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Curriculum Vitae Chen, Honglin. Ph. D. Associate Professor Address


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Curriculum Vitae
Chen, Honglin. Ph.D.

Associate Professor


Address: Department of Microbiology

Li Ka Shing Faculty of Medicine

The University of Hong Kong

L5-29, New Medical Complex

21 Sasson Road

Hong Kong


Telephone: 28199941/28199830; Fax: 2855-1241/2817-1958

Email: hlchen@hku.edu
Education:
1979-1983 B.Sc., Dept. of Biology, Xiamen University, Xiamen, China.

1983-1986 M.Sc., Dept. of Biology, Xiamen University, Xiamen, China.

M.Sc. thesis:" Molecular Biology of Plasmids in Cyanobacterium".

1988-1992 Ph.D., Dept. of Microbiology, The University of Hong Kong, Hong Kong.

PhD thesis : Transcription of Epstein-Barr virus genome in nasopharyngeal

Carcinoma".


Scholarship & Fellowships


1988-1991 Li Ka Shing Scholarship, The University of Hong Kong

1992 Academic Exchange Fellowship(British Council),

Royal Postgraduate Medical School, London, UK.

1996 China-Hong Kong-UK Tripartite Academic Exchange Fellowship,

British Council.


Employment & Professional Experience:
Research:
1986-1988 Assistant lecturer, Dept. of Biology, Shantou University, China

1993-1994 Assistant professor, Dept. of Biology, Shantou University, China

1995-1996 Associate professor, Dept. of Biology, Shantou University, China


    1. Research Officer, Dept. of Microbiology, The University of Hong Kong

1997-1/31/00 Research Fellow, Molecular Virology Lab, Dept. of Pharmacology and Molecular Sciences & Oncology Center, Johns Hopkins University School of Medicine, Baltimore, USA.

2000- 2003 Research Associate, Johns Hopkins School of Medicine, Baltimore, USA.

2003, Dec Assistant Professor, Dept. of Microbiology, The University of Hong Kong, Hong Kong.

2007, Aug Associate Professor, Dept, of Microbiology and Research Center of Infection and Immunity, The University of Hong Kong


Areas of interest: Molecular Virology; Host restriction of virus replication in cross species transmission; Aberrant cell signaling pathways associated with viral infection;

Membership: Full member, American Society for Virology

Full Member, American Society for Microbiology

Member, International Association for Epstein-Barr virus and associated Disease research.

Member of Bio-safety committee, China National Accreditation Board for Laboratory.



Editorial: Associate Editor, BMC Microbiology and BMC infectious diseases

Ad Hoc reviewer: J. Infectious Diseases, J. Virology, Emerging Infections Diseases, J. Clinical Microbiology,

Honorary appointment
2004---- Visiting Professor Shantou University

2005---- Visiting Professor. Xiamen University, China



Publications


  1. Wu WL, SY Lau1, Y Chen, G. Wang, B. Mok, X. Wen, P. Wang, W. Song, T. Lin, KH. Chan, KY Yuen and H. Chen*(2011). 2008-2009 H1N1 influenza virus exhibits reduced susceptibility to antibody inhibition: implications for the prevalence of oseltamivir resistant variant viruses. Antiviral Research. Accepted.

  2. Lai AC, Wu WL, Lau SY, Guan Y, Chen H (2011). Two-dimensional antigenic dendrogram and phylogenetic tree of avian influenza virus H5N1. FEMS Immunol Med Microbiol. 2011 Oct 31. doi: 10.1111/j.1574-695X.2011.00884.x. [Epub ahead of print]

  3. Zhang AJ, To KK, Tse H, Chan KH, Guo KY, Li C, Hung IF, Chan JF, Chen H, Tam S, Yuen KY (2011) High incidence of severe influenza among individuals aged over 50 years.. Clin Vaccine Immunol. 2011 Sep 7. [Epub ahead of print].

  4. Zhu H, Zhou B, Fan X, Lam TT, Wang J, Chen A, Chen X, Chen H, Webster RG, Webby R, Peiris JS, Smith DK, Guan Y. Novel reassortment of Eurasian Avian-like and pandemic/2009 influenza viruses in swine: infectious potential to humans. .J Virol. 2011 Aug 17. [Epub ahead of print].

  5. Zhu H, Wang J, Zheng Z, Chen R, Zheng R, Li L, Duan L, Zhang T, Yip EC, Yan Z, Chen H, Peiris JS, Guan Y (2011). Pathogenicity and transmissibility of the pandemic H1N1 2009-related influenza viruses in mice, ferrets, and pigs. Influenza Other Respiratory Viruses. 2011 May;5 Suppl 1:82-4. No abstract available.

  6. Chu YC, Cheung CL, Hung Leung CY, Man Poon LL, Chen H, Peiris JS, Guan Y (2011). Continuing evolution of H9N2 influenza viruses endemic in poultry in southern China. Influenza Other Respiratory Viruses. 2011 May;5 Suppl 1:68-71. No abstract available.

  7. Duan L, Zhu H, Wang J, Huang K, Cheung CL, Peiris JS, Chen H, Guan Y (2011). Influenza virus surveillance in migratory ducks and sentinel ducks at Poyang Lake, China. Influenza Other Respiratory Viruses. 2011 May;5 Suppl 1:65-8. No abstract available.




  1. Chen Y, Q Zheng, F Zeng, SY Lau, WL Wu, S Huang, J Zhang, H Chen* and N Xia (2011). Serological survey of antibodies to influenza A viruses on a group of people without a history of influenza vaccination. Clinical Microbiology and Infection. Sep;17(9):1347-9. doi: 10.1111/j.1469-0691.2011.03538.x. Epub 2011 Jul 13In Press




  1. Tse H, R. Kao, WL. Wu, WW. Lim, H. Chen, MY. Yeung, P. Woo, HK Sze, KY Yuen (2011). Structural basis and sequence co-evolution analysis of the hemagglutinini protein of the pandemic influenza A/H1N1 (2009) virus. Experimental Biology and Medicine, 236(8):915-25. Epub 2011 Jul 4.




  1. Vijaykrishna D, GJ. Smith, OG. Pybus, H. Zhu H, S. Bhatt S, LL. Poon, S. Riley, L. Bahl, SK Ma, CL. Cheung, RA Perera, H. Chen, KF. Shortridge, RJ Webby, RG. Webster, Y. Guan Y, JS. Peiris(2011). Long-term evolution and transmission dynamics of swine influenza A virus. Nature, 473(7348):519-22.




  1. Zheng Q, L. Xia, WL. Wu, Z. Zheng, Y. Hou, J. Wu, Y. Liu, H, Yu, Y. Chen, S-Y Lau, H. Chen*, W. Luo, N. Xia (2011). Properties and therapeutic efficacy of broadly reactive chimeric and humanized H5-specific monoclonal antibodies against H5N1 influenza viruses. Antimicrobial Agents and Chemotherapy. 55(4):1349-57 Epub 2011 Jan 18.




  1. Chan KH, KK To, IF Hung, J Zhang, JF Chan, VC Cheng, H Tse, XY Che, H Chen, Yuen KY (2011) Differences in the antibody response between individuals with natural infection of and vaccination against pandemic H1N1 2009 influenza. Clinical Vaccine Immunology. 18(5):867-73 2011 Mar 16. [Epub ahead of print]




  1. Cheng VC, Chan JF, Wen X, Wu WL, Que TL, Chen H, Chan KH, Yuen KY (2011). Infection of immunocompromised human by H9N2 influenza A virus. J Infect. 2011 Feb 25. [Epub ahead of print]




  1. Chan KC, Ko JM, Lung HL, Sedlacek R, Zhang ZF, Luo DZ, Feng ZB, Chen S, Chen H, Chan KW, Tsao SW, Chua DT, Zabarovsky ER, Stanbridge EJ, Lung ML (2011). Catalytic activity of matrix metalloproteinase-19 is essential for tumor suppressor and anti-angiogenic activities in nasopharyngeal carcinoma. Int J Cancer. 2010 Dec 16. [Epub ahead of print]




  1. Chan KH, Zhang AJ, To KK, Chan CC, Poon VK, Guo K, Ng F, Zhang QW, Leung VH, Cheung AN, Lau CC, Woo PC, Tse H, Wu W, Chen H, Zheng BJ, Yuen KY(2010). Wild type and mutant pandemic Influenza A (H1N1) Viruses Cause More Severe Disease and Higher Mortality in Pregnant BALB/c Mice. PLoS One. 2010 Oct 29;5(10):e13757.




  1. Danesh A, Cameron CM, León AJ, Ran L, Xu L, Fang Y, Kelvin AA, Rowe T, Chen H, Guan Y, Jonsson CB, Cameron MJ, Kelvin DJ(2010). Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation. Virology. 2010 Oct 27. [Epub ahead of print]




  1. Yuan Q, Cheng XD, Yang BC, Zheng QB, Chen YX, Chen QR, Zeng F, Zhang R, Ge SX, Hao XK, Chen H, Zhang J, Xia NS (2010). Diagnosis of Pandemic (H1N1) 2009 Infection by detecting Hemagglutinin Using an Enzyme-linked Immunoassay. Clin. Microbiol Infect. 2010 Nov 4. doi: 10.1111/j.1469-0691.2010.03413.x. [Epub ahead of print].




  1. Lin S., N. Liu, Z. Yang, W Song, P. Wang, H. Chen, M. Lucio P. Schmitt-Kopplin, G. Chen, Z. Cai (2010) GC/MS-based metabolomics reveals fatty acid biosynthesis and cholesterol metabolism in cell line infected with influenza virus. Talanta, 83(1):262-8.




  1. Hung IF, KK To, CK Lee, CK Lin, JF Chan, H Tse, VC Cheng, H Chen, PL Ho, CW Tse, TK Ng, TL Que, KH Chan, KY Yuen (2010). Effect of Clinical and Virological Parameters on the Level of Neutralizing Antibody against Pandemic Influenza A Virus H1N1 2009. Clin Infect Dis. 2010 Jun 24. [Epub ahead of print]




  1. Chen Y, W Luo, W L Wu, Z Fang, L Xia, X Gui, Y Chen, H Chen, J. W-K Shih, N Xia (2010).Humanized Antibodies with Broad-Spectrum Neutralization to Avian Influenza Virus H5N1. Antiviral Research 87(1):81-4.




  1. Fang Y, T Rowe, AJ Leon, D Banner, A Danesh, L Xu, L Ran, SE Bosinger, Y Guan, H Chen, CC Cameron, MJ Cameron, DJ Kelvin (2010). Characterization of in vivo Adjuvant Activity in Influenza-Vaccinated Ferrets. J Virol. 84(17):8369-88, 2010Jun 9. [Epub ahead of print]




  1. Kao R, Dan Yang, L. Shan Lau, W Tsui, P. Wang, BJ Zheng, JD Huang, J. Madar, L Hu, GH Chen, H Chen, Y Guan, Kwok-Yung Yuen (2010). Identification of influenza A nucleoprotein as novel antiviral target. Nature Biotechnology, 28(6):600-5. Epub 2010 May 30




  1. Huang K., J Bahl. X. Fan, D. CL Cheung, R. Webby, R. Webster, H. Chen, GJD Smith, M. Peiris, Y. Guan (2010) Vijaykrishna Establishment of an H6N2 influenza virus lineage in domestic ducks in southern China. J Virol. 84(14):6978-86. Epub 2010 May 12.




  1. Zheng BJ, KH Chan, JX Zhang, J Zhou, CCS Chan, PKM Poon, K Zhang, VHC Leung, DY Jin, PCY Woo, JFW Chan, KKW To, Chen H, and Yuen KY (2010). Single D225G mutation in haemagglutinin of pandemic Influenza H1N1 (2009) virus enhances its virulence in mice. Experimental Biology and Medicine. 235(8):981-8.




  1. Bao L, L Xu, L Zhang, W Deng, H Zhu, H Gao, H Sun, C Ma, Q Lv, F Li, H Chen, L Zhang, C Qin (2010). and polymorphism analysis of the novel A (H1N1) influenza virus to normal animals. Virus Research, 151(1):60-5. Epub 2010 Apr 8.




  1. Chen H, X Wen, KKW To, P Wang, H Tse, JFW Chan, HW Tsoi, KSC Fung, C WS Tse, R A Lee, KH Chan, KY Yuen (2010). Quasi species of D225G substitution in hemagglutinin of pandemic influenza A (H1N1) 2009 virus from severe cases in Hong Kong of China. J. Infectious Diseases, 201(10):1517-2 2010 Apr 2. [Epub ahead of print]




  1. Zhu, H, J. Wang, P Wang, W Song, Z Zheng; R Chen, K Guo, T Zhang, JSM Peiris, H. Chen*, Yi Guan (2010). Substitution of lysine at 627 position in PB2 protein does not change virulence of the 2009 pandemic H1N1 virus in mice. Virology, 401(1):1-5. 2010 Mar 18. [Epub ahead of print]




  1. Zheng Z, W. Luo, H. Song, Y. Chen, J. Xiong, Y. Chen, Y. Gu, H. Chen, JWK. Shih, J. Zhang and N. Xia (2010). Antibody reactivity of conformational peptide mimics of a conserved H5N1. Arch Virol. 2010;155(1):19-26. Epub 2009 Nov 13.




  1. Liu N, W. Song, P. Wang, K-C Lee, Z. Cai1and H. Chen* (2010). Identification of Unusual Truncated Forms of Nucleocapsid Protein in MDCK Cells Infected by Avian Influenza Virus (H9N2). Proteomics, 10:1875-1879




  1. Zhang J., Z. Zheng, X. Fan, Y. Liu, J. Wang, Z. Zheng, R. Chen, P. Wang, W. Song, H. Chen* and Y. Guan (2010). 2009 pandemic H1N1 influenza virus replicates in human lung tissues. J. Infectious Diseases, 201(10):1522-6.




  1. Tsang CM, Zhang G, Seto E, Takada K, Deng W, Yip YL, Man C, Hau PM, Chen H, Cao Y, Lo KW, Middeldorp JM, Cheung AL, Tsao SW (2010). Epstein-Barr virus infection in immortalized nasopharyngeal epithelial cells: Regulation of infection and phenotypic characterization. Int J Cancer. 127(7):1570-83., 2010 Jan 20. [Epub ahead of print]




  1. Chen Y, Xu F, Gui X, Yang K, Wu X, Zheng Q, Ge S, Yuan Q, Yeo AE, Zhang J, Guan Y, Chen H, Xia N (2010). rapid test for the detection of influenza A virus including pandemic influenza A/H1N1 2009. J Virol Methods. 2010 Feb 5. [Epub ahead of print]




  1. To KK, Hung IF, Li IW, Lee KL, Koo CK, Yan WW, Liu R, Ho KY, Chu KH, Watt CL, Luk WK, Lai KY, Chow FL, Mok T, Buckley T, Chan JF, Wong SS, Zheng B, Chen H, Lau CC, Tse H, Cheng VC, Chan KH, Yuen KY. (2010). Delayed Clearance of Viral Load and Marked Cytokine Activation in Severe Cases of Pandemic H1N1 2009 Influenza Virus Infection. Clin Infect Dis. 2010 Feb 5. [Epub ahead of print]




  1. Chen H., CL Cheung, Hung Tai, P. Zhao, Jasper, FW Chan, V Cheng, KY Yuen (2009). Oseltamivir resistant variant of the swine-origin influenza A H1N1 virus due to quasi species in an untreated patient infection Hong Kong SARChina. Emerg Infect Dis. 15(12):1970-2.




  1. Li IW, KH Chan, KW To, SS Wong, PL Ho, SK Lau, PC Woo, HW Tsoi, JF Chan, VC Cheng, BJ Zheng, H Chen and Yuen KY(2009). Differential susceptibility of different cell lines to swine-origin influenza A H1N1, seasonal human influenza A H1N1, and avian influenza A H5N1 viruses. J Clin Virol. 2009 Oct 2. [Epub ahead of print]




  1. Chen H, Y. Wang, W. Liu, J. Zhang, B. Dong, X. Fan, M de Jong, J Farrar, S. Riley, G. Smith and Y Guan (2009). Serology survey of pandemic (H1N1) 2009 virus, Guangxi Province, China Emerging Infectious Diseases, 15(11):1849-50. DOI:10.3210/eid1511.090868. 2009 Nov [Epub ahead of print].




  1. Liu N, G. Wang, KM Lee, Y. Guan, H. Chen* and Z. Cai (2009). Mutations in influenza virus replication and transcription: Detection of amino acid substitutions in hemagglutinin but not in viral genome of an avian influenza virus. FASEB J. 23(10):3377-82. 2009 Jun 24. [Epub ahead of print] (RGC)




  1. Ma, B.Y., V. Lui, F. Poon, S. Wong, K. To, E. Wong, H. Chen, Kwok Wai Lo, Q. Tao and A.Chan (2009). Preclinical activity of gefitinib in non-keratinizing nasopharyngeal carcinoma cell lines and biomarkers of response. Invest New Drugs. 2009 Sep 16. Epub 2009 Sep 16.




  1. Smith GJ, Bahl J, Vijaykrishna D, Zhang J, Poon LL, Chen H, Webster RG, Peiris JS, Guan Y (2009). Dating the Emergence of Pandemic Influenza viruses. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11709-12. Epub 2009 Jul 13.




  1. Wang P, W. Song, Bobo WY Mok, P. Zhao, K. Qin, A. Lai, G. Smith, J.Zhang, T. Lin, Y. Guan and H. Chen* (2009). Nuclear factor 90, NF90, negatively regulates influenza virus replication by interacting with viral nucleoprotein. J. Virol. 83(16):7850-61. 2009 Jun 3. [Epub ahead of print]. 3)




  1. Liu N, K-C Lee, W. Song, P. Wang, Z. Cai and H. Chen* (2009).  Identification of amino acid substitutions in mutated peptides of nucleoprotein from avian influenza virus. Talanta, 78: 1492-96.




  1. Zhang Z, J. Z., K. Huang, KS Li, KY. Yuen, Y. Guan, H. Chen and WF. Ng.(2009). Systemic infection of avian influenza A virus H5N1 subtype in human. Human Pathology, 40(5):735-9 2009 Jan. 2 [Equb ahead of print] doi:10.1016/j.humpath.




  1. Liu N, Song W, Lee KC, Wang P, Chen H*, Cai Z (2009). Identification of amino acid substitutions in avian influenza virus (H5N1) matrix protein 1 by using nanoelectrospray MS and MS/MS. J Am Soc Mass Spectrom. 20(2):312-20. Epub 2008 Oct 18. (RGC)




  1. Smith GJ, Vijaykrishna D, Ellis TM, Dyrting KC, Leung YH, Bahl J, Wong CW, Kai H, Chow MK, Duan L, Chan AS, Zhang LJ, Chen H, Luk GS, Peiris JS, Guan Y (2009). Characterization of avian influenza viruses A (H5N1) from wild birds, Hong Kong, 2004-2008. Emerging Infectious Diseases, 15(3):402-7




  1. Chan CM, PC Woo, SK Lau, H Tse, H Chen, F Li, BJ Zheng, L Chen, JD Huang, Yuen KY(2008) Spike Protein, S, of Human Coronavirus HKU1: Role in Viral Life Cycle and Application in Antibody Detection. Exp Biol Med (Maywood). 2008 Dec; 233(12):1527-36. Epub 2008 Oct 10.




  1. Chen Y, K. Qin, WL Wu, G. Li, J. Zhang, H. Du, MH Ng, JWK Shih, M. Peiris, Y Guan, H. Chen* and N. Xia. (2009).Broad Cross Protection Against H5N1 Avian Influenza Infection by Means of Monoclonal Antibodies that Map to conserved viral Epitopes. J. Infectious Diseases, 199(1):49-58. [Epub ahead of print] Nov. 25, 2008. (RGC)




  1. Luo, W, Y. Chen, M. Wang, Z. Zhang, H. Song, H. Chen, Y. Guan, MH. Ng, J. Zhang and N. Xia. (2009). Peptide mimics of a conserved H5N1 avian influenza virus neutralization site. Biochem. J [ Epub ahead of print] Oct. 30 2008.




  1. Chen Y, F Xu, X Fan, H Luo, S Ge, Q Zheng, N Xia, H Chen, Y Guan, J Zhang (2008). Evaluation of a rapid test for detection of H5N1 avian influenza virus. J. of Virol. Methods, 154(1-2):213-5




  1. Vijaykrishna D., J. Bahl, S. Riley, L. Duan, J. Zhang, H. Chen, M, Peiris, G. Smith and Y. Guan. (2008). Evolution Dynamics and Emergence of Panzootic H5N1 Influenza virus. PLoS Pathogens e1000161.




  1. Duan L, Bahl G.J.D. Smith, J, Wang D. Vijaykrishna L.J. Zhang J.X. Zhang K.S. Li X.H. Fan , C.L. Cheung , K. Huang , L.L.M. Poon , K.F. Shortridge , R.G. Webster, J.S.M. Peiris, H. Chen, Y Guan. (2008). The development and genetic diversity of H5N1 influenza virus in China, 1996-2006. Virology 380(2):243-54, [Epub ahead of print] 2008 Sep 4.




  1. Al-Azemi A., J. Bahl, S. Al-Zenki, Y. Al-Shayji, S. Al-Amad, H. Chen, Y. Guan, S. M. Peiris, and G.J.D. Smith (2008). Avian influenza A virus (H5N1) outbreaks, Kuwait, 2007. EID, 14(6):958-61.




  1. Liu N, W. Song, P.Wang, K. Lee, W. Wang, H. Chen* and Z. Cai (2008). Proteomics analysis of differential expression of cellular proteins in response to avian H9N2 virus in human cells. Proteomics. 8(9):1851-8.




  1. Zheng BJ, KW Chan YP Lin, GY Zhan, C. Chan, HJ Zhang, H. Chan, SY Wong, SKP Lau, PCY Woo, KH Chan, DY Jin, and KY Yuen (2008) Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus. PNAS. 105(23):8091-6. Epub 2008 Jun 3




  1. Guan Y, H. Chen, KS Li, S. Riley, GM. Leung, R. Webser, M. Peiris and KY. Yuen. (2007) A model to control the epidemic of H5N1 influenza at the source. BMC Infect Dis. Nov 13;7(1):132.




  1. Owoade AA, Ducatez MF, Hübschen JM, Sausy A, Chen H, Guan Y, Muller CP (2008). Avian metapneumovirus subtype A in China and subtypes A and B in Nigeria. Avian Dis. 52(3):502-6




  1. Ducatez, M.F, H. Chen, Y. Guan and C. P. Muller (2008). Molecular Epidemiology of Chicken Anemia Virus (CAV) in Southeastern Chinese Live Birds Markets. Avian Diseases 52:68–73,




  1. Wang J, D. Vijaykrishna, L. Duan, J. Bahl, J. X. Zhang, R. G. Webster,J. S. M. Peiris, H. Chen, Gavin J. D. Smith and Y. Guan (2008). Identification of the Progenitors of Indonesian and Vietnamese Avian Influenza A (H5N1) Viruses from Southern China. J. Virol., Vol. 82: 73405-3414.




  1. Campitelli L., A. Martino, D. Spagnolo, G. Smith, L.Trani, M. Facchini, M. Marco3, E Foni, C. Chiapponi, A.Martin5, H. Chen, Y Guan, M. Delogu and I. Donatelli (2008). Molecular analysis of avian H7 influenza viruses circulating in Eurasia in 1999-2005: detection of multiple reassortant virus genotypes. J.Gen. Virol. 89 (2008), 48-59.




  1. Wu W, Y. Chen, P. Wang, W. Song, S-Y Lau, J. M. Rayner, G. Smith, R. Webster, M. Peiris, T. Lin, N. Xia, Y. Guan and H. Chen* (2008). Antigenic profile of avian H5N1 viruses in Asia from 2002 to 2007. J. Virol. 821798-1807.




  1. Guan Y, H. Chen, KS Li, S. Riley, GM. Leung, R. Webser, M. Peiris and KY. Yuen. (2007) A model to control the epidemic of H5N1 influenza at the source. BMC Infect Dis. Nov 13;7(1):132 [Epub ahead of print].




  1. Nicholls JM, AJ. Bourne, H. Chen, Y. Guan and JS. Peiris (2007). Sialic acid receptor detection in the human respiratory tract: evidence for widespread distribution of potential binding sites for human and avian influenza viruses. Respir Res. 2007 Oct 25;8(1):73 [Epub ahead of print] .




  1. Xu KM, Smith GJ, Bahl J, Duan L, Tai H, Vijaykrishna D, Wang J, Zhang JX, Li KS, Fan XH, Webster RG, Chen H, Peiris JS, Guan Y (2007) The genesis and evolution of H9N2 influenza viruses in poultry from southern China, 2000 to 2005. J Virol. 81(19):10389-401. Epub 2007 Jul 25




  1. Jayawardena S., CY Cheung, I Barr, KH Chan, H. Chen Y. Guan, M. Peiris, L. Poon (2007 Loop-mediated isothermal amplification for influenza A (H5N1) virus. Emer. Infect. Dis. (6):899-901.




  1. Chen X, GJ Smith, B Zhou, C Qiu, WL Wu, Y Li, P Lu, L Duan, S Liu, J Yuan, G Yang, H Wang, J Cheng, H Jiang, JS Peiris, H Chen, Yuen KY, Zhong N, Y Guan (2007) influenza A (H5N1) infection in a patient in China, 2006. Influenza Other Respir Viruses. 2007 Sep-Nov;1(5-6):207-13.




  1. Bermejo-Martin JF, Kelvin DJ, Guan Y, Chen H, Perez-Brena P, Casas I, Arranz E, de Lejarazu RO (2007) Neuraminidase antibodies and H5N1: geographic-dependent influenza epidemiology could determine cross-protection against emerging strains. PLoS Med. 4(6):e212.




  1. Duan L, L. Campitelli, XH. Fan, CYH Leung, D. Vijaykrishna, RG. Webster, KF. Shortridge, JS. Peiris, GJ.Smith, H. Chen* and Y. Guan (2007) Characterization of low pathogenic H5 subtype influenza viruses from Eurasia: Implications on the origin of of highly pathogenic H5 viruses. J. Virol . 81(14):7529-39. Epub 2007 May 16.




  1. Dong BQ, W. Liu, XH Fan, D. Vijaykrishna, XC Tang, F. Gao, LF Li, JX Zhang, LQ Yang, SY, Zhang, JS, Peiris, GJ. Smith, H. Chen and Y. Guan (2007) Detection of a novel and highly divergent coronavirus from Asian leopard cat and Chinese ferret badger in southern China. J. Virol. Jul;81(13):6920-6, Apr 25 2007 (Epub ahead of print).




  1. Olive T.W, I. Barr, Y.H. Connie Leung, H. Chen, Y. Guan, JS. Peiris and LLM. Poon (2007). Reliable universal RT-PCR assays for studying influenza polymerase subunit gene sequences from all 16 haemagglutinin subtypes. J. Virol. Methods, 142(1-2):218-22. Epub 2007 Feb 26.




  1. Zhang Z, X. Fan, K. Li, K. Huang, D. Luo, Z. Feng, M. Wei, Y. Guan, H Chen and J. Zhang. Prevalence of Avian Influenza Virus Receptor in Human Respiratory Tract. Progress in Biochemistry and Biophysics. 2008, 35(12):1-7.




  1. Webster RG, DJ. Hulse-Post, KM Sturm-Ramirz, Y. Guan, M. Peiris, G. Smith, and H. Chen (2007) Changing epidemiology and ecology of highly pathogenic avian H5N1 influenza viruses. Avian Dis. 51(1 Suppl):269-72. Review.




  1. Vijaykrishna D, GJ. Smith, JX Zhang, JX. Peiris, H. Chen, Y Guan (2007) Evolutionary insights into the ecology of coronaviruses. J. Virol. 81(8):4012-20. (Epub 2007 Jan 31).




  1. Xu KM, KS. Li, GJ. Smith, JW. Li, H. Tai, JX Zhang, RG. Webster, JS. Peiris, H. Chen and Y Guan (2007) Evolution and molecular epidemiology of H9N2 influenza A viruses from quail in southern China, 2000 to 2005. J. Virol. 81(6):2635-45. Epub 2006 Dec 27.




  1. Cheung, CL D. Vijaykrishna, G. J. D. Smith, X. H. Fan, J. X. Zhang, J. Bahl, L. Duan, K. Huang, H. Tai,1 J. Wang, L. L. M. Poon, J. S. M. Peiris, H. Chen*,* and Y. Guan (2007) Establishment of influenza A virus (H6N1) in minor poultry in China. J. Virol. 81(19):10402-12.




  1. Smith GJD, XH Fan, J Wang, KS Li, K Qin, JX Zhang, D Vijaykrishna, CL Cheung, K Huang, JM Rayner, W Wong, KC Dyrting, JSM Peiris, H Chen, RG Webster and Y Guan (2006) Emergence and predominance of a H5N1 influenza virus variant in China. Proc. Nat. Acad. Sci ( USA) 7;103(45):16936-41.




  1. Boltz DA, B. Douangngeun, S. Sinthasak, P. Phommachanh, S. Rolston, H. Chen, Y. Guan, JS Peiris, JG Smith and RG Webster (2006). H5N1 influenza viruses in Lao People's Democratic Republic. Emerg Infect Dis. 12(10):1593-5.




  1. Chu D. K. W, L.L. Poon, K. H. Chan, H. Chen, Y. Guan, K. Y. Yuen and J. S. Peiris (2006) Coronaviruses in bent-winged bats (Miniopterus spp.) J. Gen. Virol 87:2461-2466 doi: 10.1099/vir.0.82203-0.




  1. Tang X. C., J. X. Zhang, S. Y. Zhang, P. Wang, X. H. Fan, L. F. Li, G. Li, B. Q. Dong, W. Liu, C. L. Cheung, K. M. Xu, W. J. Song, D. Vijaykrishna, L. L. M. Poon, J. S. M. Peiris, G. J. D. Smith, H. Chen*and Y. Guan (2006). Prevalence and genetic diversity of coronaviruses in bats from China. J. Virol. 80(15):7481-90.




  1. Smith G.J.D. T.S.P. Naipospos1, T.D. Nguyen, M.D. de Jonge, D. Vijaykrishna, T.B. Usman, S.S. Hassan, T.V. Nguyen, T.V. Dao, N.A. Bui, Y.H.C. Leung, C.L. Cheung, J.M. Rayner, J.X. Zhang, L.J. Zhang, L.L.M. Poon, K.S. Li, V.C. Nguyen, T.T. Hien, J. Farrar, R.G. Webster, H. Chen, J.S.M. Peiris and Y. Guan (2006). Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam. Virology. 2006 Jul 5;350(2):258-68. (Epub 2006 May 19).




  1. Cheung C. L., J. M. Rayner, G. J. D. Smith, P. Wang, T. S. P. Naipospos, J.  Zhang, K. Y Yuen, R. G. Webster, J. S. M. Peiris,Y Guan, and H. Chen* (2006). Distribution of Amantadine-Resistant H5N1 Avian Influenza Variants in Asia. The Journal of Infectious Diseases   Vol. 193:1626-1629.




  1. Chen H, G. J. D. Smith, K. S. Li, J. Wang, X. F. Fan, J. M. Rayner, J Zhang, D. Vijaykrishna, C. T. Guo, C. L. Cheung, K. M. Xu, L. Duan, K Huang, K. Qin, Y. H. C. Leung, W. L. Wu, H. R. Lu, Y. Chen, N. S. Xiao, T. S. P. Naipospos, S. S. Hassan, T. D. Nguyen, L. J. Zhang, K. Y. Yuen, R. G. Webster, J. S. M. Peiris & Y. Guan (2006). Establishment of multiple sub-lineages of H5N1 influenza virus in Asia – implications for pandemic control. Proc. Nat. Acad. Sci. USA. Vol. 103: 2845-2850.




  1. Wang, M, M. Yan, H. Xu, W. Liang, B. Kan, B. Zheng, H. Chen, H. Zheng, Y. Xu, E. Zhang, H. Wang, J. Ye, G. Li, M. Li, Z. Cui, Y-F. Liu, R-T. Guo, X-N. Liu, L-H. Zhan, D-H. Zhou, A. Zhan, R. Hai, D. Yu, Y. Guan and J. XU (2005). Molecular evidence for patient infected at a restaurant by SARS-CoV virus from palm civet. Emerging Infectious Diseases. Vol.11: 1860-1865.




  1. Webster, R. G., M. Peiris, H. Chen, Y. Guan (2006) The current situation of H5N1 outbreak and enzootic influenza. Emerging Infectious Diseases. Vol. 12: 3-8.




  1. Huang, J. G. Liao, H. Chen, F.Y. Wu, L. Hutt-Fletcher, G. Hayward and S.D. Hayward (2006). Contribution of C/EBP Proteins to Epstein-Barr Virus Lytic Gene Expression and Replication in Epithelial Cells. J. Virol. 80: 1098-1109.




  1. Woo, P. Y., S. K.P. Lau, H-W. Tsio, Y. Huang, R. W. S. Poon, C-M, Chu, R.A. Lee, W-K Luk, G. K. M. Wong, B.H. L. Wong, V. C. C. Cheng, B. S. F. Tang, A. K. L. Wu, R. W. H. Yung, H. Chen, Y. Guan, K-H. Chan and K-Y Yuen (2005). Clinical and Molecular Epidemiological Features of coronavirus HKU1-Associated Community-Acquired Pnemonia. J. Infectious Diseases. 192:1898-1907.




  1. Guan, Y and Chen, H (2005). Resistance to anti-influenza agents. Lancet 366(9492):1139-40.




  1. Butt, K. M., G. J. D. Smith, H. Chen, L.J. Zhang, Y H. C. Leung, K. M. Xu, W. Lim, R. G. Webster, J. S. M. Peiris and Y. Guan (2005). Human influenza with an avian H9N2 influenza A virus in Hong Kong in 2003. J. Clinical. Microbiology. 43(11):5760-67.




  1. Chen, H., G. J. D. Smith , S. Y. Zhang, K. Qin, J. Wang, K. S. Li, R. G. Webster, J. S. M. Peiris and Y. Guan (2005). Avian flu:  H5N1 virus outbreak in migratory waterfowl. Nature, 436, 191-192.| doi: 10.1038/nature03974.




  1. Cheung T.K.W, Y.Guan, S.S.F. Ng, H. Chen, C.H.K. Wong, J.S.M. Peiris and L.L..M Poon (2005). Generation of recombinant influenza A virus without M2 ion-channel protein by introduction of a point mutation at the 5’ end of the viral intron. J. Gen. Virol, 86: 1447-1454.




  1. Zhang B-J, Y. Guan, M-L He, H. Sun, L. Du, Y. Zheng, K-L Wong, H. Chen, L. Lu, J. A. Tanner, R. M. Watt, N. Niccolai, A. Berrnini, O. Spiga, P. CY. Woo, H-F. Kung, K.Y. Yuen and J-D. Huang. (2005). Synthetic peptide outside the spike protein heptad repeat regions as potent inhibitors of SARS-associated coronavirus. Antiviral Therapy, 10: 393-403.




  1. Chen, H., J. Huang, F. Wu, Lindsey Hutt-Fletcher and S. Diane Hayward.(2005). Regulation of Expression of the Epstein-Barr virus BamHI-A Rightward Transcripts. J. Virol. 79: 1724-1733.




  1. Li, K. S., Y. Guan, J. Wang, G . Smith, K. Xu, L. Duan, A. P. Rahaedjo, P. Puthavathana, C. Buranathai5 T. Nguyen, A. Estoepangeste, A. Chaisingh, P. Auewarakul, H. Long, N. Hanh, R. Webby, L. Poon, H. Chen, K. Shortridge, K. Yuen, R. Webster & J. Peiris (2004). Genesis of a Highly Pathogenic and Potentially Pandemic H5N1 Influenza Virus in Eastern Asia. Nature, 430(6996):209-13.




  1. Wang S, F. Wu, H. Chen, M. Shamay, Q. Zheng and Hayward GS (2004). Early activation of the Kaposi's sarcoma-associated herpesvirus RTA, RAP, and MTA promoters by the tetradecanoyl phorbol acetate-induced AP1 pathway. J. Virol., 78(8):4248-67.




  1. Wu, F. Y., S. E. Wang, H. Chen, L. Wang, S. D. Hayward, and G. S. Hayward(2004) CCAAT/Enhancer Binding Protein Binds to the Epstein-Barr Virus (EBV) ZTA Protein through Oligomeric Interactions and Contributes to Cooperative Transcriptional Activation of the ZTA Promoter through Direct Binding to the ZII and ZIIIB Motifs during Induction of the EBV Lytic Cycle. J. Virol. 78: 4847- 4865.




  1. J. Huang, H. Chen, L. Hutt-Fletcher, R. F. Ambinder and S. Diane Hayward (2003). Lytic Cycle of Epstein-Barr virus Contribute to the Detection of EBV in Breast Cancer Tissues. J. Virol. 77:13267-13274.




  1. Wu, F., S. E. Wang, Q-Qun Tang, M. Fujimuro, C-J. Chiou, H. Chen, S.D. Hayward, M. D. Lane and G. S. Hayward. (2003) Cell Cycle Arrest by Karposi’s Sarcoma-Associated(KSHV) Replication-Associated Protein(RAP) is Mediated at Both Transcriptional and Post-transcriptional levels by Binding to CCAAT/Enhancer-Binding Protein alpha and p21. J. Virol. 2003 77: 8893-8914.




  1. H. Chen, Lindsey Hutt-Fletcher, L. Cao, and D. S Hayward.(2003). A positive Autoregulatory Loop of LPM1 Expression and STAT Activation in Latently EBV Infected Epithelial Cells. J.Virol. 77(7):4139-4148.




  1. Wu, F. Y., H. Chen, S. Wang, S. G. Liao, M. Fujimuro, C. J. Farrell, J. Huang, S. D. Hayward and G. S. Hayward(2003).CCAAT/Enhancer Binding Protein a(C/EBP a) Mediates Zta-Induced p21CIP-1 Accumulation and G1 Cell Cycle Arrest During the Epstein-Barr Virus Lytic Cycle. J. Virol. 77(2):1481-500.




  1. Wu, F. Y., Q. Tang, H. Chen, C. ApRhys, C. J. Farrell, J. Chen, M. Fujimuro, S. Wang, S. D. Hayward, M. D. Lane, and G. S. Hayward. (2002). The Kaposi’s sarcoma-Associated Herpesvirus (KSHV) Lytic Replication-Associated Protein (ORF-K8) Cause- p21 mediated G1 Cell Cycle Arrest During Viral Lytic Phase Replication Through the Induction of CCAAT/enhancer-binding Protein a (C/EBPa) in Host Human Primary Effusion Lymphoma Cells (PEL) and Other cells. Proc. Natl. Acad. Sci. USA (2002), 99(16):10683-10688.




  1. Gao, Y.,Y-J. Lu, S-A. Xue, H. Chen, N. Wedderburn, and B.E. Griffin(2002). Hypothesis:a novel route for immortalization of epithelial cells by Epstin-Barr virus. Oncogene. 21:825-835.




  1. Cheng WM, K. Chan, H. Chen, R. Luo , S.P Ng, W. Luk, B.J. Zheng, M.F. Ji, J.S. Liang, J.S. Sham, D.K. ,Wang DK, Y.S. Zong, M.H. Ng.(2002). Assessing the risk of nasopharyngeal carcinoma on the basis of EBV antibody spectrum. Int. J. Cancer. 97(4):489-92.




  1. Zhang, J., H. Chen, G. Weinmaster and S. D. Hayward( 2001). The Epstein-Barr virus BamHI-A rightward transcript encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negative regulate the activity of EBNA2 and NotchIC. J. Virology(USA), 75(6):2946-2956.




  1. Chen, H., J. M. Lee, Y. Zong, M. H. Ng, M. Borowitz, R. Ambinder and S. D. Hayward (2001). A linkage between STAT regulation and Epstein-Barr virus gene expression intumors. J. Virology (USA), 75(6):2929-2937.




  1. Chen, H., J.M.Lee, Y.Wang, T, Hoey, D.P. Huang, R.F. Ambinder and S. D. Hayward(1999). The Epstein-Barr virus latency Qp promoter is positively regulated by STATs and Zta interference with Jak-STAT activation leads to loss of Qp activity. Proc. Natl. Acad. Sci. USA, 96:9339-9344.




  1. H. Chen, P.Smith, R. Ambinder and S. D. Hayward(1999). Expression of BamHI A rightward transcript(BART) in resting B cells in peripheral blood. Blood(USA), 93(9):3026-3032.




  1. Ng, M.H., H. Chen, R, Luo, K. Chan, P.Woo, J.S. Sham, J.Huang, W.H. Seto, P.Smith and B.E. Griffin.(1998). Serological diagnosis of nasopharyngeal carcinoma by enzyme linked immunosorbant assay: optimozation, standardization and diagnostic criteria. Chin. Med. J. (English), 111(6):531-536.




  1. Zhang, J., H. Chen, Y. Zong, J. Nicholls, J.S.T.Sham, B.E.Griffin and M.H.Ng.(1998). The Epstein-Barr virus expression within Keratinizing Nasopharyngeal Carcinoma. J. Med. Virology(USA), 55:227-233.




  1. Chan K.H., R. X. Luo, H. Chen, M.H.Ng, W. H. Seto, and J. S. M. Peiris(1998). Development and Evaluation of an Epstein-Barr Virus(EBV)Immunoglobulin M Enzyme-linked Immunosorbent Assay Based on the 18--Kilodaton Matrix Protein for Diagnosis of Primary EBV Infection. Journal of Clinical Microbiology(USA), Vol. 36(11):3359-3361.




  1. Chen, H., M.L.Lung, K.H.Chan, B.E.Griffin and M.H.Ng.(1996).Tissue Distribution of EBV Genotype. J. Virol.,(USA) 70: 7301-7305.




  1. Chen, H., Y.S.Zong, J.Sham, D.Choy and M.H.Ng(1995) Differential Prevalence of an EBV Genomic Variants in Nasopharyngeal Tissues and Exfoliated Cells From Throat Washing. The Chinese Journal of Microbiology and Immunology, 15(6):415-419.




  1. Chen, H., J. Sham, D. Choy and M.H.Ng(1995) Characterization of Epstein-Barr Virus Gene Expression in Nasopharyngeal Carcinoma. The Chinese Journal of Virology, 11:1-9.




  1. Ng. M.H., J. Sham, H. Chen, W. M. Yeung, C.C. Law, K.H.Chan, Y.S. Zong, B.E. Griffin, P.R.Smith, J.M. Nicholls and D. T. K. Choy(1993) Development of Nasopharyngeal Carcinoma: A Working Hypothesis. in T. Turz et al(eds)<<Epstein-Barr Virus and Associated Diseases>>Colloque INSERM, 225: 497-506.




  1. Griffin, B.E., P.Smith, L. Karran, D. Snudden, Y. Gao, H. Chen and M.H.Ng (1993) EBV and Nasopharyngeal Carcinoma. in T.Turz et al(eds.)<<Epstein-Barr Virus and Associated Diseases>>Colloque INSERM, 225:457-465.




  1. H. Chen, M. L. Lung, B.E. Griffin and M.H.Ng(1992) Transcription of BamHI A region of the EBV genome in NPC tissues and B cells. Virology (USA) ,191:193-201.



Patent


Co-inventors: Mun Hon Ng, Honglin Chen, Park Ng and Kow-Hong-Chan.

Newly-inventive enzyme-linked immunosorbent assay kits produced with Epstein-Barr virus recombinant peptides for serological diagnosis of nasopharyngeal carcinoma and other Epstein-Barr virus associated tumors.



Book chapters:


  1. Guan Y, Field H, Smith GJD, Chen H (2005). SARS Coronavirus – an animal reservoir? In Severe Acute Respiratory Syndrome (eds JSM Peiris, LJ Anderson, ADME Osterhaus, K Stohr & KY Yuen), Blackwell Publishing.




  1. Guan Y, Zhong NS, Chen H, Smith GJD, Zhang BJ (2006). An Averted SARS Outbreak. Chapter 6, In JCK Chan & VCW Taam Wong (eds) Challenges of Severe Acute Respiratory SyndromeElsevier. P:93-100.


Conferences/Symposium:


  1. Chen H (2011) “From SARS to bird flu-understanding the natural reservoir and mediator of wildlife borne diseases”. << Workshop on Wildlife-Borne Diseases Control and Management in Asia-Pacific Region>> , August 29-30, 2011,Beijing China. (Invited speaker)

  2. Chen H (2011) “The roles of viral determinants and host factor regulation in influenza A virus pathogenesis”. <<Recent Advance in Pathogenic Human Viruses>> , The American Society for Biochemical and Molecular Biology (ASBMB) special symposium, July 25-26, Guangzhou, China.




  1. Chen H (2010) “Regulation of influenza virus replication: the role of host factors”. <>, Chang Guan University, Taiwan, December 3-4, 2010. (Invited Speaker)




  1. Chen H (2009) “ Molecular basis of influenza virus antigenic variations: antigenic profiling of avian H5N1 virus with monoclonal antibodies”. 3rd Annual CEIRS Network Meeting, June 22-25, 2009, University of Minnesota, Minneapolis, USA.


  1. Chen H,“Identification and characterization of host factors interacting with influenza virus”. <>, June 5-7, 2009 Shantou University, China.



  1. Chen H (2008). “EBV modulates STAT signalling in Nasopharyngeal Carcinoma” in AACR <>, December 2008, Hong Kong. Invited speaker.




  1. Rayner JM, Zhang J, Smith J, Wu W, Lau S, Zhao P. M. Peiris, Y. Guan and H. Chen (2007). Naturally occurring antiviral drug resistance in avian H5N1 virus. In: Katz JM, edits. Options for the control of influenza. International Medical Press; 2007. p. 154–6.




  1. Cheung Cl, D Vijaykrishna1, GJD Smith, J Bahl, XH Fan, JX Zhang, H Chen, Y Guan (2007) Establishment of Influenza A Virus (H6N1) in Minor Poultry in Southern China In: Katz JM, edits. Options for the control of influenza. TorontoInternational Medical Press; 2007. p. 110–112.




  1. Smith GJD, XH Fan, KS Li, H Chen, JSM Peiris, Y Guan (2007)Ecology and Evolution of Influenza A (H5N1) Virus in Asia: Evidence From Systematic Influenza Surveillance。 In: Katz JM, edits. Options for the control of influenza. TorontoInternational Medical Press; 2007. p.128-130




  1. Xu KM, JX Zhang, D Lian, GJD Smith, JSM Peiris, H Chen, Y Guan (2007). Evolution of H9N2 Influenza A Viruses in Quail From Southern China. In: Katz JM, edits. Options for the control of influenza. TorontoInternational Medical Press; 2007. p.131-134.




  1. Duan L, L Campitelli, GJD Smith, J Bahl, I Donatelli, RG Webster, KF Shortridge, JSM Peiris, H Chen, Y Guan (2007). Characterization of Low Pathogenic H5 Subtype influenza Viruses From Eurasia: Implications for the Origin of Highly Pathogenic H5N1 Viruses. In Katz JM editsOptions for the control of influenza. TorontoInternational Medical Press; 2007. p.135-138.




  1. Zhang Z, X. Fan, J Zhang, K Huang, D Luo, Z Feng, M Wei, J M Rayner, K-S Li, WF Ng, Y Guan, H Chen (2007). Expression of Avian Influenza Virus Receptors and H5N1 Virus Infection in Human Respiratory Tract. In Katz JM editsOptions for the control of influenza. TorontoInternational Medical Press; 2007. p.66-68




  1. “Antigenic Profiling of Avian H5N1 Influenza Virus in Asia from 2002-2007” X International Symposium on Respiratory Viral Infections, March 2008, Singapore.




  1. “Antiviral drug resistance in H5N1 avian influenza virus”. Options for the control of influenza V, Toronto, June 17-23, 2007.




  1. “Antigenic Profiling of H5N1 avian influenza virus”. Options for the control of influenza V. Toroto, June 17-23, 2007.




  1. “Distribution of avian influenza receptors in human respiratory tract”. Options for the control of influenza V. Toronto, June 17-23, 2007.




  1. “Avian influenza and the resistance of antiviral agents” Centre for Health Protection, Department of Health, Hong Kong SAR. January 21 2006. Invited speech “Mutations and resistance in H5N1 influenza virus”




  1. VIII International Symposium on Respiratory Viral Infectious Diseases. Oral presentation “Anti-viral drug resistance in avian H5N1 viruses circulating in southeast Asia”. March 15-19, 2006, Hapuna Beach Prince Resort, The Big Island, Hawaii, USA




  1. Chen H “The role of market wild animals in mediating SARS outbreaks in Guangdong”. In the “International Symposium on Recent Advances in Molecular, Clinical and Social Medicine” organised by The University of Manitoba and the Shantou University in Shantou, China from 3 – 5 Dec 2005.




  1. “WHO Working Group on Influenza Research at the Human/Animal Interface” organised by WHO in Malta on 11 Sep 2005. Invited speech “ Outbreak of H5N1 virus in migratory birds in Qinghai lake“”.




  1. "亞熱帶地區新發傳染病應對策略高峰論壇" organised by Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control in Guangxi, China, 15 Jun – 18 Jun 2005. invited speech “ Market wild animals and SARS outbreak in Guangdong in 2002/2003”

Before 2003,


(1) Chen, H., P. Smith, D. Snudden, Y. Gao, B. E. Griffin and M. H. Ng Transcription of

Latent Membrane Protein (LMP) and Terminal Protein (TP) in Nasopharyngeal

Carcinoma. <<5th International Symposium on EBV and Associated Diseases>> French

1992, Abstract Book: 171.




  1. Smith, P.R., H.Chen, Y.Gao, L.Karran, D.Snudden, M.H.Ng and B.E. Griffin Characterization of the Family of BamHI A mRNA Transcripts in Nasopharyngeal Carcinoma (NPC), Identification of A Promoter for the Major 4.8 KB mRNA Species. <<5th International Symposium on EBV and Associated Diseases>> French 1992, Abstract Book: 119.




  1. Chen, H., H.Chiu, D.Choy, J.Sham, Y.Zong and M.H.Ng (1994) Evaluation of Epstein-Barr Virus Gene Expression and Genotypes as a Marker for Early Detection of NPC or Prediction of Localized NPC Relapse. <<Third Asia-Pacific Congress of Medical Virology>> Beijing, China, Abstract book: 167.




  1. Chen. H., M.L.Lung, K.H.Chan, J.Sham, B.E.Griffin and M.H.Ng (1996). Tissue Specific Distribution of EBV<< 7th International EBV Symposium>> November 13-16,1996, Hong Kong. Abstract book: p152.




  1. Zhang, JX. H.Chen, Y.S.Zong, K.H.Chan, J.Nicholls, J. Middeldorf, B.E. Griffin and M.H.Ng(1996) EBV Life Cycle Association With Epithelial Cell Differentiation. <<7th International EBV Symposium>>November 13-16,1996, Hong Kong. Abstract book: p155.




  1. Gao, Y., H.Chen, M.H.Ng, N. Wedderburn and B.E.Griffin (1996). EBV Genes associated With the Immortalization of Epithelial Cells. <<7th International EBV Symposium>>November 13-16,1996, Hong Kong. Abstract book: p150.



  1. Chen, H, P.Smith, R.Ambinder and S. D. Hayward. Expression of BamHI-A Rightward Transcripts (BARTs) in Resting B Cells of Peripheral Blood. <<8th International EBV Symposium>> 1998, Sweden p48.



  1. Chen, H., J. Lee, Y. Wang, T. Hoey, D. Huang, R. Ambinder and S.D. Hayward. The EBV Latency Q Promoter is Positively Regulated by the JAK-STAT Pathway and Zta Interferes with JAK-STAT Activation. <<24th International Herpesvirus Workshop>> July 17-23, 1999, Boston, USA. Abstract book: 2.001.



  1. Chen, H., J. M. Lee, Y. Zong, M. Borowitz, R. Ambinder and S. D. Hayward. STATs regulate latency promoters in EBV-associated tumors. <




  1. H. Chen, L.Cao and S.D.Hayward. Self-sustaining LMP1 expression via IL-6 induction of STAT3 and STAT5. 10thInternational symposium on Epstein-Barr virus and associated diseases. section 15, p94. 2002, July 17-21, Cairns, Austrlia



  1. J. Huang, H.Chen, L. Hutt-Fletcher and S.D. Hayward. EBV and Breast Cancer: Association Without Causality? 6th International Conference on Malignancies in AIDS and Other Immunodeficiencies: Basic, Epidemiological and Clinical Research 2002, April 22-24, Bethesda, Maryland, USA.

(12) H. Chen, F. Y. Wu, J. Huang, P.R. Smith, and S.D. Hayward. Regulation of Expression of the Epstein-Barr Vrus BamHI-A Rightward Transcripts( BARTs). 28th International Herpesvirus Workshop. Madison, Wisconsin, USA, July 26-31, 2003. P10.16.








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