Pharmacology
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| The Journal of
And Experimental Therapeutics A Publication of the American Society for Pharmacology and Experimental Therapeutics  November 2005
Vol.315, No. 2 Contents PERSPECTIVES IN PHARMACOLOGY In Silico Predictions of Blood-Brain Barrier Penetration: Considerations to "Keep in Mind" ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION Functional Characterization of Rat Organic Anion Transporter 5 (Slc22al9) at the Apical Membrane of Renal Proximal Tubules Enantiomer/Enantiomer Interactions between the S- and R-Isomers of Omeprazole in Human Cytochrome P450 Enzymes: Major Role of CYP2C19 and CYP3A4 Functional Analysis of Organic Cation Transporter 3 Expressed in Human Placenta Jay T. Goodwin and David E. Clark 477 Naohiko Anzai, Promsuk Jutabha, 534 Atsushi Enomoto, Hirokazu Yokoyama, Hiroshi Nonoguchi, Taku Hirata, Katsuko Shiraya, Xin He, Seok Ho Cha, Michio Takeda, Hiroki Miyazaki, Takeshi Sakata, Kimio Tomita, Takashi Igarashi, Yoshikatsu Kanai, and Hitoshi Endou Xue-Qing Li, Lars Weidolf, 777 Roger SJmonsson, and Tommy B. Andersson Ryoko Sata, Hisakazu Ohtani, 888 Masayuki Tsujimoto, Hideyasu Murakami, Noriko Koyabu, Takanori Nakamura, Takeshi Uchiumi, Michihiko Kuwano, Hideaki Nagata, Kiyomi Tsukimori, Hitoo Nakano, and Yasufumi Sawada
BEHAVIORAL PHARMACOLOGY Assessment of the Influence of Histaminergic Actions on Cocaine-Like Effects of 3a-Diphenylmethoxytropane Analogs Chronopharmacological Study of Antidepressants in Forced Swimming Test of Mice Characterization of a Novel Bivalent Morphinan Possessing k Agonist and [i Agonist/Antagonist Properties Effect of GABA Agonists and GABA-A Receptor Modulators on Cocaine- and Food-Maintained Responding and Cocaine Discrimination in Rats Vera C. Campbell, Theresa A. Kopajtic, 631 Amy Hauck Newman, and Jonathan L. Katz Kentarou Ushijima, Hiromi Sakaguchi, 764 Yuki Sato, Hideto To, Satoru Koyanagi, Shun Higuchi, and Shigehiro Ohdo Jennifer L. Mathews, Xuemei Peng, 821 Wennan Xiong, Ao Zhang, S. Stevens Negus, John L. Neumeyer, and Jean M. Bidlack Andrew C. Barrett, S. Stevens Negus, 858 Nancy K. Mello, and S. Barak Came Despite Similar Anxiolytic Potential, the 5-Hydroxytryptamine 2C Receptor Antagonist SB-242084 [6-Chloro-5-methyl-l-[2-(2-methylpyrid-3-yloxy)-pyrid-5-yl Carbamoyl] Indoline] and Chlordiazepoxide Produced Differential Effects on Electroencephalogram Power Spectra CARDIOVASCULAR The Effect of Dipyridamole on Vascular Cell-Derived Reactive Oxygen Species Effects of Phytoestrogens Genistein and Daidzein on Prostacyclin Production by Human Endothelial Cells Donitriptan Decreases Jugular Venous Oxygen Saturation in Rats in the Absence of Cranial Vasoconstriction: An Overlooked Mechanism of Antimigraine Action? DAF-FM (4-Amino-5-methylamino-2',7'-difluorofluorescein) Diacetate Detects Impairment of Agonist-Stimulated Nitric Oxide Synthesis by Elevated Glucose in Human Vascular Endothelial Cells: Reversal by Vitamin C and L-Sepiapterin CELLULAR AND MOLECULAR In Vitro Evaluation of the Angiostatic Potential of Drugs Using an Endothelialized Tissue-Engineered Connective Tissue Impairment of Hyperpolarization-Activated, Cyclic Nucleotide-Gated Channel Function by the Intravenous General Anesthetic Propot'ol Differential Regulation of Cystic Eibrosis Transmembrane Conductance Regulator by Interferon y in Mast Cells and Epithelial Cells Prevention of the Ultraviolet B-Mediated Skin Photoaging by a Nuclear Factor kB Inhibitor, Parthenolirte Transcriptional Regulation of Activating Transcription Factor 3 Involves the Early Growth Response-1 Gene Fibrotic Lung Fibroblasts Show Blunted Inhibition by cAMP Due to Deficient cAMP Response Element-Binding Protein Phosphorylation Analysis of Allosterism in Functional Assays Curciimin Suppresses Interleukin 1/3-Mediated Microsomal Prostaglandin E Synthase 1 by Altering Early Growth Response Gene 1 and Other Signaling Pathways Inhibition of Autoantigen Expression by (-)-Epigallocatechin-3-gaIlate (the Major Constituent of Green Tea) in Normal Human Cells Evans Blue Is a Specific Antagonist of the Human Epithelial Na+ Channel 8-Subunit Agonist-Directed Trafficking of Response by Endocannabinoids Acting at CB2 Receptors Characterization of Isoprenaline- and Salmeterol-Stimulatcd Interactions between /32-Adrenoceptors and J3-Arrestin 2 Using /3-Galactosidasc Complementation in C2C12 Cells CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY Interaction with Blood Components Plays a Crucial Role in Asialoglycoprotein Receptor-Mediated in Vivo Gene Transfer by Galactosylated Lipoplex Human U251 Glioma Cell Proliferation Is Suppressed by HET0016 [A'-Hydroxy-A''-(4-butyl-2-methylphenyl)formamidine], a Selective Inhibitor of CYP4A Sandor Kantor, Rita Jakus, Eszter Molnar, 921 Norbert Gyongyosi, Attila Toth, Laszlo Detari, and Gyorgy Bagdy Subrata Chakrabarti, Olga Vitseva, 494 David Iyu, Sonia Varghese, and Jane E. Freedman Carlos Hermenegildo, Pilar J. Oviedo, 722 Miguel Angel Garcfa-Perez, Juan J. Tarin, and Antonio Cano Robert Letienne, Jean-Christophe Blanchet, 849 Estellc Sole, Gareth W. John, and Bruno Le Grand Jian-Zhong Sheng, Dianna Wang, and 931 Andrew P. Braun Pierre-Luc Tremblay, Francois Berthod, 510 Lucie Germain, and Francois A. Auger Luisa P. Caeheaux, Norbert Topf, 517 Gareth R. Tibbs, Ulrich R. Schaefer, Roberto Levi, Neil L. Harrison, Geoffrey W. Abbott, and Peter A. Goldstein Marianna Kulka, Rene Dery, 563 Drew Nahirney, Marek Duszyk, and A. Dean Befus Kiyotaka Tanaka. Junichi Hasegawa, 624 Kaori Asamitsu, and Takashi Okamolo Frank G. Bottone, Jr., Yuseok Moon, 668 Brenda Alston-Mills, and Thomas E. Eling Xiaoqiu Liu, Shu Qiang Sun, and 678 Rennolds S. Ostrom Frederick J. Ehlert 740 Yuseok Moon, Wayne C. Glasgow, and 788 Thomas E. Eling Stephen Hsu, Douglas P. Dickinson, 805 Haiyan Qin, Carol Lapp, David Lapp, James Borke, Douglas S. Walsh, Wendy B. Bollag, Hubert Stoppler, Telsuya Yamamoto, Tokio Osaki, and George Schuster Hisao Yamamura, Shinya Ugawa, 965 Takashi Ueda, and Shoichi Shimada Jennifer L. Shoemaker, Michael B. Ruckle, 828 Philip R. Mayeux, and Paul L. Pralher Alison A. Carter and Stephen J. Hill 839 Shintaro Fumoto, Shigeru Kawakami, 484 Kosuke Shigeta, Yuriko Higuchi, Fumiyoshi Yamashita, and Mitsuru Hashida Meng Guo, Richard J. Roman, 526 John R. Falck, Paul A. Edwards, and A. Guillermo Scicli Synthetic Pyrrole-Imidazole Polyamide Inhibits Expression of the Human Transforming Growth Factor-01 Gene Coformulated Af-Octanoyl-glucosylceramidc Improves Cellular Delivery and Cytotoxicity of Liposomal Doxorubicin Pharmacoproteomic Effects of Isoniazid, Ethambutol, and JV-Geranyl-Af'-(2-adamantyl)ethane-l,2-diamine (SQ109) on Mycobacterium tuberculosis H37Rv ENDOCRINE AND DIABETES Acute and Chronic Effects of the Incretin Enhancer Vildagliptin in Insulin-Resistant Rats Yu-Mu Lai, Noboru Fukuda, Takahiro Ueno, 571 Hiroyuki Matsuda, Satoshi Saito, Koichi Matsumoto, Hirohito Ayame, Toshikazu Bando, Hiroshi Sugiyama, Hideo Mugishima, and Ka/uo Serie Robert Jan Veldman, Gerben A. Koning, 704 Albert van Hell, Shuraila Zerp, Stefan R. Vink, Gert Storm, Marcel Verheij, and Wim J. van Blitterswijk Lee Jia, Lori Coward, Gregory S. Gorman, 905 Patricia E. Noker, and Joseph E. Tomaszewski B. F. Burkey. X. Li, L. Bolognese, B. Balkan, M. Mone, M. Russell, T. E. Hughes, and P. R. Wang GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL A New ATP-Sensitive Potassium Channel Opener Protects the Kidney from Hypertensive Damage in Spontaneously Hypertensive Rats Signal Transduction for Proteinase-Activated Receptor-2-Triggered Prostaglandin E2 Formation in Human Lung Epithelial Cells DPI-221 [4-((«-S)-a-((2S,5JR)-2,5-Dimethyl-4-(3-fluorobenzyl)-l-pipera7Jnyl)henzyl)-AyV-diethylbenzamide]: A Novel Nonpeptide o" Receptor Agonist Producing Increased Micturition Interval in Normal Rats Prostanoids Secreted by Alveolar Macrophages Enhance Ionic Currents in Swine Tracheal Submucosal Gland Cells Short-Term Exposure of Renal Proximal Tubules to Gentamicin Increases Long-Term Multidrug Resistance Protein 2 (Abcc2) Transport Function and Reduces Nephrotoxicant Sensitivity The Effects of Extracellular Purines and Pyrimidines on Human Airway Smooth Muscle Cells Hao Xue, Ying-Li Zhang, Gno-Shu Liu, and 501 Hai Wang Naoyuki Kawao, Mami Nagasaki, 576 Keita Nagasawa, Satoko Kubo, Kelly Cushing, Tetsuyuki Wada, Fumiko Sekiguchi, Seiji Ichida, Morley D. Hollenberg, Wallace K. MacNaughton, Hiroyuki Nishikawa, and Atsufumi Kawabata Jonathon D. S. Holt, Michael J. Watson, 601 Jane P. Chang, Scott J. O'Neill, Ke Wei, William Pendergast, Peter J. Gengo, and Kwen-Jen Chang Huiling Liu, Abulkhair M. Mamoon, and 729 Jerry 3VL Farley, Sr. Sylvia Notenboom, David S. Miller, 912 Leon H. Kuik, Paul Smits, Frans G. M. Russel, and Rosalinde Masereeuw Vasanthi Govindaraju, James G. Martin. 941 Karim Maghni, Pasquale Ferraro, and Marie-Claire Michoud
INFLAMMATION AND IMMUNOPHARMACOLOGY Anti-Inflammatory Effects of Inhibiting the Amine Oxidase Activity of Semicarbazide-Sensitive Amine Oxidase Nociceptive Effect of Subcutaneously Injected Interleukin-12 Is Mediated by Endothelin (ET) Acting on ETB Receptors in Rats MEN16132, a Novel Potent and Selective Nonpeptide Kinin B2 Receptor Antagonist: In Vivo Activity on Bradykinin-Induced Bronchoconstriction and Nasal Mucosa Microvascular Leakage in Anesthetized Guinea Pigs Indirect CB2 Receptor and Mediator-Dependent Stimulation of Human Whole-Blood Neutrophils by Exogenous and Endogenous Cannabinoids Prostaglandin E2 Enhances Neurotrophin-4 Production via EP3 Receptor in Human Keratinocytes Gender Differences in the Endotoxin-Induced Inflammatory and Vascular Responses: Potential Role of Poly(ADP-ribose) Polymerase Activation Luisa M. Salter-Cid, Eric Wang, 553 Anne M. O'Rourke, Andrew Miller, Hongfeng Gao, Li Huang, Arnie Garcia, and Matthew D. Linnik Waldiceu A. Verri, Jr., Rodrigo O. Molina, 609 leda R. S. Schivo, Thiago M. Cunha, Carlos A. Parada, Stephen Poole, Sergio H. Ferreira, and Fernando Q. Cunha Claudio Valenti, Cecilia Cialdai, 616 Sandro Giuliani, Alessandro Lecci, Manuela Tramontana, Stefania Meini, Laura Quartara, and Carlo Alberto Maggi Birgit Kraft and Hans G. Kress 641 Naoko Kanda, Satsuki Koike, and 796 Shinichi Watanabe Jon G. Mabley, Eszter M. Horvath, 812 Kanneganti G. K. Murthy, Zsuzsanna Zsengeller, Anne Vaslin, Rita Benko, Mark Kollai, and Csaba Szabo NEUROPHARMACOLOGY Human Expanded Polyglutamine Androgen Receptor Mutants in Neurodegeneration as a Novel Ligand Target The Metabotropic Glutamate 5 Receptor Antagonist 3-[(2-MethyI-l,3-thiazoI-4-yl)ethynyl]-pyridine Reduces Ethanol Self-Administration in Multiple Strains of Alcohol-Preferring Rats and Regulates Olfactory Glutamatergic Systems Prolonged Increase in the Sensitivity of the Posterior Ventral Tegmental Area to the Reinforcing Effects of Ethanol following Repeated Exposure to Cycles of Ethanol Access and Deprivation Methyllycaconitine Prevents Methamphetamine-Induced Effects in Mouse Striatum: Involvement of al Nicotinic Receptors Effect of Morphine on Deep Dorsal Horn Projection Neurons Depends on Spinal GABAergic and Glycinergic Tone: Implications for Reduced Opioid Effect in Neuropathic Pain Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity Subnanomolar Concentrations of Thrombin Enhance the Volume-Sensitive Efflux of Taurine from Human 1321NI Astrocytoma Cells General Anesthetic-Induced Channel Gating Enhancement of 5-Hydroxytryptamine Type 3 Receptors Depends on Receptor Subunit Composition Nicotine Regulates DARPP-32 (Dopamine- and cAMP-Regulated Phosphoprotein of 32 kDa) Phosphorylation at Multiple Sites in Neostriatal Neurons Glycyl-Glutamine, an Endogenous j3-Endorphin-Derived Peptide, Inhibits Morphine-Induced Conditioned Place Preference, Tolerance, Dependence, and Withdrawal Calcium-Acting Drugs Modulate Expression and Development of Chronic Tolerance to Nicotine-Induced Antinociception in Mice TOXICOLOGY Peroxynitrite-Induced Mitochondria! and Endonuclease-Mediated Nuclear DNA Damage in Acetaminophen Hepatotoxicity Handling of the Homocysteine S-Conjugate of Methylmercury by Renal Epithelial Cells: Role of Organic Anion Transporter 1 and Amino Acid Transporters ERRATUM Corrections to "Heine-Reversible Impairment of CYP2B1/2 Induction in Heme-Depleted Rat Hepatocytes in Primary Culture: Translational Control by a Hepatic a-Subunit of the Eukaryotic Initiation Factor Kinase?" Takashi Furutani, Ken-ichi Takeyama, 545 Masahiko Tanabe, Hiroshi Koutoku, Saya Ito, Nobuaki Taniguchi, Eriko Suzuki, Masafumi Kudoh, Masayuki Shibasaki, Hisataka Shikama, and Shigeaki Kato Michael S. Cowen, Elvan Djouma, and 590 Andrew J. Lawrence Zachary A. Rodd, Richard L. Bell, 648 Victoria K. McQueen, Michelle R. Davids, Cathleen C. Hsu, James M. Murphy, Ting-Kai Li, Lawrence Lumeng, and William J. McBride Elena Escubedo, Carlos Chipana, 658 M6nica Perez-Sanchez, Jordi Camarasa, and David Pubill Yan-Ping Chen, Shao-Rui Chen, and 696 Hui-Lin Pan Richard H. P. Porter, Georg Jaeschke, 711 Will Spooren, Theresa M. Ballard, Bernd Biittelmann, Sabine Kolczewski, Jens-Uwe Peters, Eric Prinssen, Jiirgen Wichmann, Eric Vieira, Andreas Miihlemann, Silvia Gatti, Vincent Mutel, and Pari Malherbe Tooba A. Cheema, Caroline E. Ward, and 755 Stephen K. Fisher Ken Solt, Renna J. Stevens, Paul A. Davies, 771 and Douglas E. Raines Miho Hamada, Joseph P. Hendrick, 872 Gregory R. Ryan, Mahomi Kuroiwa, Hideho Higashi, Masatoshi Tanaka, Angus C. Nairn, Paul Greengard, and Akinori Nishi Sinan Cavun, Gokhan Goktalay, and 949 William R. Millington M. I. Damaj 959 Cathleen Cover, Abdellah Mansouri, 879 Tamara R. Knight, Mary Lynn Bajt, John J. Lemasters, Dominique Pessayre, and Hartmut Jaeschke Rudolfs K. Zalups and Sarfaraz Ahmad 896 Xing-Mei Han, Gene Lee, Colleen Hefner, 970 Jacquelyn J. Maher, and Maria Almira Correia |