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Research background


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張凱誌副教授




Research background

  • Microbiology and molecular biology of Helicobacter pylori


Special techniques

  • The techniques of phage expression library, transposon mutagenesis and DNA microarrays are currently used.

  • Molecular diagnosis and typing of microorganisms.


Research Interests

  • Molecular pathogenesis of Helicobacter pylori

  • Molecular epidemiology of Helicobacter pylori


Publications

  • Chang, K. C., Ho, S. W., Yang, J, C., Wang, J. T. (1997) Isolation of a genetic locus associated with metronidazole resistance in Helicobacter pylori. Biochemical Biophysical Research Communications. 236: 785-788. (SCI)

  • Chang, C. S., Chen, L. T., Yang, J. C., Lin, J. T., Chang, K. C., Wang, J. T. (1999) Isolation of a Helicobacter pylori protein, FldA, associated with mucosa-associated lymphoid tissue lymphoma of the stomach. Gastroenterology. 118(5): 988-91. (SCI)

  • Chang, K. C., Yeh, Y. C., Lin, T. L., and Wang, J. T. (2001) Identification of genes associated with natural competence in Helicobacter pylori by Transposon shuttle random mutagenesis. Biochemical Biophysical Research Communications. 288: 961-968. (SCI)

  • Yeh, Y. C., Chang, K. C., Yang, J. C., Fang, C. T., and Wang, J. T. (2002) Association of Metronidazole Resistance and Natural Competence in Helicobacter pylori. Antimicrobial Agents and Chemotherapy. 46 (5): 1564-1567. (SCI)

  • Yeh, Y. C., Lin, T. Z., Chang, K. C., and Wang, J. T. (2003) Characterization of a comE3 homologue essential for DNA transformation in Helicobacter pylori. Infection and Immunity. 71 (9): 5427-5431. (SCI)

  • Lin, T. Z., Sun, C. T., Chang, K. C., Wang, J. T. (2004) Isolation and characterization of a HpyC1I restriction-modification system in Helicobacter pylori. Journal of Biological Chemistry. 279 (12): 11156-11162. (SCI)

  • Lin, T. Z., Sun, C. T., Chang, K. C., Wang, J. T. (2006) Isolation and characterization of a competence operon associated with transformation and adhesion in Helicobacter pylori. Microbes and Infection.8(12): 2756-2765. (SCI)

  • Soo PC, Horng YT, Chang KC, Wang JY, Hsueh PR, Chuang CY, Lu CC, Lai HC.(2009) A simple gold nanoparticle probes assay for identification of Mycobacterium tuberculosis and Mycobacterium tuberculosis complex from clinical specimens. Mol Cell Probes. Oct;23(5):240-6.

  • Horng YT, Chang KC, Chien CC, Wei YH, Sun YM, Soo PC.(2009) Enhanced polyhydroxybutyrate (PHB) production via the coexpressed phaCAB and vgb genes controlled by arabinose P promoter in Escherichia coli. Lett Appl Microbiol. 2010 Feb;50(2):158-67.

  • Kae-Maw Wang, Yu-Hsien Liu, Teng-Yi Lin, Ding-Guo Liu, Po-Chi Soo, Wei-Tung Hung, Kai-Chih Chang*.(2009) Prevalence of Enterobius Vermicularis Infection among Elementary School Children in Hualien, Taiwan. J Biomed Lab Sci.21(4):132-136

  • Horng YT, Chang KC, Chien CC, Wei YH, Sun YM, Soo PC.(2010) Enhanced polyhydroxybutyrate (PHB) production via the coexpressed phaCAB and vgb genes controlled by arabinose P promoter in Escherichia coli. Lett Appl Microbiol. Feb;50(2):158-67.

  • Yu-Tze Horng, Kai-Chih Chang, Yen-Ni Liu, Hsin-Chih Lai, Po-Chi Soo.(2010) The RssB/RssA two-component system regulates biosynthesis of the tripyrrole antibiotic, prodigiosin, in Serratia marcescens. International Journal of Medical Microbiology.30(5): 304-312.

  • Ting-Mi Tsai, Hsin-Hou Chang, Kai-Chih Chang, Yu-Lin Liu, Chun-Chieh Tseng.(2010) A comparative study of the bactericidal effect of photocatalytic oxidation by TiO2 on antibiotic-resistant and antibiotic-sensitive bacteria. Journal of Chemical Technology & Biotechnology Volume 85(12):1642–1653.

  • Kai-Chih Chang, Ming-Feng Lin, Nien-Tsung Lin, Wen-Jui Wu, Han-Yueh Kuo, Teng-Yi Lin, Tsai-Lian Yang, Yu-Chuan Chen, Ming-Li Liou.(2010) Clonal spread of tigecycline and rifampicin-resistant, multidrug-resistant Acinetobacter baumannii in eastern Taiwan. Journal of Microbiology, Immunology and Infection (Accepted).

  • Ming-Feng Lin, Kai-Chih Chang, Chang-Yao Yang, Chih-Man Yang, Chih-Chuan Xiao, Han-Yeh Kuo, and Ming-Li Liou.(2010) Role of integrons in antimicrobial susceptibility patterns of Acinetobacter baumannii. Japanese Journal of Infectious Diseases 63(6):440–443.

  • Nien-Tsung Lin, Pei-Yu Chiou, Kai-Chih Chang, Li-Kuang Chen, Meng-Jiun Lai.(2010) Isolation and characterization of AB2: a novel bacteriophage of Acinetobacter baumannii. Research in Microbiology Volume 161(5):308-314.

  • Kai-Chih Chang, Nien-Tsung Lin, Anren Hu, Yu-Shan Lin, Li-Kuang Chen and Meng-Jiun Lai.(2011) Genomic analysis of bacteriophage AB1, a KMV-like virus infecting multidrug-resistant Acinetobacter baumannii. Genomics Publish online: January 2011.

  • Meng-Jiun Lai, Nien-Tsung Lin, Anren Hu, Po-Chi Soo, Li-Kuang Chen, Long-Hui Chen and Kai-Chih Chang*.(2011) Antibacterial activity of Acinetobacter baumannii phage AB2 endolysin (LysAB2) against both Gram-positive and Gram-negative bacteria. Applied Microbiology and Biotechnology Publish online: 25 January 2011.

  • Kuo, HanYueh、Chang, kai-chih、Kuo JW、Yueh HW、Liou ML*.(2012) Imipenem: a potent multidrug-resistance inducer in Acinetobacter baumannii. International Journal of Antimicrobial Agents,39:33-38.

  • Chang, KC、Lin, MF、Lin, NT、Wu, WJ、Kuo, HY、Lin, TY、Yang, TL、Chen, YC、Liou, ML. (2012) Clonal spread of multidrug-resistant Acinetobacter baumannii in eastern Taiwan. Journal of Microbiology, Immunology and Infection,45:37-42.

  • Pao-Kuei Hsiao、Wan-Ting Chen、Kai-Chih Chang、Yu-Ju Ke、Chung-Long Kuo、Chun-Chieh Tseng*. (2012) Performance of CHROMagar Staph aureus and CHROMagar MRSA for Detection of Airborne Methicillin-Resistant and Methicillin-Sensitive Staphylococcus aureus. Aerosol Science and Technology,46:297-308.

  • Ming-Li Liou、Chih-Chin Liu、Chia-Wei Lu,、Ming-Feng Hsieh、Kai-Chih Chang、Han-Yueh Kuo、Chi-Ching Lee、Chun-Tien Chang、Cheng-Yao Yang、Chuan Yi Tang. (2012) Genome Sequence of Acinetobacter baumannii TYTH-1. Journal of Bacteriology,194:6974-6974.


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