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姓名:藍先元 (Lane, Hsien-Yuan) 國家衛生研究院 主持人 (nhri study Project)

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姓名:藍先元 (Lane, Hsien-Yuan)

國家衛生研究院 <整合型研究計畫> 主持人 (NHRI Study Project):

  1. NMDA hypofunction of schizophrenia: diagnosis and treatment (NHRI-EX-94-9405PI, NHRI-EX-95-9405PI, NHRI-EX-96-9405PI, NHRI-EX-97-9405PI, NHRI-EX-98-9405PI) (2005/01/01-2009/12/31)

基因體醫學國家型科技計劃主持人 (National Research Program for Genomic Medicine):

  1. Depression patients: Chinese medicine viewpoints and mRNA expressions in peripheral lymphocytes (94DOH004; CCMP94-RD-041; CCMP94-RD-041-1)

(2005/5 – 2007/4)
生技中心「建立轉譯醫學臨床研究」計畫主持人(Development Center for Biotechnology

  1. N-methylglycine (Sarcosine) treatment for depression



國科會研究計畫主持人 (NSC Study Projects):

  1. NMDA enhancers for schizophrenia treatment (NSC-94-2314-B-039-026, NSC-95-2314-B-006-119, NSC-96-2314-B-039-002)


  1. NMDA modulation in schizophrenia: long-term efficacy of glycine transporter I inhibitor (NSC-95-2314-B-006-118-MY3)

(2006/08/01 ~ 2009/07/31)

  1. D-amino acid inhibition for NMDA modulation of schizophrenia




Evaluating sarcosine, a glycine uptake inhibitor, for cognition enhancement in schizophrenia

(NARSAD #12537-01)



  1. Lane HY, Liu YC, Huang CL, Chang YC, Wu PL, Lu CT, Chang WH (2006): Risperidone-related weight gain: genetic and nongenetic predictors. Journal of Clinical Psychopharmacology 26:128-134 (sci)

  2. Lane HY, Huang CL, Wu PL, Liu YC, Chang YC, Lin PY, Chen PW, Tsai G (2006): Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to clozapine for the treatment of schizophrenia. Biological Psychiatry 60:645-649 (sci)

  3. Hsieh CL, Chang QY, Lin IH, Lin JG, Liu CH, Tang NY, Lane HY* (2006): The study of electroacupuncture on cerebral blood flow in rats with and without cerebral ischemia. American Journal of Chinese Medicine 34:351-361 (sci) [*corresponding author]

  4. Loh EW, Lane HY, Chen CH, Chang PS, Ku LW, Wang KHZ, Cheng ATA (2006): Glutamate decarboxylase genes and alcoholism in Han Taiwanese men. Alcoholism: Clinical and Experimental Research 30:1817-1823 (sci)

  5. Chang YC, Lane HY, Yang KH, Huang CL (2006): Optimizing early prediction for antipsychotic response in schizophrenia. Journal of Clinical Psychopharmacology 26:554-559 (sci)

  6. Lin CH, Chou LS, Lin CH, Hsu CY, Chen YS, Lane HY* (2007): Early prediction of clinical response in schizophrenia patients receiving atypical antipsychotic zotepine. The Journal of Clinical Psychiatry 68:1522-1527 (sci) [*corresponding author]

  7. Lane HY, Liu YC, Huang CL, Hsieh CL, Chang YL, Chang L, Chang YC, Chang WH (2008): Prefrontal executive function and D1, D3, 5-HT2A, and 5-HT6 receptors gene variations in healthy participants. Journal of Psychiatry and Neuroscience 33:47-53 (sci)

  8. Lin CH, Lin KS, Lin CY, Chen MC, Lane HY* (2008): Time to rehospitalization in major depression patients taking venlafaxine or fluoxetine. The Journal of Clinical Psychiatry 69:54-59 (sci) [*corresponding author]

  9. Lin YC, Chen HZ, Chang TJ, Lane HY* (2008): Hypokalemia following rapid titration of quetiapine treatment. The Journal of Clinical Psychiatry 69:165-166 (sci) [*corresponding author]

  10. Lane HY, Liu YC, Huang CL, Chang YC, Wu PL, Huang CH, Tsai G (2008): RGS4 polymorphisms predict clinical manifestations and responses to risperidone treatment in patients with schizophrenia. Journal of Clinical Psychopharmacology 28:64-68 (sci)

  11. Tsai GE, Lane HY*, VanDenBerg CM, Liu YC, Tsai P, Jann MW (2008): Disposition of D-serine in Healthy Adults. The Journal of Clinical Pharmacology 48:524-527 (sci) [*shared first author]

  12. Lane HY, Liu YC, Huang CL, Chang YC, Liau CH, Tsai G (2008): Sarcosine (N-methylglycine) treatment for acute schizophrenia: a randomized, double-blind study. Biological Psychiatry 63:9-12 (sci) (selected for the commentary article)

  13. Ma WF, Lane HY, Laffrey SC (2008): A model testing factors that influence physical activity for Taiwanese adults with anxiety. Research in Nursing and Health Apr 7 [Epub ahead of print (sci)

  14. Chen CM, Hou YT, Liu JY, Wu YR, Lin CH, Fung HC, Hsu WC, Hsu Y, Lee SH, Hsieh-Li HM, Su MT, Chen ST, Lane HY, Lee-Chen GJ (2008): PPP2R2B CAG repeat length in the Han Chinese in Taiwan: Association analyses in neurological and psychiatric disorders and potential functional implications. Am J Med Genet B Neuropsychiatr Genet. 2008 May 15. [Epub ahead of print]

  15. Lin CH, Huang CW, Chen CC, Hsu YF, Chang WH, Lane HY* (2008): Time to rehospitalization in patients with bipolar I disorder on lithium or valproate with adjunctive antipsychotics. Psychopharmacology. Jun 20. [Epub ahead of print] [*corresponding author]

  16. Liu YC, Huang CL, Wu PL, Chang YC, Huang CH, Lane HY* (2008): Lack of association between AKT1 variances vs. clinical manifestations and social function in patients with schizophrenia. Journal of Psychopharmacology Jul 17. [Epub ahead of print] [*corresponding author]

  17. Lin YC, Su HK, Ouyang WC, Lane HY* (2008): Zotepine-Induced QTc prolongation. Journal of Clinical Psychopharmacology (in press) [*corresponding author]

Patent application:

US Provisional Patent Application 61/028138: Guochuan.E.Tsai and Hsien.-Yuan Lane are inventors.

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