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Pharmacokinetics and methaemoglobin reductase activity as determinants of species susceptibility and non-target risks from sodium nitrite manufactured feral pig baits


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Table 1. Published oral sodium nitrite LD50 doses/minimum lethal doses and NADH metheamoglobin reductase activities for eutherian mammals.

Species

Scientific name

Lethal gavage dose (mg/kg)

NADH methaemoglobin reductase (IU/g Hb)A

Lethal dose reference

Pig

Sus scrofa

90

12

Winks et al. 1950; Cowled et al. 2008

Human

Homo sapien

94

15

Boink and Speijers 2001

Rat

Rattus norvegicus

130

10

Druckery et al. 1963

Mouse

Mus musculus

215

53

Rieman 1950

Dog

Canis lupus familiaris

60B

8.5

Berlin 1970

Sheep

Ovis aries

50

10

Rhadostis et al. 2000

Cattle

Bos taurus

67

5

Bartik and Pisac 1981
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