Rtecs number : ww2710000 chemical name : Talc (powder), containing no asbestos fibers

TANNIC ACID

CHEMICAL NAME : Mimosa tannin

CAS REGISTRY NUMBER : 1401-55-4

LAST UPDATED : 199701

DATA ITEMS CITED : 10

COMPOUND DESCRIPTOR : Tumorigen

Natural Product

SYNONYMS/TRADE NAMES :

* Acacia mollissima tannin

* Tannin from mimosa

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 320 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of

Great

Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : >1600 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of

Great

Volume(issue)/page/year: 9,98,1957

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intravenous

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 130 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of

Great

Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : >1600 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of

Great

Volume(issue)/page/year: 9,98,1957

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 350 mg/kg/12W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Tumorigenic - tumors at site of application

REFERENCE :

BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,

Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-

Volume(issue)/page/year:

14,147,1960

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 750 mg/kg/12W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Liver - tumors

Tumorigenic - tumors at site of application

REFERENCE :

BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,

Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-

Volume(issue)/page/year:

14,147,1960

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :

NOHS - National Occupational Hazard Survey (1974)

NOHS Hazard Code - T1577

No. of Facilities: 31 (estimated)

No. of Industries: 1

No. of Occupations: 1

No. of Employees: 62 (estimated)

NOHS - National Occupational Hazard Survey (1974)

NOHS Hazard Code - 82010

No. of Facilities: 2362 (estimated)

No. of Industries: 41

No. of Occupations: 51

No. of Employees: 22302 (estimated)

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - T1577

No. of Facilities: 1650 (estimated)

No. of Industries: 19

No. of Occupations: 29

No. of Employees: 41974 (estimated)

No. of Female Employees: 19715 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

TANTALUM

CHEMICAL NAME : Tantalum

CAS REGISTRY NUMBER : 7440-25-7

LAST UPDATED : 199907

DATA ITEMS CITED : 30

MOLECULAR FORMULA : Ta

MOLECULAR WEIGHT : 180.95

WISWESSER LINE NOTATION : TA

COMPOUND DESCRIPTOR : Tumorigen

SYNONYMS/TRADE NAMES :

* Tantalum-181

* Tantalum, metal

*** HEALTH HAZARD DATA ***

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Implant

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 3760 mg/kg

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Tumorigenic - tumors at site of application

REFERENCE :

CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut

Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:

16,439,1956

*** REVIEWS ***

ACGIH TLV-TWA 5 mg/m3

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices

(BEIs) booklet issues by American Conference of Governmental Industrial

Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:

TLV/BEI,1997

*** U.S. STANDARDS AND REGULATIONS ***

MSHA STANDARD-air:TWA 5 mg/m3

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices

(BEIs) booklet issues by American Conference of Governmental Industrial

Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:

3,243,1971

OSHA PEL (Gen Indu):8H TWA 5 mg/m3

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,

Supt.

29,1910.1000,1994

OSHA PEL (Construc):8H TWA 5 mg/m3

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,

Supt.

of Documents, Washington, DC 20402) Volume(issue)/page/year:

OSHA PEL (Shipyard):8H TWA 5 mg/m3

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,

Supt.

29,1915.1000,1993

OSHA PEL (Fed Cont):8H TWA 5 mg/m3

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,

Supt.

of Documents, Washington, DC 20402) Volume(issue)/page/year:

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-ARAB Republic of Egypt:TWA 0.1 mg/m3 JAN 1993

OEL-AUSTRIA: MAK 5 mg/m3, JAN1999

OEL-AUSTRALIA:TWA 5 mg/m3 JAN 1993

OEL-BELGIUM:TWA 5 mg/m3 JAN 1993

OEL-DENMARK: TWA 5 mg/m3, JAN1999

OEL-FINLAND:TWA 5 mg/m3 JAN 1993

OEL-GERMANY:TWA 5 mg/m3 JAN 1993

OEL-THE NETHERLANDS:TWA 5 mg/m3 JAN 1993

OEL-THE PHILIPPINES:TWA 5 mg/m3 JAN 1993

OEL-POLAND: MAC(TWA) 5 mg/m3, JAN1999

OEL-RUSSIA:STEL 10 mg/m3 JAN 1993

OEL-SWITZERLAND:TWA 5 mg/m3 JAN 1993

OEL-UNITED KINGDOM:TWA 5 mg/m3;STEL 10 mg/m3 JAN 1993

OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV

OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :

NIOSH REL TO TANTALUM, metal/oxide dust-air:TWA 5 mg/m3;STEL 10 mg/m3

REFERENCE :

NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.

of

Health, Education, and Welfare, Reports and Memoranda.

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :

NOHS - National Occupational Hazard Survey (1974)

NOHS Hazard Code - 71095

No. of Facilities: 28 (estimated)

No. of Industries: 2

No. of Occupations: 5

No. of Employees: 597 (estimated)

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - X2923

No. of Facilities: 26 (estimated)

No. of Industries: 1

No. of Occupations: 3

No. of Employees: 518 (estimated)

No. of Female Employees: 155 (estimated)

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - X4238

No. of Facilities: 2 (estimated)

No. of Industries: 1

No. of Occupations: 1

No. of Employees: 35 (estimated)

No. of Female Employees: 21 (estimated)

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - X5917

No. of Facilities: 3 (estimated)

No. of Industries: 1

No. of Occupations: 1

No. of Employees: 400 (estimated)

No. of Female Employees: 400 (estimated)

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - 71095

No. of Facilities: 275 (estimated)

No. of Industries: 13

No. of Occupations: 13

No. of Employees: 7063 (estimated)

No. of Female Employees: 1255 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999