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Curriculum vitae


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CURRICULUM VITAE

Ling Li


http://www.gdcb.iastate.edu/faculty_and_research/bios/lli.shtml
Adjunct Assistant Professor, Department of Genetics, Development and Cell Biology,

443 Bessey Hall, Iowa State University, Ames, IA 50011.

Phone: 515-294-6236; Fax: 515 294-1337; liling@iastate.edu
(a) Professional Preparation

Peking University, Beijing, China Biology B.S. 1997

Peking University, Beijing, China Botany M.S. 2000

Iowa State University, Ames, IA Genetics Ph.D. 2006

Iowa State University, Ames, IA Gen, Devel Cell Biol Postdoc 2006/12-2007/11
(b) Appointments

2012/3-present Adjunct Assistant Professor, Interdepartmental Genetics, Iowa State University

2011/6-present Adjunct Assistant Professor, Interdepartmental Plant Biology, Iowa State University

2011/2-present Adjunct Assistant Professor, Genetics, Development and Cell Bio, Iowa State University

2010/3-present Associate Scientist, Genetics, Development and Cell Biology, Iowa State University

2008/9-2010/3 Assistant Scientist II, Genetics, Development and Cell Biology, Iowa State University

2007/11-2008/9 Research Associate II, Genetics, Development and Cell Biology, Iowa State University
(c) Publications

Ngaki MN, Louie GV., Philippe RN, Manning G, Pojer F, Bowman ME, Li L, Larsen E, Wurtele ES and Noel JP (2012) Evolution of the chalcone isomerase fold from fatty acid-binding to stereospecific enzyme. Nature. In Press.

Feng YP, Hurst J, Almeida-De-Macedo M, Chen X, Li L, Ransom N, and Wurtele ES (2012) A massive human co-expression-network and its medical applications. Systems Biology, Chemistry & Biodiversity. In Press.

Li X, Ilarslan H, Brachova L, Qian HR, Li L, Che P, Wurtele ES, and Nikolau BJ (2011) Reverse genetic analysis of the two biotin-containing subunit genes of the heteromeric acetyl-CoA carboxylase in Arabidopsis thaliana indicates a unidirectional functional redundancy. Plant Physiol., 155: 293-314.

Jia M, Li L, Boggess E, Wurtele ES, Dickerson JA (2010) Visualizing multivariate hierarchic data using enhanced radial space-filling layout. In: Advances in Visual Computing. Volume 6453. Berlin / Heidelberg: Springer, 350-360. DOI: 10.1007/978-3-642-17289-2_34.

Li L, Foster C, Gan Q, Nettleton D, James MG, Myers AM, and Wurtele ES (2009) Identification of the novel protein QQS as a component of the starch metabolic network in Arabidopsis leaves. Plant Journal, 58: 485-498.

Li L, Ilarslan H, James MG, Myers AM, and Wurtele ES (2007) Genome wide co-expression among the starch debranching enzyme genes AtISA1, AtISA2, and AtISA3 in Arabidopsis thaliana. Journal of Experimental Botany, 58: 3323-3342.

Wurtele ES, Li L, Berleant D, Cook D, Dickerson JA, Ding J, Hofmann H, Lawrence M, Lee EK, Li J, Mentzen W, Miller L, Nikolau BJ, Ransom N, and Wang Y (2007) MetNet: Systems Biology Software for Arabidopsis. In: Nikolau BJ and Wurtele ES, eds. Concepts in Plant Metabolomics. Chapter 10. Dordrecht, The Netherlands: Springer, 145-158.

Dickerson JA, Berleant D, Du P, Ding J, Foster CM, Li L, and Wurtele ES (2004) Creating, modeling and visualizing metabolic networks. In: Hsinchun Chen, Sherrilynne S Fuller, Carol Friedman, and

William Hersh, eds. Medical informatics: knowledge management and data mining in biomedicine. Chapter 17. New York: Springer, 491-518.



Li L, Ji C, and You R (2001) Ultrastructural studies on megasporogenesis in Triticum aestivum L.. Acta Scientiarum Naturalium Universitatis Pekinensis, 37: 444-453.

Li L, Wang M, and You R (1997) An investigation of the toxic effects of cadmium on Potamegeton crispus L.. Thesis Collection of the Plant Institute’s 70th Anniversary, China.
(d) Awarded support

Iowa State University Research Foundation, Inc.: a molecular tool to increase the protein content of commercial crop, PI: Ling Li; $30,000, 2011-2012.

United Soybean Board: High-protein soybeans (in Program of “Identify oil and meal traits and the genes that influence those traits to improve the quality and value of U.S. soybeans”), PI: Ling Li, Cooperators: Eve Wurtele, Walter Fehr; $149,015, 2011-2012.

Iowa State University Research Foundation, Inc.: QQS role in seed composition determination, PI: Ling Li; $10,000, 2011.

Iowa State University Research Foundation, Inc.: Identification of the Novel Protein QQS as a Component of the Starch Metabolic Network, PI: Ling Li; $3,672, 2011.

National Science Foundation MCB Award #0951170: Uncovering novel signaling interactions in plant metabolic networks, PI: Eve Wurtele, Co-PI: Ling Li, Co-PI: Taner Sen; $920,000, 2010-2014.



(e) Synergistic Activities

  1. Invention disclosure titled "High Protein Low Starch QQS Soybeans for Enhanced Value", ISURF docket number: ISURF #03844, Ling Li and Eve Wurtele, 2010; a provisional patent application has been filed, titled "MATERIALS AND METHOD FOR MODIFYING A BIOCHEMICAL COMPONENT IN A PLANT", provisional Patent Application No. 61/446,460, Ling Li and Eve Wurtele, 2011.

  2. Honors and awards

ICAR 2012 (International Conference on Arabidopsis Research) Travel Awards for Early Career U.S. Scientists.

ICLGG5 (International Conference on Legume Genomics and Genetics) travel award, 2010. Awarded to limited number of junior scientists from USA to cover meeting registration.

ICLGG4 (International Conference on Legume Genomics and Genetics) travel award, 2008. Funds from NSF awarded to limited number of junior scientists from USA to cover meeting registration).

NPLC (National Plant Lipid Conference) 2007 travel award. Awarded to a limited number of young researchers, to cover meeting registration and lodging costs.

Iowa State University Research Excellence Award, Fall 2006. Awarded to top 10% of graduating doctoral students for outstanding research/creativity.

Fung Award, 2006. Award for graduate student achievement in pursuit of research in department of GDCB.

Dale W. Young and W.E. Loomis Award, 2005. Award for graduate student achievement in pursuit of research in department of GDCB.

PACE Award (Premium for Academic Excellence) – Iowa State University, 2000 (award for outstanding incoming graduate students)



  1. Teaching and mentoring

Fall 2011: Section Instructor of Plant Metabolism 513, teaching respiration, lipids/fatty acids, isoprenoids, alkaloids, and regulation of metabolism.

Aug 17, 2011, University teaching Seminar organizer, prepared and presented the seminars of “International Issues and Welcome to Ames”, “Hands on with Students: Lab work, independent study, and being a boss” and “Time Management”.

Jan 2008 – present: Supervised 7 undergraduate students in Independent Study research course (2 units); created course syllabus, supervised research, data interpretation; worked with students on effective oral and written presentation of results.

2007 – present: Section Instructor of Plant Growth Regulation 512, taught paper reviews about gibberellin metabolism and presentation of MetNet softwares, taught students to use the software to identify genes for hypothesis development.

2002 – present: Trained 10 graduate students and 5 postdocs in experiment skills, designs, methods, and techniques, helped with troubleshooting, interpreting and evaluating results; Trained 9 undergraduate students in experiment skills and design, and supervised their research projects; Supervised 2 high school students in research projects, stimulated their interest in science.

2007 – 2011: Preparing Future Faculty (PFF). Participated in PFF program, including presentations of seminars, mock classes, teaching approaches, preparation of class materials. Received PFF Scholar certificate.

May 2007: Designed and led 2-day workshops for exploration of multidimensional experimental data from Arabidopsis, soybean, and Echinacea at Iowa State University; taught use of MetaOmGraph, the multidimensional data analysis software.

2006-2007: Demonstrated the use of MetNet software at ASPB (American Society of Plant Biology) 06 and ASPB 07.



  1. Invited talks

Li L (2011) "Uncovering novel signaling interactions in plant metabolic networks." Interdepartmental Plant Biology retreat, Ames, IA, USA.

Li L (2011) "Uncovering novel signaling interactions in plant metabolic networks." ASPB (American Society of Plant Biology) 2011 meeting, Minneapolis, MN, USA.

Li L (2011) "Uncovering novel signaling interactions in plant metabolic networks." International Conference on Arabidopsis Research 2011, Madison, WI, USA.

Li L (2011) "Uncovering novel signaling interactions in plant metabolic networks." GDCB Department Seminars, Iowa State University, Ames, IA, USA.

Li L (2008) “Identification of the novel protein QQS as a component of the starch metabolic network in Arabidopsis leaves.” Plant Biology Department seminars, Peking University, Beijing, China.

Li L (2007) “Down-regulation of a novel small gene confers a starch-excess phenotype in Arabidopsis.” ASPB (American Society of Plant Biology) 07 meeting, Chicago, IL, USA.

Li L (2007) “Systems biology approach to understand seed composition.” NPLC (National Plant Lipid Conference) 07 meeting, Fallen Leaf, CA, USA.

  1. Society memberships

Member of American Society of Plant Biologists: Participated in annual conferences, selected for two 20-minute presentations (2007 and 2011), exhibited my research and exchanged with others, volunteered to be a PlantingScience mentor.

Ames Chinese Language School teacher: Introduce Chinese culture and teach Chinese on Sundays to America-Born-Chinese.

Iowa State University CSSFA (Chinese Students and Scholars Friendship Association): Welcome /pick up ISU new graduate students; prepared Chinese food on the international food fair on ISU VEISHEA in 2001 (more than 1000 people visited the booth); organized Chinese Parents Party in 2004 to help make the parents of ISU scholars and students feel welcome in the Ames community.


  1. Other Affiliations

Ph.D. Advisor: Dallas Jones

Postdoc-Scholar Sponsor: Ying Zhang, and Sheng Huang

Journal Reviewer For

Plant Physiology, BMC Biology, Crop Science, and Plant Cell Reports



(f) Selected Conference Presentations

Li L, Hoel M, Wang Y, and Wurtele ES (2011) "Uncovering novel signaling interactions in plant metabolic networks". ASPB (American Society of Plant Biology) 2011 meeting, Minneapolis, MN, USA.

Li L, Zhou WX, Yu X, Demirkale Y, Ransom N, Zhou WG, Iyer V, Shanks J, Nettleton D, Westgate M, Nikolau B, and Wurtele ES (2009). “Understand soybean seed composition using systems biology approach”. 18th Growth Factor and Signal Transduction Conferences: Symposium on Systems Biology: Integrative, Comparative, and Multi-Scale Modeling, Ames, IA, USA.

Li L, Zhou WX, Zhou WG, Demirkale Y, Ransom N, Shanks J, Iyer V, Nettleton D, Westgate M, Nikolau B, and Wurtele ES (2008). “Systems biology approach to understand seed composition: A convergence of metabolomics, transcriptomics and metabolic flux data to expand the metabolic and regulatory network of developing soybean seeds”. International Conference on Legume Genomics and Genetics 4, Puerto Vallarta, Mexico.

Li L, Zhou WX, Zhou WG, Periappuram C, Nettleton D, Westgate M, Nikolau BJ, and Wurtele ES (2007). “Analyses of soybean seed transcriptomics data and metabolomics data using R: A systems biology approach to understanding seed composition”. UseR conference 2007, Ames, IA, USA.

Li L, Alabsi MS, Babka H, Berleant D, Cook D, Dickerson JA, Ding J, Etzel J, Lawrence M, Lee E, Li J, Mentzen W, Miller L, Ransom N, Zhang L, and Wurtele ES (2006) “Metnet platform for systems biology”. ASPB (American Society of Plant Biology) 06 meeting, Boston, MA, USA.

Li L, Ilarslan H, James MG, Myers AM, and Wurtele ES (2006) “Starch Metabolism in Arabidopsis: the Debranching Enzymes”. ASPB (American Society of Plant Biology) 06 meeting, Boston, MA, USA.

Li L, Foster CM, Ilarslan H, Ransom N, McCarty S, Yakobson A, Du P, Dickerson J, James MG, Myers AM, and Wurtele ES (2005) “Starch granule metabolism and acetyl-CoA utilization”. ASPB (American Society of Plant Biology) 05 meeting, Seattle, WA, USA.

(g) Manuscript Submitted/In Preparation

Li L, Wurtele ES (2012) Control of seed composition by proteins with obscure features (To be submitted to Plant Journal).

Li L, Zhou WX, Zhou WG, Ranson N, Periappuram C, Nettleton D, Westgate M, Wurtele ES, and Nikolau BJ (2012) System biology approach to understand seed composition (To be submitted to Plant Physiology).

Li L, Zhou WX, Demirkale Y, Ransom N, Zhou WG, Iyer V, Shanks J, Nettleton D, Westgate M, Nikolau BJ, and Wurtele ES (2012) Systems biology approach to understand seed composition: A convergence of metabolomics, transcriptomics and metabolic flux data to expand the metabolic and regulatory network of developing soybean seeds (To be submitted to Plant Journal).

Ransom N, Li L, and Wurtele ES (2012) MetaOmGraph: a systems biology tool for analysis of large datasets (To be submitted to BMC Bioinformatics).

Yu X, Li L, Nikolau BJ, Cooper B, Wurtele ES (2012) Integrated transcriptomic and proteomic analysis of near-isogenic soybean lines differing in seed protein content (In preparation).

Iyer V, Li L, Studham M, Westgate ME, Wurtele ES, Shanks J (2011) Metabolic flux and transcriptional profiling of soybean lines varying in capacity for protein accumulation, submitted to Biochemical Journal.



Sucaet Y, Li J, Sivakumar S, Ransom N, Choi SY, Babka H, Li L, Miller L, Dickerson J, and Wurtele ES (2011) MetNet Online and MetNetDB: A Plant Biological Network Database and Web Portal, submitted to DATABASE.




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