Name : Hicham Hussein Khodr
Date of Birth : 6 February 1963
69 Millet Road
London UB6 9SH, UK .
Web site: http://www.hichamkhodr.synthasite.com/
Temporary Address :
C/O Mrs Noha Khodr,
PO Box 23123,
1980 - 1981: Mathelene
Kalmoon, North Lebanon, Lebanon
1981 - 1985: BSc. Chemistry
Department of Chemistry
University of Mousel, Mousel, Iraq.
1986 - 1987 : MSc. In Chemical Spectroscopy
Thesis title : 31P NMR studies of phosphorus containing biomolecules
(Superviser Prof. G. R. Moore)
School of Chemical Sciences,
University of East Anglia, Norwich, UK.
1988 - 1992: Ph.D.
Thesis title : 1H and 31P NMR studies of small molecules and their interaction with
proteins. (Superviser Prof. G. R. Moore)
School of Chemical Sciences,
University of East Anglia, Norwich, UK.
3. Work Experience
1993 – 2003: Postdoctoral Research Fellowship
Research Topic (physical-chemical characterization of metal chelators). Pharmacy Department,
King’s College London.
2003-2005: Senior Scientist at MedPharm Company, King’s College London:
Research involved : physical-chemical characteristion of therapeutic ligands and drug formulations for different delivery systems.
November, 2006: Presenting my research interest at Qatar University, Chemistry
2006 – 2007 : A visiting Staff, CSIRO, Sydney Australia.
2008 – up to present : Self employed, and project development and design in
collaboration with the Imperial College London, Department of
Material Sciences and University of West Sydney, Australia.
2012-up to present : Part time staff, Qatar University Department of Chemistry.
4. Professional Membership
1986-1992 Member of the royal society of Chemistry.
1988 – 1995 Member of Inorganic Biology Discussion Group (ibdg)
English, French and Arabic (Written and Spoken).
6. Professional Experience
Since completing my Ph.D. I have been involved, in the application of computers to develop a fully automated system to characterize ligands by measuring the ionization constants (pKa), affinity constants () with a range of metals and partition coefficients (Kpart). This automated system I designed has been developed to simultaneously obtain the spectrophotometric and potentiometric titration data as well as the kinetic data, where over this period of time, I have been focusing on the development and designing of novel compounds for metal chelation therapy.
During my Ph.D. and MSc. programme, I was involved in the application of spectroscopy techniques and in particular NMR for characterising and identifying compounds under investigation in solid and in solution state. In addition, I have developed software to simulate solid state NMR spectra. Furthermore, I used the solid state NMR technique to investigate the polymorphism of the lyophilized form of phosphorus compounds.
I have extensive experience with molecular modeling, particularly the HyperChem software release 2 for Silicon Graphics. Interested in molecular graphics (MD, MM) for understanding size and physical properties of drug delivery systems. Furthermore, I gained a considerable experience in HPLC, Drugs Formulations, TGA and DSC.
Joint supervision of Ph.D. and M.Sc. Students.
1993-1996 Lotfollah Dehkordi PhD;
1994 - 1997 Majed Moridani PhD;
1995 - 1998 Zu Dong Liu PhD;
1997-1998 Karen Pleban (Vienna) M.Pharm; Ruth Michaelis (Frankfurt) M.Pharm.
1998-2000 Lubna Baydoun PhD; Feluke Fakorede PhD.; Sirivipa Piyamongkol PhD; Mutlu Aytemir ( Istanbul) Ph.D.
1999 - 2000 Contract work for Strakan involving the physical chemistry of zinc clindamycin phosphate complexes.
I would be interested to lecture subjects related to physical-chemical properties of organic molecules as prodrugs and their relative stabilities(oxidation, hydrolysis, side interaction). I will undertake a teaching responsibility in the area of physical and inorganic chemistry in particular spectroscopy techniques and numerical recipe. Furthermore, I have a considerable interest in teaching pharmaceutical chemistry covering the subjects of drug delivery, medicinal chemistry, analytical sciences, formulations and drug charaterisations.
Computer programming using various languages including (Basic, Visual Basic,
H. H Khodr, G R Moore, A J Strike and D Williamson, ‘Solid-State and Solution-State 31P Nuclear Magnetic Resonance Studies of the Heamoglobin-Inositol Hexaphosphate, Biomedical Society Transactions, 16, 839-840, (1988).
S. Singh, H. Khodr, M. I. Taylor and R. C. Hider, “Therapeutic iron chelators and their potential side-effects”, Biochem. Soc. Symp. 61, 127 - 137, (1995).
Anne-Kathrin Duhme, Robert C. Hider & Hicham Khodr, “Spectrophotometric Competition Study between Molybdate and Fe(III) Hydroxide on N,N’-bis(2,3-Dihydroxybenzoyl)-L-lysine, a naturally occuring siderophore synthesized by Azotobacter vinelandii”, Biometals, 9, 245-248, (1996).
G. Paganga, H. Al-Hashim, H. Khodr, B. C. Scott, O. I. Aruoma, R. C. Hider, B. Halliwell, C. A. Rice-Evans, “Mechanisms of Antioxidant Activities of Quercitin and Catechin”, Redox Report, 6, 359-364, (1996).
Anne-Kathrin Duhme, Robert C. Hider & Hicham Hussein Khodr, “Synthesis and iron-binding properties of protochelin, the tris(catecholamide) siderophore of Azotobacter vinelandii”, Chem. Ber., 130, 969 - 973 (1997).
Reem Kayyali, Ananth Sekher Pannala, Hicham Khodr, Robert C Hider, “Comparative radical scavenging ability of bidendate iron(III) chelators, Biochem. Pharmacol. 55, 1327 – 1332, (1998).
Bijaya L Ray, Lotfullah S Dehkordi, Hicham Khodr, Yi Jin, Zudong Liu and Robert C Hider “ Synthesis, Physical Chemical Properties and Evaluation of N-Substituted 2-Alkyl-3 Hydroxy 4(1H) -Pyridinones”, J. Med. Chem. 41, 3347 – 3359, (1998) .
Jonathan E Brown, Hicham Khodr, Robert C Hider and Catherine A Rice-Evans, “Structural-Dependence of Flavonoid Interactions with Copper Ions: Implications for their Antioxidant Properties”, Biochemical Journal, 330, 1173 – 1178, (1998).
Hider R. C., Khodr H.H, Zu-Dong Liu & Tilbrook G., “Optimization of pFe3+ values of Iron(III) ligands with clinical potential”, Metal Ions in Biology and Medicine, 5, 51-57, 1998.
Bijaya L. Rai, Hicham Khodr and Robert Hider, “Synthesis, Physico-Chemical and Iron(III)-Chelating properties of Novel Hexadentate 3-Hydroxy-2(1H)pyridinone Ligands”, Tetrahedron 55, 1129 - 1142, (1999).
Zu D. Liu, Hicham H. Khodr, Ding Y. Liu, Shu L. Lu and Robert C Hider, “Synthesis, physicochemical characterisation and biological evaluation of 2-(1’-hydroxyalkyl)-3-hydroxypyridin-4-ones: Novel iron chelators with enhanced pFe3+ values”, J. Med. Chem. 42, 4814-4823, (1999).
Mark D. Hadgood, Zu Don Liu, Lotfollah S. Dehkordi, Hicham H. Khodr, Joan Abbott and Robert C. Hider, "Investigating in the correlation between the structure of hydroxypyridinones and blood-brain barrier permeability", Biochemical Pharmacology, 57, 1305 - 1310, (1999).
Nicolaus von Wiren, Suhkbinder Klair, Suhkibar Bansal, Jean-Francois Briat, Hicham Khodr, Takayuki Shioiri, Roger A. Leigh and Robert C. Hider, " Nicotianamine chelates both FeIII and FeII. Implications for metals transport in plants", Plant Physiology, 119, 1107-1114, (1999).
Zu D. Liu, Hicham H. Khodr, Shu L. Lu and Robert C Hider, “Design, synthesis and evaluation of N-Basic Subsitituted 3-Hydroxypyridin-4-ones: Orally active iron chelators with lysosomotrophic potential”, J. Pharm. Parmacol. 52, 263-272, (2000.)
Robert C. Hider, Zu D. Liu and Hicham H. Khodr, ”Metal chelation of polyphenols”, Methods in Enzymology, 335, 191-203, (2001).
R. C. Hider and H. Khodr, "Aqueous iron chelation chemistry relevant to plant mineral nutrition", Plant and Soil, 2001 (in press).
Zu D. Liu, S. Piyamongkol, Ding Y. Liu, Hicham H. Khodr, Shu L. Lu and Robert C Hider, "Synthesis of 2-amido-3-hydroxypyridin-4(1H)-ones: Novel iron chelators with enhanced pFe3+ values", Bioorganic & Medicinal Chemistry, 9, 563-573 (2001).
Majid Y. Moridani, Gary S. Tilbrook, Hicham H. Khodr and Robert C. Hider, " Synthesis and physico-chemical assessment of novel 2-substituted-3-hydroxypyridin-4-ones, novel iron chelators.", Eur. J. Med. Chem. 2001.
Nicolaus von Wiren, Hicham Khodr and Robert C. Hider, "Hydroxylated phytosiderophore species possess an enhanced chelating efficiency and affinity for iron(III).", Plant Physiology 124, 1149-1157, 2000.
Ben Forbes, Hicham Khodr, Alison Lansley, “Differences in 2-agonist transport
across bronchial and gastrointestinal cell culture drug absorption models ”,
International Journal of Pharmaceutics, in preparation.
Zu D. Liu, Ruth Michaelis, Sue Moody-Haupt, Hava Glickstein, Hicham H. Khodr,
Ioav Z. Cabantchik, Robert C. Hider, " Basic 3-Hydroxypyridin-4-ones as Novel
Antimalarials", Journal of Clinical Virology, 16, 89, (2000).
H. H. Khodr, R. C. Hider and A.-K Duhme-Klair, “The iron-binding properties of aminochelin, the mono(catecholamide) siderophore of Azotobacter vinelandii”, J Biol. Inorg. Chem.7, 891-896 (2002).
Etsuro Yoshimura, Zu Dong Liu, Hicham Khodr and Robert C. Hider, “Purity of Commercial morin products and their spectrophotometric chrarcterisation”, The Japan Society for Analytical Chemistry, 51, 979-982 (2002).
Elizabeth A Lewis, Hicham H. Khodr, Robert C. Hider John R. Lindsay Smith and Paul H. Walton, “A manganese superoxide dismutase mimic based on cis, cis-1,3,4-triaminocyclohexane”, Dalton Trans, 187, 187-188 (2004). And “Novel enzyme mimic could be used to help treat inflammatory diseases, Taking the danger out of breathing”, Chemistry World”, 1, 15, (2004).
Robert C. Hider, Etsuro Yoshimura, Hicham Khodr and Nicolaus von Wiren” Competition or complementation: the iron-chelating abilities of nicotianamine and phytosiderophores”, New Phytologist, Letter ,164, 204-208, (2004).
Sirivipa Piyamongkol, Tao Zhou, Zu D. Liu, Hicham H. Khodr and Robert C. Hider, “Design and characterization of novel hexadentate 3-hydroxypyridin-4-one ligands”, Tetrahedron Letters, 46, 1333-1336, (2005).
Reem Kayyali, Patricia Evans, Catherine J. Waterfield, Hicham Khodr, Hendrik Neubert, Lakshmi D. Devanur and Robert C. Hider “The Fenton-like activity of iron(III) in the presence of 3-hydroxy- pyridin-4-ones and its effect on intracellular glutathione levels”, For Submission to Biochemical Pharmacology.
8. Conferences presentations
H Khodr, F Kadir & G R Moore, “Chemical and spectroscopic analysis of ferritin and bacterioferritin, Inorganic Biochemistry Discussion Groups (IBDG), University of East Anglia, Norwich, 1990
H Khodr & G R Moore “NMR studies of the transport of small molecules across the protein shell of ferritin, Inorganic Biochemistry Discussion Groups (IBDG), University of East Anglia, Norwich, 1990.
G S Tilbrook, H H Khodr, P D Taylor and R C Hider “The Study of the Physical Properties of Hexadentate and Bidentate Ligands as Potential Therapeutic Iron Chelating Agents”, LogP an International Symposium on Lipophilicity in Drug Research and Toxicology, Lausanne, March, 1994.
H Khodr, B Rai, L Dehkordi & R Hider, “ Physical-Chemical Characterization of Iron Chelator”, European Iron Club, Hamburg, 1995.
M Y Moridani, R C Hider & H Khodr,, “Synthesis and Evaluation of 3-Hydroxy-pyridin-4-one (HPO) Chelators”, European Iron Club, Hamburg, 1995.
Hicham H Khodr, Gary S Tilbrook, Robert C Hider, “The Development of an Automated System for the Determination of Physico-Chemical Constants of Ionizable Species”, British Pharmaceutical Conference, Scarborough, 1997.
Khodr H. H., Tilbrook G. S. & Hider R. C., “The Methodology in Operating the Automated System for Characterising the Physical Chemical Properties of Ligands and Metal Complexes”, 5th International Symposium on Metal Ions in Biology and Medicine, Neuherberg/Munich, May, 1998.
S. Piyamongkol, Z. D. Liu, H. Khodr and R. C. Hider, " Design of 3-Hydroxypyridin-4-one Chelators with High pFe3+ Values, British Pharmaceutical Conference, Eastbourne, 1998.
Z. D. Liu, S. Piyamongkol, H. Khodr and R. C. Hider, " Design of 3-Hydroxypyridin-4-one Chelators with High pFe3+ Values, The 2nd International Conference on Thalassemia, China, 1998.
Z. D. Liu, H. Khodr, S. L. Lu, D. Y. Liu and R. C. Hider, " 2-(1'-Hydroxyalkyl)-3-Hydroxypyridin-4-one are Potent Iron Chelators, 9th International Conference on Oral Chelation in the Treatment of Thalassemia and Other Diseases, Hamburg, 1999.
R. C. Hider, Z. D. Liu, S. Piyamongkol, H. Khodr and D. Y. Liu, " 2-Acetamido-3-Hydroxypyridin-4-ones: Novel Iron Chelators with Enhanced pFe3+ Values, 9th International Conference on Oral Chelation in the Treatment of Thalassemia and Other Diseases, Hamburg, 1999.
R. C. Hider, Z. D. Liu, D. Y. Liu, H. Khodr and S. Piyamongkol, " The Design of Non-Toxic Orally Active Iron Chelators.", World Congress on Iron Metabolism BIOIRON'99, Sorrento, Italy, 1999.
Zu D. Liu, Ruth Michaelis, Sue Moody-Haupt, Hava Glickstein, Hicham H. Khodr, Ioav Z. Cabantchik, Robert C. Hider, " Basic 3-Hydroxypyridin-4-ones as Novel Antimalarials", Journal of Clinical Virology, 16, 89, (2000).
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Faculty of Life Sciences
London Metropolitan University
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London N7 8DB
Tel: + 44 (0)2071334337
Prof. Jamshed Anwar, Professor of Computational Drug Delivery
University of Bradford, Richmond Road, Bradford,
West Yorkshire, BD7 1DP, UK.
Tel. +44 (0)1274 236145
Fax + 44 (0) 1274 234769 e.mail: firstname.lastname@example.org
Dr Alex F. Drake Senior Lecturer
Optical Spectroscopy Pharmacy Department.
King’s College London,
Franklin-Wilkins Building 150 Stamford Street.
London SE1 9NN. (UK)
Tel. 020 7 848 4839
Fax 020 7 848 4800