Rajiv gandhi university of health sciences

RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES

FOR THE DEGREE OF AYURVEDA VACHASPATHI

1^st year M.D. Scholar,

Department of Post graduate studies in Rasashastra,

G.A.M.C, Bangalore.

Rajiv Gandhi University of Health Sciences,

Bangalore, Karnataka.

The Principal and Head of Post Graduate Studies In Rasashastra.

Government Ayurvedic Medical College,

Bangalore - 560009

Respected Sir,

Yours faithfully

Place: Bangalore

Date: 20.04.2012

(Dr. Malavi Shayan).


RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES

BANGALORE, KARNATAKA.

ANNEXURE – II

PROFORMA FOR REGISTRATION OF SUBJECT FOR DISSERTATION

1.	Name Of The Candidate and Residential Address	DR. MALAVI SHAYAN 1st M.D. Scholar Department of P.G. studies in Rasashastra. D/O DR. Vasukishayan #15, “INCHARA” 2nd cross, 1st main, Soudhamini layout, Konanakunte, Bangalore - 560062
2.	Name of Institution:	Government Ayurvedic Medical College, Bangalore - 560009
3.	Course of Study & Subject:	M.D. (Ayurveda) RASASHASTRA
4.	Date of Admission of course:	29th OCT 2011
5.	Title of the topic:	A PHARMACEUTICO-ANALYTICAL STUDY OF MRUGANKA POTTALI RASA AS PER RASA RATNA SAMUCCHAYA

6. BRIEF RESUME OF THE INTENDED WORK:
6.1. NEED FOR THE STUDY:

Rasashastra, a pharmaco-therapeutic branch of Ayurveda, deals with the drugs of various nature, may be herbal, mineral, metal or of animal source. Among all drugs, nucleus of the study of Rasashastra is Parada/Mercury. The various mercurial preparations include- Bhasma, Kharaliya Rasayanas, Parpati, Kupipakva, Pottali, Pishti etc.

Pottali is one such mercurial preparation, where the term “Pottali” literally means bundle¹ or to put together. The general features of Pottali kalpas are, they are more potent, quick in action with minimal dosage and easy to administer. The ultimate advantage of pottali is its ability to preserve the therapeutic efficiency for a long time.

Pottali kalpana is first described by Nityanatha Siddha of 12^th century A.D and parallelly by Sharangadhara. Pottali can be prepared by two methods, viz:

1. 
   By using Gandhaka Drava method.(Hemagarbha pottali, Tamragarbha pottali).
   
2. 
   By puta method using Shankha/Kaparda. (Mruganka pottali and Lokanatha pottali).
   

Since, no work has been carried out on Mruganka pottali rasa, this preparation has been selected for pharmaceutico-analytical study.

1. 
   Information regarding Mruganka Pottali Rasa , it’s ingredients, preparation, properties and uses will be reviewed .This contains, Shuddha Shankha Nabhi Choorna, Parada Bhasma (Rasa Sindoora),^3,4 Shuddha Gandhaka.
   
2. 
   Here, Rasa Sindoora is taken in place of Parada Bhasma as per the commentaries mentioned in Rasa Ratna Samucchaya and Ayurveda Prakasha.^3,4
   
3. 
   Information regarding necessary instrumental analysis will be reviewed and compiled.
   

1. 
   On review, it is found that no work has been carried out on Mruganka Pottali Rasa, under RGUHS and other universities.
   
2. 
   Many works have been carried out on individual ingredients and on different Pottalis.
   

3. 
   OBJECTIVES OF THE STUDY:
   

1. 
   Identification, collection and shodhana of selected raw materials will be done.
   
2. 
   Preparation of Mruganka Pottali Rasa by puta method as explained in Rasa Ratna
   

3. 
   Physico-chemical analysis of Mruganka Pottali rasa.
   

1. Source of drug: The raw materials required for the preparation will be collected from genuine sources and the data pertaining to it will be reassessed and recorded.

2. Source of formulation: Preparation of formulation will be done as per Rasa Ratna Samucchaya text in the post-graduate department of Rasashastra, G.A.M.C., Bangalore.

3. Place of work:

a. Necessary processing of raw materials and preparation will be carried out in pharmacy section of post graduate department of Rasashastra at G.A.M.C, Bangalore.

b. Basic analysis will be accomplished in the laboratory of post-graduate department of Rasashastra, G.A.M.C Bangalore, and other related tests will be carried out in accredited laboratories.

a).All the relavant available classical literature on Mruganka Pottali Rasa will be reviewed and compiled.

b). All the relavant classical available and up to date literature available on individual ingredient of Mruganka Pottali Rasa viz: Shankha Nabhi Choorna, Rasa Sindoora, Gandhaka, will be reviewed and compiled.
2. Pharmaceutical Data:

a). The collected raw materials used for the study will be screened for their genuineness.

b). Shankha Nabhi shodhana in nimbu swarasa using Dola yantra.⁵

c). Hingula shodhana will be done by giving bhavana with nimbu svarasa for seven times in Khalwa yantra ^5a

d). Extraction of Parada from Hingula will be done by Urdhvapatana method .^5b

e). Gandhaka shodhana will be done by Bhudhara Yantra method .^5c

f). Preparation of Rasa Sindoora.^5d

Shuddha Parada and Shuddha Gandhaka taken in equal quantity kajjali is prepared triturated with vatankura swarasa, filled in Kanchakupi subjected to trividha agni paka. After swanga sheeta, kantastha Rasa Sindoora is collected.

g). Preparation of Mruganka Pottali rasa.²

Rasa Sindoora - ½ part.

Shuddha Gandhaka - 3 parts.

Method of preparation: Shuddha Shankha Nabhi churna is triturated with go-ksheera and a musha is prepared out of it. Rasa Sindoora+Gandhaka is triturated and kept inside prepared musha and covered with same musha material and cloth is covered on it. Mud is smeared on it and puta is given. After svangasheeta it is triturated along with musha and pills of 1 gunja size will be prepared.

3. Assessment Criteria:

Analytical study of the formulation will be carried out in the following manner.

1. 
   Organoleptic analysis:
   

• 
  Form
  
• 
  Colour
  
• 
  Taste
  
• 
  Odour
  
• 
  Consistency
  

2. 
   Physio-chemical analysis:
   

• 
  Loss on drying at 110⁰C
  
• 
  Total ash value
  
• 
  Acid insoluble ash
  
• 
  Water soluble ash
  
• 
  Determination of pH
  
• 
  Moisture content
  

3. 
   Chemical analysis:
   

4. 
   Special instrumental methods:
   

• 
  XRD
  
• 
  AAS
  

1. 
   Vaman Shivram Apte. Sanskrit-English Dictionary, 2000 edition. Delhi: Motilal Banarasidas publication, Pg. no. 348.
   

2. 
   Vagbhatacharya. Rasa Ratna Samucchaya- edited by Dr. Indra Dev Tripathi, Translated with “Rasprabha” Hindi commentary, 2^ndedition 2003. Chaukamba Publications, 14^th chapter shloka 20 to 22, Pg. no. 160.
   

3. 
   Sri Vagbhatacharya. Rasa Ratna Samucchaya- edited by Kaviraj Sri Ambikadatta Shastry, Translated with ’Suratnojjvala’ Hindi commentary, 6^th edition 1978. Chaukamba Amarabharthi Prakashan, 14^th chapter shloka 20-22, Pg. no.248.
   

4. 
   Acharya Sri Madhava. Ayurveda Prakasha-edited by Sri Gulrajsharma Mishra, Translated with ‘Arthavidyotini’ and ‘Arthaprashini’ Sanskrit and Hindi commentaries, 1962 edition. Varanasi: Chaukhambha Vidya Bhawan, 1^st chapter shloka 128 Pg.no.73.
   

5. 
   Pranacharya Sri Sadanand Sharma. Rasa Tarangini- edited by Pandit Kashinath Shastry.2004 edition. Delhi: Motilal Banarasidas publications, 12^th taranga shloka 7. Pg.no.286.
   

5b. Ibid 5^th taranga shloka 38 to 41. Pg. no. 82.

5c. Ibid 8th taranga shloka 13 to 17 Pg. no. 177

5d. Ibid 6^th taranga shloka 168 to 173. Pg. no.136.