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Curriculum Vitae Ming-Daw Tsai, Ph. D


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Mentoring of Graduate Students and Postdoctors

I have trained 55 Ph. D. graduates and 16 master graduates, and 30 postdoctors. A number of former students and former postdoctors have taken faculty positions in academic institutions in the U. S. and Taiwan, as listed below:




  1. Yund-Jung (John) Shyy, Ph. D. 1987 (Chemistry), Professor, Department of Bioengineering, University of California at San Diego.

  2. Charles R. Sanders, Ph. D. 1988 (Chemistry), Professor, Dept. of Biochemistry and Biophysics, Vanderbilt University School of Medicine.

  3. Tsung-Chung (Alan) Tsai, postdoctor 1982-85, Professor (retired), Tunghai Univ, Taiwan.

  4. William M. Loffredo, Ph. D. 1988 (Chemistry), Professor, Dept. of Chemistry, East Strasburg University, Pennsylvania.

  5. Gialih (Hoffman) Lin, Ph. D. 1989 (Chemistry), Professor of Chemistry, Chung-Hsing U., Taiwan.

  6. Joseph P. Noel, Ph. D. in 1990 (Chemistry), Professor, SALK Institute and Dept. of Chemistry, University of California at San Diego.

  7. Honggao Yan, Ph. D. 1991 (OSBP), Professor, Dept. of Biochemistry, Michigan State University.

  8. Karol Bruzik, former postdoctor, Professor, Dept. of Medicinal Chemistry, University of Illinois at Chicago.

  9. Cynthia M. Dupureur (Chemistry), Ph. D. 1992, Associate Professor, Dept. of Chemistry and Biochemistry, University of Missouri, St Louis.

  10. Robert Hondal, Ph. D. 1997 (Chemistry), Assistant Professor, Department of Biochemistry, University of Vermont.

  11. In-Ja L. Byeon, Senior NMR Research Scientist, Department of Structural Biology, University of Pittsburgh School of Medicine.

  12. Karen Ericson, Ph. D. 1998 (Chemistry), Assistant Professor at Indiana University-Purdue University Fort Wayne.

  13. Thomas Selby, Ph. D. 1999 (Chemistry), Assistant Professor, Central Florida State University.

  14. Junan Li, Ph. D. 2000 (Biochemistry), Postdoctor 2002-2005, Assistant Professor, College of Public Health, OSU, 2007.

  15. Paul O’Maille, Ph. D. 2001, Assistant Professor, Department of Metabolic Biology, John Innes Centre (JIC) Plant Natural Products and Health, Institute of Food Research (IFR) Colney Lane, Norwich NR4 7UH, UK.

  16. Kuo-Hsiang Joseph Tang, Postdoctor, Assistant Professor, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, New York.

  17. Yi Guo, Ph. D. 2009 (OSBP), Assistant Professor (2012 – present), Department of Health Outcomes and Policy, College of Medicine, University of Florida, Gainesville, FL

  18. Jinwoo Ahn, Assistant Professor (2012 – present), Dept of Structural Biology, University of Pittsburgh, PA.


Professional Membership
American Chemical Society (USA)

American Society of Biochemistry and Molecular Biology (USA)

American Association for the Advancement of Science (Elected Fellow in 1992) (USA)

Taiwan Biophysical Society

Taiwan Magnetic Resonance Society

Taiwan Society of Biochemistry and Molecular Biology


Training Grants (as Principal Investigator/Program Director)
1. "Chemistry/Biology Interface Training Grant", NIH, T32 GM 08512, 7/1/96-6/30/01, annual direct cost ca. $300,000; renewed for 7/1/01-6/30/06. (Dr. Dehua Pei took over the directorship and the PI starting 7/1/03).
Equipment Grants (as Principal Investigator only; co-PI of many other proposals.)


  1. "Purchase of a 600 MHz NMR Spectrometer", $200,000, NIH, RR 08299, 8/15/93-8/14/94.

  2. "Purchase of a 600 MHz NMR Spectrometer", $200,000, NSF, BIR-9221639, 6/1/93-5/31/95.

  3. "500 MHz Console Upgrade", $258,000, NSF, 5/96.

  4. "800 MHz NMR", $1,870,000, Ohio Board of Regents, 4/96.

  5. “Ohio NMR Consortium”, $2,000,000, Ohio Board of Regents (the funding is distributed among several universities in Ohio; Tsai serve as PI of the Consortium proposal), June 2002.


Past Research Grants (as Principal Investigator)


  1. "Stereochemistry of Enzyme Reactions Involving a Proprochiral Phosphorus Center". (NSF) 8/1/79 - 7/31/82, Total cost: $108,000.

  2. "17O and 31P NMR of Biophosphates". (NIH) GM 29041, 8/1/82 - 11/30/85, Direct cost: $182,545.

  3. Research Award, A. P. Sloan Foundation, 9/15/83 - 9/14/85, Total cost: $25,000.

  4. Dreyfus Teacher-Scholar Award, 12/1/85 - 11/30/90, Direct Cost: $47,000, Total cost: $50,000.

  5. "Productive Versus Nonproductive Binding of Kinases". (NSF) DMB-8603553, 9/86 - 8/89, Total Cost: $232,133.

  6. "Mechanism of Adenylate Kinase". (NSF) DMB 89-04727, 3/90-2/93, Tootal Cost: $285,000.

  7. "The Role of Aspartate in the Catalytic Diad". NIH, F32 GM15973, 12/93 - 11/96, direct cost $72,900. (Postdoctoral Fellowship to Brian Werneburg).

  8. “Stereochemistry of Enzyme Reactions at Phosphorus”, NIH, GM30327, 7/79 – 11/93, final year direct cost $112,585.

  9. "Mechanism of Inositide-Related Enzymes", NIH, GM30327, 12/93 - 11/97, final year direct cost $137,578. This was continuation of GM30327 with a change of title.

  10. “Mechanism of p19ARF – Bridging Two Major Tumor Suppression Pathways”, PI, a grant from American Cancer Society through Comprehensive Cancer Center, $35,000 from 7/1/98 to 6/30/99.

  11. "Mechanism of Adenylate Kinase". NIH, GM43268, 8/92 – 7/96, final year (year 04) direct cost $155,357.

  12. "Mechanism of Phospholipase A2". NIH, GM41788, 4/89 – 3/01, final year (year 12) direct cost $153,514.

  13. "Structure Function of FHA Domain in Signaling and Cancer". NIH, CA87031, 3/1/01-2/28/05 (four years), final year direct cost $157,000.

  14. “Conformational Changes in Phospholipase C”, NIH, GM57568, 12/98-12/08. This is continuation of GM30327. K. Bruzik became the PI of this grant. My share is ca. $50K/year direct cost.

  15. "Mechanism of DNA Polymerases". NIH GM43268, 12/97 – 6/06, final year (year 12) direct cost $222,300.

  16. "Functional Genomics Approach to the Virulence of Klebsiella pneumonia". AS, 94F008-1, PI, 1/05-12/07, current year cost $NT3,000,000.

  17. "Functional and Genomic Studies of Capsular synthesis Region of Tissue Invasive Klebsiella pneumoniae". NSC, 95-3112-B-001 -021-, PI, 08/06-07/07, current year total cost $NT2,500,000.

  18. "Structure-Function Relationship of Tumor Suppressors". NIH, CA69472, PI, 6/00-6/09, final year total cost $292,000.

  19. "Mechanism of Catalysis by the RNA Polymerase of Avian Flu Virus". NSC, 95-2745-B-001 -004-, PI, 08/06-07/09, total cost $NT7,500,000.

  20. "Enzymes in the biosynthesis of the capsular polysaccharide of Klebsiella pneumoniae". NSC, 98-3112-B-001 -003-, PI, 05/07-04/10, current year cost $NT5,950,000, total cost $NT18,331,000. Extended to 04/11.

  21. "Protein-Phosphoprotein Interaction in Cancer-related Signaling". NHRI, EX95-9508NI, PI, 1/06-12/10, current year total cost $NT2,355,000.

22. Academia Sinica Investigator Award, Academia Sinica

計畫編號: 100-深耕計畫-11

補助期限: 2011-1-1~2015-12-31

Research Theme:

Mechanism of biophosphates: from DNA repair polymerases to DNA damage signaling

生物磷酸鹽之反應機制：從DNA修復聚合酶到DNA損害之訊息傳遞

每一年度金額: 2,000,000


23. NHRI

計畫編號: NHRI-EX100-10002NI

補助期限: 2011-1-1~2015-12-31

Research Theme:

Protein-Phosphoprotein Interaction in Cancer related Signaling

蛋白質與磷酸化蛋白質的相互作用在癌症信號傳導中的功能研究

每一年度金額: 1,600,000

24. Academia Sinica Thematic Project

計畫編號: AS-101-TP-B02

補助期限: 2012-1-1~2014-12-31

Research Theme:

Roles of NIFK in Cancer (NIFK與癌症之關聯)

B02-2NIFK:  Roles of NIFK phosphorylation and its binding with Ki67 in the cancer relevance

NIFK磷酸化及其與Ki67連結與癌症之關聯

每一年度計畫總金額: 8,000,000
Active Research Grants
MOST

計畫編號: 103-2113-M-001 -016 -MY3

補助期限: 2014-8-1~2017-7-31

Research Theme: How low-fidelity DNA polymerases catalyze non-Watson-Crick incorporation

低準確度DNA複製酶如何催化非Watson-Crick鹼對

每一年度金額: 2,500,000


2015 Academia Sinica Thematic Project

計畫編號: AS-104-TP-B05

補助期限: 2015-1-1~2017-12-31

Research Theme: Structure and mechanism of protein-phosphoprotein interaction and PTM crosstalk　

(蛋白質與磷酸化蛋白質交互作用及後修飾交叉感應之結構與機制)

每一年度計畫總金額: 9,255,000 NTD for three subprojects


2016 行政院部會署政策額度計畫

計畫編號:


補助期限: 2016-1-1 to 2019-12-31

打造世界級蛋白質研發重鎮：開創次世代生技產業




General Publications


  1. “Learning Is a Lifelong Process” in Reflections on Multiliterate Lives, Diane Dewhurst Belcher, Ulla Connor, Eds., Multilingual Matters, 2001.



Research Publications (http://www.bc.sinica.edu.tw/MDTsai/)
The h-index is 47. The papers cited 47 times or more are bolded. Reviews are indicated.


  1. "Terpenes and Sterols of Cunninghamia Konishii," Y. S. Cheng and M.-D. Tsai, Phytochemistry, 11, 2108-2109 (1972).




  1. "Air Oxidation of -Terpineol," M.-D. Tsai and Y. S. Cheng, J. Chinese Chem. Soc., 22, 149-155 (1974).




  1. "Dye-sensitized Photooxidation of -Terpineol," Y. S. Cheng, M.-D. Tsai, J. M. Fang and S. S. Hsu, Chemistry (The Chinese Chem. Soc., Taiwan, China), 8-11 (1975).




  1. "Conformational Analysis of Pyridoxal Amino Acid Schiff's Bases," H. J. R. Weintraub, M.-D. Tsai, S. R. Byrn, C.-j. Chang and H. G. Floss, Int. J. Quantum Chem., QBS 3, 99-105 (1976).




  1. "Conformational Analysis of Pyridoxal Schiff's Bases," M.-D. Tsai, S. R. Byrn, C.-j. Chang, H. G. Floss and H. J. R. Weintraub, Biochemistry 17, 3177-3182 (1978).




  1. "Conformation-Reactivity Relationship for Pyridoxal Schiff's Bases,"M.-D. Tsai, H. J. R. Weintraub, S. R. Byrn, C.-j. Chang and H. G. Floss, Biochemistry, 17, 3183-3188 (1978).




  1. "Stereochemistry and Mechanism of Reactions Catalyzed by Tryptophan Synthetase and its 2 Subunit, M.-D. Tsai, E. Schleicher, R. Potts, G. E. Skye and H. G. Floss, J. Biol. Chem., 253, 5344-5349 (1978).




  1. "Stereochemistry and Mechanism of Reactions Catalyzed by Tryptophanase from Escherichia coli, J. C. Vederas, E. Schleicher, M.-D. Tsai and H. G. Floss, J. Biol. Chem., 253, 5350-5354 (1978).




  1. "Stereochemistry of the -Cyanoalanine Synthetase and S-Alkylcysteine Lyase Reactions," M.-D. Tsai, J. Weaver, H. G. Floss, E. E. Conn, R. K. Creveling and M. Mazelis, Arch. Biochem. Biophys., 190, 553-559 (1978).




  1. "Stereochemistry of Enzymatic Transmethylation," H. G. Floss, L. Mascaro, M.-D. Tsai and R. W. Woodard, in Transmethylation (E. Usin, R. T. Borchardt and C. R. Creveling, Eds.), Elsevier North-Holland, New York (1979), pp. 135-141. (Review)




  1. "Chiral Methyl Groups," H. G. Floss and M.-D. Tsai, Adv. Enzymol. 50, 243-302 (1979). (Review)




  1. "Stereochemistry and Mechanism of Reactions Catalyzed by Indolyl-3-alkane -Hydroxylase," M.-D. Tsai, H. G. Floss, H. J. Rosenfeld and J. Roberts, J. Biol. Chem., 254, 6437-6443 (1979).




  1. "Stereochemical Course of the Transmethylation Catalyzed by Catechol O-Methyltransferase," R. W. Woodard, M.-D. Tsai, H. G. Floss, P. A. Cook and J. K. Coward, J. Biol. Chem., 255, 9124-9127 (1980).




  1. "First Observation of Amino Acid Side Chain Dynamics in Membrane Proteins Using High Field Deuterium NMR Spectroscopy," R. A. Kinsey, A. Kintanar, M.-D. Tsai, R. L. Smith, N. Janes and E. Oldfield, J. Biol. Chem., 256, 4146-4149 (1981).




  1. "Protein Crystals, Membrane Proteins and Membrane Lipids." E. Oldfield, N. James, R. Kinsey, A. Kintanar, R. W. K. Lee, T. M. Rotngeb, S. Schramm, R. Skarjune, R. Smith and M.-D. Tsai, Biochem. Soc. Trans., 45, 155-181 (1981).


Papers from independent research:


  1. "Use of 31P Nuclear Magnetic Resonance to Distinguish Bridge and Nonbridge Oxygens of 17O-enriched Nucleoside Triphosphates. Stereochemistry of Acetate Activation by Acetyl CoA Synthetase," M.-D. Tsai, Biochemistry 18, 1468-1472 (1979). (This and a few subsequent papers were highlighted in Science 1984 in pdf.)




  1. "Applicability of the 31P(17O) NMR Method in the Study of Enzyme Mechanism Involving Phosphorus," M.-D. Tsai, S. L. Huang, J. F. Kozlowski and C. C. Chang, Biochemistry 19, 3531-3536 (1980).




  1. "Chirality at a Pro-pro-prochiral Phosphorus Center, Stereochemical Course of the 5'-Nucleotidase-Catalyzed Reaction," M.-D. Tsai and T. T. Chang, J. Am. Chem. Soc., 102, 5416-5418 (1980).




  1. "Stereochemistry of the Hydrolysis of Adenosine 5'-Thiophosphate Catalyzed by Venom 5'-Nucleotidase," M.-D. Tsai, Biochemistry 19, 5310-5316 (1980).




  1. "Does the Magnesium(II) Ion Interact with the α-Phosphate of ATP? An Investigation by 17O NMR," S.-L. Huang and M.-D. Tsai, Biochemistry 21, 951-959 (1982).




  1. "Use of 31P(18O), 31P(17O), and 17O NMR Methods to Study Enzyme Mechanism Involving Phosphorus," M.-D. Tsai, Methods Enzymol. 87, 235-279 (1982). (Review)




  1. "Phospholioids Chiral at Phosphorus. 1. Stereochemistry of Transphosphatidylation Catalyzed by Phospholipase D," K. Bruzik and M.-D. Tsai, J. Am. Chem. Soc. 104, 863-865 (1982).




  1. "Phospholipids Chiral at Phosphorus. 2. Preparation, Property, and Application of Chiral Thiophospholipids" K. Bruzik, S. M. Gupte and M.-D. Tsai, J. Am. Chem. Soc. 104, 4682-4684 (1982).




  1. "Phospholipids Chiral at Phosphorus. 3. Preparation and Spectral Properties of Chiral Thiophospholipids," K. Bruzik, R.-T. Jiang and M.-D. Tsai, Biochemistry 22, 2478-2486 (1983).




  1. "Phospholipids Chiral at Phosphorus. 4. Could Membranes be Chiral at Phosphorus?" M.-D. Tsai, R.-T. Jiang and K. Bruzik, J. Am. Chem. Soc. 105, 2478-2480 (1983)




  1. "Phospholipids Chiral at Phosphorus. Synthesis, Absolute Configurations and Applications." K. Bruzik, R.-T. Jiang and M.-D. Tsai, Phosphorus and Sulfur 18, 369-372 (1983).




  1. "Effects of 17O and 18O on 31P NMR: Further Investigation and Applications," R. D. Sammons, P. A. Frey, K. Bruzik and M.-D. Tsai, J. Am. Chem. Soc. 105, 5455-5461 (1983). – This paper was featured in an one-page news article in Science 224, 377 (1984).




  1. "NMR Methods Involving Oxygen Isotopes in Biophosphates," M.-D. Tsai and K. Bruzik, in Biological Magnetic Resonance, Vol. 5, L. J. Berliner and J. Reuben, Eds., Plenum Press, New York, pp. 129-181 (1983). (Review)




  1. "Phospholipids Chiral at Phosphorus. 5. Synthesis and Configurational Analysis of Chiral [17O,18O]-Phosphatidylethanolamine." K. Bruzik and M.-D. Tsai, J. Am. Chem. Soc. 106, 747-754 (1984).




  1. "Phospholipids Chiral at Phosphorus. 6. Synthesis of Chiral Phosphatidylcholine and Stereochemistry of Phospholipase D." K. Bruzik and M.-D. Tsai, Biochemistry 23, 1656-1661 (1984).




  1. "Phospholipids Chiral at Phosphorus. 7. Absolute Configuration of Chiral Thiophospholipids and Stereochemistry of Phospholipase D." R.-T. Jiang, Y.-J. Shyy, and M.-D. Tsai, Biochemistry 23, 1661-1667 (1984).




  1. "Phospholipids Chiral at Phosphorus. 8. Properties of Small Unilamellar Vesicles of Chiral Thiophosphatidylcholine." T.-C. Tsai, R.-T. Jiang and M.-D. Tsai, Biochemistry 23, 5564-5570 (1984).




  1. "Stereochemistry of Biological Reactions at Proprochiral Centers." H. G. Floss, M.-D. Tsai, and R. W. Woodard, Topics in Stereochemistry, E. L. Eliel, N. L. Allinger and S. H. Wilen, Eds., John Wiley & Sons, pp. 253-321 (1984). (Review)




  1. "Use of Chiral thiophosphates and the Stereochemistry of Enzymatic Phosphoryl Transfer." M.-D. Tsai, in 31P NMR: Principles and Applications, D. Gorenstein. Ed.. Academic Press, pp. 175-197 (1984). (Review)




  1. "Phospholipids Chiral at Phosphorus. 9. Use of Chiral Thiophosphatidylcholine to Study the Metal-Binding Properties of Bee Venom Phospholipase A2,"T.-C. Tsai, J. Hart, R.-T. Jiang, K. Bruzik and M.-D. Tsai, Biochemistry 24, 3180-3188 (1985).




  1. " Metal-Nucleotide Interactions. 3. 17O, 31P and 1H NMR Studies on the Interactions of Sc(III) , La(III) and Lu(III) with ATP," Y.-J. Shyy, T.-C. Tsai and M.-D. Tsai, J. Am. Chem. Soc. 107, 3478-3484 (1985).




  1. "Mechanism of Adenylate Kinase. 1. Use of 17O NMR to Study the Binding Properties of Substrates," D. A. Wisner, C. Steginsky, Y.-J. Shyy and M.-D. Tsai, J. Am. Chem. Soc. 107, 2814-2815 (1985).




  1. "Phospholipids Chiral at Phosphorus. 10. Use of Chiral Thiophospholipids to Study the Mechanism of Phospholipase A2," M.-D. Tsai, K. Bruzik, J. Hart, R.-T. Jiang, T. Rosario-Jansen, T.-C. Tsai and D. A. Wisner, in "Mechanisms of Enzymatic Reactions: Stereochemistry", P. A. Frey, ed., Elsevier, 115-126 (1986). (Review)




  1. "Phospholipids Chiral at Phosphorus. 11. FT-IR Study on the Gel-Liquid Crystalline Transition of Chiral Thiophosphatidylcholine," S.-B. Chang, J. O. Alben, D. A. Wisner and M.-D. Tsai, Biochemistry 25, 3435-3440 (1986).




  1. "Phospholipids Chiral at Phosphorus. 12. Configurational Effect on the Thermotropic Properties of Chiral Dipalmitoylthiophosphatidylcholine," D. A. Wisner, T. Rosario-Jansen and M.-D. Tsai, J. Am. Chem. Soc., 108, 8064-8068 (1986).




  1. "Phospholipids Chiral at Phosphorus. 13. Stereochemical Comparison of Phospholipase A2, Lecithin-Cholesterol Acyl Transferase, and Platelet-Activating Factor," T. Rosario-Jansen, H. J. Pownall, J. P. Noel and M.-D. Tsai, Phosphorus and Sulfur 30, 601-604 (1987).




  1. Phospholipids Chiral at Phosphorus. 14. Stereochemical Effects on the Thermotropic Properties of Thiophosphatidylcholines and Thiosphingomyelins,"M.-D. Tsai, K. S. Bruzik, D. Wisner and S.-H. Liu, in"Biophosphates and Their Analogues, Synthesis, Structure, Metabolism and Activity", K.S. Bruzik and W.J. Stec, Eds., Elsevier, pp. 561-570 (1987). (Review)




  1. "Is the Binding of Mg2+ to Calmodulin Significant? An Investigation by 25Mg NMR," M.-D. Tsai, T. Drakenberg, E. Thulin and S. Forsen, Biochemistry, 26, 3635-3643 (1987).




  1. "Magnesium Binding to Calcium-Binding Proteins: A Regulatory Function?" T. Drakenberg, S. Forsen, E. Thulin, and M.-D. Tsai, in Calcium-Binding Proteins in Health and Disease, Norman, A. W., Vanaman, T. C., and Means, A. R., Eds., Academic Press, pp. 430-432 (1987). (Review)




  1. "Phospholipids Chiral at Phosphorus. 15. Steric Course of the Reactions Catalyzed by Phosphatidylserine Synthases from E. coli and Yeast," C. R. H. Raetz, G. M. Carman, W. Dowhan, R.-T. Jiang, W. Waszkuc, W. Loffredo and M.-D. Tsai, Biochemistry, 26 4022-4027 (1987).




  1. "A Calorimetric Study of the Thermotropic Behavior of Pure Sphingomyelin Diastereomers," K. S. Bruzik and M.-D. Tsai, Biochemistry 26, 5364-5368 (1987).




  1. "Mechanism of Adenylate Kinase. 2. Does ATP bind to the AMP Site?" Y. J. Shyy, G. Tian, and M.-D. Tsai, Biochemistry, 26, 6411-6415 (1987).




  1. "Mechanism of Adenylate Kinase. 3. Use of Deuterium NMR to Show Lack of Correlation Between Local Substrate Dynamics and Local Binding Energy." C. R. Sanders II and M.-D. Tsai, J. Am. Chem. Soc. 110, 3323-3324 (1988).




  1. "Steric Course of the Reaction Catalyzes by Phosphatidylserine Decarboxylase from E. coli". Z. No, C. R. Sanders II, W. Dowhan, and M.-D. Tsai, Bioorg. Chem., 16, 184-188 (1988).




  1. "Phospholipids Chiral at Phosphorus. 16. Synthesis and Stereospecificity of Phosphorothioate Analogues of Platelet-Activating Factor." T. Rosario-Jansen, R.-T. Jiang, D. J. Hanahan, and M.-D. Tsai, Biochemistry, 27, 4619-4624 (1988).




  1. "Phospholipids Chiral at Phosphorus. 17. Characterization of the Subgel Phase of Thiophosphatidylcholines by Use of X-Ray Diffraction, P-31 NMR, and FT-IR Spectroscopy". H. E. Sarvis, W. Loffredo, R. A. Dluhy, L. Hernqvist, D. A. Wisner, and M.-D. Tsai, Biochemistry, 27, 4625-4631 (1988).




  1. "Mechanism of Adenylate Kinase. 4. Histidine-36 Is Not Directly Involved in Catalysis, But Protects Cysteine-25 and Stabilizes the Tertiary Structure." G. Tian, C. R. Sanders II, F. Kishi, A. Nakazawa, and M.-D. Tsai, Biochemistry, 27, 5544-5552 (1988).




  1. "Use of Short-Chain Cyclopentano-phosphatidylcholines to Probe the Mode of Activation of Phospnolipase A2 from Bovine Pancreas and Bee Venom". G. L. Lin, J. Noel, W. Loffredo, H. Sable, and M.-D. Tsai, J. Biol. Chem., 263, 13208-13214 (1988).




  1. "Phospholipase A2 Engineering: Design, Synthesis, and Expression of a Gene for Bovine (Pro)Phospholipase A2". J. P. Noel and M.-D. Tsai, J. Cellular Biochem. 40 (UCLA Symposium Series), 309-320 (1989).




  1. "Phospholipids Chiral at Phosphorus. 18. Stereochemistry of Phosphatidylinositide-specific Phospholipase C". G. Lin and M.-D. Tsai, J. Am. Chem. Soc., 111, 3099-3101 (1989).




  1. "Ligand-Protein Interactions Via NMR of Quadrupolar Nuclei". C. R. Sanders II and M.-D. Tsai, Methods. Enzymol. 177, 317-333 (1989). (Review)




  1. "Mechanism of Adenylate Kinase. 5. Is There a Relationship Between Local Substrate Dynamics, Local Binding Energy, and the Catalytic Mechanism?" C. R. Sanders II, G. Tian and M.-D. Tsai, Biochemistry 28, 9028-9043 (1989).




  1. "Phospholipids Chiral at Phosphorus. 19. Synthesis and Configurational Assignment of Phosphorothioate Analogues of Phosphatidylserine". W. M. Loffredo and M.-D. Tsai, Bioorg. Chem. 18, 78-84 (1990).



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