Vanderbilt University Medical Center

CURRICULUM VITAE

Vanderbilt University Medical Center

Room CC-2102M

1161 Twenty-First Avenue South

Nashville, TN 37232-2158

(615) 293-6739 (cell phone)

Home Address: 1187 Cross Creek Drive, Franklin, TN 37067-4035

Children - Michael, Virginia

M.S. in Biostatistics (1991)

Graduate School of Health Sciences

Valhalla, New York 10595

Thesis: "Trauma Mortality and Non- injury Factors -

A Hybrid of Matching and Logistic Regression"

State University of New York at Albany

B.A. in Biology (1983)

Albany, New York 12222

Areas of Research Interest: Real-time decision-support predictive modeling, translational research, continuous quality improvement


Present Position: Director of Quality Improvement & Program Evaluation,

Department of Biostatistics

Vanderbilt University, School of Medicine
Senior Associate in Biostatistics

Vanderbilt University, School of Medicine

Design, Biostatistics, and Research Ethics Core

Vanderbilt Institute for Clinical and Translational Research

(Clinical and Translational Science Award grant)

Senior Associate in Biostatistics

Department of Biostatistics

Vanderbilt University Medical Center

Secondary faculty appointments:

Senior Associate in Medicine

Division of General Internal Medicine

Department of Medicine

Vanderbilt University Medical Center

Adjunct Associate Professor

Tokai University School of Medicine

Isehara-shi, Japan

Created a hospital-wide predictive modeling decision-support system to improve quality

of care of hospitalized patients by converting admission variables into real-time

probabilities of outcomes.

Member of the Vanderbilt Preventing Avoidable Readmissions Team. Developed a

decision support system to convert a statistical model into real-time probability of

readmission.

Instrumental in writing the biostatistical section of, and generating pilot data for, the largest grant ($46M) in the history of Vanderbilt University. Member of the VICTR Operations Committee and assist with strategic planning and management.

4. Clinical and Translational Science Award (2011).

Lead the team that wrote the biostatistical section of the CTSA 5-year renewal, which

received the best score in the country (13) and resulted in an additional $55M.
5. Vanderbilt “Go for the Gold” Employee Wellness Incentive Program.

Wrote the proposal and coined the name for the successful empolyee wellness program,

which has shifted funding from illness to wellness, resulting in >$37M savings and the C.

Everett Koop National Health Award (2008) for the best wellness program in the country.

Helped manage this program and wrote the evaluation report for the Koop Award.

http://www.sph.emory.edu/healthproject/documents/2008/vanderbilt_go_for_gold.pdf

6. Fortune 100 Great Places to Work.

Analyzed the employee survey data, created graphs and presentations to help Vanderbilt win this award in 2009. Worked with senior leaders between 2002 and 2009 to develop a strategic plan to close the gap between Vanderbilt and the top 100 companies.
7. Biostatistics Clinics.

Created the highly successful clinics, which provide free drop-in statistical expertise every

weekday to the Vanderbilt community.
8. Clinical Research Center Research Skills Workshops.

Together with Paul Harris created the popular training sessions, held every Friday morning

in the Clinical Research Center.
9. Corporate Health Achievement Award.

Supervised 37 quality improvement projects in Health & Wellness and provided program

evaluation analysis that resulted in Vanderbilt winning this prestigious award.
10. Clinical Research Publications.

Significantly increased quantity and quality of publications from the Clinical Research

Center during the past 12 years.
11. Improved the quality of biostatistics teaching.

Revised the curriculum of the traditional Biostatistics I course in the MSCI program and

turned it into the most popular course in the program. Won numerous teaching awards.
12. Helped recruit talented biostatisticians and build the Department of Biostatistics.

Active in recruiting biostatisticians, which resulted in increasing the number from 6 to 70

in an 9-year period.
13. Studios.

Together with Bob Dittus, helped build the successful CTSA initiatives of Studios and

published a paper describing the first four years in Academic Medicine. (107)
Summary of Qualifications: Thirty years of broad experience in biostatistics and medical research, both academic and industry. Strong interest and demonstrated success in clinical, translational, and basic research. Excellent leadership skills. Experienced in directing and developing biostatistical cores and working as part of a multidisciplinary team of statisticians. Successful record of administrative leadership in an academic medical setting. Able to work independently and as a team member. Able to communicate and teach complex statistical methods to nonstatisticians. Able to motivate and supervise others regarding continuous quality improvement projects. Advanced computer skills with extensive experience in R, SAS, Stata, and SPSS. Strong written and verbal communication skills. Ability to prioritize, meet deadlines and multi-task. Highly successful at collaborating with clinical and basic scientists.
Current Responsibilities: Review more than 100 clinical research protocols per year for VICTR, both investigator-initiated and industry-sponsored.

Analyze and interpret confidential data from a variety of

sources. Participate in the design and review of clinical protocols and case report forms, including preparation of statistical considerations, sample size calculations, interim analyses, and study design recommendations.

Participate in database design, data collection guidelines, and

computerized logic checks.

Create analysis plans, generate and implement prospective

analysis validation plans.

Review statistical reports, randomization designs.

Provide statistical expertise and support to clients.

Prepare and review FDA statistical responses.

Provide expert guidance and training to biostatistics staff on

statistical procedures, methods, and concepts.

Supervise and mentor junior biostatisticians. Supervise

continuous quality improvement projects.

May 4, 2010

Elected to the Vanderbilt Academy for Excellence in Teaching.
2002-2005 Teaching Awards,

Vanderbilt University, Master of

Science in Clinical Investigation Program

(The award was retired in 2005.)

Who's Who in the World

Who's Who in Science and Engineering
Book Awards: “Publishing Your Medical Research Paper”

American Medical Writers Association

1. Will Solimene Award (6/11/98)

Outstanding quality - Print media

2. Ralph A. Deterling Award (6/11/98)

Distinction in Medical Communication

3.Morris Fishbein Award (5/1/99)

Honorable mention for excellence in medical communication

2012 Award with Distinction for Innovations in Research Training and Education from the Association of American Medical Colleges (AAMC).

Clinical and Translational Research Studios: An Interdisciplinary Model
2008 C. Everett National Health Award.

Awarded to Vanderbilt University.

Responsible for writing the initial proposal for the “Go For The

Gold” Employee Wellness incentive program at Vanderbilt,

developing the program over the 5-year period (2003-2008),

performing the evaluation, and writing the Koop application

report.
2003 Newman Prize for Best Clinical

Research Paper in the Department of

Medicine, Vanderbilt. Dishy V, Sofowora G,

Xie HG, Byrne D, Kim RB, Stein CM, Wood AJJ. The effect of

common polymorphisms of the beta-2 adrenergic receptor

agonist-mediated vascular desensitization in vivo. New England

Journal of Medicine 2001; 345:1030-5.

2002 Corporate Health Achievement Award

Awarded to Dr. Mary Yarbrough and Vanderbilt University’s Health & Wellness program by the American College of Environmental and Occupational Medicine

(Responsible for managing 37 Health & Wellness quality improvement projects).

2002 Joint Statistical Meetings,

American Statistical Association

Section on Teaching Statistics in the Health Sciences, Best Contributed Poster, “Improving the Quality of an Introductory Biostatistics Course for Physicians”


Scholarship: David E. Guertin Award – 1976

Outstanding Athlete and Sportsman

Millbrook, NY

Professional Societies:

American Association for the Advancement of Science

International Biometric Society (Eastern North

American Region - ENAR)

Association of Clinical and Translational Statisticians

Society for Clinical Trials

Society for Epidemiologic Research

Drug Information Association

Byrne Research, Franklin, TN (1983-present)

Hospira, Inc. Consultant, 2008-2009

ABDiagnostics, Inc., Consultant, 2006-2009

Pfizer, NY (1998)

Yale University, New Haven, CT (1995-1998)

Westchester Medical Center, Vahalla, NY (1983-1998)

New York University (1990-1998)

Harrison and Star, NY (2011)

Healthcare Resources Group, NY (2002-2011)

Saatchi and Saatchi Healthcare Communications (2007-2011)

Maimonides Medical Center, Brooklyn, NY (1994-1999)

Catholic Medical Center, Queens, NY (1997-1999)

Jamaica Hospital Center, Queens, NY (1999)

- Dr. P. David Charles

- Dr. Grant Wilkinson

- Clinical Research Center

- Dr. Wes Ely

- Dr. Julia Lewis

- Dr. Mias Pretorius

- Dr. C. Michael Stein

- Dr. Dawood Darbar

- Dr. John Oates

Dafer Rashid Al-Jalahma – Statistical advisor for PhD dissertation “Information Technology: An Assessment of the Unique Factors Leading to IT Adoption and Use in the Developing Countries.”

(4 credit hours)

Every September, 3 hours per day, Monday-Friday
2002 - present Medical Writing for Clinical Investigators

(2 credit hour2)

Every January, 1 hour, Monday-Thursday

Previous:
Clinical Research Center, Vanderbilt

2000 – 2009 CRC Research Skills Workshops

Organized and taught weekly workshops.

http://www.mc.vanderbilt.edu/gcrc/workshop.html

Master of Clinical Biomedical Science, Tokai University, Japan

2 week course each February for 5 years.

2005 GCRC Data Analysis and Publishing Seminar Series
Department of Neurology, Vanderbilt University
2006 Data Analysis and Publishing Seminar Series
Joint Statistical Meetings, 2006 Seattle, WA.
2006 Roundtable Session Leader – Extreme Consulting – A Novel

Method of Improving Efficiency.

New York Medical College

Department of Biostatistics

1990 Designed and taught "Directed Research in Biostatistics"

Department of Community and Preventive Medicine

1991 - 1999 Research Assistant Professor

Department of Orthopedics

1991 - 1996 Taught "Seminars in Orthopaedic Research" to orthopaedic residents

Maimonides Medical Center, Brooklyn, NY

Department of Obstetrics & Gynecology

1994 – 1999 Taught "Research workshops"

to OB/GYN residents

Catholic Medical Center, Queens, NY

Department of Obstetrics & Gynecology

1997 - 1999 Taught "Research workshops"

to OB/GYN residents

Jamaica Hospital Center, Queens, NY

Department of Obstetrics & Gynecology

1999 – 1999 Taught "Research workshops"

to OB/GYN residents

Vanderbilt

2004 Biostatistics II

(4 credit hours)

Course director along with Dr. Frank Harrell and Dr. Ayumi Shintani

Review Responsibilities:
2003 to 2009.

Book Review Editor – Teaching Statistics in the Health Sciences Newsletter.

A newsletter for 800 members of the section of the American Statistical Association for

teaching statistics in the health sciences.

The New England Journal of Medicine

Journal of Obstetrics and Gynecology

Clinical Pharmacology and Therapeutics

ZAT1 PK-02 (Basic Science) Review Committee

ZAT1 SM (25)

3/1/12 - present

Grant Participation:
In 2001, assisted Vanderbilt researchers obtain more than $46,000,000 in research funding.

Annual average grant support > $21,000,000.

CURRENT ACTIVE:

NIH/NCRR

"Clinical and Translational Science Award"

This is an NCATS/NCRR grant to support Vanderbilt Institute of Clinical and Translational Research.

Previous (selected grants):

Vanderbilt University Medical Center (previous grants)

NIH/NCRR

"Clinical and Translational Science Award"

This is an NCRR grant to support Vanderbilt Institute of Clinical and Translational Research.
2P01 GM31304-20 (Stein) 07/01/03-06/30/07 3%

NIH/NIGMS $902,239 (total $4,500,000)

Determinants of Individual Responsiveness to Drugs
This is a program project grant supporting 4 projects involving 6 investigators, and supports research aimed at the elucidation of factors determining interindividual variability and responsiveness to drugs. Project I is concerned with determinants of cytochrome P-4503A mediated metabolism whereas Project II focuses on establishing the feasibility and validity of pre-prescription genotyping to improve drug efficacy in individual patients. Project III investigates several aspects of the genetics of intestinal and hepatic drug transporters, and Project IV addresses the in vivo pharmacological modulation of P-glycoprotein.
5M01 RR00095-43 (Balser) 12/1/05-11/30/06 50%

NIH/NCRR (RR) $7,049,208/yr (total $33,197,553)

General Clinical Research Center
The major goal of this project is to support clinical research.
5M01 RR00095-41 (Wood) 12/1/01-11/30/04 50%

NIH/NCRR (RR) $4,293,625 (total $18,711,589)

General Clinical Research Center
The major goal of this project is to support clinical research.
1RO1 HL67964-01 (Stein) 09/01/01-07/31/02 10%

NIH/NHLBI (HL) $225,000 (total $900,000)

Atherosclerosis in Rheumatoid Arthritis.
The purpose of this study is to assess the association between atherosclerosis and rheumatoid arthritis.
5RO1 HL65193-02 (Brown) 08/1/01-07/31/02 10%

NIH/NHLBI $175,000 (total $525,000)

Genes and Fibrinolytic Capacity of Human Endothelium
The purpose of this grant is to test the hypothesis that genetic or pharmacological factors that decrease ACE activity favorably alter cardiovascular morbidity and mortality by enhancing the effect of bradykinin on fibrinolytic balance.
5P01 GM31304-17 (Wilkinson)07/01/97-06/30/02 10%

NIH/NIGMS $722,735 (total $3,600,000)

Determinants of Individual Responsiveness to Drugs
This is a program project grant supporting 3 projects and an Analytical Core involving 4 investigators, and supports research aimed at the elucidation of factors determining interindividual variability and responsiveness to drugs. Project I is concerned with inter-racial differences in cytochrome P-450 mediated metabolism especially that involving CYP2E1 and CYP3A, whereas Project II focuses on dietary and gastro-intestinal factors which may determine such metabolism. Project III addresses several aspects of intestinal and hepatic drug transporters particularly P-glycoprotein.

New York Medical College

EMS System Factors and Trauma Survival Study

(1987-1990)

Validation of Existing Data Source as a Trauma Registry

(1989-1992)

Research Project funded by New York State Department of Health and The Eastern Paralyzed Veterans Association

(1992-1998)

Other Grant Support:
Epilepsy Foundation (Dr. Annette Chihorek, sleep and epilepsy fellow)

Obstructive Sleep Apnea in Older Adults with Epilepsy (Approved 2/13/05)

Department of Neurology

Epilepsy Foundation of America $40,000

July 1, 2005- June 30, 2006

NR00140-03 (Cook, Tom) 2003-2006

K01 $250,801.00

Energy Balance in Children

2RO1 HL60906-05 (Brown) 08/1/02-07/31/03

NIH/NHLBI $354,382 (total $1,893,252)

Genes and Fibrinolytic Capacity of Human Endothelium
The purpose of this grant is to test the hypothesis that genetic or pharmacological factors that decrease ACE activity favorably alter cardiovascular morbidity and mortality by enhancing the effect of bradykinin on fibrinolytic balance.

1RO1 HL67308-01A2 (Brown) 07/01/02

NIH/NHLBI (HL) $250,000 (total $1,250,000)

PAI-1 and the vascular toxicity of aldosterone.
The goal of this project is to understand the relationship between PAI-1 and the vascular toxicity of aldosterone.

American Diabetes

Association (Elasy) 01/01/04-12/31/04

Relapse in the Primary $85,000 (total $85,000)

Care Setting.

The major goal of this project is to determine the factors related to poor glycemic control in the primary care setting.

(Robertson)

Autonomic Cardiovascular Regulation
R01

(Biaggioni)

Autonomic Regulation in Obesity and Metabolic Syndrome.
R01

(Gainer)

Sleep Disorders and fMRI.

Effect of Selective COX-2 Inhibitor on the Elevated Thromboxane Metabolite

Excretion in Aspirin Treated Patients.
(Burk)

Nutritional and Metabolic Significance of Selenium.

Defining the Physiological and Behavioral Components of Insomnia in Children

with Autism Spectrum

Disorders

NIH/NHLBI (HL) $116,592 (total $480,000)

Weight Loss Adherence in African Americans with Type 2 Diabetes

This clinical trial will examine problem based skill training and stress management as strategies for improving adherence to weight loss regimens in African Americans with Type 2 diabetes.

AutonoMix (Keller) 07/01/02-06/30/03 5%

Autonomic phenotyping in mice.

The purpose of this project is to develop reliable methods of assessing the autonomic effect of drugs in mice.
1P50 HL70118-01 (Vaughan) 04/01/02-03/31/03 10%

NIH/NHLBI (HL) $1,349,767 (total $7,093,679)

SCOR: Molecular medicine and atherosclerosis.

This study is design to better understand the molecular medicine of atherosclerosis.

NIH (NICHD)

Pediatric Pharmacology Research Unit Networks

The objective of this grant is to create a clinical research infrastructure that can perform pediatric pharmaceutical and device clinical trials.

Teaching biostatistics

Continuous quality improvement

Statistical analysis in translational science

Statistical graphics

Medical writing and publishing

Westchester Medical Center

Valhalla, New York 10595
1983 - 1989 Biostatistician/Bioinformatics specialist

Department of Surgery

Designed biomedical software.

Created research databases, performed statistical analyses.

Worked as an internal consultant. Co-authored numerous papers.

Taught medical students, residents, and faculty: statistics, study

design, and computer applications in medical research.
1988 - 1999 Research Assistant Professor

Department of Surgery

Department of Community and Preventive Medicine

Ridgefield, CT 06877

1989 – 1999 Independent Biostatistical Consultant

Self-employed consultant for 10 years, provided biostatistical and technical writing expertise to physician-scientists and the pharmaceutical industry in New York City, Westchester, and Yale University Medical Center.

Original Investigations

1. Hodgson WJB, Mittelman A, Katz S, Friedland M, Berman H, Morgan J, Ahmed T, Byrne D: "Treatment of Colorectal Hepatic Metastases by Intrahepatic Chemotherapy Alone or as an Adjuvant to Complete or Partial Removal of Metastatic Disease" Annals of Surgery 1986;203(4):420-425.

(4):504-511.

"Development of a Computerized Data Base to Evaluate Pressure Ulcers" Decubitus (Advances in Wound Care) 1990;3(3):29-36.

"Central catheter-related infections: comparison of pulmonary artery catheters and triple lumen catheters for the delivery of hyperalimentation in a critical care setting." Journal of Parenteral and Enteral Nutrition 1990;14(6):588-592.

Trauma Patients. NAEMSP - National Association of EMS Physicians. Prehospital and Disaster Care Medicine, June 15,1990.

of Diagnostic Related Group Length of Stay Outliers: Motor Vehicle Crash Versus Penetrating Injuries" Accident Analysis and Prevention. 1991;23(4):317-322.

"Limitations of the TRISS Method for Interhospital Comparisons: A Multihospital Study" The Journal of Trauma 1991;31(4):471-482; discussion 481-482.

163:246-250.

garments in severely hypotensive trauma patients" Journal of Trauma 1993;34(5):728-735;

discussion 733-735.
15.Byrne DW. Increasing computer productivity while reducing costs. MD-Computing 1994;11(2):75.
16.Petro JA, Klein SA, Niazi Z, Salzberg CA, Byrne DW. Evaluation of ultrasound as a tool in the

follow up of patients with breast implants: a preliminary, prospective study. Annals of Plastic

Surgery 1994;32(6):580-587.
17.Horowitz HW, Pavia CS, Bittker S, Forseter G, Cooper D, Nadelman RB, Byrne D, Johnson RC, Womser GP. "Sustained cellular immune responses to Borrelia burgdorferi: Lack of correlation with clinical presentation and serology."

Clinical & Diagnostic Laboratory Immunology, 1994

Jul;1(4):373-378.
18.Devine PA, Bracero LA, Lysikiewicz A, Evans R, Womack S, Byrne DW. Middle cerebral to umbilical artery Doppler ratio in post-date pregnancies. Obstetrics & Gynecology 1994;84(5):856-860.
19.Hodgson WJB, Byrne DW, Savino JA, Liberis G. Laparoscopic cholecystectomy. The early experience of surgical attendings compared with that of residents trained by apprenticeship. Surgical Endoscopy 1994;8(9):1058-1062.
20.Salzberg CA, Cooper-Vastola SA, Perez FJ, Viehbeck MG, Byrne DW. The effects of non-

thermal pulsed electro-magnetic energy (Diapulse) on wound healing of pressure

ulcers in spinal cord-injured patients: a randomized, double-blind study. Wounds

1995;7(1):11-16.

thermal pulsed electro-magnetic energy (Diapulse) on wound healing of pressure

ulcers in spinal cord-injured patients: a randomized, double-blind study. Ostomy Wound

Management 1995;41(3):42-48.

nutritional status as a predictor of outcome after elective total hip replacement

surgery." Clinical Orthopaedics and Related Research Clin Orthop 1996;326:153-161.
27.Bracero LA, Figueroa R, Byrne DW, Han HJ. "Comparison of umbilical Doppler velocimetry,

nonstress testing, and biophysical profile in pregnancies complicated by diabetes." Journal of

Ultrasound in Medicine. 1996;15(4): 301-308.
28. Niazi ZM, Salzberg CA, Byrne DW, Viehbeck M. Recurrence of initial pressure sores in spinal cord injured patients. Advances in Wound Care. 1997 May;10(3):38-42.
29. Salzberg CA, Byrne DW. A new pressure ulcer risk assessment scale for individuals with spinal cord injury. Am J Phys Med Rehabil 1996 Mar;75(2):96-104.
30. Bracero LA, Byrne DW. Doppler velocimetry discordancy of the uterine arteries in pregnancies complicated by diabetes. J Ultrasound Med 1997 Jun;16(6):387-393.
31. Salzberg CA, Byrne DW, Cayten CG, Kabir R, Niewerburgh PV, Viehbeck M, Long H, Jones EC. Predicting and preventing pressure ulcers in adults with paralysis. Adv Wound Care 1998 Sep;11(5):237-46.
32. Bracero LA, Byrne DW. Optimal maternal weight gain during singleton pregnancy. Gynecol Obstet Invest 1998;46(1):9-16.
33. Byrne DW. How to get your medical research paper published. The New Physician. Mar 1999:11-

15.
34. Fitch JC, Geary KL, Mirto GP, Byrne DW, Hines RL. Heparin management test versus

activated coagulation time during cardiovascular surgery: correlation with

anti-Xa activity. J Cardiothorac Vasc Anesth 1999 Feb;13(1):53-7.

http://oncology.medscape.com/Medscape/psychiatry/journal

/1997 /v02.n09/mh3068.blumenfeld/mh3068.blumenfeld.html
38. Byrne DW. How to get your medical research paper published. The New Physician. Mar 1999:11-15.
39. Bracero LA, Roshanfekr D, Byrne DW. Analysis of antepartum fetal heart rate tracing by physician

and computer. J Matern Fetal Med 2000;9(3):181-5.

peer reviewers. Science Editor (formerly CBE Views) March-April 2000 Vol 23, No 2:39-44.

Jun;5(2):143-51.

42. Dishy V, Sofowara GG, Xie HG, Kim RB, Byrne DW, Stein CM, Wood AJJ. The effect of common polymorphisms of the B₂-adrenergic receptor on agonist-mediated vascular desensitization. N Engl J Med 2001;345:1030-1035.
43. Brown NJ, Abbas A, Byrne DW, Schoenhard JA, Vaughan DE. Comparative effects of

estrogen and ACE inhibition on plasminogen activator inhibitor-1 in healthy

postmenopausal women. Circulation 2002;105(3):304-9.
44. Rosenbaum DA, Pretorius M, Gainer JV, Byrne D, Murphey LJ, Painter CA, Vaughan DE, Brown NJ. Ethnicity affects vasodilation, but not endothelial tissue plasminogen activator release, in response to bradykinin. Arterioscler Thromb Vasc Biol 2002 Jun 1;22(6):1023-8
45. Liveris D, Wang G, Girao G, Byrne DW, Nowakowski J, McKenna D, Nadelman R, Wormser GP, Schwartz I. Quantitative Detection of Borrelia burgdorferi in 2-Millimeter Skin Samples of Erythema Migrans Lesions: Correlation of Results with Clinical and Laboratory Findings. J Clin Microbiol 2002 Apr;40(4):1249-53.

46. Liveris D, Wang G, Girao G, Byrne DW, Nowakowski J, McKenna D, Nadelman R, Wormser GP, Schwartz I. Quantitative detection of Borrelia burgdorferi in 2-millimeter skin samples of erythema migrans lesions: correlation of results with clinical and laboratory findings. J Clin Microbiol 2002 Apr;40(4):1249-53. 47. Bracero LA, Haberman S, Byrne DW. Maternal glycemic control and umbilical artery Doppler velocimetry. J Matern Fetal Neonatal Med. 2002;12(5)12:342-8. 48. Kuhn KP, Byrne DW, Arbogast PW, Doyle TP, Loyd JE, Robbins IM. Outcome in 91 Consecutive Patients with Pulmonary Arterial Hypertension Receiving Epoprostenol. Am J Respir Crit Care Med 2002;167(4):580-6. 49. Buchowski MS, Chen KY, Byrne D, Wang WC. Equation to estimate resting energy expenditure in adolescents with sickle cell anemia. Am J Clin Nutr 2002, Dec;76(6):1335- 44. 50. Bracero LA, Byrne DW. Ultrasound determination of chorionicity and perinatal outcome in twin pregnancies using dividing membrane thickness. Gynecol Obstet Invest. 2003;55(1):50-7. 51. Dishy V, Gupta S, Landau R, Xie HG, Kim RB, Smiley RM, Byrne DW, Wood AJJ, Stein CM. G-protein 3 subunit 825 C/T polymorphism is associated with weight gain during pregnancy. Pharmacogenetics. 2003 Apr;13(4):241-2. 52. Malave HA, Biaggioni I, Byrne DW, Vaughan DE, Murphey LJ, Brown NJ. Bradykinin and its metabolite bradykinin 1-5.Circulation. 2003. (Accepted for publication.) 53. Dignan R, Byrne DW. Aortic Valve Allograft Structural Deterioration is Associated with a Subset of Antibodies to Human Leukocyte Antigens. J Heart Valve Dis. 2003 May;12(3):382-90. 54. Lavely WC, Delbeke D, Greer JP, Morgan DS, Byrne DW, Price RR, Hallahan DE. FDG PET in the Follow-up Management of Patients with Newly-diagnosed Hodgkin’s and Non-Hodgkin’s Lymphoma after First-line Chemotherapy. Int J Radiat Oncol Biol Phys. 2003;57(2):307-315. 55. Tarquinio GT, Dittus RS, Byrne DW, Kaiser A, Neilson EG. Effect of performance-based compensation and faculty track on the clinical activity, research portfolio, and teaching mission of a large academic department of medicine. Acad Med. 2003 Jul;78(7):690-701. 56. Carcoana OV, Mathew JP, Davis E, Byrne DW, Hayslett JP, Hines RL, Garwood S. Manitol and Dopamine in Patients Undergoing Cardiopulmonary Bypass: A Randomized Clinical Trial. Anesth Analg. 2003 Nov;97(5):1222-9. 57. Sofowora GG, Dishy V, Muszkat M, Xie HG, Kim RB, Harris PA, Prasad HC, Byrne DW, Nair UB, Wood AJ, Stein CM. A common beta1-adrenergic receptor polymorphism (Arg389Gly) affects blood pressure response to beta-blockade. Clin Pharmacol Ther. 2003 Apr;73(4):366-71. 58. Lu CC, Diedrich A, Tung CS, Paranjape SY, Harris PA, Byrne DW, Jordan J, Robertson D. Water Ingestion as Prophylaxis Against Syncope. Circulation. Nov 2003. Circulation. 2003 Nov 25;108(21):2660-5. 259. Singleton CD, Robertson D, Byrne DW, Joos KM. Effect of posture on blood and intraocular pressures in multiple system atrophy, pure autonomic failure, and baroreflex failure. Circulation. 2003 Nov 11;108(19):2349-54. 60. Donahue BS, Byrne DW, Gailani D, George AL Jr. Tissue factor and platelet glycoprotein Ib-alpha alleles are associated with age at first coronary bypass operation. Anesthesiology. 2003 Dec;99(6):1287-94. 4 661. Cohen JA, Arain A, Harris PA, Byrne DW, Holzman MD, Sharp KW, Richards WO. Surgical Trial Investigating Nocturnal Gastroesophageal Reflux and Sleep (STINGERS). Surgical Endoscopy 2003;17(3):394-400. 62. Haberman S, Bracero LA, Byrne DW. Spectral Doppler indices mapping of the umbilicoplacental circulation and pregnancy outcome. Gynecol Obstet Invest. 2004;58(1): 1-7. 63. Kuhn KP, Wickersham NE, Robbins IM, Byrne DW. Acute effects of sildenafil in patients with primary pulmonary hypertension receiving epoprostenol. Exp Lung Res. 2004 Mar;30(2):135-45. 64. Murff HJ, Rothman RL, Byrne DW, Syngal S. The impact of family history of diabetes on glucose testing and counseling behavior in primary care. Diabetes Care. 2004 Sep;27(9):2247-8. 65. Dishy V, Landau R, Sofowora GG, Xie HG, Smiley RM, Kim RB, Byrne DW, Wood AJ, Stein CM. Beta2-adrenoceptor Thr164Ile polymorphism is associated with markedly decreased vasodilator and increased vasoconstrictor sensitivity in vivo. Pharmacogenetics. 2004 Aug;14(8):517-22. 66. Lavely WC, Scarfone C, Cevikalp H, Li R, Byrne DW, Cmelak AJ, Dawant B, Price RR, Hallahan DE, Fitzpatrick JM. Phantom validation of coregistration of PET and CT for image-guided radiotherapy. Med Phys. 2004 May;31(5):1083-92. 67. Sofowora GG, Dishy V, Landau R, Xie HG, Prasad HC, Byrne DW, Smiley RM, Kim RB, Wood AJ, Stein CM. Alpha 1A-adrenergic receptor polymorphism and vascular response. Clin Pharmacol Ther. 2004 Jun;75(6):539-45. 68. Cho DG, Mulloy MR, Chang PA, Johnson MD, Aharon AS, Robison TA, Buckles TL, Byrne DW, Drinkwater DC Jr. Blockade of the extracellular signal-regulated kinase pathway by U0126 attenuates neuronal damage following circulatory arrest. J Thorac Cardiovasc Surg. 2004 Apr;127(4):1033-40. 69. Murff HJ, Byrne D, Syngal S. Cancer risk assessment: quality and impact of the family history interview. Am J Prev Med. 2004 Oct;27(3):239-45. 70. Richards WO, Torquati A, Holzman MD, Khaitan L, Byrne D, Lutfi R, Sharp KW. Heller myotomy versus Heller myotomy with Dor fundoplication for achalasia: a prospective randomized double-blind clinical trial. Ann Surg. 2004 Sep;240(3):405-12; discussion 412- 5. 71. Shah SA, Shankar V, Churchwell KB, Taylor MB, Scott BP, Bartilson R, Byrne DW, Christian KG, Drinkwater DC. Clinical outcomes of 84 children with congenital heart disease managed with extracorporeal membrane oxygenation after cardiac surgery. ASAIO J. 2005 Sep-Oct;51(5):504-7. 72. Garland EM, Winker R, Williams SM, Jiang L, Stanton K, Byrne DW, Biaggioni I, Cascorbi I, Phillips JA 3rd, Harris PA, Rudiger H, Robertson D. Endothelial NO synthase polymorphisms and postural tachycardia syndrome. Hypertension. 2005 Nov;46(5):1103-10. Epub 2005 Oct 3. 73. Ma J, Albornoz F, Yu C, Byrne DW, Vaughan DE, Brown NJ. Differing effects of mineralocorticoid receptor-dependent and -independent potassium-sparing diuretics on fibrinolytic balance. Hypertension. 2005 Aug;46(2):313-20. 74. Rosenbloom ST, Chiu KW, Byrne DW, Talbert DA, Neilson EG, Miller RA. Interventions to regulate ordering of serum magnesium levels: report of an unintended consequence of decision support. J Am Med Inform Assoc. 2005 Sep-Oct;12(5):546-53. 75. Wormser GP, McKenna D, Carlin J, Nadelman RB, Cavaliere LF, Holmgren D, Byrne DW, Nowakowski J. Brief communication: hematogenous dissemination in early Lyme disease. Ann Intern Med. 2005 May 3;142(9):751-5. 76. Kallianpur AR, Hall LD, Yadav M, Byrne DW, Speroff T, Dittus RS, Haines JL, Christman BW, Summar ML. The hemochromatosis C282Y allele: a risk factor for hepatic veno-occlusive disease after hematopoietic stem cell transplantation. Bone Marrow Transplant. 2005 Jun;35(12):1155-64. 77. Xia Y, Hill KE, Byrne DW, Xu J, Burk RF. Effectiveness of selenium supplements in a low-selenium area of China. Am J Clin Nutr. 2005 Apr;81(4):829-34. 78. Raj SR, Biaggioni I, Yamhure PC, Black BK, Paranjape SY, Byrne DW, Robertson D. Renin-aldosterone paradox and perturbed blood volume regulation underlying postural tachycardia syndrome. Circulation. 2005 Apr 5;111(13):1574-82. 79. Taneja I, Diedrich A, Black BK, Byrne DW, Paranjape SY, Robertson D. Modafinil elicits sympathomedullary activation. Hypertension. 2005 Apr;45(4):612-8. 80. Willers ED, Newman JH, Loyd JE, Robbins IM, Wheeler LA, Prince MA, Stanton KC, Cogan JA, Runo JR, Byrne D, Humbert M, Simonneau G, Sztrymf B, Morse JA, Knowles JA, Roberts KE, McElroy JJ, Barst RJ, Phillips Iii JA. Serotonin Transporter Polymorphisms in Familial and Idiopathic Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2005 Dec 9. 81. McAdam BF, Byrne D, Morrow JD, Oates JA. Contribution of cyclooxygenase-2 to elevated biosynthesis of thromboxane A2 and prostacyclin in cigarette smokers. Circulation. 2005 Aug 16;112(7):1024-9. 82. Murff HJ, Byrne D, Haas JS, Puopolo AL, Brennan TA. Race and family history assessment for breast cancer. J Gen Intern Med. 2005 Jan;20(1):75-80. 83. Toprak O, Cirit M, Yesil M, Byrne DW, Postaci N, Bayata S, Majchrzak KM, Esi E. Metabolic syndrome as a risk factor for contrast-induced nephropathy in non-diabetic elderly patients with renal impairment. Kidney Blood Press Res 2006;29:2-9. 84. Parekh AD, Trusler LA, Pietsch JB, Byrne DW, DeMarco RT, Pope JC 4th, Adams MC, Deshpande JK, Brock JW 3rd. Prospective, longitudinal evaluation of health related quality of life in the pediatric spina bifida population undergoing reconstructive urological surgery. J Urol. 2006 Oct;176(4 Pt 2):1878-82. 85. Murff HJ, Pichert JW, Byrne DW, Hedstrom C, Black M, Churchill L, Speroff T. General clinical research center staff nurse perceptions and behaviors regarding informed consent: results of a national survey. IRB. 2006 Jul-Aug;28(4):8-12. 86. Schadt CR, Cox KL, Tramontana MG, Byrne DW, Davis TL, Fang JY, Konrad PE, Padaliya B, Mutter RW, Gill CE, Richardson CR, Charles PD. Depression and intelligence in patients with Parkinson's disease and deep-brain stimulation. J Natl Med Assoc. 2006 Jul;98(7):1121-5. 87. Murphey LJ, Malave HA, Petro J, Biaggioni I, Byrne DW, Vaughan DE, Luther JM, Pretorius M, Brown NJ. Bradykinin and its metabolite bradykinin 1-5 inhibit thrombin-induced platelet aggregation in humans. J Pharmacol Exp Ther. 2006 Sep;318(3):1287-92. 88. Buchowski MS, Majchrzak KM, Blomquist K, Chen KY, Byrne DW, Bachorowski JA. Energy expenditure of genuine laughter. Int J Obes (Lond). 2007; 31(1):131-137. 89. Burk RF, Norsworthy BK, Hill KE, Motley AK, Byrne DW. Effects of chemical form of selenium on plasma biomarkers in a high-dose human supplementation trial. Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):804-10. 90. Agarwal HS, Churchwell KB, Doyle TP, Christian KG, Drinkwater DC Jr, Byrne DW, Taylor MB. Inhaled nitric oxide use in bidirectional Glenn anastomosis for elevated Glenn pressures. Ann Thorac Surg. 2006 Apr;81(4):1429-34. 91. Shibao C, Gamboa A, Diedrich A, Ertl AC, Chen KY, Byrne DW, Farley G, Paranjape SY, Davis SN, Biaggioni I. Autonomic contribution to blood pressure and metabolism in obesity. Hypertension. 2007;49(1):27-33. 92. Johnston PE, France DJ, Byrne DW, Murff HJ, Lee B, Stiles RA, Speroff T. Assessment of adverse drug events among patients in a tertiary care medical center. Am J Health Syst Pharm. 2006 Nov 15;63(22):2218-27. 93. Schadt CR, Byrne DW, Charles PD. Gender, intelligence, and medication cost in Parkinson's disease treated with deep brain stimulation. Annals of Neurology. 2006 60: S82-S83 Suppl. 10. 94. Murff HJ, Pichert JW, Byrne DW, Hedstrom C, Black M, Churchill L, Speroff T. Research participant safety and systems factors in general clinical research centers. IRB. 2006 Nov-Dec;28(6):8-14. 95. Tai JH, Udoji MA, Barkanic G, Byrne DW, Rebeiro PF, Byram BR, Kheshti A, Carter JD, Graves CR, Raffanti SP, Sterling TR. Pregnancy and HIV disease progression during the era of highly active antiretroviral therapy. J Infect Dis. 2007 Oct 1;196(7):1044-52. 96. Dzurik MV, Diedrich A, Black B, Paranjape SY, Raj SR, Byrne DW, Robertson D. Endogenous substance P modulates human cardiovascular regulation at rest and during orthostatic load. J Appl Physiol. 2007 Jun;102(6):2092-7. 97. Hebert PR, Coffey CS, Byrne DW, Scott TA, Fagard RH, Rottman JN, Murray KT, Oates JA. Treatment of Elderly Hypertensive Patients with Epithelial Sodium Channel Inhibitors Combined with a Thiazide Diuretic Reduces Coronary Mortality and Sudden Cardiac Death. J Am Soc Hypertens. 2008 Sep;2(5):355-365. 98. Mathew RP, Byrne DW, Linton MF, Vaughan DE, Fazio S, Russell WE. Evidence of metabolic syndrome in lean children with premature pubarche at diagnosis. Metabolism. 2008 Jun;57(6):733-40. 99. Brown AM, Morrow JD, Limbird LE, Byrne DW, Gabbe SG, Balser JR, Brown NJ. Centralized oversight of physician-scientist faculty development at Vanderbilt: early outcomes. Acad Med. 2008 Oct;83(10):969-75. 100. Robbins IM, Newman JH, Johnson RF, Hemnes AR, Fremont RD, Piana RN, Zhao DX, Byrne DW. Association of the metabolic syndrome with pulmonary venous hypertension. Chest. 2009 Jul;136(1):31-6. 101. Riker RR, Shehabi Y, Bokesch PM, Ceraso D, Wisemandle W, Koura F, Whitten P, Margolis BD, Byrne DW, Ely EW, Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. Rocha MG; SEDCOM (Safety and Efficacy of Dexmedetomidine Compared With Midazolam) Study Group. JAMA. 2009 Feb 4;301(5):489-99. 102. Birdwell KA, Ikizler MR, Sannella EC, Wang L, Byrne DW, Ikizler TA, Wright PF. Decreased antibody response to influenza vaccination in kidney transplant recipients: a prospective cohort study. Am J Kidney Dis. 2009 Jul;54(1):112-21. 103. Xia Y, Hill KE, Li P, Xu J, Zhou D, Motley AK, Wang L, Byrne DW, Burk RF. Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects. Am J Clin Nutr. 2010 Sep;92(3):525-31. 104. Moss JR, Cofer S, Hersey S, Goudy S, Werkhaven J, Swanson E, Mantle C, Stowell N, Byrne D, Wang L, Labadie R. Comparison of clonidine, local anesthetics, and placebo for pain reduction in pediatric tonsillectomy. Arch Otolaryngol Head Neck Surg. 2011 Jun;137(6):591-7. 105. Maron DJ, Stone GW, Berman DS, Mancini GB, Scott TA, Byrne DW, Harrell FE Jr, Shaw LJ, Hachamovitch R, Boden WE, Weintraub WS, Spertus JA. Is cardiac catheterization necessary before initial management of patients with stable ischemic heart disease? Results from a Web-based survey of cardiologists. Am Heart J. 2011 Dec;162(6):1034-1043. 106. Byrne DW, Goetzel RZ , McGown PW, Holmes MC, Beckowski MS, Tabrizi MJ, Kowlessar N, Yarbrough MI. Seven-Year Trends in Employee Health Habits from a Comprehensive Workplace Health Promotion Program at Vanderbilt University. Journal of Occupational and Environmental Medicine. 2011 Dec,53(12):1372-1381. 107. Byrne DW, Biaggioni I, Bernard GR, Helmer TT, Boone LR, Pulley JM, Edwards T, Dittus RS. Clinical and Translational Research Studios: A Multidisciplinary Internal Support Program. Accepted for publication in Academic Medicine (2012). Reviews, Case Reports, Letters, Editorials 108. Byrne DW, Salzberg CA. "Major risk factors for pressure ulcers in the spinal cord disabled: a literature review.” Spinal Cord (Paraplegia). 1996;34(5):255-263. Book Reviews (http://www.bio.ri.ccf.org/ASA_TSHS/html/newsletter.htm) 1. Byrne DW. Book review of “Essential Medical Statistics” by Kirkwood. Teaching Statistics in the Health Sciences Newsletter. Jan 2004. 2. Byrne DW. Book review of “Statistics with Confidence” by Altman. Teaching Statistics in the Health Sciences Newsletter. June 2004. 3. Byrne DW. Book review of “SPSS 12.0 Guide to Data Analysis” by Norusis. Teaching Statistics in the Health Sciences Newsletter. Dec 2004. 4. Byrne DW. Book review of “Dicing with Death: Chance, Risk and Health” by Senn. Teaching Statistics in the Health Sciences Newsletter. Feb 2005. 5. Byrne DW. Book review of “Introductory Statistics with R” by Dalgaard. Teaching Statistics in the Health Sciences Newsletter. June 2005. 6. Byrne DW. Book review of “Statistical Methods in Medical Research” by Armitage. Teaching Statistics in the Health Sciences Newsletter. Dec 2005. 7. Byrne DW. Book review of “Teacher Man” by McCourt. Teaching Statistics in the Health Sciences Newsletter. June 2006. 8. Byrne DW. Book review of “Study Design and Statistical Analysis” by Katz. Teaching Statistics in the Health Sciences Newsletter. Dec 2006. 9. Byrne DW. Book review of “Biostatistics – A Guide to Design, Analysis, and Discovery” by Forthofer. Teaching Statistics in the Health Sciences Newsletter. June 2008.
Selected Recent Posters: 1. Byrne DW. Statistical methods and software used in studies published by two leading medical journals. General Clinical Research Centers Annual Meeting, Arlington, Virginia. March 11, 2000. 2. Byrne DW. Improving the quality of biostatistics teaching. General Clinical Research Centers Annual Meeting, Arlington, Virginia. March 9, 2001. 3. Byrne DW, Arbogast P, Gautam S, Dittus R. “Improving the Quality of an Introductory Biostatistics Course for Physicians” 2002 Joint Statistical Meetings (NY, NY), American Statistical Association Section on Teaching Statistics in the Health Sciences, (Best Contributed Poster), August 2002. 4. Dittus RS, Byrne DW, Biaggioni I, Bernard GR, Helmer TT, Boone LR, Pulley JM, Edwards T. Clinical and Translational Research Studios: An Interdisciplinary Model. AAMC, September 2012. Books: 1. Byrne DW: Publishing Your Medical Research Paper - What They Don't Teach in Medical School. Lippincott-Williams & Wilkins, 1998. (Currently writing a second edition.) 2. Japanese Edition of Publishing Your Medical Research Paper published in 2000 by Medical Sciences International, Ltd., Tokyo. Selected Presentations: “Extreme Consulting – A Novel Method of Improving Efficiency” Joint Statistical Meetings. Seattle, WA. August 8, 2006.

Selected continuing education courses taken:
1. Effective and Efficient Programming in R. Short Course. Ross Daniel and Nick Ellis. July, 2008, Dublin (IBC)
2. Adaptive Analysis of Data: Tests of Significance and Confidence Intervals - Short Course. Tom O’Gormon,. August 2008, Denver, (JSM).
3. Determining Sample Size and Power in Study Planning: nQuery Advisor – Short Course. Janet D. Elashoff. August 2008, Denver, (JSM).
4. Introduction to Bayesian Analysis Using SAS Software. – Short Course. Fang Chen. August 2008, Denver, (JSM).
5. Statistical Genetics Short Course. Kenneth Lange, July 2007, Salt Lake City (JSM).
6. Classification and Regression Trees. Wei-Yin Loh, July 2007, Salt Lake City (JSM).
7. Analysis of Multivariate Failure Time Data. Danyu Lin, August 2006, Seattle, (JSM).
8. Creating More Effective Graphs. Naomi B. Robbins, August 2006, Seattle, (JSM).
9. Regression Modeling Strategies. Frank E. Harrell, 2006, Nashville.
10. Effective Scientific Writing. Judith A. Swan. August 2006, Seattle, (JSM).

11. Bayesian Clinical Trials. Scott M. Berry. Fairbanks, Alaska, (WNAR 2005)

30. Interim Monitoring of Clinical Trials for Efficacy, Safety and Futility. August 2003, San Francisco (JSM).

31. Design, Monitoring, and Analysis of Group Sequential Clinical Trials. August 2002 (JSM).

32. Introduction to Regression Modeling of Survival (Time to Event) Data. August 2002 (JSM).

35. Complex Power and Sample-Size Analyses Using SAS-Based Tools. August 2001 (JSM).