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Curriculum Vitae Jin-Biao Ma Assistant Professor, Tenure-track Department of Biochemistry and Molecular Genetics University of Alabama at Birmingham 720 20th St. S., Birmingham, al 35294 Education

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Curriculum Vitae
Jin-Biao Ma

Assistant Professor, Tenure-track

Department of Biochemistry and Molecular Genetics

University of Alabama at Birmingham

720 20th St. S., Birmingham, AL 35294
1992-1997 B. Sc., Chemistry, Department of Chemistry, Fudan University

1997-2002 Ph. D., Organic Chemistry, State Key Lab of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

Professional Positions
2002-2004 Research Fellow, Structural Biology Program

Memorial Sloan-Kettering Cancer Center

2004-2005 Research Associate, Structural Biology Program

Memorial Sloan-Kettering Cancer Center

2005-2007 Senior Research Scientist, Structural Biology Program

Memorial Sloan-Kettering Cancer Center

2007- Assistant Professor of Biochemistry and Molecular Genetics, Tenure-track,

University of Alabama at Birmingham, Birmingham, AL

Honors and awards
2004 Winner Poster Prize in Structural Biology, 2004 RNA Society Meeting, Madison, Wisconsin

2008 V Scholar, The V Foundation for Cancer Research, Cary, North Carolina

2009 Junior Faculty Development Grants, Comprehensive Cancer Center, UAB

Invited Lectures
Nov., 2001 The studies of the interactions between Cyclophilin A and its ligands, 1st China National Conference on Chemical Biology, Hangzhou, China

Sept., 2005 Prokaryotic Argonautes: Site-specific DNA Guide Strand-mediated Endoribonucleases, RNAi 2005 Meeting, Cold Spring Harbor, New York

Apr., 2006 Crystal structure of the human Dicer PAZ-siRNA complex and its functional implications, RNAi discussion group, New York Academy of Sciences, New York, New York

Jan., 2007 Structural basis for siRNA recognition by viral suppressor 2b from Tomato Aspermy Virus, 24th Symposium in Plant BiologyGene Silencing: The Biology of Small RNAs and Epigenenome, University of California, Riverside, California, USA

Aug., 2007 Structures and functions of the PAZ domain in RNA silencing, Gordon Conference: Chromosome Dynamics, University of New England, Biddeford, ME

Apr., 2009 Structural insights into molecular mechanisms of small RNA methyltransferase HEN1, 2009 Keystone Symposia Conference: The Biology of RNA Silencing, Victoria, Canada


  1. Ying Huang, Lijuan Ji, Qichen Huang, Dmitry G. Vassylyev, Xuemei Chen, Jin-Biao Ma, Structural insights into mechanisms of small RNA methylatransferase HEN1(2009) Nature (accepted)

  2. Dinshaw J. Patel, Jin-Biao Ma, Yu-Ren Yuan, Keqiong Ye, Yi Pei, Vitaly Kuryavyi, Lucy Malinina, Gunter Meister, and Thomas Tuschl, Structural Biology of RNA silencing and its functional implication (2007) Cold Spring Harbor Symposia on Quantitative Biology: Regulatory RNAs, Volume 71

  3. Jin-Biao Ma, Yu-Ren Yuan, Gunter Meister, Yi Pei, Thomas Tuschl and Dinshaw J. Patel, Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein (2005) Nature 434, 666-670

  4. Yu-Ren Yuan, Yi Pei, Jin-Biao Ma, Vitaly Kuryavyi, Maria Zhadina, Gunter Meister, Hong-Ying Chen, Zbigniew Dauter, Thomas Tuschl, and Dinshaw J. Patel, Crystal structure of A. aeolicus Argonaute, a site-specific DNA-guided RNA endonuclease, provides insights into RISC-mediated mRNA cleavage (2005) Mol. Cell 19, 405-19

  5. Jin-Biao Ma, Keqiong Ye and Dinshaw J. Patel, Structural basis for overhang-specific small interfereing RNA recognition by the PAZ domain (2004) Nature 429, 318-322

  6. Anh Tuan Phan, Vitaly Kuryavyi, Jin-Biao Ma, Marie-Line Andreola and Dinshaw J. Patel, An interlocked dimmeric parallel-stranded DNA quadruplex: a potent inhibitor of HIV-1 integrase (2005) Proc. Natl. Acad. Sci. USA 102, 634-639

  7. Li Ou, Jinbiao Ma, Xunhai Zheng, Xiang Chen, Guangyao Li and Houming Wu, The expression and refolding of isotopically labeled recombinant Matrilysin for NMR studies. (2006) Protein Expr. Purif. 47, 367-373

  8. Xiang Chen, Xiaotian Tong, Youhua Xie, Yuan Wang, Jinbiao Ma, DaMing Gao, Houming Wu, and Haibao Chen, Over-expression and purification of isotopically labeled recombinant ligand-binding domain of orphan nuclear receptor human B1-binding factor/human liver receptor homologue 1 for NMR studies (2006) Protein Expr. Purif. 45, 99-106

  9. Li Ou, Qi Zhang, Jinbiao Ma, Wengeng Wu, Zhonghua Wang, Fang Zhang, Dawei Ma and Houming Wu, 1H, 13C and 15N backbone resonance assignments of matrilysin (MMP7) complexed with a sulfonamide hydroxamate-type inhibitor (2004) J. Biomol. NMR 29, 537-538.

  10. Cunyang Cao, Qi Zhang, Lin-Long Xue, Jinbiao Ma, Yun-Hua Wang, Houming Wu and Zhong-Xian Huang, The solution structure of the oxidized bovine microsomal cytochrome b5 mutant V61H, (2003) Biochem. Biophys. Res. Comm. 307, 600-609

  11. Yuefeng Wang, Hong Dou, Chunyang Cao, Naixia Zhang, Jinbiao Ma, Jifang Mao and Houming Wu, Solution structure and biological activity of recombinant salmon calcitonin S-sulfonated analog (2003) Biochem. Biophys. Res. Comm. 306, 582-589

  12. Hui Jiang, Jinbiao Ma, Xiang-Ming Zhu, Yong-Zheng Hui, Hou-Ming Wu and Hai-Bao Chen, Synthesis of Biotinylated Cyclosporin A and Studies on Its Interaction with Human Cyclophilin A (2001) Acta Chim. Sinica 9, 1745-1750

  13. 唐功利, 麻锦彪, 吴厚铭, 陈海宝, 生物活性小分子与靶点相互作用研究中的新方法和新技术, (2000) 科学通报 45, 1345-1357

  14. Jinbiao Ma and Houming Wu, A New Method to Discover High-Affinity Ligand for Biomolecules: SAR-by-NMR (1999) Progress in Chemistry 11, 265-274

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