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Curriculum vitae gregory j. Hannon

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1986 Case Western Reserve University, Cleveland, OH B.A., Biochemistry

1992 Case Western Reserve University, Cleveland, OH Ph.D. Mol. Biology



1982-86 Andrew J. Squire Scholar

1986 Phi Beta Kappa

1992-95 Damon Runyon-Walter Winchell Cancer Research Fund Fellowship

1997-00 Pew Scholar in the Biomedical Sciences

2000- Rita Allen Scholar

    1. U.S. Army Breast Cancer Research Program Innovator Award

2003-2005 Faculty of 1000

2005 AACR Award for Outstanding Achievement in Cancer Research

2007 National Academy of Sciences Award in Molecular Biology

2007 Memorial Sloan-Kettering Cancer Center Paul Marks Prize for Cancer Research


Research and Professional Experience

1986-1992 Ph.D. Thesis, Case Western Reserve University, Cleveland, OH

1992-1994 Postdoctoral Fellow, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

1994-1995 Staff Associate II, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

1996-2000 Assistant Professor, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

2000-2002 Associate Professor, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

2002- Professor, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

2005- Adjunct Professor, Dept. of Microbiology, Stony Brook University

2005- Investigator, Howard Hughes Medical Institute

2007- Chair, Program in Genetics and Bioinformatics

Teaching Experience and Other Educational Activities

1995-1997 Instructor, Graduate Cell Biology, SUNY Stony Brook

1998-2001 Instructor, Graduate Genetics, SUNY Stony Brook

    1. Co-Director, Graduate Genetics Course, SUNY Stony Brook

    2. Instructor, Scientific Reasoning and Logic, Watson School of Biological Sciences, Cold Spring Harbor Laboratory

2001- Associate Director, Undergraduate Research Program, Cold Spring Harbor Laboratory

2002- Lead Instructor, Scientific Reasoning and Logic, Watson School of Biological Sciences, Cold Spring Harbor Laboratory

Program Affiliations

1997-present Member, Genetics Graduate Program, SUNY Stony Brook

1997-present Member, Molecular and Cellular Biology Graduate Program, SUNY Stony Brook

1999 Admissions Committee Genetics and Molecular and Cellular Biology Programs, SUNY Stony Brook

1999-present Admissions Committee, Watson School of Biological Sciences, Cold Spring Harbor Laboratory (2005-, chair)

2006- Member, Biomedical Engineering Graduate Program, Stony Brook University
Commercial Relations

1998 Co-founder, Genetica inc.

2005 Consultant, Alnylam

2006- Consultant, Open Biosystems

2006- Co-founder, Rxi pharmaceuticals

2006- Scientific Advisory Board, Rxi pharmaceuticals

Books and Chapters (6)

Hannon, GJ (1995) Expression of cell cycle proteins using recombinant baculoviruses. In Cell cycleMaterials and methods (ed. M. Pagano), pp. 231242. Springer-Verlag, Berlin.

Zhu, Li, Hannon, Gregory J. (2000) Yeast hybrid technologies. BioTechniques Books/Eaton Publishing.

Hannon, GJ (2003) RNAi, A guide to gene silencing. Cold Spring Harbor Laboratory Press.

Zamore, PD and Hannon, GJ Small RNAs, Big Biology, in RNAi, A guide to Gene Silencing.

Carmell, M and Hannon, GJ (2004) Achieving stable, heritable gene silencing in the mouse, in RNA interference, nuts and bolts of RNAi technology (ed. D. Engelke), pp. 217-234. DNA Press.

Paddison, PJ and Hannon GJ (2004) RNA interference in mammals : journey to the center of human disease. In Molecular Cancer Therapeutics (ed. G. Prendergast) pp. 55-72 Wiley and Sons, Hoboken, NJ.

Rossi, JJ and Hannon GJ (2007) Methods in Enzymology; MicroRNA Methods

Publications (161)

Hannon GJ, Jentoft JE. 1985. MOLECULAR DESIGNER: an interactive program for the display of protein structure on the IBM-PC. Comput Appl Biosci 1(3):177-81.

Ransohoff RM, Denker JA, Takacs AM, Hannon GJ, Nilsen TW. 1989. Organization and expression of 5S rRNA genes in the parasitic nematode, Brugia malayi. Nucleic Acids Res 17(10):3773-82.

Maroney PA, Hannon GJ, Denker JA, Nilsen TW. 1990. The nematode spliced leader RNA participates in trans-splicing as an Sm snRNP. Embo J 9(11):3667-73.

Hannon GJ, Maroney PA, Branch A, Benenfield BJ, Robertson HD, Nilsen TW. 1989. Accurate processing of human pre-rRNA in vitro. Mol Cell Biol 9(10):4422-31.

Maroney PA, Hannon GJ, Nilsen TW. 1989. Accurate and efficient RNA polymerase III transcription in a cell-free extract prepared from Ascaris suum embryos. Mol Biochem Parasitol 35(3):277-83.

Hannon GJ, Maroney PA, Ayers DG, Shambaugh JD, Nilsen TW. 1990. Transcription of a nematode trans-spliced leader RNA requires internal elements for both initiation and 3' end-formation. Embo J 9(6):1915-21.

Hannon GJ, Maroney PA, Denker JA, Nilsen TW. 1990. Trans splicing of nematode pre-messenger RNA in vitro. Cell 61(7):1247-55.

Maroney PA, Hannon GJ, Nilsen TW. 1990. Transcription and cap trimethylation of a nematode spliced leader RNA in a cell-free system. Proc Natl Acad Sci U S A 87(2):709-13.

Hannon GJ, Maroney PA, Nilsen TW. 1991. U small nuclear ribonucleoprotein requirements for nematode cis- and trans-splicing in vitro. J Biol Chem 266(34):22792-5.

*1Maroney PA, Hannon GJ, Shambaugh JD, Nilsen TW. 1991. Intramolecular base pairing between the nematode spliced leader and its 5' splice site is not essential for trans-splicing in vitro. Embo J 10(12):3869-75.

Hannon GJ, Maroney PA, Yu YT, Hannon GE, Nilsen TW. 1992. Interaction of U6 snRNA with a sequence required for function of the nematode SL RNA in trans-splicing. Science 258(5089):1775-80.

Hannon GJ, Demetrick D, Beach D. 1993. Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. Genes Dev 7(12A):2378-91.

Serrano M, Hannon GJ, Beach D. 1993. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366(6456):704-7.

Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D. 1993. p21 is a universal inhibitor of cyclin kinases. Nature 366(6456):701-4.

Feilotter HE, Hannon GJ, Ruddell CJ, Beach D. 1994. Construction of an improved host strain for two hybrid screening. Nucleic Acids Res 22(8):1502-3.

Hannon GE, Hannon GJ, Maroney PA, Nilsen TW. 1994. Transcription of a nematode U1 small nuclear RNA in vitro. 3'-end formation requires cis-acting elements within the coding sequence. J Biol Chem 269(17):12387-90.

Hannon GJ, Beach D. 1994. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature 371(6494):257-61.

Hannon GJ, Casso D, Beach D. 1994. KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases. Proc Natl Acad Sci U S A 91(5):1731-5.

Li R, Waga S, Hannon GJ, Beach D, Stillman B. 1994. Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature 371(6497):534-7.

*2Shambaugh JD, Hannon GE, Nilsen TW. 1994. The spliceosomal U small nuclear RNAs of Ascaris lumbricoides. Mol Biochem Parasitol 64(2):349-52.

Waga S, Hannon GJ, Beach D, Stillman B. 1994. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 369(6481):574-8.

Zhang H, Hannon GJ, Beach D. 1994. p21-containing cyclin kinases exist in both active and inactive states. Genes Dev 8(15):1750-8.

Zhang H, Hannon GJ, Casso D, Beach D. 1994. p21 is a component of active cell cycle kinases. Cold Spring Harb Symp Quant Biol 59:21-9.

Bolwig GM, Del Vecchio M, Hannon G, Tully T. 1995. Molecular cloning of linotte in Drosophila: a novel gene that functions in adults during associative learning. Neuron 15(4):829-42.

Brugarolas J, Chandrasekaran C, Gordon JI, Beach D, Jacks T, Hannon GJ. 1995. Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 377(6549):552-7.

Demetrick DJ, Matsumoto S, Hannon GJ, Okamoto K, Xiong Y, Zhang H, Beach DH. 1995. Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3). Cytogenet Cell Genet 69(3-4):190-2.

Halevy O, Novitch BG, Spicer DB, Skapek SX, Rhee J, Hannon GJ, Beach D, Lassar AB. 1995. Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science 267(5200):1018-21.

Macleod KF, Sherry N, Hannon G, Beach D, Tokino T, Kinzler K, Vogelstein B, Jacks T. 1995. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev 9(8):935-44.

Okamoto A, Hussain SP, Hagiwara K, Spillare EA, Rusin MR, Demetrick DJ, Serrano M, Hannon GJ, Shiseki M, Zariwala M and others. 1995. Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer. Cancer Res 55(7):1448-51.

*3Orlow I, Lacombe L, Hannon GJ, Serrano M, Pellicer I, Dalbagni G, Reuter VE, Zhang ZF, Beach D, Cordon-Cardo C. 1995. Deletion of the p16 and p15 genes in human bladder tumors. J Natl Cancer Inst 87(20):1524-9.

Quelle DE, Ashmun RA, Hannon GJ, Rehberger PA, Trono D, Richter KH, Walker C, Beach D, Sherr CJ, Serrano M. 1995. Cloning and characterization of murine p16INK4a and p15INK4b genes. Oncogene 11(4):635-45.

Ranade K, Hussussian CJ, Sikorski RS, Varmus HE, Goldstein AM, Tucker MA, Serrano M, Hannon GJ, Beach D, Dracopoli NC. 1995. Mutations associated with familial melanoma impair p16INK4 function. Nat Genet 10(1):114-6.

Suzuki H, Zhou X, Yin J, Lei J, Jiang HY, Suzuki Y, Chan T, Hannon GJ, Mergner WJ, Abraham JM and others. 1995. Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancers. Hum Mol Genet 4(10):1883-7.

Alcorta DA, Xiong Y, Phelps D, Hannon G, Beach D, Barrett JC. 1996. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci U S A 93(24):13742-7.

Balbin M, Hannon GJ, Pendas AM, Ferrando AA, Vizoso F, Fueyo A, Lopez-Otin C. 1996. Functional analysis of a p21WAF1,CIP1,SDI1 mutant (Arg94 --> Trp) identified in a human breast carcinoma. Evidence that the mutation impairs the ability of p21 to inhibit cyclin-dependent kinases. J Biol Chem 271(26):15782-6.

Li R, Hannon GJ, Beach D, Stillman B. 1996. Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damage. Curr Biol 6(2):189-99.

Terry LA, Boyd J, Alcorta D, Lyon T, Solomon G, Hannon G, Berchuck A, Beach D, Barrett JC. 1996. Mutational analysis of the p21/WAF1/CIP1/SDI1 coding region in human tumor cell lines. Mol Carcinog 16(4):221-8.

Xie Q, Sanz-Burgos AP, Hannon GJ, Gutierrez C. 1996. Plant cells contain a novel member of the retinoblastoma family of growth regulatory proteins. Embo J 15(18):4900-8.

Zhou X, Suzuki H, Lei J, Cole K, Yin J, Suzuki V, Abraham JM, Shimada Y, Imamura M, Chan T and others. 1996. Growth suppression of esophageal cancer cells by p16INK4 and p15INK4B in vitro. Cancer J Sci Am 2(4):221-4.

*4Carnero A, Hannon GJ. 1998. The INK4 family of CDK inhibitors. Curr Top Microbiol Immunol 227:43-55.

Fearnhead HO, Rodriguez J, Govek EE, Guo W, Kobayashi R, Hannon G, Lazebnik YA. 1998. Oncogene-dependent apoptosis is mediated by caspase-9. Proc Natl Acad Sci U S A 95(23):13664-9.

LaMontagne KR, Jr., Hannon G, Tonks NK. 1998. Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of rat-1 fibroblasts and promotes differentiation of K562 cells. Proc Natl Acad Sci U S A 95(24):14094-9.

Sun P, Dong P, Dai K, Hannon GJ, Beach D. 1998. p53-independent role of MDM2 in TGF-beta1 resistance. Science 282(5397):2270-2.

Wang J, Xie LY, Allan S, Beach D, Hannon GJ. 1998. Myc activates telomerase. Genes Dev 12(12):1769-74.

Hannon GJ, Sun P, Carnero A, Xie LY, Maestro R, Conklin DS, Beach D. 1999. MaRX: an approach to genetics in mammalian cells. Science 283(5405):1129-30.

Hudson JD, Shoaibi MA, Maestro R, Carnero A, Hannon GJ, Beach DH. 1999. A proinflammatory cytokine inhibits p53 tumor suppressor activity. J Exp Med 190(10):1375-82.

Maestro R, Dei Tos AP, Hamamori Y, Krasnokutsky S, Sartorelli V, Kedes L, Doglioni C, Beach DH, Hannon GJ. 1999. Twist is a potential oncogene that inhibits apoptosis. Genes Dev 13(17):2207-17.

Carnero A, Hudson JD, Hannon GJ, Beach DH. 2000. Loss-of-function genetics in mammalian cells: the p53 tumor suppressor model. Nucleic Acids Res 28(11):2234-41.

Hammond SM, Bernstein E, Beach D, Hannon GJ. 2000. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 404(6775):293-6.

*5Wang J, Hannon GJ, Beach DH. 2000. Risky immortalization by telomerase. Nature 405(6788):755-6.

Bernstein E, Denli AM, Hannon GJ. 2001. The rest is silence. Rna 7(11):1509-21.

Bernstein E, Caudy AA, Hammond SM, Hannon GJ. 2001. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409(6818):363-6.

Hammond SM, Boettcher S, Caudy AA, Kobayashi R, Hannon GJ. 2001. Argonaute2, a link between genetic and biochemical analyses of RNAi. Science 293(5532):1146-50.

Hammond SM, Caudy AA, Hannon GJ. 2001. Post-transcriptional gene silencing by double-stranded RNA. Nat Rev Genet 2(2):110-9.

Ketting RF, Fischer SE, Bernstein E, Sijen T, Hannon GJ, Plasterk RH. 2001. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev 15(20):2654-9.

Sherman R, Chapman WC, Hannon G, Block JE. 2001. Control of bone bleeding at the sternum and iliac crest donor sites using a collagen-based composite combined with autologous plasma: results of a randomized controlled trial. Orthopedics 24(2):137-41.

Stolarov J, Chang K, Reiner A, Rodgers L, Hannon GJ, Wigler MH, Mittal V. 2001. Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor. Proc Natl Acad Sci U S A 98(23):13043-8.

Carmell MA, Xuan Z, Zhang MQ, Hannon GJ. 2002. The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev 16(21):2733-42.

Caudy AA, Myers M, Hannon GJ, Hammond SM. 2002. Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev 16(19):2491-6.

*6Du J, Hannon GJ. 2002. The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1. Nucleic Acids Res 30(24):5465-75.

Ferbeyre G, de Stanchina E, Lin AW, Querido E, McCurrach ME, Hannon GJ, Lowe SW. 2002. Oncogenic ras and p53 cooperate to induce cellular senescence. Mol Cell Biol 22(10):3497-508.

Hannon GJ. 2002. RNA interference. Nature 418(6894):244-51.

McCaffrey AP, Meuse L, Pham TT, Conklin DS, Hannon GJ, Kay MA. 2002. RNA interference in adult mice. Nature 418(6893):38-9.

Paddison PJ, Caudy AA, Bernstein E, Hannon GJ, Conklin DS. 2002. Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev 16(8):948-58.

Paddison PJ, Caudy AA, Hannon GJ. 2002. Stable suppression of gene expression by RNAi in mammalian cells. Proc Natl Acad Sci U S A 99(3):1443-8.

Paddison PJ, Hannon GJ. 2002. RNA interference: the new somatic cell genetics? Cancer Cell 2(1):17-23.

Seger YR, Garcia-Cao M, Piccinin S, Cunsolo CL, Doglioni C, Blasco MA, Hannon GJ, Maestro R. 2002. Transformation of normal human cells in the absence of telomerase activation. Cancer Cell 2(5):401-13.

Silva JM, Hammond SM, Hannon GJ. 2002. RNA interference: a promising approach to antiviral therapy? Trends Mol Med 8(11):505-8.

Bernstein E, Kim SY, Carmell MA, Murchison EP, Alcorn H, Li MZ, Mills AA, Elledge SJ, Anderson KV, Hannon GJ. 2003. Dicer is essential for mouse development. Nat Genet 35(3):215-7.

*7Carmell MA, Zhang L, Conklin DS, Hannon GJ, Rosenquist TA. 2003. Germline transmission of RNAi in mice. Nat Struct Biol 10(2):91-2.

Caudy AA, Ketting RF, Hammond SM, Denli AM, Bathoorn AM, Tops BB, Silva JM, Myers MM, Hannon GJ, Plasterk RH. 2003. A micrococcal nuclease homologue in RNAi effector complexes. Nature 425(6956):411-4.

Denli AM, Hannon GJ. 2003. RNAi: an ever-growing puzzle. Trends Biochem Sci 28(4):196-201.

Hemann MT, Fridman JS, Zilfou JT, Hernando E, Paddison PJ, Cordon-Cardo C, Hannon GJ, Lowe SW. 2003. An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nat Genet 33(3):396-400.

Narita M, Nunez S, Heard E, Narita M, Lin AW, Hearn SA, Spector DL, Hannon GJ, Lowe SW. 2003. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113(6):703-16.

Paddison PJ, Hannon GJ. 2003. siRNAs and shRNAs: skeleton keys to the human genome. Curr Opin Mol Ther 5(3):217-24.

Palmer LE, O'Shaughnessy AL, Preston RR, Santos L, Balija VS, Nascimento LU, Zutavern TL, Henthorn PS, Hannon GJ, McCombie WR. 2003. A survey of canine expressed sequence tags and a display of their annotations through a flexible web-based interface. J Hered 94(1):15-22.

Silva JM, Sachidanandam R, Hannon GJ. 2003. Free energy lights the path toward more effective RNAi. Nat Genet 35(4):303-5.

Song JJ, Liu J, Tolia NH, Schneiderman J, Smith SK, Martienssen RA, Hannon GJ, Joshua-Tor L. 2003. The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nat Struct Biol 10(12):1026-32.

Carmell MA, Hannon GJ. 2004. RNase III enzymes and the initiation of gene silencing. Nat Struct Mol Biol 11(3):214-8.

*8Caudy AA, Hannon GJ. 2004. Induction and biochemical purification of RNA-induced silencing complex from Drosophila S2 cells. Methods Mol Biol 265:59-72.

Cleary MA, Kilian K, Wang Y, Bradshaw J, Cavet G, Ge W, Kulkarni A, Paddison PJ, Chang K, Sheth N and others. 2004. Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis. Nat Methods 1(3):241-8.

Denli AM, Tops BB, Plasterk RH, Ketting RF, Hannon GJ. 2004. Processing of primary microRNAs by the Microprocessor complex. Nature 432(7014):231-5.

Dike S, Balija VS, Nascimento LU, Xuan Z, Ou J, Zutavern T, Palmer LE, Hannon G, Zhang MQ, McCombie WR. 2004. The mouse genome: experimental examination of gene predictions and transcriptional start sites. Genome Res 14(12):2424-9.

Du J, Hannon GJ. 2004. Suppression of p160ROCK bypasses cell cycle arrest after Aurora-A/STK15 depletion. Proc Natl Acad Sci U S A 101(24):8975-80.

Gupta S, Schoer RA, Egan JE, Hannon GJ, Mittal V. 2004. Inducible, reversible, and stable RNA interference in mammalian cells. Proc Natl Acad Sci U S A 101(7):1927-32.

Hannon GJ, Conklin DS. 2004. RNA interference by short hairpin RNAs expressed in vertebrate cells. Methods Mol Biol 257:255-66.

Hannon GJ, Rossi JJ. 2004. Unlocking the potential of the human genome with RNA interference. Nature 431(7006):371-8.

He L, Hannon GJ. 2004. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 5(7):522-31.

Hemann MT, Zilfou JT, Zhao Z, Burgess DJ, Hannon GJ, Lowe SW. 2004. Suppression of tumorigenesis by the p53 target PUMA. Proc Natl Acad Sci U S A 101(25):9333-8.

*9Liu J, Carmell MA, Rivas FV, Marsden CG, Thomson JM, Song JJ, Hammond SM, Joshua-Tor L, Hannon GJ. 2004. Argonaute2 is the catalytic engine of mammalian RNAi. Science 305(5689):1437-41.

Murchison EP, Hannon GJ. 2004. miRNAs on the move: miRNA biogenesis and the RNAi machinery. Curr Opin Cell Biol 16(3):223-9.

Paddison PJ, Caudy AA, Sachidanandam R, Hannon GJ. 2004. Short hairpin activated gene silencing in mammalian cells. Methods Mol Biol 265:85-100.

Paddison PJ, Cleary M, Silva JM, Chang K, Sheth N, Sachidanandam R, Hannon GJ. 2004. Cloning of short hairpin RNAs for gene knockdown in mammalian cells. Nat Methods 1(2):163-7.

Paddison PJ, Silva JM, Conklin DS, Schlabach M, Li M, Aruleba S, Balija V, O'Shaughnessy A, Gnoj L, Scobie K and others. 2004. A resource for large-scale RNA-interference-based screens in mammals. Nature 428(6981):427-31.

Silva J, Chang K, Hannon GJ, Rivas FV. 2004. RNA-interference-based functional genomics in mammalian cells: reverse genetics coming of age. Oncogene 23(51):8401-9.

Silva JM, Mizuno H, Brady A, Lucito R, Hannon GJ. 2004. RNA interference microarrays: high-throughput loss-of-function genetics in mammalian cells. Proc Natl Acad Sci U S A 101(17):6548-52.

Song JJ, Smith SK, Hannon GJ, Joshua-Tor L. 2004. Crystal structure of Argonaute and its implications for RISC slicer activity. Science 305(5689):1434-7.

Svoboda P, Stein P, Anger M, Bernstein E, Hannon GJ, Schultz RM. 2004. RNAi and expression of retrotransposons MuERV-L and IAP in preimplantation mouse embryos. Dev Biol 269(1):276-85.

Paddison PJ, Hannon GJ. 2004 RNA interference in mammals : journey to the center of human disease. In: Prendergast G, editor. Molecular Cancer Therapeutics. Hoboken, NJ: Wiley and Sons. p 55-72.

*10Dickins RA, Hemann MT, Zilfou JT, Simpson DR, Ibarra I, Hannon GJ, Lowe SW. 2005. Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nat Genet 37(11):1289-95.

Elledge SJ, Hannon GJ. 2005. An open letter to cancer researchers. Science 310(5747):439-41.

He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, Goodson S, Powers S, Cordon-Cardo C, Lowe SW, Hannon GJ and others. 2005. A microRNA polycistron as a potential human oncogene. Nature 435(7043):828-33.

Liu J, Rivas FV, Wohlschlegel J, Yates JR, 3rd, Parker R, Hannon GJ. 2005. A role for the P-body component GW182 in microRNA function. Nat Cell Biol 7(12):1261-6.

Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R. 2005. MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat Cell Biol 7(7):719-23.

Murchison EP, Partridge JF, Tam OH, Cheloufi S, Hannon GJ. 2005. Characterization of Dicer-deficient murine embryonic stem cells. Proc Natl Acad Sci U S A 102(34):12135-40.

Qi Y, Denli AM, Hannon GJ. 2005. Biochemical specialization within Arabidopsis RNA silencing pathways. Mol Cell 19(3):421-8.

Qi Y, Hannon GJ. 2005. Uncovering RNAi mechanisms in plants: biochemistry enters the foray. FEBS Lett 579(26):5899-903.

Rivas FV, Tolia NH, Song JJ, Aragon JP, Liu J, Hannon GJ, Joshua-Tor L. 2005. Purified Argonaute2 and an siRNA form recombinant human RISC. Nat Struct Mol Biol 12(4):340-9.

Schramke V, Sheedy DM, Denli AM, Bonila C, Ekwall K, Hannon GJ, Allshire RC. 2005. Retraction: RNA-interference-directed chromatin modification coupled to RNA polymerase II transcription. Nature 437(7061):1057.

*11Schramke V, Sheedy DM, Denli AM, Bonila C, Ekwall K, Hannon GJ, Allshire RC. 2005. RNA-interference-directed chromatin modification coupled to RNA polymerase II transcription. Nature 435(7046):1275-9.

Silva JM, Li MZ, Chang K, Ge W, Golding MC, Rickles RJ, Siolas D, Hu G, Paddison PJ, Schlabach MR and others. 2005. Second-generation shRNA libraries covering the mouse and human genomes. Nat Genet 37(11):1281-8.

Siolas D, Lerner C, Burchard J, Ge W, Linsley PS, Paddison PJ, Hannon GJ, Cleary MA. 2005. Synthetic shRNAs as potent RNAi triggers. Nat Biotechnol 23(2):227-31.

Stegmeier F, Hu G, Rickles RJ, Hannon GJ, Elledge SJ. 2005. A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc Natl Acad Sci U S A 102(37):13212-7.

Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ and others. 2005. A genetic screen for candidate tumor suppressors identifies REST. Cell 121(6):837-48.

Zender L, Xue W, Cordon-Cardo C, Hannon GJ, Lucito R, Powers S, Flemming P, Spector MS, Lowe SW. 2005. Generation and analysis of genetically defined liver carcinomas derived from bipotential liver progenitors. Cold Spring Harb Symp Quant Biol 70:251-61.

Andl T, Murchison EP, Liu F, Zhang Y, Yunta-Gonzalez M, Tobias JW, Andl CD, Seykora JT, Hannon GJ, Millar SE. 2006. The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol 16(10):1041-9.

Chang K, Elledge SJ, Hannon GJ. 2006. Lessons from Nature: microRNA-based shRNA libraries. Nat Methods 3(9):707-14.

Girard A, Sachidanandam R, Hannon GJ, Carmell MA. 2006. A germline-specific class of small RNAs binds mammalian Piwi proteins. Nature 442(7099):199-202.

Golding MC, Long CR, Carmell MA, Hannon GJ, Westhusin ME. 2006. Suppression of prion protein in livestock by RNA interference. Proc Natl Acad Sci U S A 103(14):5285-90.

*12Hannon GJ, Rivas FV, Murchison EP, Steitz JA. 2006. The expanding universe of noncoding RNAs. Cold Spring Harb Symp Quant Biol 71:551-64.

Mason DX, Keppler D, Zhang J, Jackson TJ, Seger YR, Matsui S, Abreo F, Cowell JK, Hannon GJ, Lowe SW and others. 2006. Defined genetic events associated with the spontaneous in vitro transformation of ElA/Ras-expressing human IMR90 fibroblasts. Carcinogenesis 27(2):350-9.

Olson A, Sheth N, Lee JS, Hannon G, Sachidanandam R. 2006. RNAi Codex: a portal/database for short-hairpin RNA (shRNA) gene-silencing constructs. Nucleic Acids Res 34(Database issue):D153-7.

Qi Y, He X, Wang XJ, Kohany O, Jurka J, Hannon GJ. 2006. Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation. Nature 443(7114):1008-12.

Valencia-Sanchez MA, Liu J, Hannon GJ, Parker R. 2006. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev 20(5):515-24.

Zender L, Spector MS, Xue W, Flemming P, Cordon-Cardo C, Silke J, Fan ST, Luk JM, Wigler M, Hannon GJ and others. 2006. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell 125(7):1253-67.

Aravin AA, Hannon GJ, Brennecke J. 2007. The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race. Science 318(5851):761-4.

Aravin AA, Sachidanandam R, Girard A, Fejes-Toth K, Hannon GJ. 2007. Developmentally regulated piRNA clusters implicate MILI in transposon control. ScienceExpress 316(5825):744-7.

Brennecke J, Aravin AA, Stark A, Dus M, Kellis M, Sachidanandam R, Hannon GJ. 2007. Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell 128(6):1089-103.

Carmell MA, Girard A, van de Kant HJ, Bourc'his D, Bestor TH, de Rooij DG, Hannon GJ. 2007. MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. Dev Cell 12(4):503-14.

*13Dickins RA, McJunkin K, Hernando E, Premsrirut PK, Krizhanovsky V, Burgess DJ, Kim SY, Cordon-Cardo C, Zender L, Hannon GJ and others. 2007. Tissue-specific and reversible RNA interference in transgenic mice. Nat Genet 39(7):914-21.

Draviam VM, Stegmeier F, Nalepa G, Sowa ME, Chen J, Liang A, Hannon GJ, Sorger PK, Harper JW, Elledge SJ. 2007. A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. Nat Cell Biol 9(5):556-64.

Haiser HJ, Karginov FV, Hannon GJ, Elliot MA. 2007. Developmentally regulated cleavage of tRNAs in the bacterium Streptomyces coelicolor. Nucleic Acids Res.

He L, He X, Lim LP, de Stanchina E, Xuan Z, Liang Y, Xue W, Zender L, Magnus J, Ridzon D and others. 2007. A microRNA component of the p53 tumour suppressor network. Nature 447(7148):1130-4.

He L, He X, Lowe SW, Hannon GJ. 2007. microRNAs join the p53 network--another piece in the tumour-suppression puzzle. Nat Rev Cancer 7(11):819-22.

He X, He L, Hannon GJ. 2007. The Guardian's Little Helper: MicroRNAs in the p53 Tumor Suppressor Network. Cancer Res 67(23):11099-11101.

Hodges E, Xuan Z, Balija V, Kramer M, Molla MN, Smith SW, Middle CM, Rodesch MJ, Albert TJ, Hannon GJ and others. 2007. Genome-wide in situ exon capture for selective resequencing. Nat Genet 39(12):1522-7.

Houwing S, Kamminga LM, Berezikov E, Cronembold D, Girard A, van den Elst H, Filippov DV, Blaser H, Raz E, Moens CB and others. 2007. A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish. Cell 129(1):69-82.

Ibarra I, Erlich Y, Muthuswamy SK, Sachidanandam R, Hannon GJ. 2007. A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells. Genes Dev 21(24):3238-43.

Karginov FV, Conaco C, Xuan Z, Schmidt BH, Parker JS, Mandel G, Hannon GJ. 2007. A biochemical approach to identifying microRNA targets. Proc Natl Acad Sci U S A 104(49):19291-6.

*14Kim J, Inoue K, Ishii J, Vanti WB, Voronov SV, Murchison E, Hannon G, Abeliovich A. 2007. A MicroRNA feedback circuit in midbrain dopamine neurons. Science 317(5842):1220-4.

Murchison EP, Stein P, Xuan Z, Pan H, Zhang MQ, Schultz RM, Hannon GJ. 2007. Critical roles for Dicer in the female germline. Genes Dev 21(6):682-93.

Stark A, Kheradpour P, Parts L, Brennecke J, Hodges E, Hannon GJ, Kellis M. 2007. Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes. Genome Res 17(12):1865-79.

Stark A, Lin MF, Kheradpour P, Pedersen JS, Parts L, Carlson JW, Crosby MA, Rasmussen MD, Roy S, Deoras AN and others. 2007. Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature 450(7167):219-32.

Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN and others. 2007. Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. Genes Dev 21(1):98-111.

Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, 3rd, Li MZ, Hannon GJ, Sorger PK and others. 2007. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature 446(7138):876-81.

Zhao T, Li G, Mi S, Li S, Hannon GJ, Wang XJ, Qi Y. 2007. A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii. Genes Dev 21(10):1190-203.

Tyler DM, Okamura K, Chung WJ, Hagen JW, Berezikov E, Hannon GJ, Lai EC. 2008. Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci. Genes Dev 22(1):26-36.

Olson AJ, Brennecke J, Aravin AA, Hannon GJ, Sachidanandam R. 2008. Analysis of large-scale sequencing of small RNAs. Pac Symp Biocomput: 126-36.

Schlabach MR, Luo J, Solimini NL, Hu G, Xu Q, Li MZ, Zhao Z, Smogorzewska A, Sowa ME, Ang XL and others. 2008. Cancer proliferation gene discovery through functional genomics. Science 319(5863):620-4.

*15Silva JM, Marran K, Parker JS, Silva J, Golding M, Schlabach MR, Elledge SJ, Hannon GJ, Chang K. 2008. Profiling essential genes in human mammary cells by multiplex RNAi screening. Science 319(5863):617-20.

Chen JF, Murchison EP, Tang R, Callis TE, Tatsuguchi M, Deng Z, Rojas M, Hammond SM, Schneider MD, Selzman CH and others. 2008. Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A 105(6):2111-6.

Girard A, Hannon GJ. 2008. Conserved themes in small-RNA-mediated transposon control. Trends Cell Biol. Mar;18(3):136-48

Haiser HJ, Karginov FV, Hannon GJ, Elliot MA. 2008. Developmentally regulated cleavage of tRNAs in the bacterium Streptomyces coelicolor. Nucleic Acids Res. 36(3): 732-741.

Du J, Jablonski S, Yen TJ, Hannon GJ. 2008. Astrin regulates Aurora-A localization. Biochem Biophys Res Commun. May 30;370(2):213-9

Mi S, Cai T, Hu Y, Chen Y, Hodges E, Ni F, Wu L, Li S, Zhou H, Long C, Chen S, Hannon GJ, Qi, Y. 2008. Sorting of Small RNAs into Arabidopsis Argonaute Complexes Is Directed by the 5' Terminal Nucleotide. Cell.Apr4;133(1):116-27

Benetti R, Gonzalo S, Jaco I, Munoz P, Gonzalez S, Schoeftner S, Murchison E, Andl T, Chen T, Klatt P, Li E, Serrano M, Millar S, Hannon G, Blasco MA. 2008. A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol 15(3):268-79.

Tworkowski, K. A., Chakraborty, A. A., Samuelson, A. V., Seger, Y. R., Narita, M., Hannon, G. J., Lowe, S. W., and Tansey, W. P. (2008). Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc. Proc Natl Acad Sci U S A. Apr 22;105(16):6103-8

Tam, O. H., Aravin, A. A., Stein, P., Girard, A., Murchison, E. P., Cheloufi, S., Hodges, E., Anger, M., Sachidanandam, R., Schultz, R. M., and Hannon, G. J. (2008). Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature. Apr10.

Murchison, E. P., Kheradpour, P., Sachidanandam, R., Smith, C., Hodges, E., Xuan, Z., Kellis, M., Grutzner, F., Stark, A., and Hannon, G. J. (2008). Conservation of small RNA pathways in platypus. Genome Res. May 7

*16Warren, W. C., Hillier, L. W., Marshall Graves, J. A., Birney, E., Ponting, C. P., Grutzner, F., Belov, K., Miller, W., Clarke, L., Chinwalla, A. T., et al. (2008). Genome analysis of the platypus reveals unique signatures of evolution. Nature 453, 175-183.

Czech, B., Malone, C. D., Zhou, R., Stark, A., Schlingeheyde, C., Dus, M., Perrimon, N., Kellis, M., Wohlschlegel, J. A., Sachidanandam, R., et al. (2008). An endogenous small interfering RNA pathway in Drosophila. Nature. May 7

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