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Bangalore karnataka completed proforma for registratation of subject for dissertation


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RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES

BANGALORE – KARNATAKA

COMPLETED PROFORMA FOR REGISTRATATION

OF SUBJECT FOR DISSERTATION

A COMPREHENSIVE CLINICAL STUDY ON

MEDASAKA [LITSEA GLUTINOSA Lour.] WITH SPECIAL REFERENCE TO

JANU SANDHIGATA VATA



BY

DR.SOUMYA P.K

M.D. (AYU) SCHOLAR,

DEPT. OF P.G. STUDIES IN DRAVYAGUNA,

S.D.M. COLLEGE OF AYURVEDA,

KUTHPADY, UDUPI-574118


GUIDE:
DR. T. SHRIDHARA BAIRY,

M.D. (AYU), G.A.U.

ASST. PROFESSOR,

DEPT. OF P.G. STUDIES IN DRAVYAGUNA,

S.D.M. COLLEGE OF AYURVEDA,

KUTHPADY, UDUPI-574118



S.D.M. COLLEGE OF AYURVEDA,

KUTHPADY, UDUPI - 574118


KARNATAKA
2007-2008

From

Dr. Soumya P.K

M.D. Scholar,

Dept of P.G. studies in Dravyaguna,

S.D.M. College of Ayurveda,

Kuthpady,Udupi-574118



To

The Registrar,

Rajiv Gandhi University Of Health Sciences,

Bangalore, Karnataka


Through,

The Principal,

S.D.M.College of Ayurveda,

Kuthpady ,Udupi.- 574118

Respected sir,


Sub: Submission of completed proforma for registration of subject for Dissertation.
I request you to kindly register the below mentioned subject against my name for the submission of dissertation to the Rajiv Gandhi University of Health Sciences, Bangalore, for the partial fulfillment of M.D. (Ayu) in Dravyaguna.


TITLE OF DISSERTATION:


A COMPREHENSIVE CLINICAL STUDY ON MEDASAKA (LITSEA GLUTINOSA Lour.)
WITH SPECIAL REFERENCE TO JANUSANDHI GATA VATA.

Here with I am enclosing completed proforma for registration of subject for dissertation.

Thanking you,

Place: UDUPI Yours Sincerely,

Date : (SOUMYA P.K.)


  1. Name of the candidate : DR. SOUMYA.P.K.


Address (in block letters ) : M..D. SCHOLAR

DEPT. OF P.G. STUDIES IN DRAVYAGUNA,

S.D.M. COLLEGE OF AYURVEDA,

KUTHPADY, UDUPI -574118.




Permanent Address : SOUPARNIKA

ANJUKUNNU (P.O)

MANANTHAVADY

WAYANAD


KERALA

  1. Name of the institution : S.D.M. COLLEGE OF AYURVEDA,

KUTHPADY, UDUPI – 574118.


  1. Course of study and subject : M.D. (AYU ) IN DRAVYAGUNA.


  1. Date of admission of course : 11th JUNE 2007

5.Title of the Topic :

A COMPREHENSIVE CLINICAL STUDY ON MEDASAKA (LITSEA GLUTINOSA Lour.)


WITH SPECIAL REFERENCE TO JANUSANDHI GATA VATA.

6.Brief resume of intended work :-
6.1 Need for study :-
Ayurveda the science of life covers not only the knowledge of life but also deals about healthy living and longevity. It basically relates the life of an individual with universe. The human race has been in pursuits of remedies for its ailments since time immemorial.

rÉÉåaÉqÉÌmÉcÉÉæwÉkÉqÉåuÉqÉç mÉUϤÉãiÉ | CSqÉåuÉÇ UxÉ uÉÏrÉï ÌuÉmÉMüqÉåuÉÇ aÉÑhÉqÉåuÉÇ SìurÉqÉåuÉÇ MüqÉïqÉåuÉÇ

mÉëpÉÉuÉqÉÎxqÉlÉ SåzÉ..........................(Acarya Vagbhata)

Vagbhata explains that if a drug is found suitable still it should be examined to

determine its rasa, virya, vipaka, guna ,karma, prabhava, procedure of use, dosage, and type of patient for whom it is meant.

The drug Medasaka (Litsea glutinosa Lour.) which is available in Udupi and it has been successfully used by folklore practitioners both externally and internally in the management of fracture , joint disorders, diarrhoea, dysentry and as a general tonic.

Janusandhi (Knee joint) is the largest and most complex synovial joint of the body and is a great importance. Janusandhigata vata (Osteoarthitis knee) is a vata vyadhi dominated by pain, swelling and stiffness. This is prevalent nowdays because of modern life style and food habits.

The root bark, stembark and leaf are proved for its anti inflammatory and analgesic activity on experimental animals (Menon Saritha et al., 2007). By looking this preclinical results we planned to evaluate the effect of stembark and leaf in the management of Janusandhigata vata.


6.2. Review of Literature:

The drug Medasaka (Litsea glutinosa Lour.) is been used by various folklore practitioners in various ailments as per the information collected from Folklore Medicine Research Centre, SDMCA Udupi. There is no reference of Medasaka observed in Samhitha, Purana and Veda. Botanical description, properties and therapeautic uses of Litsea glutinosa mentioned in recent books (Kirtikar, K. R. & Basu, B. D., 1933, Nadkarni, K. M. 1979, Bhat, Gopalakrishna K., 2003 ).

A study on anthelminthic activity against earthworm and tapeworm by using essential oil from Litsea glutinos (Mishra, et al., 1979).

A study on hypotensive effecting anasthetized dogs in a dose of 125mg/ kg by using essential oil obtained from Litsea glutinosa (Kar, et al., 1970). Acarya Susruta has mentioned Janusandhi as kora sandhi among the 8 type of sandhi and also mentioned sandhigata vata.( Acarya Susruta). In Caraka Samhitha Janu pramana and the disease Sandhigata vata mentioned under Vatavyadi ( Acarya Agnivesa).



6.3 Objective of study


  • Research updates on the drug Medasaka (Litsea glutinosa Lour).




  • Clinical study to evaluate the efficacy of stem bark powder orally and external application of leaf powder paste in Janusandhigata vata (Osteoarthritis Knee).


7. Materials and Methods:-

7.1 Source of data:


  • Literary and update research information of Medasaka (Litsea glutinosa) will be

collected from the folklore and other literatures.

  • The plant material the stem bark and leaf of Medasaka will be collected in and around Udupi.

  • A minimum of 20 patient of age group above 30yrs fulfilling the inclusive criteria will be selected for the clinical study from the OPD/IPD of SDM Ayurvedic Hospital Udupi.



7.2 Method of collection of the data:
Clinical study


  • It is single blind clinical study with pretest and post test design.




  • Patient of either sex will selected randomly.




  • A special proforma containing details necessary for the subject will be prepared.




  • Necessary investigation will be carried out.



Materials used;

Oral administration;


  • Tablet: Prepared with stembark powder of Medasaka with hot water.



External application


  • Pradeha: Leaf powder paste is prepared with hot water and applied over the joint.


Duration & Dose;



  • 15days.




  • Tab: 1tid with hot water orally ( 1tab =500mg).




  • Pradeha 10gm/ day.


Inclusion criteria.



  • Patient with Pratyatma lakshana of Janusandhigata vata.




  • Patient in the age group of above 30yrs.


Exclusion criteria;


  • Reactive arthritis.




  • Patient suffering from Sandhigata vata as Upadrava of Amavata , Vatarakta and Phiranga.




  • Malignant condition.






Assessment criteria :
The patient’s response will be assessed on Subjective and Objective parameters.

  • Pain.

  • Tenderness.

  • Swelling.

  • Tempearture.

  • Crepitus.

  • Range of Movement, will be assessed on the basis of standard parameters.



7.3 Investigations :-

Hb%, TC DC. ESR, RA factor.

X-ray knee.

Intervention:

Tablet prepared with stembark powder of Medasaka will be given with hot water

orally.
Leaf powder paste of Medasaka prepared with hot water (pradeha) for external

application.


7.4. Has ethical clearance has been obtained from institution in case of 7.3?
Yes.

8. List of References:-

Acarya Vagbhata, Ashtanga samgraha vol-1 published by charu printers golghar, translated

by Shrikanth murthy Chaukamba orientalia, Varanasi. first Edition 1995 pg411.
Kirtikar, K.R. & Basu, B. D., Indian Medicinal plants vol-3 published at Alhabad by

Lalit Mohan Basu 2nd edition sept 1933 pg 2157-2161.

Nadkarni, K.R., Indian Materia Medica,Vol.-I, by Bombay Popular Prakashan, 3rd

edition – 1954, pp: 1319 pg-749

Bhat, Gopalakrishna K., Flora Of Udupi, Published by Indian Naturalist (Regd) Udupi, 2003.

pg : 544-545


Mishra, et al., Antihelminthic activity of essential oil of Litsea glutinosa 1979. Dravya guna

vijnana vol-2 by Dr.Shastry JLN forword by Prof;K.C Chunekar 1st edition 2004 Chaukamba orientalia , Varanasi U.P.pp 1134 pg 921.


Kar, et.al Hypotensive effect of the essential of Litsea glutinosa 1970.Dravya guna vijnana

vol-3 by Dr. Shastry JLN forworded by Prof. K.C Chunekar 1st edition 2004

Chaukamba orientalia , Varanasi, U.P.pp 1134. pg 921.
Acarya Susruta, Susruta samhitha with Nibandha sangraha commentary of Acharya

Dalhana; edited by Vaidya Yadavji Trikamji Acarya 7th edtion chaukamba orientalia Varanasi 2002 pp824. pg no; 367(shareerasthana 5/27) pp824 pgno;261( Nidanasthana 1/ 28).

Acarya Agnivesa, Caraka samhitha with Ayurveda deepika commenty of Chakrapanidutta

edited by Vaidya Yadavji Trikamji Acarya 5th edition Chaukamba orientalia Sanskrit sansthana , Varanasi. 2001. pp738 pgno279( vimanasthana 8/117) pg no;618, (chikitsasthana 28/ 37).


Menon Saritha , Srikanth P & Bairy T.S., 2007, A pharmacognostic & Experimental study on

Medasaka w.s.r. to its sothahara & vedanasthapana karma. The dissertation submitted to RGUHS Bangalore from Dept. of Dravyaguna, SDM College of Ayurveda Udupi.

9. Signature of the Candidate :


10. Remarks of the Guide :

11. Name and Designation :
11.1. Guide : DR. T. SHRIDHARA BAIRY

M.D. (AYU), G.A.U.

ASST. PROFESSOR,

DEPT. OF P.G. STUDIES IN DRAVYAGUNA,

S.D.M. COLLEGE OF AYURVEDA,

KUTHPADY, UDUPI - 574118.

Signature :

11.2 Head of the Department : DR.SETHU MADHAVA MURTHY

M.D (Ayu)

H.O.D. & PROFESSOR,

DEPT. OF P.G. STUDIES IN DRAVYAGUNA,

S.D.M. COLLEGE OF AYURVEDA,

KUTHPADY, UDUPI - 574118.
Signature :


12.1 Remarks of the Chairman :

and Prncipal
Signature :


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