjunction

TEST SYSTEM : Rodent - hamster Lung

DOSE/DURATION : 190 umol/L

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

182,135,1987

*** REVIEWS ***

ACGIH TLV-Animal carcinogen

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices

(BEIs) booklet issues by American Conference of Governmental Industrial

Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:

TLV/BEI,1997

ACGIH TLV-STEL 685 mg/m3 (100 ppm)

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices

(BEIs) booklet issues by American Conference of Governmental Industrial

Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:

TLV/BEI,1997

ACGIH TLV-TWA 170 mg/m3 (25 ppm)

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices

(BEIs) booklet issues by American Conference of Governmental Industrial

Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:

TLV/BEI,1997

IARC Cancer Review:Animal Sufficient Evidence

IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49

Sheridan Ave., Albany, NY 12210) No.1- 1979-

Volume(issue)/page/year:

7,355,1987

IARC Cancer Review:Animal Sufficient Evidence

IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of

Chemicals

to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY

12210)

IARC Cancer Review:Human Limited Evidence

IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of

Chemicals

to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY

12210)

IARC Cancer Review:Human Inadequate Evidence

IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49

Sheridan Ave., Albany, NY 12210) No.1- 1979-

Volume(issue)/page/year:

7,355,1987

IARC Cancer Review:Group 2B

IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49

Sheridan Ave., Albany, NY 12210) No.1- 1979-

Volume(issue)/page/year:

7,355,1987

IARC Cancer Review:Group 2A

IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of

Chemicals

to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY

12210)

TOXICOLOGY REVIEW

CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park,

Elmsford, NY 10523) V.1- 1972- Volume(issue)/page/year: 6,517,1977

TOXICOLOGY REVIEW

AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave.,

New

York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965

EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION

FEREAC Federal Register. (U.S. Government Printing Office, Supt. of

Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:

54,7740,1989

MSHA STANDARD-air:TWA 100 ppm (670 mg/m3)

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices

(BEIs) booklet issues by American Conference of Governmental Industrial

Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:

3,201,1971

OSHA PEL (Gen Indu):8H TWA 100 ppm;CL 200;Pk 300/5M/3H

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,

Supt.

of Documents, Washington, DC 20402) Volume(issue)/page/year:

OSHA PEL (Construc):8H TWA 100 ppm (670 mg/m3)

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,

Supt.

29,1926.55,1994

OSHA PEL (Shipyard):8H TWA 100 ppm (670 mg/m3)

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,

Supt.

of Documents, Washington, DC 20402) Volume(issue)/page/year:

OSHA PEL (Fed Cont):8H TWA 100 ppm (670 mg/m3)

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,

Supt.

41,50-204.50,1994

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-ARAB Republic of Egypt:TWA 5 ppm (35 mg/m3);Skin JAN 1993

OEL-AUSTRIA: MAK 50 ppm (345 mg/m3), Suspected Carcinogen, JAN1999

OEL-AUSTRALIA:TWA 50 ppm (335 mg/m3);STEL 150 ppm;Carcinogen JAN 1993

OEL-BELGIUM:TWA 50 ppm (339 mg/m3);STEL 200 ppm (1368 mg/m3) JAN 1993

OEL-DENMARK: TWA 10 ppm (70 mg/m3), Skin, JAN1999

OEL-FINLAND:TWA 50 ppm (335 mg/m3);STEL 75 ppm (520 mg/m3);Skin JAN 1993

OEL-JAPAN: OEL 50 ppm (340 mg/m3), 2B Carcinogen, JAN1999

OEL-GERMANY:TWA 50 ppm (345 mg/m3);Carcinogen JAN 1993

OEL-HUNGARY:STEL 50 mg/m3;Skin;Carcinogen JAN 1993

OEL-POLAND: MAC(TWA) 60 mg/m3, MAC(STEL) 480 mg/m3, JAN1999

OEL-JAPAN:TWA 50 ppm (340 mg/m3) JAN 1993

OEL-THE NETHERLANDS:TWA 35 ppm (240 mg/m3);Skin JAN 1993

OEL-THE PHILIPPINES:TWA 100 ppm (670 mg/m3) JAN 1993

OEL-RUSSIA:TWA 50 ppm;STEL 10 mg/m3 JAN 1993

OEL-SWEDEN:TWA 10 ppm (70 mg/m3);STEL 25 ppm (170 mg/m3) JAN 1993

OEL-SWITZERLAND:TWA 50 ppm (345 mg/m3);STEL 100 ppm;Skin JAN 1993

OEL-THAILAND:TWA 100 ppm;STEL 200 ppm JAN 1993

OEL-UNITED KINGDOM:TWA 50 ppm (335 mg/m3);STEL 150 ppm JAN 1993

OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV

OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :

NIOSH REL TO TETRACHLOROETHYLENE-air:CA lowest feasible conc.

REFERENCE :

NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.

of

Health, Education, and Welfare, Reports and Memoranda.

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :

NOHS - National Occupational Hazard Survey (1974)

NOHS Hazard Code - 54790

No. of Facilities: 52013 (estimated)

No. of Industries: 288

No. of Occupations: 155

No. of Employees: 549154 (estimated)

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - 54790

No. of Facilities: 49025 (estimated)

No. of Industries: 268

No. of Occupations: 151

No. of Employees: 688110 (estimated)

No. of Female Employees: 177342 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo

EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S

cerevisiae-homozygosis

EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-reversion

EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat

EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA Section 8(e) Risk Notification, 8EHQ-1292-8618;8EHQ-0393-8618

EPA TSCA Section 8(e) Risk Notification, 8EHQ-0294-8618;8EHQ-0393-8762

On EPA IRIS database

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999

NIOSH CURRENT INTELLIGENCE BULLETIN 20, 1978

NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003

NIOSH Analytical Method, 1996: Volatile organic compound, 2549

NCI Carcinogenesis Bioassay (gavage);clear evidence:mouse

NCITR* National Cancer Institute Carcinogenesis Technical Report Series.

(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.

Volume(issue)/page/year: NCI-TR-13,1977

NTP Carcinogenesis Studies (inhalation);clear evidence:mouse,rat

NTPTR* National Toxicology Program Technical Report Series. (Research

Triangle Park, NC 27709) No.206- Volume(issue)/page/year:

NTP-TR-311,1986

NCI Carcinogenesis Bioassay (gavage);inadequate studies:rat

NCITR* National Cancer Institute Carcinogenesis Technical Report Series.

(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.

Volume(issue)/page/year: NCI-TR-13,1977

NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be

Human Carcinogen