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CURRICULUM VITAE




Prof.Y. NARSIMHA REDDY

M.Pharm, PhD

 

University College of pharmaceutical sciences,



Kakatiya University

Warangal 506009, A.P., INDIA

Email: ynrku@yahoo.co.in

nyellu@gmail.com



Contact: Work: 0870-2438844 (O); Personal: 09440705384

Education:

  • PhD majoring Pharmaceutical Sciences, Kakatiya University, Warangal, India, Nov.2004.

  • M.Pharm majoring in Pharmacology, Kakatiya University, Warangal,, India. Jannuary 1996.

  • B.Pharm majoring in Pharmaceutical Sciences, Kakatiya University, Warangal, Oct 1990

  • Professional Diploma in Clinical Research (PDCR) Catalyst Clinical Services, New Delhi


Professional (Teaching & Research) experience: 18years

Teaching Pharmacology, Clinical Pharmacy & Therapeutics and Biopharmaceutics, at UG & PG levels.



RESEARCH INTERESTS:


1. Clinical Pharmacokinetics

2. Population Pharmacokinetics

3. Pharmacovigilance

4. Cancer Biology

5. Evaluation of Biological and Toxicological Effects of Nanomaterials using in vitro &

in vivo Models

6. Pharmacological screening of herbal drugs with specific interest in

Cardiovascular Pharmacology and Diabetes
Professional Fellowships & memberships :

Fellow of Institution of Chemists India (FIC)

Fellow of Academy of Sciences for Animal Welfare (FASAW)

 Associate fellow of A.P Academy of science

Life Member of Indian Pharmaceutical Association (IPA).

Life Member of Association of Pharmaceutical teachers of India (APTI).

Life Member ofIndian Pharmacological Society (IPS)

Life Member of Indian Pharmacy Graduates Association (IPGA)

Life Member of Society of Toxicology, India (STOX)

Life Member of Laboratory Animal Scientists Association (LASA)



Other positions:

Member- Board of Studies of some Indian Universities

 Examiner for some Indian universities
Completed and on going research Projects:

Completed:1. DST (Rs. 13,48,000/-): Cytotoxicity of carboan nanomaterals

2.UGC- MRP (Rs.12 Lakhs) – Population Pharmacokinetics of some Cardiovascular

Drugs.


3.AICTE- RPS (Rs. 13 Lakhs) – Cytotoxicity of some Engineered nanomaterials

4.AICTE –MODROBS (Rs 18 Lakhs) – Population Pharmacokinetics and clinical

response of some anti-hypertensive drugs

On going: AICTE – RPS (Rs 22.5 Lakhs)- .Neuroimmune and neuroprotective activities of some

Indian Medicinal plants.
Number of research projects guided:

PG level:

Completed: 24 students

Guiding presently: 05 students

Ph. D level:

Completed: 15 students



Guiding presently: 08 students
Research Publications: 70 (National & International)

Research Presentations: 25 (National & International)
Research Publications:


  1. Venkateshwarlu Kodhati, Malla Reddy Vanga and Narsimha Reddy Yellu (2014).Synthesis and Anti Bacterial and Anti-ulcer Evaluation of New S-mannich Bases of 4,6-diaryl-3,4-dihydropyrimidin-2(1H)-thiones.Journal of the Korean Chemical Society 2013;57(2):234-240.

  2. E. Rajanarendar , K. Govardhan Reddy , S. Rama Krishna ,B. Shireesha , Y. N. Reddy , M. V. Rajam (2013). Design, synthesis, antimicrobial, anti-inflammatory, and analgesic activity of novel dihydrobenzo furo[3,2-e]isoxazolo[4,5-b]azepin-5(5aH)-ones. Med Chem Res,44(13):598-601.

  3. Mohammad Zubair Shareef, Narsimha Reddy Y , Venkata Narsimha Appa Rao A (2013). Neuropharmacological screening of essential oil from oleo gum resin of Gardenia lucida Roxb. Journal of Ethnopharmacology,149(3):621-625.

  4. E. Rajanarendar , S. Ramakrishna , K. Govardhan Reddy , D. Nagaraju ,Y. N. Reddy. A facile synthesis, anti-inflammatory and analgesicactivity of isoxazolyl-2,3-dihydrospiro[benzo[f]isoindole-1,30- indoline]-20,4,9-triones. Bioorganic & Medicinal Chemistry Letters 23 (2013) 3954–3958.




  1. Venkateshwarlu Kodhati, Malla Reddy Vanga, Narsimha Reddy Yellu (2013). Synthesis and Anti Bacterial and Anti-ulcer Evaluation of New S-mannich Bases of 4,6-diaryl-3,4-dihydropyrimidin-2(1H)-thiones. Journal of the Korean Chemical Society, 57(2):234-240.



  1. E.Rajanarendar,K.GovardhanReddy,S.RamaKrishna,M.NagiReddy,B.Shireesha,G.Durgaiah,Y.N. Reddy (2012). Synthesis and in vitro and in vivo anticancer activity of novel 3-methyl,4,6] Pyrido [2,3-b] indoles. Bioorganic & Medicinal Chemistry Letters. 22(21): 6677-6680.

  2. Venkateshwarlu Kodhati, Malla Reddy Vanga, Narsimha Reddy Yellu (2013). Synthesis and Anti Bacterial and Anti-ulcer Evaluation of New S-mannich Bases of 4,6-diaryl-3,4-dihydropyrimidin-2(1H)-thiones. Journal of the Korean Chemical Society, 57(2):234-240.

  3. E.Rajanarendar, M.NagiReddy ,S.RamaKrishna, K.Rama Murthy ,Y.N. Reddy,M.V.Rajam (2012).Design,Synthesis,antimicrobial,anti-inflammatory and analgesic activity of novel isoxazolyl Pyrimido[4,5-b]quinolines and isoxazolylchromeno[2,3-d]pyrimidin-4-ones. European Journal of Medicinal Chemistry, 55:273-2283.

  4. E. Rajanarendar, S.Raju, M. Nagi Reddy,S.Rama Krishna,L.hari Kiran,A.Rama Narsimha Reddy, Y.Narsimha Reddy (2012). Multi-component synthesis and in vitro and in vivo anticancer activity of novel arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides. European Journal of Medicinal Chemistry, 50:274-279.

  5. E. Rajanarendar , M. Nagi Reddy , S. Rama Krishna, K. Govardhan Reddy , Y.N. Reddy , M.V. Rajam (2012). Design, synthesis, in vitro antimicrobial and anticancer activity of novel methylenebis-isoxazolo[4,5-b]azepines derivatives. European Journal of Medicinal Chemistry, 50:344-349.

  6. E. Rajanarendar, M. Nagi Reddy , K. Rama Murthy , P. Surendar , R.N. Reddy , Y.N. Reddy(2012). Synthesis and in vitro and in vivo anticancer activity of novel phenylmethylene bis-isoxazolo[4,5-b]azepines. Bioorganic & Medicinal Chemistry Letters. 22: 149–153.

  7. P.Shankaraiah, D.Raju Y.NarsimhaReddy (2012).Alpha amylase inhibitory activity of flavonoids in diabetic induced rats. Journal of Pharmacy Research, 5(2):1183-1187.

  8. J.C. Hanish Singh, V. Alagarsamy, Prakash V. Diwan, S. Sathesh Kumar,J.C. Nisha, Y. Narsimha Reddy(2011).Neuroprotective effect of Alpinia galanga (L.) fractions on A_(25–35) induced amnesia in mice.

Journal of Ethnopharmacology, 138: 85– 91.

  1. J. C. Hanish Singh, V. Alagarsamy,S. Sathesh Kumar and Y. Narsimha Reddy (2011). Neurotransmitter Metabolic Enzymes and Antioxidant Status onAlzheimer’sDisease Induced Mice Treated with Alpinia galanga (L.) Willd. Phytother. Res. 25: 1061–1067.

  2. J. C. Hanish Singh, V.Alagarsamy, P.Prtibhan, P.Selva Kumar and Y. Narsimha Reddy (2011).Neuroprotective potential of ethanolic extract of Pseudathria viscida(L) Wight and Arn againest B-amyloid induced amnesia in mice. Ind J Biochem. Biohys., 48:197-201.

  3. CH Ravikanth, A Anil Kumar, V Uday Kiran, S.Prashanth, B.Madhu, Y. Narsimha Reddy (2011).Sensitive and rapid HPLC method for the determination of pioglitazone in rat serum. Int. J Pharm. Sci. Drug Res., 3(1): 38-41.

  4. H. Parameshwar, B. Babu Rao, B. Ravi Kumar, Y. Narsimha Reddy and G. Krishna Mohan (2011). Hepatoprotective effect of methanolic extract of the leaves of Kydia calycina on carbon tetrachloride induced hepatotoxicity in albino rats. African Journal of Pharmacy and Pharmacology,5(16): 1920-1924.

  5. H. Parameshwar, B. Ravi kumar, G. Krishna Mohan, V. Raju and Y. Narsimha Reddy (2011). Hepatoprotective effect of the methanolic extract of whole plant of Borreria articularis on carbon tetrachloride induced hepatotoxicity in albino rats. JPRHC, 2(4):285-292.

  6. P.Shankaraiah,Y.N.Reddy (2011). Alpha Amylase expressions in Indian Type-2 diabetic patients. J.Med.Sci. 11(7):280-284.

  7. H. Parameshwar, B. Ravi kumar, G. Krishna Mohan, V. Raju and Y. Narsimha Reddy (2010).Protective effect of methanoloic fruit extract of Solina amplexicaulis in carbon tetrachloride induced hepatotoxicity on rats.S.j.Pharm.Sci.,3(2):1-6.

  8. A.Rama Narsimha Reddy, Y.Narsimha Reddy, D.R.Krishna and V.Himabindu(2010). Multi wall carbon nanotubes induce oxidative stress and cytotoxicity in human embryonic kidney (HEK293) cells. Toxicology. 272: 11-16.

  9. A.Rama Narsimha Reddy, M. Venkateswar Rao, Devarakonda R. Krishna, V. Himabindu and Y. Narsimha Reddy (2010).Evaluation of oxidative stress and anti-oxidant status in rat serum following exposure of carbon nanotubes .Regulatory Pharmacology & Toxicology59(2):251-257.

  10. U.K.Veldandi, N.R.Yellu, N.Malothu, R.K.Devarakonda (2010). Development and Validation of HPLC Method for the determination of Losartan in Human plasma. Reviews in Analytical Chemistry, 29(1):59-67.

  11. V.Uday Kiran,N.Venkat Rajaiah,D.R.Krishna, Y.Narsimha Reddy (2010).Effect of Losartan and Ramipril on oxidative stress and antioxidant status in south Indian hypertensive patients.Int.J Pharmacology,6(6):916-920.

  12. A.Rama Narsimha Reddy, Y.Narsimha Reddy, R. K. Devarakonda and V.Himabindu (2010). In Vitro Toxicity of Multi Wall Carbon Nanoparticles on Hep G32 Liver Cell Lines. Journal of Pharmacology & Toxicology,5(4):146-151.

  13. A.Rama Narsimha Reddy, Y.Narsimha Reddy, D.R.Krishna and V.Himabindu(2010). In vitro cytotoxicity of multi wall carbon nanotubes on human cell lines. Toxicological and Environmental Chemistry,92(9):1697-1703.

  14. A.Rama Narsimha Reddy, Y. Narsimha Reddy, D. R. Krishna and V .Himabindu (2010). Pulmonary Toxicity Assessment of Multi-wall Carbon Nanotubes in Rats following Intratracheal Instillation. Environmental Toxicology, 27(1):3-10.

  15. A.Rama Narsimha Reddy, Y. Narsimha Reddy, D.R.Krishna and V.Himabindu (2010). Translocation and extra pulmonary toxicity of Multi-wall Carbon Nanotubes in Rats. Toxicology Mechanisms and Methods, 20(5):267-272.

  16. P. Shankaraiah, Y.Narsimha Reddy, A.Venkatesham, N.Venkata Rajaiah D.R.Krishna (2010).Differential Expression of Glucokinase activity in Type -2 Indian diabetes patients. Int. J. Pharmacology, 6(4):496-500.

  17. R.N.R.Anreddy, M.Porika, N.R.Yellu and R.K.Devarakonda (2010). Hypoglycemic and Hypolipidemic activities of Trianthema portulacastrum Linn. Plant in normal and alloxan induced diabetic rats .Int. J. Pharmacology, 6(2):29-133.

  18. Shankaraiah Puligilla, Venkatesham Allenki , Rama Krishna Devarakonda, Narsimha Reddy Yellu (2010). Influence of HbA1C on Dipeptidyl Peptidase-IV activity in Indian type-2 diabetic patients. Journal of Pharmacy Research, 3(9):2300-2302

  19. Nagulu Malothu, Uday Kiran Veldandi, Narsimha Reddy Yellu, Nalini Yadala, Rama Krishna Devarakonda(2010). Population Pharmacokinetics of 5-Flouro Uracil In Indian Cancer Patient Population. Asian J.Pharm. & Clin. Res., 3(3):197-200.

  20. M.Nagulu, V. Uday Kiran, Y.Nalini, Y Narsimha Reddy, D Rama Krishna (2010). Population Pharmacokinetics of Methotrexate in Indian Cancer Patients. Asian Pacific Journal of Cancer Prevention, 11: 403-410.

  21. Bhukya Baburao, Anreddy Rama Narsimha Reddy, Gangarapu Kiran, Yellu Narsimha Reddy, Gottumukkala Krishna Mohan (2010). Antioxidant, analgesic and anti-inflammatory activities of Leucas cephalotes (Roxb.ex Roth) Spreng. Brazilian Journal of Pharmaceutical Sciences, 46(3):526-529.

  22. T.Radhika, P.Mahender, A.Venkatesham, A.R.N.Reddy, Y.Narsimha Reddy, A.Sadanandam,T.Christopher (2010). Hypoglycemic activity of red kino tree in normal and streptozotocin induced diabetic rats. Int.J.Pharmacplogy, 6(3):301-305.

  23. A.Venkatesham, N. Prasad, D.R. Krishna and Y.Narsimha Reddy (2009). Dipeptidyl Peptidase-IV Inhibitory Activity of Parotid Exudate of Bufo Melanostictus. Phcog Res., 1(2):98-101

  24. M.Nagulu, V.Uday Kiran, K.Nalini, R.Dharak, Y.Narsimha Reddy, D.Rama Krishna (2009). Oxidative stress and anti-oxidant status in breast cancer patients. J. Pharm. Res., 2(1):62-65.

  25. S .Martha, U.K.Veldandi, R.Devarakonda Krishna, N .Pantam, S.Thungathurthi, N. Reddy Yellu (2009).Protective Effect of Aspirin in Relation to IGF-I in Streptozotocin Induced Type-II Diabetic Rats. Int J Endocrinol Metab., (1): 20-25.

  26. K. Harish Kaushik, S. Vijay Kumar, B.Satish Kumar, Y.Narsimha Reddy, V .K Raghavaiah and R.Krishna Devarakonda (2009). Population Pharmacokinetics of Cisplatin in Asian Indian Cancer Patients. Clin. Res. Regul. affairs, 26(4):84-92.

  27. S. Vijay Kumar, K.Harish Kaushik, B. Satish Kumar, Y. Narsimha Reddy, V .K. Raghavaiah and R. Krishna Devarakonda (2009). Population Pharmacokinetics of Doxorubicin in Indian Cancer Patients .Clin. Res. Regul. affairs, 26(4):93-100.

  28. M.Srinivas , A.Rama Narsimha Reddy, D.R.Krishna ,P.Narayana , Y.Narsimha Reddy & Surender T(2009).Role of Liver in Progression of Insulin Resistance in Relation to IGF-I and Insulin Levels in Rats with Acute Hepatotoxicity . Lat. Am. J. Pharm. 28 (6):914-8.

  29. A.Venkatesham , D.R.Krishna, A. Rama Narsimha Reddy, P.Narayana, Y.Narsimha Reddy (2009). Fasting and Post Prandial Monitoring of Dipeptidyl Peptidase-IV (DPP-IV)- A biomarker to assess Incretin response in type-2 diabetes. Stamford J Pharm Sci. 2(2): 81-85.

  30. Y.Narsimha Reddy, S.Vasudeva Murthy, D.R.Krishna and M.C.Prabhakar (2009). Oxidative metabolic changes in pleural fluid of tuberculosis patients. Bangladesh J Pharmacol, 4: 69-72.

  31. K.Prasanna Kumar, A. Janaki, A. Rama Narsimha Reddy and Y.Narsimha Reddy (2009). Pharmacokinetics and Pharmacodynamics of Atorvastatin alone and in Combination with Lercanidipine in Hyperlipidemic Rats. J. Pharm. Res., 2(1):65-69.

  32. P. Shankaraiah, A.Venkatesham, N.Prasad, Y.Narsimha Reddy, D.R.Krishna (2009).Does aspirin pretreatment prevents the diabetes in rats? Pharmacology-online, 3: 596-605.

  33. G.Kranthi, A.Rama Narsimha Reddy, Pavan Umate, Y.Narsimha Reddy(2009). Sadanandam Abbagani (2009). Antioxidant and anti-diabetic activities from leaf extracts of Streblus asper Lour. BTAIJ, 3(4): 232-235.

  34. V.Venkata Rajesham ,A.Rama Narsimha Reddy , G.Rajyalakshmi , J.Anbu, Y. Narsimha Reddy(2008). Pharmacokinetics of Nifedipine in Hyperlipidemic Rats. Online J Pharmacokinetics, 4:18-23.

  35. A.Venkatesham, D.R .Krishna and Y.Narsimha Reddy (2008).Dipeptidyl Peptidase – IV (DPP-IV) inhibitory activity of metformin. Pharmacology online, 2: 372-378.

  36. M.Srinivas, A. Annapurna , Y.Narsimha Reddy (2008). Anti- atherosclerotic effects of atorvastatin and clopidogrel alone and in combination in rats. Indian J Exptl Biol, 46: 698-700.

  37. K. Prasanna Kumar, A. Rama Narsimha Reddy, J. Anbu and Y. Narsimha Reddy (2008). Simultaneous determination of atorvastatin and lercanidipine in rat plasma by HPLC and pharmacokinetic studies.AJPP, 8(4):299-304.

  38. T.Radhika, P. Mahendar, A.V.Rao, A.Sadanandam, Y.Narasimha Reddy and T.Christopher (2008). Analgesic Activity of Root Extract of Acorus Calamus Linn. Pharmacologyonline, 3: 240-243.

  39. K.Prasanna Kumar, A.Janaki, A.Rama Narsimha Reddy and Y.Narsimha Reddy (2008).Effect of hyperlipidemia on Pharmacokinetics of Lercanidipine in experimental Rats. Pharmacology online 3: 581-585.

  40. A.Rama Narsimha Reddy, D. R. Krishna and Y. Narsimha Reddy (2008). A review on concepts of nanotechnology. Pharmacology online. 3: 175-186.




  1. Y.Narsimha Reddy , V.Anil Kumar, M.Srinivas , V.Narayana Reddy (2008).Study on Oxidative Metabolic Changes to Differentiate Exudative from Transudative Pleural Effusions. S. J. Pharm. Sci., 1(1&2): 39-44.




  1. M.Nagulu, N.Prasad, M.C. Prabhakar, Y.N.Reddy (2008).Frog rectum as a new experimental model in Pharmacology.IJCAP, 25(2):12-15.

  2. B.Chandrasekhar Reddy, A.V.Jithan , Y.Narsimha Reddy and V.Malla Reddy (2008).Fabrication and investigations on hepatoprotective activity of sustained release biodegradable piperine microspheres. IJPSN, 1(1):87-96.

  3. B.R.Chandrasekhar , R.Srinivas . Challa, Y.Narsimha Reddy, A.Murali , A.V.Jithan (2007). Preparation and characterization of piperine multilamellar vesicular liposomes Intended for Testing Anticonvulsant Activity in Rats. Indian Drugs, 44(6):458-465.

  4. K .Venkateswarlu, R.K .Venisetty, N. R. Yellu, S .Keshetty, M.G. Pai (2007). Development of HPTLC - UV absorption densitometry method for the analysis of alprazolam and sertraline in combination and its application in the evaluation of marketed preparations. J. Chromatographic Science, 45:1-3.

  5. P.Govardhan, P.Laxmi ,B. Diwakar , K.Thirupathi ,M.B.Krishna, Y.Narsimha Reddy, B.Ravikumar, G.KrishnMohan,P.RajeswaraRao(2007).Antinociceptive and Anti-inflammatory effects of Cleome chelidonni Linn. roots in experimental animals. Phcog Mag, 4(13):32-36.

  6. K.Venkateswarlu, Y. N. Reddy, K.Srisailam,V. Rajkumar and M.G.Pai (2007). Determination of tramadol in Capsules by high performance thin layer chromatography – densitometry. CTBP, 2(3):421-425.

  7. Y.N. Reddy, S.V. Murthy, D.R. Krishna, M.C. Prabhakar. (2004). Role of free radicals and antioxidants in tuberculosis patients. Indian J. Tuberc., 52:213-218.

  8. Y.N. Reddy, S.V. Murthy, D.R. Krishna, M.C. Prabhakar. (2004). Determination of antioxidant activity of some anti-tubercular drugs by using HPLC. Indian J. Pharmaceutical Sciences, September-October, 702-703.

  9. Y.N. Reddy, S.V. Murthy, D.R. Krishna, M.C. Prabhakar (2003). Oxidative stress and antioxidant status in leprosy patients. Indian J. Lepr., 75(4): 1-10.

  10. N.C. Srikanth, S.Gangadhar, Y. Narsimha Reddy, S.S.Apte, V. Laxmipathi, A.V.N. Apparao, D.R. Krishna and M.C. Prabhakar (1997). Characterization of Leprosy based on the nasal lipid profile. Indian J. Lepr., 69(2): 179-181.

Papers presented in international conferences:




  1. H.Kaushik, Y.N.Reddy, V. Sripuram, N. Malothu, R.K.Devarakonda. Population Pharmacokinetics of Cisplatin (T3321).AAPS Annual meeting and Expositio, USA, November 16-20, 2008.




  1. V. Sripuram ,Y.N.Reddy, H.Kaushik, S.Bedada, R.K.Devarakonda.Development and validation of rapid and sensitive HPLC method for the determination of Doxorubucin in human plasma(M1004). AAPS Annual meeting and Expositio, USA, November 16-20, 2008.




  1. H.Kaushik, Y.N.Reddy, V. Sripuram, S.Bedada, R.K.Devarakonda.A simple and sensitive HPLC method for the determination of Cisplatin(M1005). AAPS Annual meeting and Expositio, USA, November 16-20, 2008.




  1. A.Venkatesham, Y.N.Reddy, P.Narayana, R.K.Devarakonda. Differential expression of Dipeptidyl Peptidase – IV (DPP-IV) in Asian Indian NIDDM patient population (T2009). AAPS Annual meeting and Expositio, USA, November 16-20, 2008.

Papers presented in national conferences:




  1. HV.Chauhan , U.Venkatesham , L.Harikiran ,K.Venkateshwar Rao and Y.Narsimha Reddy. Evaluation of antidiabetic activity of lawsone and its o-alkyl derivatives (D1086).RIPE-2012,JNTU,Hyderabad,17-18 August,2012.




  1. N.Valya, G.Durgaiah, Y.Narsimha Reddy, Ch.Bhanu. Evaluation of antihyperglycemic and antihyperlipidemic activity of some novel piperonal derivatives (D1083). RIPE-2012,JNTU,Hyderabad,17-18 August,2012.



  1. Y.Narsimha Reddy,V.Udaykiran,N.Venkata Rajaiah,D.R.Krishna.Apopulation Pharmacokinetic analysis of losartan in Indian hypertensive patients(PPp-16).XXXXIII Annual Conference of Indian Pharmacological Society,Hyderabad,December 13-16,2010.




  1. P.Shankaraiah,A.Venkatesham,Y.Narsimha Reddy.Influence of flavonoids on glucokinase activity in diabetic rats (PPLa-44). XXXXIII Annual Conference of Indian Pharmacological Society,Hyderabad,December 13-16,2010.

Venkateshwarlu Kodhati, Malla Reddy Vanga and Narsimha Reddy Yellu (2014).Synthesis and Anti Bacterial and Anti-ulcer Evaluation of New S-mannich Bases of 4,6-diaryl-3,4-dihydropyrimidin-2(1H)-thiones Journal of the Korean Chemical Society 2013;57(2):234-240.


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