Curriculum vitae name

NAME:

Shanghai Key Laboratory for Reproductive Medicine

Dept. of Histology & Embryology

School of Medicine, Shanghai Jiaotong University (SJTU)

280 South Chongqing Road, Shanghai, 200025

P.R. China

E-mail: chenx@shsmu.edu.cn

Fax: 86-21-64663160

Tel: 86-21-63846590 Ext: 776435 (O); 86-21-64663160 (O)

Mobile Phone: 13601759955

Degree Year Institute Major

M.B. 1984 Anhui Medical University Medicine

M.S. 1989 Nanjing Medical University Histo-Embryology

Ph.D./ M.D. 1993 SJTU Histo-Embryology & Reproductive

Biology

1984.08.-1986.08. Assistant, Faculty of Medicine, Wannan Medical College, Wuhu, Anhui, China

1986.09.-1990.08. Instructor, Faculty of Medicine, Wannan Medical College, Wuhu, Anhui, China

1990.09.-1995.09. Instructor, Faculty of Medicine, Shanghai Second Medical University, Shanghai, China

1995.10.-1997.10. Associate Professor, INSERM U430, 96 Rue Didot, 75014 Paris, France

1997.12.-1999.10. Associate Professor and Director, Dept of Histo-Embryology, Faculty of Medicine,

Shanghai Jiaotong University (SJTU)

1999.11.- present Professor and Director, Dept. of Histology & Embryology, Faculty of Medicine,

Shanghai Jiaotong University (SJTU)

2000.12.- present Director of Shanghai Key Laboratory for Reproductive Medicine

Member, Society for the Study of Reproduction (SSR)

Member, International Society of Andrology (ISA)

Member, American Society of Andrology (ASA)

Member, Chinese Committee of Andrology

Deputy Director, Research & Training Centre for Reproductive Medicine, Shanghai

Member, the Board of Chinese Society of Reproductive Biology

Vice-Chairman, the Board of Society for Anatomical Sciences, Shanghai

Member, the Board of Chinese Society for Anatomical Sciences

Member, the Board of Chinese Society for Medical Cell Biology

On Board of Society of Family Planning & Reproductive Health, Shanghai

Member, Editors Board of Asian Journal of Andrology

Member, Editorial Board of National Journal of Andrology

Member, Editorial Board of Chinese Journal of Andrology

Member, Editorial Board of Reproduction & Cotraception

Member, Editorial Board of Journal of Anatomy

Member, Editors Board of Asian Journal of Andrology

Member, Editors Board of Journal of Shanghai Jiaotong University (Medical Science)

Shanghai Education Committee Scientific Research Fellowship (No. Z93-03), 1993–1995, RMB 50,000

Chinese National Natural Scientific Foundation (No. 39470369), 1994–1997, RMB 100,000

State Family Planning Committee Foundation, China (No. 94 -03), 1995–1998, RMB 60,000

Chinese National Natural Scientific Foundation (No. 39870374), 1999–2001, RMB 110,000

Shanghai Education Committee: Dawn Project (No. 99 SG42), 2000– 2002, RMB 80,000

Chinese National Natural Scientific Foundation (No. 30070391), 2001–2003, RMB 150,000

Chinese National Natural Scientific Foundation (No.30470909), 2005–2007, RMB 210,000

Shanghai Science and Technology Committee: Scaling Project (No.06JC14046), 2006–2008, RMB 250,000

Chinese National Natural Scientific Foundation (No.30771139), 2008–2010, RMB 270,000

Shanghai Leading Academic Discipline, 2009-2011(No. S30201), RMB 10,000,000

Chinese National Natural Scientific Foundation (No.30640031), 2007.1–2007.12, RMB 100,000

Chinese National Natural Scientific Foundation (No.81070526), 2011.1–20013.12, RMB 350,000

Co-PI:

“973” Basic Research Funding Scheme of China (No. G1999055901), 2000–2005, RMB 350,000

State Family Planning Committee Foundation, China (No.99-02), 2000–2003, RMB 74,000

Shanghai Population and Family Planning Committee Foundation, China (No. 01 -09), 2001–2004, RMB 30,000

Awards given for improving science and technology, the Ministry of Health of China, Sept 1998

Awards given for improving science and technology, State Family Planning Committee, Aug 1998

Awards given for improving science and technology, Shanghai Municipality, Dec 1998

Awards given for contribution to life science, Mei Ji Diary Industry Administrative Committee, Japan, Nov 1999

Award for the best paper at Third Asian and Oceanic Congress of Andrology, AOCA, Japan, May 2000

Awards given for improving science and technology, Shanghai Municipality, Nov 2005

Awards given for improving science and technology, the Ministry of Health of China, Dec 2005

Awards given for improving science and technology, State Population and Family Planning Committee, Feb 2006

Awards given for Excellent Teacher, Bao Steel Group, Dec 2005

1. 
   Lv ZM, Wang M, Xu C. Antifertility Characteristics of the N-terminal Region of Mouse Equatorial Segment Protein. Anat Rec 2010；293(1): 171-81.
   
2. 
   Bao J, Zhang J, Zheng H, Xu C, Yan W. UBQLN1 interacts with SPEM1 and participates in spermiogenesis. Mol Cell Endocrinol 2010; 327: 89-97.
   
3. 
   Min Wang, Jianli Shi, Guoyan Cheng, Yanqin Hu, and Chen Xu. The antibody against a nuclear autoantigenic sperm protein can result in reproductive failure. Asian J Androl 2009；11(1): 183-192.
   
4. 
   Min Wang, Zhenmei Lv, Jianli Shi, Yanqin Hu, and Chen Xu. Immuno- contraceptive Potential of the Ig-Like Domain of Izumo. Mol Reprod Dev 2009; 76 :794-801
   
5. 
   Yi Shi, Dongsheng Hou, and Chen Xu. Preliminary characterization of vaginal microbiota in healthy Chinese women using cultivation-independent methods. J Obstet Gynaecol Res 2009; 35(3):525-532
   
6. 
   Shao-Feng Cao, Ding Li, Qing yuan, Xin Guan, Chen Xu. Spatial and temporal expression of c-mos in mouse testis during postnatal development. Asian J Androl 2008; 10(2):277-285.
   
7. 
   Jin-Wen Wu, Ru-Yao Wang, Qiang-Su Guo, Chen Xu. Expression of the retinoic acid-metabolizing enzymes RALDH2 and CYP26b1 during postnatal testis development. Asian J Androl 2008; 10(4):569-576.
   
8. 
   Jianli Shi, Zhengmin Yang, Min Wang, Guoyan Cheng, Ding Li, Yifei Wang, Yuan cong Zhou, Xiaolong Liu, and Chen Xu. Screening an antigen target for immuno-contraceptives from cross-reactive antigens between human sperm and U. urealyticum. Infect Immun 2007; 75 (4): 2004-2011.
   
9. 
   Qing Yuan, Qiansu Guo, Gail A. Cornwall, Chen Xu, and Yifei Wang. Age-dependent expression of the Cres gene in mouse testie and epididymis. Asian J Androl 2007; 9(3):305-311. (co-corresponding author)
   
10. 
    DIND LI, SHAOFENG CAO, CHEN XU. Polypeptide Backbone Derived from Carboxyl Terminal of Mouse ZP3 Inhibits Sperm-Zona Binding. Mol Reprod Dev 2007; 74:1327-1336.
    
11. 
    Guo-Yan Cheng, Jian-Li Shi, Min Wang, Yan-Qin Hu, Chun-Meng Liu, Yi-Fei Wang, Chen Xu. Inhibition of acrosome reaction and sperm- zona pellucide binding by anti-human sperm membrane protein antibody. Asian J Androl 2007; 9 (1): 23-29.
    
12. 
    Jianli Shi, Min Wang, Guoyan Chen, Yan-Qin Hu, Chen Xu. Effect of antiserum against UreG on mouse in vitro fertilization. Reprod Contracept (in Chinese) 2006; 26(5):265-270.
    
13. 
    Min Wang, Jian-Li Shi, Chen Xu. Cloning, expression and purification of human nuclear autoantigenic sperm protein (hNASP) and preparation of its polyclonal antibody. National Journal Andrology (in Chinese) 2006; 12(10):867-871.
    
14. 
    Lu Mei-ge，Xu C. Germ cell apoptosis induced by microbe infection. Chinese Journal of Clinical Medicine 2005; 3(8):1-4.
    
15. 
    Xu C, Zhou ZY, Guo QS, Wang YF. Expression of germ cell nuclear factor (GCNF) in mouse germ cells and sperm during postnatal period. Asian J Androl 2004; 6(3):217-222.
    
16. 
    Zhou ZY, Xu C, Guo QS, Hu YX, Zhang YL, Wang YF. Spatial and temporal expression of germ cell nuclear factor (GCNF) in murine epididymis. Asian J Androl 2004; 6(1):23-28.
    
17. 
    Yuanxin Hu, Zongyao Zhou, Chen Xu, Quan Shang, Youduan Zhang, Yonglian Zhang: Androgen down - regulated and region–specific expression of GCNF in mouse epididymis. Endocrinology 2003; 144: 1612-1619.
    
18. 
    MG Lu, JL Shi, C Xu: The effect of Ureaplasma urealyticum on the secretion of IL-1 and IL-6 by Sertoli cells in vitro. Reprod Contracept (in Chinese) 2003; 23(2): 69-72.
    
19. 
    JL Shi, MG Lu, C Xu: The cross-reactive antigens between Ureaplasma urealyticum and human sperm membrane protein. Reprod Contracept (in Chinese) 2003; 23(3): 153-157.
    
20. 
    Chen XU, Guang-fang, SUN, Xiao-ai LIU, Zhu-ru PAN, Su-ying HONG: The correlation of Ureaplasma urealyticum infection with pregnant outcome and neonatal complications. Reprod Contracept (in Chinese) 2001; 21(4): 227-232.
    
21. 
    Chen XU, Mei-Ge LU, Jing-Sheng FENG, Qiang –Su GUO, Yi-Fei WANG: Germ cell apoptosis induced by Ureaplasma urealyticum infection. Asian J Androl 2001; 3(3):199-204.
    
22. 
    Chen Xu, Yifei Wang, Huixin Zhang: The relation of Ureaplasma urealyticum infection to urogenital stone formation. J SSMU 1999; 11(2):71-75.
    
23. 
    C Xu, B Poirier, N Lucchiarri, O Michel, J Chevalier, S Kaveri: Modulation of endothelial cell function by normal polyspecific human immunoglobulins (IVIg): a possible mechanism of action in vascular diseases. Am J Pathol 1998; 153(4):1257-1266.
    
24. 
    C Xu, GF Sun, YF Zhu, YF Wang: The correlation of Ureaplasma urealyticum infection with infertility. Andrologia. 1997; 29:219-226.
    
25. 
    C Xu, GF Sun, YF Zhu, YF Wang: Effects of Ureaplasma urealyticum infection on reproduction as well as embryonic development of rat. Reprod Contracept (in Chinese). 1996; 16:125-129.
    
26. 
    C Xu, GF Sun, S Xu, YF Wang: Establishment of an animal model infected by Ureaplasma urealyticum - Morphological effects on the testes. Reprod Contracept (in Chinese). 1995; 15:205-209.
    
27. 
    C Xu, YF Wang: Localization of Ureaplasma urealyticum on human spermatozoa. Reprod Contracept 1994; 5:181-188.
    
28. 
    C Xu, YF Wang: Gametes and Fertilization. In: Tang XM, Cheng SS (eds).Cellular and Molecular Biology of Medicine. Shanghai, Shanghai Medical University Press, 1994.
    
29. 
    C Xu, RK Lu: Effects of testosterone and LRH-A on the testes and pituitary of dogs. Chinese Journal of Andrology 1993; 7:25-29.
    
30. 
    C Xu, YF Wang: Ureaplasma urealyticum infection and male infertility. Journal of Reproductive Medicine (in Chinese) 1992; 1:20-24.
    
31. 
    C Xu, QX Shi, YF Wang, ZH Zhang: Pathogenic mechanisms of male infertility caused by Ureaplasma urealyticum infection - Effects on sperm zona-free egg penetrating capability. Chinese Journal of Andrology 1992; 6:197-202.
    

Second International Conference on Reproductive Endocrinology. Sept 1992, Beijing, China

First Asian and Oceanic Congress of Andrology. Nov 1992, Nanjing, China

The Second International Symposium on Fertility Regulation. May 1995, Beijing, China

XXXIV Congress of the European Renal Association and EDTA. Sept 1997, Geneva, Switzerland

Workshop on the Frontiers in Reproductive Biology, Oct 1999, Beijing, China

The Second Asian Pacific International Congress of Anatomists. August 1999, Beijing, China

Third Asian and Oceanic Congress of Andrology, May 2000, Chiba, Japan

International Symposium on Cell Signaling -- from diseases to drug discovery, Oct 2001, Hong Kong, China

3rd International Conference on the Epididymis, May 2002, Charlottesville, USA

First Asia-Pacific Forum on Andrology, Co-Chair of Symposium “Reproductive tract infections (RTIs)”, Oct 2002, Shanghai, China

American Society of Andrology 29th Annual Meeting, April 17-20, 2004, Baltimore, USA

American Society of Andrology 30th Annual Meeting, April 17-20, 2005, Seattle, USA

Second Asia-Pacific Forum on Andrology, Oct 2006, Shanghai, China

4th International Conference on the Epididymis, Dec 2006, Clerment Ferrant, France

American Society of Andrology 32th Annual Meeting, April 21-24, 2007, Tampa, USA

SSR 41st Annual Meeting, May 27-30, 2008, Hawaii, USA
RESEARCH FIELDS:

The relationship between Uu and human reproductive health

Molecular mechanisms of sperm-ovum interaction and fertilization.

Microbiological genomics in human reproductive system.