Rtecs number : ww2710000 chemical name : Talc (powder), containing no asbestos fibers

TCDD

CHEMICAL NAME : Dibenzo-p-dioxin, 2,3,7,8-tetrachloro-

CAS REGISTRY NUMBER : 1746-01-6

OTHER CAS REGISTRY NOS. : 56795-67-6

BEILSTEIN REFERENCE NO. : 0271116

REFERENCE : 5-19-02-00041 (Beilstein Handbook Reference)

LAST UPDATED : 199907

DATA ITEMS CITED : 153

MOLECULAR FORMULA : C12-H4-Cl4-O2

MOLECULAR WEIGHT : 321.96

WISWESSER LINE NOTATION : T C666 BO IOJ EG FG LG MG

COMPOUND DESCRIPTOR : Tumorigen

Mutagen

Reproductive Effector

Primary Irritant

SYNONYMS/TRADE NAMES :

* 2,3,7,8-Czterochlorodwubenzo-p-dwuoksyny

* Dibenzo(b,e)(1,4)dioxin, 2,3,7,8-tetrachloro-

* Dioksyny

* Dioxine

* Dioxin (herbicide contaminant)

* NCI-C03714

* TCDBD

* 2,3,7,8-TCDD

* 2,3,7,8-Tetrachlorodibenzo(b,e)(1,4)dioxan

* 2,3,7,8-Tetrachlorodibenzo-p-dioxin

* 2,3,7,8-Tetrachlorodibenzo-1,4-dioxin

* Tetradioxin

*** HEALTH HAZARD DATA ***

** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Standard Draize test

ROUTE OF EXPOSURE : Administration into the eye

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 2 mg

REACTION SEVERITY : Moderate

REFERENCE :

EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing

Office, Supt of Documents, Washington, DC 20402) No.1- 1972-

Volume(issue)/page/year: 5,87,1973

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Administration onto the skin

SPECIES OBSERVED : Human

DOSE/DURATION : 107 ug/kg

TOXIC EFFECTS :

Skin and Appendages - dermatitis, allergic (after topical exposure)

REFERENCE :

SCAMAC Scientific American. (Scientific American, Inc., 415 Madison

Ave.,

New York, NY 10017) V.1- 1859- Volume(issue)/page/year: 254,29,1986

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 20 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,

Switzerland) V.1- 1945- Volume(issue)/page/year: 38,879,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 24600 ng/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

45,513,1978

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 114 ug/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)

Behavioral - convulsions or effect on seizure threshold

Cardiac - other changes

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

29,229,1974

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Administration onto the skin

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 80 ug/kg

TOXIC EFFECTS :

Gastrointestinal - other changes

REFERENCE :

RCOCB8 Research Communications in Chemical Pathology and Pharmacology.

(PJD

Volume(issue)/page/year: 20,101,1978

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 120 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

SCAMAC Scientific American. (Scientific American, Inc., 415 Madison

Ave.,

New York, NY 10017) V.1- 1859- Volume(issue)/page/year: 254,29,1986

ROUTE OF EXPOSURE : Unreported

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 200 ug/kg

TOXIC EFFECTS :

Liver - fatty liver degeneration

Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :

ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of

Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-

Volume(issue)/page/year: 320,204,1979

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Mammal - dog

DOSE/DURATION : 1 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,

Switzerland) V.1- 1945- Volume(issue)/page/year: 38,879,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Primate - monkey

DOSE/DURATION : 2 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,

Switzerland) V.1- 1945- Volume(issue)/page/year: 38,879,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 115 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

35,553,1976

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Administration onto the skin

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 275 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing

Office, Supt of Documents, Washington, DC 20402) No.1- 1972-

Volume(issue)/page/year: 5,87,1973

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 252 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

SCAMAC Scientific American. (Scientific American, Inc., 415 Madison

Ave.,

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - guinea pig

DOSE/DURATION : 500 ng/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring

St.,

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - hamster

DOSE/DURATION : 1157 ug/kg

TOXIC EFFECTS :

Gastrointestinal - other changes

Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

55,67,1980

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - hamster

DOSE/DURATION : >3 mg/kg

TOXIC EFFECTS :

Endocrine - changes in thymus weight

Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

55,67,1980

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Bird - chicken

DOSE/DURATION : 25 ug/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - dyspnea

Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :

FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.

For

publisher information, see FCTOD7. Volume(issue)/page/year: 11,585,1973

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Bird - chicken

DOSE/DURATION : 25 ug/kg

TOXIC EFFECTS :

Behavioral - food intake (animal)

Nutritional and Gross Metabolic - weight loss or decreased weight gain

Nutritional and Gross Metabolic - other changes

REFERENCE :

JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,

1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-

Volume(issue)/page/year: 35,187,1992

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Amphibian - frog

DOSE/DURATION : 1 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

SCAMAC Scientific American. (Scientific American, Inc., 415 Madison

Ave.,

New York, NY 10017) V.1- 1859- Volume(issue)/page/year: 254,29,1986

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Mammal - species unspecified

DOSE/DURATION : 4200 ng/kg

TOXIC EFFECTS :

Liver - other changes

Kidney, Ureter, Bladder - other changes

Blood - changes in spleen

REFERENCE :

AECTCV Archives of Environmental Contamination and Toxicology.

(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,

NJ

070944) V.1- 1973- Volume(issue)/page/year: 17,33,1988

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 30 ug/kg/30D-I

TOXIC EFFECTS :

Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood - changes in platelet count

Biochemical - Enzyme inhibition, induction, or change in blood or tissue

levels - multiple enzyme effects

REFERENCE :

EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing

Office, Supt of Documents, Washington, DC 20402) No.1- 1972-

Volume(issue)/page/year: 5,111,1973

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 6500 ng/kg/13W-I

TOXIC EFFECTS :

Liver - changes in liver weight

Endocrine - changes in thymus weight

Blood - pigmented or nucleated red blood cells

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

35,553,1976

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 7300 mg/kg/2Y-C

TOXIC EFFECTS :

Liver - hepatitis (hepatocellular necrosis), zonal

Liver - changes in liver weight

Kidney, Ureter, Bladder - other changes in urine composition

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

46(2),279,1978

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 16 ug/kg/16W-I

TOXIC EFFECTS :

Liver - other changes

Kidney, Ureter, Bladder - other changes in urine composition

Biochemical - Metabolism (Intermediary) - porphyrin including bile

pigments

REFERENCE :

BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,

Fairview Park, Elmsford, NY 10523) V.1- 1958-

Volume(issue)/page/year:

31,1607,1982

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 120 ug/kg/3D-I

TOXIC EFFECTS :

Liver - other changes

Nutritional and Gross Metabolic - changes in iron

Biochemical - Enzyme inhibition, induction, or change in blood or tissue

levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,

etc.)

BECTA6 Bulletin of Environmental Contamination and Toxicology.

(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,

NJ

07094) V.1- 1966- Volume(issue)/page/year: 45,436,1990

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 450 ng/kg/45W-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - other changes in urine composition

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

57,156,1981

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 140 ug/kg/14D-I

TOXIC EFFECTS :

Blood - change in clotting factors

Blood - changes in erythrocyte (RBC) count

Blood - changes in platelet count

REFERENCE :

EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing

Office, Supt of Documents, Washington, DC 20402) No.1- 1972-

Volume(issue)/page/year: 5,119,1973

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 588 ug/kg/14D-I

TOXIC EFFECTS :

Liver - changes in liver weight

Endocrine - changes in spleen weight

Endocrine - changes in thymus weight

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

112,128,1992

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 20 ug/kg/4W-I

TOXIC EFFECTS :

Endocrine - other changes

Endocrine - changes in thymus weight

Immunological Including Allergic - decrease in cellular immune response

REFERENCE :

EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing

Office, Supt of Documents, Washington, DC 20402) No.1- 1972-

Volume(issue)/page/year: 5,149,1973

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 520 ug/kg/13W-I

TOXIC EFFECTS :

Liver - other changes

Related to Chronic Data - death

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research

Triangle Park, NC 27709) No.206- Volume(issue)/page/year:

NTP-TR-209,1982

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 336 ug/kg/8W-C

TOXIC EFFECTS :

Blood - other changes

Blood - changes in leukocyte (WBC) count

Immunological Including Allergic - decrease in humoral immune response

REFERENCE :

JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest

South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.

Volume(issue)/page/year: 4(2-3),401,1980

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Administration onto the skin

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 97 ug/kg/13W-I

TOXIC EFFECTS :

Liver - hepatitis (hepatocellular necrosis), diffuse

Blood - changes in spleen

Related to Chronic Data - death

REFERENCE :

NCITR* National Cancer Institute Carcinogenesis Technical Report Series.

(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.

Volume(issue)/page/year: NCI-TR-201-82

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 150 ug/kg/6W-I

TOXIC EFFECTS :

Liver - fatty liver degeneration

Endocrine - changes in thymus weight

Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

29,229,1974

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 9260 ng/kg/4W-I

TOXIC EFFECTS :

Liver - changes in liver weight

Endocrine - changes in thymus weight

Blood - changes in erythrocyte (RBC) count

REFERENCE :

TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year:

60,247,1992

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 180 ug/kg/6W-I

TOXIC EFFECTS :

Liver - changes in liver weight

Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical - Enzyme inhibition, induction, or change in blood or tissue

levels - transaminases

REFERENCE :

CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park,

Elmsford, NY 10523) V.1- 1972- Volume(issue)/page/year: 14,949,1985

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 120 ug/kg/12W-I

TOXIC EFFECTS :

Liver - changes in liver weight

Endocrine - changes in thymus weight

Blood - changes in other cell count (unspecified)

REFERENCE :

CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park,

Elmsford, NY 10523) V.1- 1972- Volume(issue)/page/year: 19,927,1989

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Primate - monkey

DOSE/DURATION : 10 ug/kg/12D-C

TOXIC EFFECTS :

Gastrointestinal - ulceration or bleeding from stomach

Nutritional and Gross Metabolic - other changes

Related to Chronic Data - death

REFERENCE :

BECTA6 Bulletin of Environmental Contamination and Toxicology.

(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,

NJ

07094) V.1- 1966- Volume(issue)/page/year: 18,108,1977

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - guinea pig

DOSE/DURATION : 441 ng/kg/90D-C

TOXIC EFFECTS :

Liver - changes in liver weight

Endocrine - changes in thymus weight

Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :

FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,

see TOSCF2 Volume(issue)/page/year: 6,454,1986

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - guinea pig

DOSE/DURATION : 1600 ng/kg/8W-I

TOXIC EFFECTS :

Endocrine - changes in thymus weight

Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :

EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing

Office, Supt of Documents, Washington, DC 20402) No.1- 1972-

Volume(issue)/page/year: 5,101,1973

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - guinea pig

DOSE/DURATION : 5 ug/kg/5W-I

TOXIC EFFECTS :

Endocrine - other changes

Kidney, Ureter, Bladder - other changes

Related to Chronic Data - death

REFERENCE :

EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing

Office, Supt of Documents, Washington, DC 20402) No.1- 1972-

Volume(issue)/page/year: 5,125,1973

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - hamster

DOSE/DURATION : 600 ug/kg/3D-I

TOXIC EFFECTS :

Liver - other changes

Biochemical - Enzyme inhibition, induction, or change in blood or tissue

levels - other oxidoreductases

Biochemical - Enzyme inhibition, induction, or change in blood or tissue

levels - other transferases

REFERENCE :

BECTA6 Bulletin of Environmental Contamination and Toxicology.

(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,

NJ

07094) V.1- 1966- Volume(issue)/page/year: 31,649,1983

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 52 ug/kg/2Y-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria

Liver - tumors

Endocrine - thyroid tumors

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research

Triangle Park, NC 27709) No.206- Volume(issue)/page/year:

NTP-TR-209,1982

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 52 ug/kg/2Y-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria

Liver - tumors

Endocrine - thyroid tumors

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research

Triangle Park, NC 27709) No.206- Volume(issue)/page/year:

NTP-TR-209,1982

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Administration onto the skin

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 62 ug/kg/2Y-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria

Skin and Appendages - tumors

REFERENCE :

NCITR* National Cancer Institute Carcinogenesis Technical Report Series.

(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.

Volume(issue)/page/year: NCI-TR-201,1982

TYPE OF TEST : TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 328 ug/kg/78W-C

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Lungs, Thorax, or Respiration - tumors

REFERENCE :

PESTC* Pesticide & Toxic Chemical News. (Food Chemical News, Inc., 400

Wyatt Bldg., 777 14th St., NW, Washington, DC 20005) V.1- 1972-

Volume(issue)/page/year: 5,12,1977

TYPE OF TEST : TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 137 ug/kg/65W-C

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Liver - tumors

Kidney, Ureter, Bladder - Kidney tumors

REFERENCE :

FEPRA7 Federation Proceedings, Federation of American Societies for

Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.

Volume(issue)/page/year: 36,396,1977

TYPE OF TEST : TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 73 ug/kg/2Y-C

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria

Liver - tumors

REFERENCE :

ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of

Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-

Volume(issue)/page/year: 320,397,1979

TYPE OF TEST : TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 1 ug/kg/2Y-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Liver - tumors

Endocrine - thyroid tumors

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research

Triangle Park, NC 27709) No.206- Volume(issue)/page/year:

NTP-TR-209,1982

TYPE OF TEST : TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 1 ug/kg/2Y-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Liver - tumors

Endocrine - thyroid tumors

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research

Triangle Park, NC 27709) No.206- Volume(issue)/page/year:

NTP-TR-209,1982

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 164 ug/kg/78W-C

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria

Lungs, Thorax, or Respiration - tumors

Liver - tumors

REFERENCE :

CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park,

Elmsford, NY 10523) V.1- 1972- Volume(issue)/page/year: 6,625,1977

TYPE OF TEST : TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 190 ug/kg/95W-C

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Lungs, Thorax, or Respiration - tumors

Liver - tumors

REFERENCE :

CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park,

Elmsford, NY 10523) V.1- 1972- Volume(issue)/page/year: 6,537,1977

TYPE OF TEST : TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 27 ug/kg/65W-C

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Liver - tumors

Kidney, Ureter, Bladder - Kidney tumors

REFERENCE :

FEPRA7 Federation Proceedings, Federation of American Societies for

Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.

Volume(issue)/page/year: 36,396,1977

TYPE OF TEST : TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 36 ug/kg/52W-I

TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria

Lungs, Thorax, or Respiration - tumors

Liver - tumors

REFERENCE :

NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ

08736)

V.1- 1869- Volume(issue)/page/year: 278,548,1979

ROUTE OF EXPOSURE : Administration onto the skin

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 80 ug/kg

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Skin and Appendages - tumors

Tumorigenic - tumors at site of application

REFERENCE :

BECTA6 Bulletin of Environmental Contamination and Toxicology.

(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,

NJ

07094) V.1- 1966- Volume(issue)/page/year: 18,552,1977

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE : 1500 ng/kg

SEX/DURATION : female 1-3 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,

e.g., stunted fetus)

Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development.

(Alan

R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE : 1250 ng/kg

SEX/DURATION : female 6-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetal death

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,

e.g., stunted fetus)

Reproductive - Specific Developmental Abnormalities - other developmental

abnormalities

REFERENCE :

FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.

For

publisher information, see FCTOD7. Volume(issue)/page/year: 9,405,1971

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE : 1 ug/kg

SEX/DURATION : female 15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetal death

Reproductive - Specific Developmental Abnormalities - urogenital system

Reproductive - Effects on Newborn - other neonatal measures or effects

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

150,254,1998

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE : 1270 ng/kg

SEX/DURATION : multigenerations

TOXIC EFFECTS :

Reproductive - Fertility - other measures of fertility

Reproductive - Specific Developmental Abnormalities - blood and lymphatic

systems (including spleen and marrow)

Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced

weight

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

50,241,1979

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE : 1 ug/kg

SEX/DURATION : lactating female 15 day(s) post-birth

TOXIC EFFECTS :

Reproductive - Effects on Newborn - physical

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

140,146,1996

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE : 20 ug/kg

SEX/DURATION : female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :

TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,

Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 21,77,1981

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - rat

DOSE : 6 ug/kg

SEX/DURATION : female 17 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :

BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,

Fairview Park, Elmsford, NY 10523) V.1- 1958-

Volume(issue)/page/year:

26,1383,1977

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE : 5 mg/kg

SEX/DURATION : female 6-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

20,396,1971

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - rat

DOSE : 2200 ng/kg

SEX/DURATION : female 19 day(s) after conception

lactating female 21 day(s) post-birth

TOXIC EFFECTS :

Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced

weight

REFERENCE :

CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park,

Elmsford, NY 10523) V.1- 1972- Volume(issue)/page/year: 25,1227,1992

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Unreported

SPECIES OBSERVED : Rodent - rat

DOSE : 1500 mg/kg

SEX/DURATION : male 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct

Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's

gland,

accessory glands

ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,

Inc.,

Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE : 1 ug/kg

SEX/DURATION : female 10 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :

EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing

Office, Supt of Documents, Washington, DC 20402) No.1- 1972-

Volume(issue)/page/year: 5,81,1973

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE : 9 ug/kg

SEX/DURATION : female 12 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - craniofacial

(including nose and tongue)

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

98,487,1989

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE : 13500 mg/kg

SEX/DURATION : female 6-14 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - endocrine system

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development.

(Alan

Volume(issue)/page/year: 44,385,1991

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE : 235 ug/kg

SEX/DURATION : female 28 day(s) pre-mating - 21 day(s)

post-birth

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - immune and

reticuloendothelial system

REFERENCE :

DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,

New

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE : 20 ug/kg

SEX/DURATION : female 14 day(s) after conception

lactating female 3 day(s) post-birth

TOXIC EFFECTS :

Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced

weight

Reproductive - Effects on Newborn - other postnatal measures or effects

REFERENCE :

IJIMDS International Journal of Immunopharmacology. (Pergamon Press

Inc.,

Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1979-

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - mouse

DOSE : 12 ug/kg

SEX/DURATION : female 10-13 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development.

(Alan

R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE : 12 ug/kg

SEX/DURATION : female 10 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - cytological changes

(including

somatic cell genetic material)

Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development.

(Alan

Volume(issue)/page/year: 55,326,1997

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE : 25 ug/kg

SEX/DURATION : female 7-11 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,

e.g., stunted fetus)

Reproductive - Specific Developmental Abnormalities - craniofacial

(including nose and tongue)

REFERENCE :

TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,

Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 20,299,1981

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE : 20 ug/kg

SEX/DURATION : female 11 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - craniofacial

(including nose and tongue)

REFERENCE :

ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,

Inc.,

Volume(issue)/page/year: 8,43,1985

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 250 ug/kg

SEX/DURATION : female 7-16 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - craniofacial

(including nose and tongue)

Reproductive - Specific Developmental Abnormalities - musculoskeletal

system

REFERENCE :

BECTA6 Bulletin of Environmental Contamination and Toxicology.

(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,

NJ

07094) V.1- 1966- Volume(issue)/page/year: 16,674,1976

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 250 ug/kg

SEX/DURATION : female 7-16 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - litter size (e.g. # fetuses per litter;

measured

Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :

BECTA6 Bulletin of Environmental Contamination and Toxicology.

(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,

NJ

07094) V.1- 1966- Volume(issue)/page/year: 16,674,1976

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 100 ug/kg

SEX/DURATION : female 2 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

REFERENCE :

TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,

Inc.,

41 E. 11th St., New York, NY 10003) V.1- 1980-

4,427,1984

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 30 ug/kg

SEX/DURATION : female 10 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - craniofacial

(including nose and tongue)

REFERENCE :

MOPMA3 Molecular Pharmacology. (Williams & Wilkins Co., 428 E. Preston

St.,

Baltimore, MD 21202) V.1- 1965- Volume(issue)/page/year: 17,86,1980

ROUTE OF EXPOSURE : Subcutaneous

SPECIES OBSERVED : Rodent - mouse

DOSE : 100 ug/kg

SEX/DURATION : female 10 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - craniofacial

(including nose and tongue)

REFERENCE :

TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,

Inc.,

41 E. 11th St., New York, NY 10003) V.1- 1980-

4,427,1984

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Primate - monkey

DOSE : 92 ng/kg

SEX/DURATION : female 46 week(s) pre-mating - 17 week(s)

post-birth

TOXIC EFFECTS :

Reproductive - Effects on Newborn - behavioral

Reproductive - Effects on Newborn - delayed effects

REFERENCE :

NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell

House,

Volume(issue)/page/year:

11,13,1989

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Primate - monkey

DOSE : 107 mg/kg

SEX/DURATION : male 4 year(s) pre-mating

TOXIC EFFECTS :

Reproductive - Effects on Newborn - behavioral

REFERENCE :

CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park,

Elmsford, NY 10523) V.1- 1972- Volume(issue)/page/year: 20,1103,1990

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Primate - monkey

DOSE : 123 ng/kg

SEX/DURATION : female 30 week(s) pre-mating - 17 week(s)

post-birth

TOXIC EFFECTS :

Reproductive - Effects on Newborn - behavioral

REFERENCE :

TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,

Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 3,68,1983

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Primate - monkey

DOSE : 163 ng/kg

SEX/DURATION : female 3.5 year(s) pre-mating

TOXIC EFFECTS :

Reproductive - Effects on Newborn - behavioral

REFERENCE :

NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell

House,

Volume(issue)/page/year:

14,433,1992

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rabbit

DOSE : 2500 ng/kg

SEX/DURATION : female 6-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :

ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,

Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 27,74,1982

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rabbit

DOSE : 10 ug/kg

SEX/DURATION : female 6-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - pre-implantation mortality (e.g. reduction in

number of implants per female; total number of implants per corpora

lutea)

REFERENCE :

ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,

Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 27,74,1982

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rabbit

DOSE : 1 ug/kg

SEX/DURATION : female 6-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - musculoskeletal

system

ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,

Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 27,74,1982

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - hamster

DOSE : 18 ug/kg

SEX/DURATION : female 9 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :

CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park,

Elmsford, NY 10523) V.1- 1972- Volume(issue)/page/year: 20,1117,1990

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms

TEST SYSTEM : Bacteria - Salmonella typhimurium

DOSE/DURATION : 2 mg/L

REFERENCE :

AMBOCX Ambio. A Journal of the Human Environment. (Pergamon Press Inc.,

Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-

Volume(issue)/page/year: 1,32,1972

TYPE OF TEST : Mutation in microorganisms

TEST SYSTEM : Bacteria - Escherichia coli

DOSE/DURATION : 2 mg/L

REFERENCE :

AMBOCX Ambio. A Journal of the Human Environment. (Pergamon Press Inc.,

Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-

Volume(issue)/page/year: 1,1,1972

TYPE OF TEST : Phage inhibition capacity

TEST SYSTEM : Bacteria - Escherichia coli

DOSE/DURATION : 500 ug/L

REFERENCE :

AMBOCX Ambio. A Journal of the Human Environment. (Pergamon Press Inc.,

Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-

Volume(issue)/page/year: 1,1,1972

TYPE OF TEST : Mutation in microorganisms

TEST SYSTEM : Yeast - Saccharomyces cerevisiae

DOSE/DURATION : 10 mg/L

REFERENCE :

CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park,

Elmsford, NY 10523) V.1- 1972- Volume(issue)/page/year: 12,549,1983

TYPE OF TEST : Mutation in microorganisms

TEST SYSTEM : Yeast - Saccharomyces cerevisiae

DOSE/DURATION : 2 mg/L

REFERENCE :

PSSID2 Pergamon Series on Environmental Science. (Oxford, UK) V.1-7,

1978-82. Discontinued. Volume(issue)/page/year: 5,429,1982

TYPE OF TEST : Gene conversion and mitotic recombination

TEST SYSTEM : Yeast - Saccharomyces cerevisiae

DOSE/DURATION : 10 mg/L

REFERENCE :

CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park,

Elmsford, NY 10523) V.1- 1972- Volume(issue)/page/year: 12,549,1983

TYPE OF TEST : Unscheduled DNA synthesis

TEST SYSTEM : Human Cells - not otherwise specified

DOSE/DURATION : 100 pmol/L

REFERENCE :

CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,

Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-

Volume(issue)/page/year: 11,1335,1990

TYPE OF TEST : DNA inhibition

TEST SYSTEM : Human Cells - not otherwise specified

DOSE/DURATION : 10 nmol/L

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

77,434,1985

TYPE OF TEST : DNA damage

ROUTE OF EXPOSURE : Oral

TEST SYSTEM : Rodent - rat

DOSE/DURATION : 100 ug/kg

REFERENCE :

CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.

Ireland

39,281,1988

TYPE OF TEST : Unscheduled DNA synthesis

ROUTE OF EXPOSURE : Intravenous

TEST SYSTEM : Rodent - rat

DOSE/DURATION : 4 ug/kg

REFERENCE :

BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,

Fairview Park, Elmsford, NY 10523) V.1- 1958-

Volume(issue)/page/year:

31,2459,1982

TYPE OF TEST : Unscheduled DNA synthesis

ROUTE OF EXPOSURE : Oral

TEST SYSTEM : Rodent - rat

DOSE/DURATION : 5 ug/kg

REFERENCE :

TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,

Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 28,133,1983

TYPE OF TEST : DNA inhibition

ROUTE OF EXPOSURE : Intraperitoneal

TEST SYSTEM : Rodent - rat

DOSE/DURATION : 10 ug/kg

REFERENCE :

CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.

Ireland

Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:

TYPE OF TEST : DNA inhibition

ROUTE OF EXPOSURE : Oral

TEST SYSTEM : Rodent - rat

DOSE/DURATION : 200 ug/kg

REFERENCE :

CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.

Ireland

8,31,1974

TYPE OF TEST : Cytogenetic analysis

ROUTE OF EXPOSURE : Oral

TEST SYSTEM : Rodent - rat

DOSE/DURATION : 100 ug/kg

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

47,141,1978

TYPE OF TEST : Cytogenetic analysis

ROUTE OF EXPOSURE : Intraperitoneal

TEST SYSTEM : Rodent - rat

DOSE/DURATION : 10 mg/kg

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

47,141,1978

TYPE OF TEST : Morphological transformation

TEST SYSTEM : Rodent - mouse Fibroblast

DOSE/DURATION : 200 nmol/L

REFERENCE :

ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For

publisher information, see EMMUEG. Volume(issue)/page/year: 6,461,1984

TYPE OF TEST : Mutation test systems - not otherwise specified

TEST SYSTEM : Rodent - mouse Cells - not otherwise specified

DOSE/DURATION : 1 nmol/L

REFERENCE :

JBCHA3 Journal of Biological Chemistry. (428 E. Preston St., Baltimore,

MD

21202) V.1- 1905- Volume(issue)/page/year: 259,12357,1984

ROUTE OF EXPOSURE : Oral

TEST SYSTEM : Rodent - mouse

DOSE/DURATION : 800 pmol/kg

REFERENCE :

CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,

Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-

Volume(issue)/page/year: 8,1433,1987

TYPE OF TEST : DNA inhibition

ROUTE OF EXPOSURE : Intraperitoneal

TEST SYSTEM : Rodent - mouse

DOSE/DURATION : 400 ug/kg

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

46,305,1977

TYPE OF TEST : Mutation test systems - not otherwise specified

ROUTE OF EXPOSURE : Oral

TEST SYSTEM : Rodent - mouse

DOSE/DURATION : 50 ug/kg

REFERENCE :

TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,

Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 56,239,1989

TYPE OF TEST : Cytogenetic analysis

ROUTE OF EXPOSURE : Oral

TEST SYSTEM : Rodent - mouse

DOSE/DURATION : 100 ug/kg

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

29,229,1974

TYPE OF TEST : Cytogenetic analysis

ROUTE OF EXPOSURE : Intraperitoneal

TEST SYSTEM : Rodent - mouse

DOSE/DURATION : 10 ug/kg

REFERENCE :

PSSID2 Pergamon Series on Environmental Science. (Oxford, UK) V.1-7,

1978-82. Discontinued. Volume(issue)/page/year: 5,419,1982

TYPE OF TEST : Mutation in mammalian somatic cells

TEST SYSTEM : Rodent - mouse Lymphocyte

DOSE/DURATION : 50 mg/L

REFERENCE :

ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For

publisher information, see EMMUEG. Volume(issue)/page/year: 4,391,1982

TYPE OF TEST : Host-mediated assay

TEST SYSTEM : Rodent - mouse Yeast - Saccharomyces cerevisiae

DOSE/DURATION : 25 ug/kg

REFERENCE :

CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park,

Elmsford, NY 10523) V.1- 1972- Volume(issue)/page/year: 12,549,1983

*** REVIEWS ***

IARC Cancer Review:Animal Sufficient Evidence

IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of

Chemicals

to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY

12210)

IARC Cancer Review:Animal Inadequate Evidence

IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of

Chemicals

to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY

12210)

IARC Cancer Review:Human Sufficient Evidence

IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49

Sheridan Ave., Albany, NY 12210) No.1- 1979-

Volume(issue)/page/year:

7,350,1987

IARC Cancer Review:Human Limited Evidence

IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of

Chemicals

to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY

12210)

V.1- 1972- Volume(issue)/page/year: 69,33,1997

IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of

Chemicals

to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY

12210)

V.1- 1972- Volume(issue)/page/year: 69,33,1997

RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center,

44

Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year:

TOXICOLOGY REVIEW

ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50;

V.70-99, 1960-75. For publisher information, see APLMAS.

Volume(issue)/page/year: 94,125,1972

TOXICOLOGY REVIEW

CHRYAQ Chemistry. (Washington, DC) V.18-52, 1944-79.

Volume(issue)/page/year: 47(2),15,1974

TOXICOLOGY REVIEW

TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,

Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 3,187,1975

TOXICOLOGY REVIEW

RPZHAW Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001,

00-068

TOXICOLOGY REVIEW

BIOGAL Biologico. (Instituto Biologica, Av. Cons. Rodriques Alves, 1252,

CEP 04014, Sao Paulo, Brazil) V.1- 1935- Volume(issue)/page/year:

40(2),44,1974

TOXICOLOGY REVIEW

STEVA8 Science of the Total Environment. (Elsevier Science Pub. B.V.,

POB

Volume(issue)/page/year:

2,305,1974

TOXICOLOGY REVIEW

EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing

Office, Supt of Documents, Washington, DC 20402) No.1- 1972-

Volume(issue)/page/year: 15,121,1976

TOXICOLOGY REVIEW

FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.

For

TOXICOLOGY REVIEW

PHTHDT Pharmacology and Therapeutics. (Pergamon Press Ltd., Headington

Hill

7,513,1979

TOXICOLOGY REVIEW

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

47,141,1978

TOXICOLOGY REVIEW

ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,

D-1000

Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:

TOXICOLOGY REVIEW

EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring

St.,

TOXICOLOGY REVIEW

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: PB82-922905

TOXICOLOGY REVIEW

MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001,

00-068

TOXICOLOGY REVIEW

VHTODE Veterinary and Human Toxicology. (American College of Veterinary

and

Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 22,31,1980

TOXICOLOGY REVIEW

MGLFDB Monographs of the Giovanni Lorenzini Foundation. (New York, NY)

V.1,

1978. Discontinued. Volume(issue)/page/year: -,123,1978

FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell

House,

Fairview Park, Elmsford, NY 10523) V.20- 1982-

25,257,1987

TOXICOLOGY REVIEW

ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews,

Inc.,

POB 10139, Palo Alto, CA 94303) V.16- 1976- Volume(issue)/page/year:

TOXICOLOGY REVIEW

ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,

D-1000

44,211,1980

TOXICOLOGY REVIEW

DMTRAR Drug Metabolism Reviews. (Marcel Dekker, 270 Madison Ave., New

York,

NY 10016) V.1- 1972- Volume(issue)/page/year: 13,387,1982

OEL-FINLAND;Carcinogen JAN 1993

OEL-AUSTRIA: Carcinogen, JAN1999

OEL-GERMANY;Carcinogen JAN 1993

OEL-SWITZERLAND;Carcinogen JAN 1993

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :

NIOSH REL TO TCDD-air:CA lowest feasible concentration

REFERENCE :

NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.

of

Health, Education, and Welfare, Reports and Memoranda.

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - X7301

No. of Facilities: 3 (estimated)

No. of Industries: 1

No. of Occupations: 1

No. of Employees: 14 (estimated)

No. of Female Employees: 5 (estimated)

*** STATUS IN U.S. ***

ATSDR TOXICOLOGY PROFILE

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: PB/89/214522/AS

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat

EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999

NIOSH CURRENT INTELLIGENCE BULLETIN 40, 1984

NTP Carcinogenesis Bioassay (gavage);clear evidence:mouse,rat

NTPTR* National Toxicology Program Technical Report Series. (Research

Triangle Park, NC 27709) No.206- Volume(issue)/page/year:

NTP-TR-209,1982

NCI Carcinogenesis Bioassay (dermal);clear evidence:mouse

NCITR* National Cancer Institute Carcinogenesis Technical Report Series.

(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.

Volume(issue)/page/year: NCI-TR-201,1982

NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be

Human Carcinogen

NTP Carcinogenesis studies; on test (two year studies), May 1999

NTP Carcinogenesis studies; on test (prechronic studies), May 1999