Supplementary Tables
Table 1
Studies including more than 100 patients published since 2000 reporting stroke aetiology in young patients by TOAST criteria. All figures are percentages. Total percentage figures are from pooled numbers obtained from the individual papers. LAA Large artery Atherosclerosis, CE Cardiac embolism, SVD Small Vessel Disease, ODA Other Determined Aetiology UDA Undetermined Aetiology. a TIAs excluded from total reported cases.
Authors
|
Year Published
|
Years Studied
|
Country
|
Number
|
Age
|
LAA
|
SVD
|
CE
|
ODA
|
UDA
|
Chan et al.
|
2000
|
1993-1997
|
Canada
|
356
|
15-45
|
6
|
8
|
14
|
28
|
44
|
Kwon et al
|
2000
|
1994-7
|
Korea
|
149
|
15-44
|
21
|
17
|
18
|
27
|
17
|
Lee et al
|
2002
|
1997-2001
|
Taiwan
|
264
|
15-45
|
8
|
22
|
20
|
25
|
26
|
Naess et al
|
2004
|
1988-97
|
Norway
|
232
|
15-49
|
15
|
15
|
8
|
15
|
48
|
Cerrato et al
|
2004
|
1994-2001
|
Italy
|
273
|
16-49
|
16
|
17
|
24
|
19
|
24
|
Nedeltchev et al
|
2005
|
1997-2000
|
Switzerland
|
203
|
16-45
|
4
|
9
|
24
|
30
|
33
|
Rasura et al
|
2005
|
1992-2001
|
Italy
|
394
|
14-47
|
12
|
3
|
34
|
28
|
24
|
Varona et al
|
2007
|
1974-2002
|
Spain
|
272
|
15-45
|
20
|
5
|
18
|
22
|
36
|
Arnold M et al
|
2008
|
2000-06
|
Switzerland
|
137
|
16-45
|
2
|
3
|
37
|
31
|
27
|
Putaala J et al
|
2009
|
1994-2007
|
Finland
|
1008
|
15-49
|
8
|
14
|
20
|
26
|
33
|
Spengos and Vemmos
|
2010
|
1999-2008
|
Greece
|
253
|
≤45
|
7
|
17
|
16
|
27
|
34
|
Total (pooled numbers)
|
|
|
|
3541
|
|
10
|
12
|
21
|
25
|
32
|
Table 2
Table S2 Cases excluded from analysis, including causes of stroke mimics. Other causes include 1 each of transient global amnesia, Bells palsy, vestibular symptoms, musculoskeletal symptoms, and previous stroke. TIA transient ischaemic attack.
Cause
|
|
n
|
%
|
Stroke mimic
|
158
|
|
|
Migraine
|
|
76
|
48.4
|
Unspecified
|
|
34
|
21.7
|
Syncope/near syncope
|
|
14
|
8.9
|
Neuropathy
|
|
8
|
5.1
|
Seizure
|
|
7
|
4.5
|
Conversion
|
|
6
|
3.8
|
Visual other
|
|
4
|
2.5
|
Cervical myelitis
|
|
2
|
1.3
|
Other
|
|
7
|
4.6
|
TIA
|
29
|
|
|
Haemorrhage
|
14
|
|
|
Incomplete details
|
9
|
|
|
Table S3 cases of cardiac embolism by TOAST, ASCO1 and ASCO2 criteria with attributed cause. ASA atrial septal aneurysm, DCM dilated cardiomyopathy, MI myocardial infarction
|
TOAST
|
ASCO1
|
ASCO2
|
Isolated PFO
|
14
|
0
|
0
|
PFO with ASA
|
4
|
0
|
4
|
Atrial fibrillation
|
6
|
6
|
6
|
Atrial septal defect
|
2
|
2
|
2
|
Congestive heart failure
|
1
|
1
|
1
|
DCM ( 1 with recent MI)
|
2
|
2
|
2
|
Infective endocarditis
|
1
|
1
|
1
|
Total
|
30
|
12
|
16
|
Supplementary References
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