Rtecs number : ww2710000 chemical name : Talc (powder), containing no asbestos fibers

TETRACHLOROPHTHALIC ANHYDRIDE

CHEMICAL NAME : Phthalic anhydride, tetrachloro-

CAS REGISTRY NUMBER : 117-08-8

BEILSTEIN REFERENCE NO. : 0211560

REFERENCE : 5-17-11-00260 (Beilstein Handbook Reference)

LAST UPDATED : 199907

DATA ITEMS CITED : 12

MOLECULAR FORMULA : C8-Cl4-O3

MOLECULAR WEIGHT : 285.88

COMPOUND DESCRIPTOR : Tumorigen

Primary Irritant

SYNONYMS/TRADE NAMES :

* CP 626

* 1,3-Isobenzofurandione, 4,5,6,7-tetrachloro-

* NCI-C61585

* Niagathal

* 4,5,6,7-Tetrachloro-1,3-isobenzofurandione

* Tetrachlorophthalic anhydride

* Tetrathal

*** HEALTH HAZARD DATA ***

** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Standard Draize test

ROUTE OF EXPOSURE : Administration into the eye

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 100 mg

REACTION SEVERITY : Mild

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research

Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-93-3351

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : >15800 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research

Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-93-3351

TYPE OF TEST : LC - Lethal concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : >3600 mg/m3/4H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research

Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-93-3351

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Administration onto the skin

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : >5 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research

Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-93-3351

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 68250 mg/kg/13W-I

TOXIC EFFECTS :

Liver - changes in liver weight

Kidney, Ureter, Bladder - changes in tubules (including acute renal

failure,

Related to Chronic Data - death

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research

Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-93-3351

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 5 mg/m3/6H/13W-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - changes in lung weight

Endocrine - hyperglycemia

Blood - changes in leukocyte (WBC) count

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: OTS0538630

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :

NOHS - National Occupational Hazard Survey (1974)

NOHS Hazard Code - M3316

No. of Facilities: 55 (estimated)

No. of Industries: 2

No. of Occupations: 3

No. of Employees: 142 (estimated)

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - M3316

No. of Facilities: 43 (estimated)

No. of Industries: 4

No. of Occupations: 6

No. of Employees: 2067 (estimated)

No. of Female Employees: 786 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8912

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999

NTP Toxicity studies, RPT# TOX-28, May 1999

TETRACYANOETHYLENE

CHEMICAL NAME : Ethenetetracarbonitrile

CAS REGISTRY NUMBER : 670-54-2

LAST UPDATED : 199809

DATA ITEMS CITED : 8

MOLECULAR FORMULA : C6-N4

MOLECULAR WEIGHT : 128.10

WISWESSER LINE NOTATION : NCYCN&UYCN&CN

SYNONYMS/TRADE NAMES :

* delta(sup 2,2')-Bimalononitrile

* Tetracyanoethene

* 1,1,2,2-Tetracyanoethene

* Tetracyanoethylene

* 1,1,2,2-Tetracyanoethylene

* Tetrakyanethylen

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 5 mg/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - effect, not otherwise specified

Behavioral - somnolence (general depressed activity)

Skin and Appendages - hair

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: OTS0536977

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 5 mg/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - effect, not otherwise specified

Behavioral - somnolence (general depressed activity)

Skin and Appendages - hair

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: OTS0536977

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 5 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold

Vascular - regional or general arteriolar or venous dilation

Lungs, Thorax, or Respiration - dyspnea

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: OTS0536977

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 1 mg/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - effect, not otherwise specified

Behavioral - somnolence (general depressed activity)

Skin and Appendages - hair

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: OTS0536977

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intravenous

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 4500 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

CSLNX* U.S. Army Armament Research & Development Command, Chemical

Systems

21010)

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Administration onto the skin

SPECIES OBSERVED : Rodent - guinea pig

DOSE/DURATION : 100 mg/kg

TOXIC EFFECTS :

Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: OTS0536977

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999