Name Xiao-bing Yuan
Birth Date March 31, 1973
Place of Birth Daye, Hubei, China
Laboratory of Neural Circuit Development,
Institute of Neuroscience, SIBS, CAS
Shanghai 200031, China
Telephone: (86) -21-54921812; Fax: (86) –21-54921735
1991-1995: Department of Biology, East China Normal University. Bachelor’s degree
1995-2001: Shanghai Brain Research Institute, CAS. Ph.D. degree
Advisor: Professor Mu-ming Poo, Prof. Shumin Duan, Prof. Chien-pin Wu
1999-2000: Biology Department, UCSD. Exchange student
Advisor: Professor Mu-ming Poo
2001-2002: Assistant Investigator, Institute of Neuroscience, SIBS, CAS
2003-2004: Associate Investigator, Institute of Neuroscience, SIBS, CAS
2005- : Investigator, Institute of Neuroscience, SIBS, CAS
Honors and Services:
2003 Rising star of Science and Technology, Shanghai
2004 Top 100 excellent Ph.D. Dissertation Award of China
2006 National Science Fund for Distinguished Young Scholars of China
2007 9th National Science and Technology Award for Young Scholars of China
2007 Special Government Allowances from State Department of China
2008 Program Committee Local Organization Committee Member of the 8th Biennial Meeting for APSN
2008 Excellent Mentoring Award, Chinese Academy of Sciences
2009 P&G Excellent Supervisor Award, Chinese Academy of Sciences
2010 Program Committee Member of the 11th Biennial Meeting for APSN
• Stem cell and generation of neurons. Graduate Neurobiology Courses in SIBS (04-08)
• Apoptosis and neurotrophic protection. Graduate Neurobiology Courses in SIBS (04)
• Axon guidance and neuronal migration. Graduate Neurobiology Courses in SIBS (04-10)
• Cell fate determination and neural patterning. Graduate Neurobiology Courses in SIBS (09-10)
Invited Talks (international conferences and symposia):
11th International Neuroscience Winter Conference, Sölden, Austria, 2009/3/31-4/4
IBRO 2007 Satellite Meeting “Stem cells, axon guidance, and cell migration in the developing and adult brain”, Cairns, Australia, 2007/7/8
The 1st Australia-China Biomedical Research Conference, Melbourne, Australia, 2007/2/1
The 6th Congress of Federation of the Asian and Oceanian Physiological Societies, Seoul, Korea, 2006/10/18
The 4th International Chinese Neuroscience Symposium, KunMin, 2006/7/3
The 3rd Crouch Advanced Research Institute, Hong Kong University of Science & Technology 2006/1/18
Sino-Canadian Symposium on Neuroscience, Shanghai, 2005/11/2
Gordon Research Conference, Mechanisms of Cell Signalling, Hong Kong University of Science & Technology 2005/6/12
CAS-Columbia Symposium on Neuroscience, Shanghai, 2005/5/15
The First Shanghai Symposium on Signal Transduction and Cancer, SIBS, Shanghai, 2004/8/29
The 1st Crouch Advanced Research Institute, Hong Kong University of Science & Technology 2002/1/12
Research field: Mechanisms underlying the guidance of neuronal migration in developing brain
My laboratory was set up in March 2005. The long-term goal of the laboratory is to understand the molecular mechanisms underlying the proper migration and distribution of different types of neurons in developing brain, one of the key steps for brain morphogenesis. Currently, we focus on the guidance mechanism for the radial migration of cortical neurons by diffusible guidance factors and the intracellular molecular machinery to drive the neuronal migration. A combination of approaches including single neuron migration assay, embryo electroporation, tissue culture, molecular manipulations, and optical imaging, are used to tackle these questions. Human genetic studies showed that many neurological disorders are caused by defects in and neuronal migration axon pathfinding during development. This line of study will shed a new light on the diagnosis and therapy of this group of diseases.
2. Main Topics
(1) Guidance of the cortical radial migration by extracellular and intracellular factors
Formation of the laminar structure of the mammalian cerebral cortex requires a well-coordinated migration of cohorts of post-mitotic neurons along radial glial fibers from the ventribular zone (VZ) towards superficial layers of the cortical plate (CP) during early development. We aim to clarify whether a chemotropic guidance mechanism is also engaged in the proper radial migration and lamination of cortical neurons (see Figure. 1). Intracellular signaling mechanisms underlying the guidance of cortical radial migration by diffusible factors are also analyzed.
(2) Molecular machinery underlying the neuronal migration and its guidance
Dissociated culture of cerebellar granule cells exhibits active neuronal migration, and provides an excellent model system for monitoring the molecular dynamics that correlates with the migratory behavior of the neuron. We also take advantage of the local rather than global perfusion of guidance factors and pharmacological agents at different sub-cellular regions of migrating neurons to dissect how the motilities of different parts of neurons are generated and coordinated during neuronal migration.
Ming G, Wong S, Henley J, Yuan XB, Song H, Spitzer N and Poo MM* (2002) Adaptation in the chemotactic guidance of nerve growth cones. Nature, 417: 411-8.
Xiang Y, Li Y, Zhang Z, Cui K, Wang S, Yuan XB, Wu CP, Poo MM, Duan SM* (2002) Nerve growth cone guidance mediated by G protein coupled receptors. Nature Neurosci., 5: 843-8
Yuan XB*, Jin M, Xu X, Song YQ, Wu CP, Poo MM and Duan SM* (2003). Signaling and crosstalk of rho-GTPases in mediating axon guidance. Nature Cell Biology, 5: 38-45.
Wang B, Xiao Y, Ding BB, Zhang N, Yuan X, Gui L, Qian KX, Duan S, Chen Z, Rao Y, Geng JG* （2003） Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity. Cancer Cell. 4:19-29.
Xu H, Yuan XB, Guan C, Duan S, Wu CP, Feng L* (2004) Calcium Signaling in Slit2-Dependent Regulation of Neuronal Migration. PNAS. 101: 4296-301.
Jin M, Guan CB, Jiang YA, Zhao CT, Cui K, Song YQ, Wu CP, Duan SM, Poo MM*, Yuan XB* (2005) Ca2+-dependent regulation of Rho GTPases can trigger turning of nerve growth cones. J. Neuroscience, 25: 2338-47.
Li Y, Cui K, Jia YC, Li N, Zhen ZY, Wang YZ*, Yuan XB* (2005) Essential role of TRPC channels in the guidance of nerve growth cone by BDNF. Nature, 14:835-8.
Xu X, Fu AK, IP, FC, Wu CP, Duan SM, Poo, MM, Yuan XB, IP NY* (2005) Agrin regulates growth cone turning of Xenopus spinal motoneurons. Development, 132: 4309-16.
Cui K, Yuan XB*. (2006). “TRP channels and axon pathfinding” TRP Ion Channels in Transduction of Sensory Stimuli and Cellular Signaling Cascades. Chapter 4.
Zhang YJ*, Gu XF, Yuan XB (2007) Phenylalanine activates the mitochondria-mediated apoptosis through the RhoA/Rho-associated kinase pathway in cortical neurons. Europ. J. Neurosci. 25: 1341-1348
Guan CB, Xu HT, Jin M, Yuan XB*, and Poo MM* (2007) Long-Range Ca2+ Signaling from Growth Cone to Soma Mediates Reversal of Neuronal Migration Induced by Slit-2. Cell 129: 385-395.
Ding S, Luo JH, and Yuan, XB* (2007) Semaphorin-3F attracts the growth cone of cerebellar granule cells through cGMP signaling pathway. Biochem. Biophys. Res. Commun. 356: 857-863.
Zhang YJ*, Zhang HW, Yuan XB, Gu XF (2007) Differential effects of phenylalanine on Rac1, Cdc42, and RhoA expression and activity in cultured cortical neurons. Pediatric Research 62: 8-13.
Chen G, Sima J, Jin M, Zheng W, Wang KY, Xue XJ, Ding YQ, Yuan XB* (2008) Semaphorin-3A guides radial migration of cortical neurons during development. Nature Neurosci., 11: 36-44.
Zheng W, Yuan XB* (2008).Guidance of cortical radial migration by gradient of diffusible factors. Cell Adhesion and Migraiton, 2: 48-50 (extraview).
Huang ZH, Wang Y, Cao L, Su ZD, Zhu YL, Chen YZ, Yuan XB, He C* (2008) Migratory properties of cultured olfactory ensheathing cells by single-cell migration assay. Cell Res. 18:479-90.
Scolnick JA, Cui K, Duggan CD, Xuan S, Yuan XB, Efstratiadis A, Ngai J*. （2008）Role of IGF signaling in olfactory sensory map formation and axon guidance. Neuron. 57:847-57.
Samson WK, Zhang JV, Avsian-Kretchmer O, Cui K, Yosten GL, Klein C, Lyu RM, Wang YX, Chen XQ, Yang J, Price CJ, Hoyda TD, Ferguson AV, Yuan XB, Chang JK, Hsueh AJ*. (2008) Neuronostatin encoded by the somatostatin gene regulates neuronal, cardiovascular, and metabolic functions. J. Biol Chem. 283:31949-59.
Ding C, Liang XJ, Ma L, Yuan XB, Zhu XL*. (2009) Opposing effects of Ndel1 and alpha 1 or alpha 2 on cytoplasmic dynein through competitive binding to Lis1 J. Cell Sci. 122: 2820-2827.
Zhang X, Lei K, Yuan X, Wu X, Zhuang Y, Xu T, Xu R, Han M*. (2009) SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron.64:173-87.
Zhao CT, Li K, Li JT, Zheng W, Liang XJ, Geng AQ, Li N, and Yuan XB* (2009) PKCδ regulates cortical radial migration by stabilizing the Cdk5 activator p35. PNAS. 106: 21353-21358.
Yuan XB* (2010) Axon guidance and neuronal migration research in china. Science China Life Science. doi: 10.1007/s11427-010-0068-6 (Review)
Li N, Zhao CT, Wang Y, Yuan XB* (2010) The transcription factor Cux1 regulates dendritic morphology of cortical pyramidal neurons. PlosOne 5(5): e10596. doi:10.1371/journal.pone.0010596
Xue XJ, Yuan XB* (2010) Nestin Is Essential for Mitogen-stimulated Proliferation of Neural Progenitor Cells. Mol. Cell. Neurosci. doi: 10.1016/j.mcn.2010.05.006.
He M, Zhang ZH, Guan CB, Xia D, Yuan XB* (2010) Leading tip drives soma translocation via forward F-actin flow during neuronal migration. J. Neurosci. (in press)