1. Personal Name

Curriculum Vitae

Name : Hicham Hussein Khodr

Date of Birth : 6 February 1963

Sex: Male

Status: Married

Nationality: British

69 Millet Road

Greenford, Middlesex,

London UB6 9SH, UK .

Email hicham_khodr@hotmail.com

Web site: http://www.hichamkhodr.synthasite.com/

C/O Mrs Noha Khodr,

Aljazeera Channel,

PO Box 23123,

Doh, Qatar.

Tel +97455927283

Kalmoon, North Lebanon, Lebanon

Department of Chemistry

University of Mousel, Mousel, Iraq.

Thesis title : ³¹P NMR studies of phosphorus containing biomolecules

(Superviser Prof. G. R. Moore)

School of Chemical Sciences,

University of East Anglia, Norwich, UK.

1988 - 1992: Ph.D.

Thesis title : ¹H and ³¹P NMR studies of small molecules and their interaction with

proteins. (Superviser Prof. G. R. Moore)

School of Chemical Sciences,

University of East Anglia, Norwich, UK.

3. Work Experience
1993 – 2003: Postdoctoral Research Fellowship

Research Topic (physical-chemical characterization of metal chelators). Pharmacy Department,

King’s College London.
2003-2005: Senior Scientist at MedPharm Company, King’s College London:

Research involved : physical-chemical characteristion of therapeutic ligands and drug formulations for different delivery systems.

Department.

collaboration with the Imperial College London, Department of

Material Sciences and University of West Sydney, Australia.
2012-up to present : Part time staff, Qatar University Department of Chemistry.


4. Professional Membership
1986-1992 Member of the royal society of Chemistry.

1988 – 1995 Member of Inorganic Biology Discussion Group (ibdg)

5. Languages

• 
  Since completing my Ph.D. I have been involved, in the application of computers to develop a fully automated system to characterize ligands by measuring the ionization constants (pK_a), affinity constants () with a range of metals and partition coefficients (Kpart). This automated system I designed has been developed to simultaneously obtain the spectrophotometric and potentiometric titration data as well as the kinetic data, where over this period of time, I have been focusing on the development and designing of novel compounds for metal chelation therapy.
  

• 
  During my Ph.D. and MSc. programme, I was involved in the application of spectroscopy techniques and in particular NMR for characterising and identifying compounds under investigation in solid and in solution state. In addition, I have developed software to simulate solid state NMR spectra. Furthermore, I used the solid state NMR technique to investigate the polymorphism of the lyophilized form of phosphorus compounds.
  

• 
  I have extensive experience with molecular modeling, particularly the HyperChem software release 2 for Silicon Graphics. Interested in molecular graphics (MD, MM) for understanding size and physical properties of drug delivery systems. Furthermore, I gained a considerable experience in HPLC, Drugs Formulations, TGA and DSC.
  

• 
  Academic supervision
  
  • 
    Joint supervision of Ph.D. and M.Sc. Students.
    
  • 
    1993-1996 Lotfollah Dehkordi PhD;
    
  • 
    1994 - 1997 Majed Moridani PhD;
    
  • 
    1995 - 1998 Zu Dong Liu PhD;
    
  • 
    1997-1998 Karen Pleban (Vienna) M.Pharm; Ruth Michaelis (Frankfurt) M.Pharm.
    
  • 
    1998-2000 Lubna Baydoun PhD; Feluke Fakorede PhD.; Sirivipa Piyamongkol PhD; Mutlu Aytemir ( Istanbul) Ph.D.
    

• 
  1999 - 2000 Contract work for Strakan involving the physical chemistry of zinc clindamycin phosphate complexes.
  

• 
  Teaching experience
  

• Computing experience

  • 
    Computer programming using various languages including (Basic, Visual Basic,
    
  • 
    FORTRAN, Pascal).
    

1. 
   H. H Khodr, G R Moore, A J Strike and D Williamson, ‘Solid-State and Solution-State ³¹P Nuclear Magnetic Resonance Studies of the Heamoglobin-Inositol Hexaphosphate, Biomedical Society Transactions, 16, 839-840, (1988).
   

2. 
   S. Singh, H. Khodr, M. I. Taylor and R. C. Hider, “Therapeutic iron chelators and their potential side-effects”, Biochem. Soc. Symp. 61, 127 - 137, (1995).
   

3. 
   Anne-Kathrin Duhme, Robert C. Hider & Hicham Khodr, “Spectrophotometric Competition Study between Molybdate and Fe(III) Hydroxide on N,N’-bis(2,3-Dihydroxybenzoyl)-L-lysine, a naturally occuring siderophore synthesized by Azotobacter vinelandii”, Biometals, 9, 245-248, (1996).
   

4. 
   G. Paganga, H. Al-Hashim, H. Khodr, B. C. Scott, O. I. Aruoma, R. C. Hider, B. Halliwell, C. A. Rice-Evans, “Mechanisms of Antioxidant Activities of Quercitin and Catechin”, Redox Report, 6, 359-364, (1996).
   

5. 
   Anne-Kathrin Duhme, Robert C. Hider & Hicham Hussein Khodr, “Synthesis and iron-binding properties of protochelin, the tris(catecholamide) siderophore of Azotobacter vinelandii”, Chem. Ber., 130, 969 - 973 (1997).
   

6. 
   Reem Kayyali, Ananth Sekher Pannala, Hicham Khodr, Robert C Hider, “Comparative radical scavenging ability of bidendate iron(III) chelators, Biochem. Pharmacol. 55, 1327 – 1332, (1998).
   

7. 
   Bijaya L Ray, Lotfullah S Dehkordi, Hicham Khodr, Yi Jin, Zudong Liu and Robert C Hider “ Synthesis, Physical Chemical Properties and Evaluation of N-Substituted 2-Alkyl-3 Hydroxy 4(1H) -Pyridinones”, J. Med. Chem. 41, 3347 – 3359, (1998) .
   

8. 
   Jonathan E Brown, Hicham Khodr, Robert C Hider and Catherine A Rice-Evans, “Structural-Dependence of Flavonoid Interactions with Copper Ions: Implications for their Antioxidant Properties”, Biochemical Journal, 330, 1173 – 1178, (1998).
   

9. 
   Hider R. C., Khodr H.H, Zu-Dong Liu & Tilbrook G., “Optimization of pFe³⁺ values of Iron(III) ligands with clinical potential”, Metal Ions in Biology and Medicine, 5, 51-57, 1998.
   

10. 
    Bijaya L. Rai, Hicham Khodr and Robert Hider, “Synthesis, Physico-Chemical and Iron(III)-Chelating properties of Novel Hexadentate 3-Hydroxy-2(1H)pyridinone Ligands”, Tetrahedron 55, 1129 - 1142, (1999).
    

11. 
    Zu D. Liu, Hicham H. Khodr, Ding Y. Liu, Shu L. Lu and Robert C Hider, “Synthesis, physicochemical characterisation and biological evaluation of 2-(1’-hydroxyalkyl)-3-hydroxypyridin-4-ones: Novel iron chelators with enhanced pFe³⁺ values”, J. Med. Chem. 42, 4814-4823, (1999).
    

12. 
    Mark D. Hadgood, Zu Don Liu, Lotfollah S. Dehkordi, Hicham H. Khodr, Joan Abbott and Robert C. Hider, "Investigating in the correlation between the structure of hydroxypyridinones and blood-brain barrier permeability", Biochemical Pharmacology, 57, 1305 - 1310, (1999).
    

13. 
    Nicolaus von Wiren, Suhkbinder Klair, Suhkibar Bansal, Jean-Francois Briat, Hicham Khodr, Takayuki Shioiri, Roger A. Leigh and Robert C. Hider, " Nicotianamine chelates both FeIII and FeII. Implications for metals transport in plants", Plant Physiology, 119, 1107-1114, (1999).
    

14. 
    Zu D. Liu, Hicham H. Khodr, Shu L. Lu and Robert C Hider, “Design, synthesis and evaluation of N-Basic Subsitituted 3-Hydroxypyridin-4-ones: Orally active iron chelators with lysosomotrophic potential”, J. Pharm. Parmacol. 52, 263-272, (2000.)
    

15. 
    Robert C. Hider, Zu D. Liu and Hicham H. Khodr, ”Metal chelation of polyphenols”, Methods in Enzymology, 335, 191-203, (2001).
    

16. 
    R. C. Hider and H. Khodr, "Aqueous iron chelation chemistry relevant to plant mineral nutrition", Plant and Soil, 2001 (in press).
    

17. 
    Zu D. Liu, S. Piyamongkol, Ding Y. Liu, Hicham H. Khodr, Shu L. Lu and Robert C Hider, "Synthesis of 2-amido-3-hydroxypyridin-4(1H)-ones: Novel iron chelators with enhanced pFe³⁺ values", Bioorganic & Medicinal Chemistry, 9, 563-573 (2001).
    

18. 
    Majid Y. Moridani, Gary S. Tilbrook, Hicham H. Khodr and Robert C. Hider, " Synthesis and physico-chemical assessment of novel 2-substituted-3-hydroxypyridin-4-ones, novel iron chelators.", Eur. J. Med. Chem. 2001.
    

19. 
    Nicolaus von Wiren, Hicham Khodr and Robert C. Hider, "Hydroxylated phytosiderophore species possess an enhanced chelating efficiency and affinity for iron(III).", Plant Physiology 124, 1149-1157, 2000.
    

20. 
    Ben Forbes, Hicham Khodr, Alison Lansley, “Differences in ­₂-agonist transport
    

21. 
    Zu D. Liu, Ruth Michaelis, Sue Moody-Haupt, Hava Glickstein, Hicham H. Khodr,
    

Antimalarials", Journal of Clinical Virology, 16, 89, (2000).

22. 
    H. H. Khodr, R. C. Hider and A.-K Duhme-Klair, “The iron-binding properties of aminochelin, the mono(catecholamide) siderophore of Azotobacter vinelandii”, J Biol. Inorg. Chem.7, 891-896 (2002).
    

23. 
    Etsuro Yoshimura, Zu Dong Liu, Hicham Khodr and Robert C. Hider, “Purity of Commercial morin products and their spectrophotometric chrarcterisation”, The Japan Society for Analytical Chemistry, 51, 979-982 (2002).
    

24. 
    Elizabeth A Lewis, Hicham H. Khodr, Robert C. Hider John R. Lindsay Smith and Paul H. Walton, “A manganese superoxide dismutase mimic based on cis, cis-1,3,4-triaminocyclohexane”, Dalton Trans, 187, 187-188 (2004). And “Novel enzyme mimic could be used to help treat inflammatory diseases, Taking the danger out of breathing”, Chemistry World”, 1, 15, (2004).
    

25. 
    Robert C. Hider, Etsuro Yoshimura, Hicham Khodr and Nicolaus von Wiren” Competition or complementation: the iron-chelating abilities of nicotianamine and phytosiderophores”, New Phytologist, Letter ,164, 204-208, (2004).
    

26. 
    Sirivipa Piyamongkol, Tao Zhou, Zu D. Liu, Hicham H. Khodr and Robert C. Hider, “Design and characterization of novel hexadentate 3-hydroxypyridin-4-one ligands”, Tetrahedron Letters, 46, 1333-1336, (2005).
    

27. 
    Reem Kayyali, Patricia Evans, Catherine J. Waterfield, Hicham Khodr, Hendrik Neubert, Lakshmi D. Devanur and Robert C. Hider “The Fenton-like activity of iron(III) in the presence of 3-hydroxy- pyridin-4-ones and its effect on intracellular glutathione levels”, For Submission to Biochemical Pharmacology.
    

• 
  H Khodr, F Kadir & G R Moore, “Chemical and spectroscopic analysis of ferritin and bacterioferritin, Inorganic Biochemistry Discussion Groups (IBDG), University of East Anglia, Norwich, 1990
  

• 
  H Khodr & G R Moore “NMR studies of the transport of small molecules across the protein shell of ferritin, Inorganic Biochemistry Discussion Groups (IBDG), University of East Anglia, Norwich, 1990.
  

• 
  G S Tilbrook, H H Khodr, P D Taylor and R C Hider “The Study of the Physical Properties of Hexadentate and Bidentate Ligands as Potential Therapeutic Iron Chelating Agents”, LogP an International Symposium on Lipophilicity in Drug Research and Toxicology, Lausanne, March, 1994.
  

• 
  H Khodr, B Rai, L Dehkordi & R Hider, “ Physical-Chemical Characterization of Iron Chelator”, European Iron Club, Hamburg, 1995.
  

• 
  M Y Moridani, R C Hider & H Khodr,, “Synthesis and Evaluation of 3-Hydroxy-pyridin-4-one (HPO) Chelators”, European Iron Club, Hamburg, 1995.
  

• 
  Hicham H Khodr, Gary S Tilbrook, Robert C Hider, “The Development of an Automated System for the Determination of Physico-Chemical Constants of Ionizable Species”, British Pharmaceutical Conference, Scarborough, 1997.
  

• 
  Khodr H. H., Tilbrook G. S. & Hider R. C., “The Methodology in Operating the Automated System for Characterising the Physical Chemical Properties of Ligands and Metal Complexes”, 5^th International Symposium on Metal Ions in Biology and Medicine, Neuherberg/Munich, May, 1998.
  

• 
  S. Piyamongkol, Z. D. Liu, H. Khodr and R. C. Hider, " Design of 3-Hydroxypyridin-4-one Chelators with High pFe³⁺ Values, British Pharmaceutical Conference, Eastbourne, 1998.
  

• 
  Z. D. Liu, S. Piyamongkol, H. Khodr and R. C. Hider, " Design of 3-Hydroxypyridin-4-one Chelators with High pFe³⁺ Values, The 2^nd International Conference on Thalassemia, China, 1998.
  

• 
  Z. D. Liu, H. Khodr, S. L. Lu, D. Y. Liu and R. C. Hider, " 2-(1'-Hydroxyalkyl)-3-Hydroxypyridin-4-one are Potent Iron Chelators, 9^th International Conference on Oral Chelation in the Treatment of Thalassemia and Other Diseases, Hamburg, 1999.
  

• 
  R. C. Hider, Z. D. Liu, S. Piyamongkol, H. Khodr and D. Y. Liu, " 2-Acetamido-3-Hydroxypyridin-4-ones: Novel Iron Chelators with Enhanced pFe³⁺ Values, 9^th International Conference on Oral Chelation in the Treatment of Thalassemia and Other Diseases, Hamburg, 1999.
  

• 
  R. C. Hider, Z. D. Liu, D. Y. Liu, H. Khodr and S. Piyamongkol, " The Design of Non-Toxic Orally Active Iron Chelators.", World Congress on Iron Metabolism BIOIRON'99, Sorrento, Italy, 1999.
  

• 
  Zu D. Liu, Ruth Michaelis, Sue Moody-Haupt, Hava Glickstein, Hicham H. Khodr, Ioav Z. Cabantchik, Robert C. Hider, " Basic 3-Hydroxypyridin-4-ones as Novel Antimalarials", Journal of Clinical Virology, 16, 89, (2000).
  

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