Basic Science
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UNIVERSITY OF CENTRAL FLORIDA – 4 Studies
Presenter: Alexander M. Cole, Ph.D.
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Basic Science/Virology
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Retrocyclins: circular defensins active against HIV-1 (NIH R01 grant AI052017)
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Alexander M. Cole, Ph.D. (PI)
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Microbiology and Molecular Biology
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Topical microbicides to prevent HIV-1 transmission
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Basic Science/Virology
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Project 2. Development of RC-101 as an intravaginal topical microbicide. (NIH U19 grant AI082623)
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Alexander M. Cole, Ph.D. (PD of Project 2); Phalguni Gupta, Ph.D. (PI; PD of Project 3; U. Pitt); other project and core directors
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Microbiology and Molecular Biology
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Topical microbicides to prevent HIV-1 transmission
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Basic Science/Virology
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Aminoglycoside microbicides restore natural anti-HIV-1 retrocyclins (NIH R21 grant AI082693)
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Alexander M. Cole, Ph.D. (PI)
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Microbiology and Molecular Biology
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Innate host defense against HIV-1
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Basic Science/Virology
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Reawakening retrocyclins to prevent mucosal STIs (Gates Grand Challenges Explorations Award)
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Alexander M. Cole, Ph.D. (PI)
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Microbiology and Molecular Biology
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Innate host defense against STIs, including HIV
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UNIVERSITY OF MIAMI – 36 Studies
Presenter: Savita Pahwa, M.D.
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Basic Science/Virology
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Targeted siRNA delivery as an anti-HIV microbicide
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Derek Dykxhoorn
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Dr. John T. Macdonald Foundation Department of Human Genetics and the Department of Microbiology and Immunology
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Microbicide development
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Behavioral/Epidemiological
Basic Science/Virology
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Longitudinal analysis of a high risk HIV negative cohort
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Derek Dykxhoorn (Human Genetics, Microbiology and Immunology, DCFAR), Lisa Metsch (Epidemiology and Public Health, DCFAR), Jose Castro (Medicine, DCFAR), Savita Pahwa (Microbiology and Immunology, DCFAR), Margaret Fischl (Medicine, DCFAR), Rafick Sekaly (VGTI-Florida, DCFAR), Lydie Trautmann (VGTI-FL, DCFAR)
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Human Genetics, Microbiology and Immunology, Epidemiology and Public Health, Medicine, VGTI-FL, Developmental Center for AIDS Research (DCFAR)
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Genetics and Genomics of HIV infection, Acute HIV infection (AHI)
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Basic Science/Virology
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Identification of genetic variations associated with viral set point control in long term non-progessors
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Derek Dykxhoorn (Human Genetics, Microbiology and Immunology, DCFAR), Hector Bolivar (Medicine, DCFAR), William Scott (Human Genetics, DCFAR)
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Human Genetics, Microbiology and Immunology, Medicine, VGTI-FL, Developmental Center for AIDS Research (DCFAR)
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Genetics of HIV infection
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Basic Science/Virology
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Activation of CD40 by HIV and Role in AIDS Dementia
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Mario Stevenson (PI)
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Medicine
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Identify mechanism by which HIV induces neuronal destruction in AIDS dementia
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Basic Science/Virology
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Role of Monocytotropism in HIV/SIV Pathogenicity
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Mario Stevenson (PI) Keith Mansfield (Harvard)
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Medicine
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Examine the role of myeloid lineage cells in the persistence & pathogenicity of HIV/SIV
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Basic Science/Virology
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Cellular Co-Factors of HIV-1 Infection
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Mario Stevenson (PI)
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Medicine
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Identify cellular factors that are commandeered by HIV in its replication cycle. The goal is to identify new targets for therapeutic intervention
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Basic Science/Virology
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Preclinical Development of HIV-1 Vif Antagonists
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Mario Stevenson (PI) Tariq Rana (Burnham), Keith Mansfield (Harvard), Brigitte Beer (Bioqual)
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Medicine
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Undertake preclinical development of a lead molecule that interferes with the action of the HIV Vif protein.
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Basic Science/Virology
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Molecular characterization of cryptic HIV-1 replication during HAART (Project 1)
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Mario Stevenson (PI) Tim Schacker (U. Minnesota)
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Medicine
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To identify the viral reservoirs that persist in the face of antiretroviral therapy. Our analysis focuses on the role of the gut lymphoid tissue in viral persistence.
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Basic Science/Virology
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Pharmacokinetics of HIV-1 with the integrase inhibitor Raltegravir
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Mario Stevenson, Rafael Campo (PI)
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Medicine
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To evaluate whether intensification of ART with Raltegravir reduces the extent of aberrant immune activation and improves on-treatment CD4 gains in HIV infection individualS
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Basic Science/Virology
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The Role of Myeloid Cells in Viral Replication, Persistence and Neuroinvasion
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Mario Stevenson (PI)
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Medicine
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To determine whether macrophage are a source of persistent virus in patients on ART & to develop a strategy to remove infected macrophage reservoirs using agents that promote macrophage apoptosis
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Basic Science/Virology
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HIV Exposed Uninfected: Adaptive Immunity
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Jose Castro, Margaret Fischl, Rafick Sekaly
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Microbiology and Immunology, Medicine, VGTI
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Pathogenesis, Mucosal Immunity
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Basic Science/Virology
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UM Developmental Center For AIDS Research Int'l AIDS Malignancy Initiative Program
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Enrique Mesri
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Microbiology and Immunology
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NCI
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Basic Science/Virology
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DCFAR- SCCC International Collaborations in AIDS- Malignancies
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Enrique Mesri, Gail Shor-Posner, Juan Carlos Ramos
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Microbiology and Immunology, Medicine, Pediatrics
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AIDS Malignancies Projects in Brazil and Argentina
NIH
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Basic Science/Virology
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International Maternal Pediatric Adolescents AIDS Clinical Trails Group Immunology Laboratory
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Savita Pahwa,
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Microbiology and Immunology
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NIAID
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Basic Science/Virology
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Role of IL21 in HIV infection
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Savita Pahwa
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Microbiology and Immunology
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NIAID
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Basic Science/Virology
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Effect of Raltegravir on immune activation, immune reconstitution and gut microbial translocation in patients with chronic HIV infection
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Savita Pahwa
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Microbiology and Immunology
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Merck
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Basic Science/Virology
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Induction of mucosal SIV immunity in non human primates by secreted Hsp-Gp96
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Eckhard Podack, Savita Pahwa
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Microbiology and Immunology
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NIAID
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Basic Science/Virology
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HIV Exposed Uninfected: Innate Immunology
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Lydie Trautmann, Margaret Fischl, Rafick Sekaly
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Microbiology and Immunology, Medicine, VGTI
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Pathogenesis, Mucosal Immunity
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Basic Science/Virology
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Targeted therapy for Burkitt Lymphoma in Resource Poor Settings
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Barber Glen
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Medicine
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NCI
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Basic Science/Virology
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Targeting of EBV Latency in Burkitt's Lymphoma
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Juan Carlos Ramos
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Medicine
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NCI
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Basic Science/Virology
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Biochemical Mechanisms of Drug Resistance in HIV RT
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Walter A. Scott
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Biochemistry & Molecular Biology
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NIAID
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Basic Science/Virology
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Mitochondrial determinations metabolic disease in HIV-infected children
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Tracie Miller
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Pediatric Metabolic/
Pathogenesis Research
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NINR
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Basic Science/Virology
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Ologonucelotide apatmer ligands to reverse T cell anergy HIV-infected patients
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Eli Gilboa
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Novel therapeutics and pathogenesis
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NIAID
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Clinical Trial
Basic Science/Virology
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Effect of Raltegravir on immune activation, immune reconstitution and gut microbial translocation in patients with chronic HIV infection
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Rafael Campo
Savita Pahwa
Mario Stevenson
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Novel therapeutics and pathogenesis
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Merck
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Basic Science/Virology
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HIV-1 C clade progression and neuroaids
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Mahendra Kumar
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Pathogenesis
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NINDS
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Basic Science/Virology
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Gp96-Ig HIV and SIV vaccines;
HPV based HIV vaccines
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Podack, E. R; Franchini, G (NCI); Haddad, E (VGTI); Sekaly, R. (VGTI) Pahwa, S; Altman, N
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Vaccine Research
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R21, R33 funded; PO1, UO1 pending (NIAID)
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Basic Science/Virology
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Novel adjuvants
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Stone, G.
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Vaccine Research
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R21, K22, R21 pending NIAID
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Basic Science/Virology
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TL1A and LMP1
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Strbo, N; Stone, G.
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Vaccine Research
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DCFAR/ NIAID Supplements
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Basic Science/Virology
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Hu-mice for HIV vaccine research
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Gonzales, L; Strbo, N; Podack E.R.
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Vaccine Research
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Predoctoral stipend from HIV training grant (NIMH)
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Basic Science/Virology
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Host Defense Regulation and Viral Oncogenesis
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Glen Barber
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AIDS Malignancies
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NCI
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Basic Science/Virology
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Role of RAC and Reactive Oxygen Species in Kaposi’s Sarcoma Viral Oncogenesis
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Enrique Mesri
P Goldschmidt
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AIDS Malignancies
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NCI
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Basic Science/Virology
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Biology of KSHV/HHV8 G Protein Coupled Receptor
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Enrique Mesri
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AIDS Malignancies
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NCI
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Basic Science/Virology
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A Prospective, Open-Label, Double-Arm, Crossover, Single-Center Pilot Study to Evaluate the Addition of Raltegravir to Established Suppressive Antiretroviral Therapy while Monitoring Changes in Markers of Immune Activation among HIV-1 Infected Individuals Without Adequate Immune Restoration. (35835)
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Rafael Campo
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Medicine
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Immune reconstitution
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Basic Science/Virology
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140 - Clinical Evaluation of the Xpert® CT/NG Assay
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Jose Castro
New – enrolling soon
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Medicine
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Efficacy
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Basic Science/Virology
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73B - Evaluation of the Xpert® CT/NG Assay
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Jose Castro
New Enrolling soon
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Medicine
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Efficacy
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Basic Science/Virology
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Effect of Raltegravir on immune activation, immune reconstitution and gut microbial translocation in patients with chronic HIV infection
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Industry Studies
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Immune reconstitution
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UNIVERSITY OF SOUTH FLORIDA – 13 Studies
Presenter: John W. Sleasman, M.D.
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Basic Science/Virology
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R01 AI47723-04A1; NIAID. Impact of HIV-1 Genotype on Therapy Response in Children
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John Sleasman, MD (PI), Carina Rodriguez, MD, Soichi Haraguchi, PhD, Patricia Emmanuel, MD (Co-Investigators)
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Allergy and Immunology
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Impact of HIV resistance in immunologic and viral responses in HIV-1 infected children and adolescents
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Basic Science/Virology
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Defective immunoglobulin somatic hypermutation results in pneumococcal vaccination hyporesponsiveness in HIV infected children. Center for Florida AIDS Research
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Carina Rodriguez, MD (PI), John Sleasman, MD, Li Yin, PhD, Maureen Goodenow, PhD.
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Pediatric Infectious Diseases, Allergy and Immunology (USF) and Pathology (UF)
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Impact of HIV infection on B cell repertoire and somatic mutation and the role of vaccine response
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Basic Science/Virology
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Do children with HIV have disregulated amyloid loads in their blood?
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Brian Giunta, MD (PI), Carina Rodriguez, MD, Patricia Emmanuel, MD, John Sleasman, MD, Jaime Fernandez, MD, Frank Fernandez, MD
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Psychiatry and Pediatric Infectious Diseases
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Changing levels of amyloid beta in peripheral blood and HIV viral infection. Basic/translational, immune response
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Basic Science/Virology
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Substance use and immunity function in HIV+ adolescents by systems biology
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Maureen Goodenow, John Sleasman
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Pathology, UF Allergy and Immunology, USF
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Substance use and immunity function in HIV adolescents
Sponsor: NIDA
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Basic Science/Virology
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Impact of HIV-1 Genotype on Therapy Response in Children.
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Maureen Goodenow, John Sleasman
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Pathology, UF Allergy and Immunology, USF
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Structure function relationships between HIV-1 protease and p7NC.
Sponsor: NIAID
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Basic Science/Virology
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Role of HIV-1 Env Diversityin Cellular Tropism
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Maureen Goodenow, John Sleasman
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Pathology, UF Allergy and Immunology, USF
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HIV-1 envelope and CD4 target cells.
Sponsor: NICHD
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Basic Science/Virology
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Studies of Ocular Complications of AIDS (SOCA)
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Peter Pavan (PI)
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Ophthalmology
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Complications, ocular diseases, AIDS, CMV
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Basic Science/Virology
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Defective immunoglobulin somatic hypermutation results in pneumococcal vaccination hyporesponsiveness in HIV infected children
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Carina Rodriguez (PI)
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Pediatrics
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basic/translational, immune response
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Basic Science/Virology
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Changes in the B cell repertoire following vaccination with novel H1N1 inactivated influenza vaccine in immune deficient adolescents and young adults chronically infected with HIV
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Carina Rodriguez (PI)
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Pediatrics
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basic/translational, immune response
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Basic Science/Virology
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The Role of HIV-TAT in Alzheimer’s Disease
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Richard Dembo (PI)
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Psychiatry and Neurosciences
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Prevention; Drug Use
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Basic Science/Virology
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Uncovering Co-stimulatory T Cell Help Defects in Common Variable Immunodeficiency
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Elena Perez (PI)
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Pediatrics
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Basic Science/Virology
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Green Tea Derived EGCG Opposes AIDS Dementia-Like Neuronal Damage
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Jun Tan (PI)
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Psychiatry and Neurosciences
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Basic Science/Virology
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Role of Cannabinoid 2 Receptors in B Lymphocyte Function
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Catherin Patterson (PI)
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Biochemistry
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UNIVERSITY OF FLORIDA
Presenter: Maureen Goodenow, Ph.D. - 14 studies
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Basic Science/Virology
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Substance use and immunity in HIV+ infected adolescents by systems biology
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Maureen Goodenow (PI), Li Yin (Co-PI), Mark Wallet; John W. Sleasman, USF, co PI; Sharon Nichols, University of California, San Diego
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Pathology
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HIV and adolescents
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Basic Science/Virology
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Human Immunodeficiency Virus Proteinase
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Ben Dunn (PI), Maureen Goodenow (Co-I)
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Pathology
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Mechanisms of HIV drug resistance to protease inhibitors
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Basic Science/Virology
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Role of HIV-1 Env Diversity in Cellular Tropism
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Maureen Goodenow (PI), Li Yin (Co-PI); John W. Sleasman, co-PI USF
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Pathology
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Mechanisms of HIV-1 entry into macrophages and genetic determinants in envelope that modulate macrophage infection; deep pyrosequencing of HIV-1 variants in longitudinal study
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Basic Science/Virology
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Impact of HIV-1 Genotype on Therapy Response in Children
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John Sleasman (PI), USF, Maureen Goodenow (Co-PI)
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Pathology
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Mechanisms of HIV-1 genotype and therapy outcome in children
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Basic Science/Virology
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Characterization of novel polyreactive anti-HIV antibodies in autoimmunity
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Maureen Goodenow (PI), Li Yin (Co-I), Mark Wallet; John W. Sleasman, co-PI USF
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Pathology
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HIV vaccine; deep pyrosequencing of human immunoglobulin repertoire and novel phage display library from autoimmune individuals to identify broadly neutralizing antibodies against HIV-1
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Basic Science/Virology
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Molecular mechanisms of skeletal muscle loss in HIV-infected older persons
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Marco Pahor (PI), Christiaan Leeuwenburgh, Maureen Goodenow, Todd Manini, Bradley Bender, Madhuri Sankuratri, Kevin Yarasheski, Martin Rhee
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Geriatrics and Aging Research; Pathology
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Effects of HIV-1 on strength and fatigue in older infected individuals; peripheral blood biomarkers of inflammation and innate immune activation
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Basic Science/Virology
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Viral evolution in peripheral macrophages and brain during progression to AIDS
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Marco Salemi (PI), Maureen Goodenow (Co-I), Rebecca Gray
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Pathology
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Viral dynamics of neuroAIDS in macaque model
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Basic Science/Virology
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Alveolar Macrophage Proteomics in HIV-Induced Emphysema
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Thomas Clanton (PI)
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Exercise and Sports Sciences
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Pathogenesis
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Basic Science/Virology
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Rational design of HIV fusion inhibitors targeting GP 41
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Alan R. Katritzky (PI)
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Chemistry
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Drug Design
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Basic Science/Virology
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Human Immunodeficiency Virus Proteinase
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Ben M. Dunn (PI), Maureen Goodenow (Co-PI)
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Biochemistry and Molecular Biology
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Drug Therapy
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Basic Science/Virology
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Combination of CCR5 32 and SIRNAS targeting HIV
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Lung-Ji Chang
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Molecular Genetics & Micro
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Gene Therapy
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Basic Science/Virology
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Analysis of HIV sequence data
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Marco Salemi (PI)
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Pathology
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Molecular Epidemiology
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Basic Science/Virology
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Foamy virus vector for Immunodeficiency viruses therapy
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Ayalew Mergia (PI)
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Pathobiology
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Gene Therapy
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Basic Science/Virology
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Protective CMI mechanisms of a dual subtype FIV Vaccine
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Janet K. Yamamoto (PI)
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Pathobiology
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Vaccine
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