Rtecs number : ww2710000 chemical name : Talc (powder), containing no asbestos fibers

TEREPHTHALALDEHYDE

CHEMICAL NAME : Terephthalaldehyde

CAS REGISTRY NUMBER : 623-27-8

LAST UPDATED : 199701

DATA ITEMS CITED : 2

MOLECULAR FORMULA : C8-H6-O2

MOLECULAR WEIGHT : 134.14

WISWESSER LINE NOTATION : VHR DVH

SYNONYMS/TRADE NAMES :

* p-Benzenedicarboxaldehyde

* 1,4-Benzenedicarboxaldehyde

* 1,4-Diformylbenzene

* p-Formylbenzaldehyde

* 4-Formylbenzaldehyde

* p-Phthalaldehyde

* Terephtaldehyde

* Terephtaldehydes

* Terephthalic aldehyde

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Unreported

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 1154 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.

(Paris, France) V.1-261, 1835-1965. For publisher information, see

CRASEV.

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

TEREPHTHALIC ACID

CHEMICAL NAME : Terephthalic acid

CAS REGISTRY NUMBER : 100-21-0

BEILSTEIN REFERENCE NO. : 1909333

REFERENCE : 4-09-00-03301 (Beilstein Handbook Reference)

LAST UPDATED : 199904

DATA ITEMS CITED : 16

MOLECULAR FORMULA : C8-H6-O4

MOLECULAR WEIGHT : 166.14

WISWESSER LINE NOTATION : QVR DVQ

COMPOUND DESCRIPTOR : Drug

Mutagen

SYNONYMS/TRADE NAMES :

* Acide terephtalique

* p-Benzenedicarboxylic acid

* 1,4-Benzenedicarboxylic acid

* p-Carboxybenzoic acid

* p-Dicarboxybenzoic acid

* Kyselina tereftalova

* TA-33MP

* Terephthalic acid

* WR 16262

*** HEALTH HAZARD DATA ***

** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Standard Draize test

ROUTE OF EXPOSURE : Administration into the eye

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 500 mg/24H

REACTION SEVERITY : Mild

REFERENCE :

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,

Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:

-,317,1986

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : >6400 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)

Volume(issue)/page/year: 21MAY1971

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 3200 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)

Volume(issue)/page/year: 21MAY1971

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 1430 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co.,

USA,

Volume(issue)/page/year: 16,1655,1968

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Intravenous

SPECIES OBSERVED : Mammal - dog

DOSE/DURATION : 767 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

18,469,1971

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 364 gm/kg/1Y-C

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - effect, not otherwise specified

Liver - changes in liver weight

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: OTS0570926

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 104 gm/kg/2Y-C

TOXIC EFFECTS :

Brain and Coverings - changes in brain weight

Cardiac - changes in heart weight

Kidney, Ureter, Bladder - changes in bladder weight

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: OTS0543783

TYPE OF TEST : TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE : Inhalation

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 5 mg/m3/2H/26W-I

TOXIC EFFECTS :

Vascular - BP lowering not characterized in autonomic section

Blood - pigmented or nucleated red blood cells

Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :

TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.

Toxicology of New Industrial Chemical Substances. For English

translation,

see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

Volume(issue)/page/year: 7,91,1965

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 5964 mg/kg/7D-I

TOXIC EFFECTS :

Liver - liver function tests impaired

REFERENCE :

CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co.,

USA,

1255 Howard St., San Francisco, CA 94103) V.6- 1958-

*** REVIEWS ***

ACGIH TLV-TWA 10 mg/m3

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices

(BEIs) booklet issues by American Conference of Governmental Industrial

Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:

TLV/BEI,1997

TOXICOLOGY REVIEW

BPCT** Progress Report from the Environmental Protection Agency to NIOSH

on

Benzenepolycarboxylates, 1974 Volume(issue)/page/year: -,183,1974

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :

NOHS - National Occupational Hazard Survey (1974)

NOHS Hazard Code - 82013

No. of Facilities: 1682 (estimated)

No. of Industries: 26

No. of Occupations: 42

No. of Employees: 22732 (estimated)

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - 82013

No. of Facilities: 282 (estimated)

No. of Industries: 8

No. of Occupations: 16

No. of Employees: 6456 (estimated)

No. of Female Employees: 2563 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999