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黃奇英 (Chi-Ying F. Huang)


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黃奇英 (Chi-Ying F. Huang)


(112)台北市立農街二段155號圖資大樓623室

國立陽明大學生物藥學研究所 所長

臨床醫學研究所 合聘

生物醫學資訊研究所 合聘

醫學生物技術暨檢驗學系暨研究所 合聘

電話: 02-28267000分機7904/6047/6048
傳真: 02-28224045
手機: 0922292811
E-mail: cyhuang5@ym.edu.tw; cyhuang1963@yahoo.com.tw

Professional Experience


  • Professor and chairman in Institute of Biopharmaceutical Sciences, National Yang-Ming University (陽明大學臨醫所) (2011-present)

  • Join appointments: Institute of Clinical Medicine, Institute of BioMedical Informatics and Institute of Biotechnology in Medicine, National Yang-Ming University (陽明大學生藥所,生資所,醫技所合聘) (2007-present)

  • Associate Investigator in Institute of Cancer Research, National Health Research Institutes (國家衛生研究院癌症研究所) (2005-2007)

  • Associate Investigator in Division of Molecular and Genomic Medicine, NHRI (國家衛生研究院分子與基因醫學組) (2003-2005)

  • Adjunct Associate Professor in Department of Computer Science and Information Engineer, National Taiwan University (台灣大學資訊工程研究所) (2003-2009)

  • Adjunct Associate Professor in Institute of Biotechnology in Medicine and Institute of Bio-Pharmaceutical Sciences, National Yang-Ming University (陽明大學生物醫學技術研究所(2003-2007)及生物藥學研究所(2006-2007)

  • Adjunct Associate Professor in Graduate Institute of Life Sciences, National Defense Medical Center (國防大學生命科學研究所) (1999-2007)

  • Assistant Investigator in Division of Molecular and Genomic Medicine (National Health Research Institutes) (1998-2003)

  • Postdoctoral Fellow (Stanford University) (1994-1998) (Laboratory of James E. Ferrell, Jr.)

  • Ph.D. in Biochemistry and Biophysics (Iowa State University) (1988-1994) (Laboratory of Donald J. Graves)

  • Research Assistant in Institute of Botany (Academia Sinica) (1987-1988) (Laboratory of Li-Chun Huang)

  • Military Service (Taiwan) (1985-1987)

  • B.S. in Chemistry (Tunghai University) (1981-1985)



Honors


Leukemia Society of America Career Development Award (1998-1999)

Leukemia Society of America Fellowship (1996-1998)

Keystone Symposium Travel Award (1997)

Stanford Dean’s Postdoctoral Fellowship (1994-1995)

Graduate Research Excellence Award (Iowa State University) (1994)

The Honor Society of Agriculture (Gamma Sigma Delta) (1989)


Publications (2004-present)

  1. An-Chi Tien, Ming-Hong Lin, Li-Jen Su, Yi-Ren Hong, Tai-Shan Cheng, Yuan-Chii G. Lee, Wey-Jinq Lin, Ivan Still, and Chi-Ying F. Huang*. Identification of the substrates and interaction proteins of Aurora kinases from a protein-protein interaction model. Molecular and Cellular Proteomics 3, 93-104 (2004).

  2. Fu-Hsiung Chang, Chien-Hsin Lee, Ming-Ta Chen, Chun-Chen Kuo, Yi-Lin Chiang, Chi-Ying F. Huang, and Steve Roffler. Surfection: a new platform for transfected cell arrays. Nucleic Acids Res. 32, e33 (2004).

  3. Jung-Mao Hsu, Yuan-Chii G. Lee, Chang-Tze R. Yu, and Chi-Ying F. Huang*. Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated HURP proteolysis by proline-rich region. J. Biol. Chem. 279, 32592-32602 (2004).

  4. Wan-Shu Lee, Chiung-Yueh Hsu, Pei-Ling Wang, Chi-Ying F. Huang, Chia-Hua Chang, and Chiun-Jye Yuan. Identification and characterization of the nuclear import and export signals of the mammalian Ste20-like protein kinase 3. FEBS Letters 13, 41-45 (2004).

  5. Cheng-Yan Kao, D. Frank Hsu, Han-Yu Chuang, Chi-Ying F. Huang, and Kuang-Chi Chen. To combine or not to combine. International Chinese Statistical Association Bulletin, 37-39 (2004).

  6. Tao-Wei Huang, An-Chi Tien, Wen-Shien Huang, Yuan-Chii G. Lee, Chin-Lin Peng, Huei-Hun Tseng, Cheng-Yan Kao, and Chi-Ying F. Huang*. POINT: a database for the prediction of protein-protein interactions based on the orthologous interactome. Bioinformatics 20, 3273-3276 (2004).

  7. Jiunn-Chyi Wu, Tzong-Yueh Chen, Chang-Tze R. Yu, Si-Jie Tsai, Jung-Mao Hsu, Ming-Jer Tang, Chen-Kung Chou, Wey-Jinq Lin, Chiun-Jye Yuan and Chi-Ying F. Huang*. Identification of V23RalA-Ser194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening. J. Biol. Chem. 280, 9013-9022 (2005).

  8. Chi-Chih Cheng, Shu-Mei Yang, Chi-Ying F. Huang, Jung-Chou Chen, Wei-Mao Chang, and Shih-Lan Hsu. Molecular mechanisms of ginsenoside Rh2-mediated G1 growth arrest and apoptosis in human lung adenocarcinoma A549 cells. Cancer Chemotherapy and Pharmacology 55, 531-40 (2005).

  9. Te-Jung Lu, Chi-Ying F. Huang, Chiun-Jye Yuan, Yuan-Chii Lee, Tzeng-Horng Leu, Wen-Chang Chang, Te-Ling Lu, Wen-Yih Jeng, Ming-Derg Lai. Zinc ion acts as a cofactor for serine/threonine kinase MST3 and has a distinct role in autophosphorylation of MST3. J. Inorg. Biochem. 99, 1306-1313 (2005).

  10. Chang-Tze Ricky Yu, Jung-Mao Hsu, Yuan-Chii Gladys Lee, Ann-Ping Tsou, Chen-Kung Chou and Chi-Ying F. Huang. Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A. Mol. Cell. Biol. 25, 5789-5800 (2005).

  11. Kuang-Chi Chen, Tse-Yi Wang, Huei-Hun Tseng, Chi-Ying F. Huang and Cheng-Yan Kao. A stochastic differential equation model for quantifying transcriptional regulatory network in Saccharomyces cerevisiae. Bioinformatics 21, 2883-2890 (2005).

  12. Kuo-Ting Chang, Chi-Ying F. Huang, Chun-Ming Tsai, Chao-Hua Chiu and Ying-Yung Lok. Role of IL-6 in Neuroendocrine Differentiation and Chemosensitivity of Non-Small Cell Lung Cancer. American Journal of Physiology: Lung Cellular and Molecular Physiology 289, 438-445 (2005).

  13. Kuo-Ting Chang, Chun-Ming Tsai, Yih-Chy Chiou, Chao-Hua Chiu, King-Song Jeng and Chi-Ying F. Huang. IL-6 induces neuroendocrine de-differentiation and cell proliferation in non-small cell lung cancer cells. American Journal of Physiology: Lung Cellular and Molecular Physiology 289, 446-453 (2005).

  14. Yong-Shiang Lin, Li-Jen Su, Chang-Tze Ricky Yu, Fen-Hwa Wong, Hsu-Hua Yeh, Su-Liang Chen, Jiunn-Chyi Wu, Wey-Jinq Lin, Yow-Ling Shiue, Hsiao- Sheng Liu, Shih-Lan Hsu, Jin-Mei Lai and Chi-Ying F. Huang. Gene Expression Profiles of the Aurora Family Kinases. Gene Expression 13, 15-26 (2006).

  15. Shih-Lan Hsu, Chang-Tze Ricky Yu, Sui-Chu Yin, Ming-Jer Tang, An-Chi Tien, Yi-Mi Wu, and Chi-Ying F. Huang. Caspase 3, periodically expressed and activated at G2/M transition, is required for nocodazole-induced mitotic checkpoint. Apoptosis 11, 765-771 (2006).

  16. Cheng-Ming Lee, Shih-Yin Chen, Yuan-Chii G. Lee, Chi-Ying F. Huang and Yi-Ming Arthur Chen. Benzo[a]pyrene and Glycine N-methyltransferse Interactions: Gene Expression Profiles of the Liver Detoxification Pathway. Toxicology and Applied Pharmacology 214, 126-135 (2006).

  17. Li-Jen Su, Shih-Lan Hsu, Jyh-Shyue Yang, Huei-Hun Tseng, Shiu-Feng Huang, and Chi-Ying F. Huang. Global gene expression profiling of dimethylnitrosamine induced liver fibrosis: from pathological and biochemical data to microarray analysis. Gene Expression 13, 107-132 (2006).

  18. He-Yen Chou, Shen-Long Howng, Tai-Shan Cheng, Yun-Ling Hsiao, Ann-Shung Lieu, Joon-Khim Loh, Shiuh-Lin Hwang, Ching-Chih Lin, Ching-Mei Hsu, Chihuei Wang, Chu-I Lee, Pei-Jung Lu, Chen-Kung Chou, Chi-Ying F. Huang and Yi-Ren Hong. GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta. Biochemistry 45, 11379-11389 (2006).

  19. Ya-Shih Tseng, Ching-Cherng Tzeng, Chi-Ying F. Huang, Ping-Hong Chen, Allen Wen-Hsiang Chiu, Pei-Yin Hsu, Guan-Cheng Huang, Yu-Chun Wang, Hsiao-Sheng Liu. Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer. Cancer Letters 241, 93-101 (2006).

  20. Te-Jung Lu, Wen-Yang Lai, Chi-Ying F. Huang, Wan-Jung Hsieh, Jau-Song Yu, Ya-Ju Hsieh, Wen-Tsan Chang, Tzeng-Horng Leu, Wen-Chang Chang, Woei-Jer Chuang, Ming-Jer Tang, Tzong-Yueh Chen, Te-Ling Lu, Ming-Derg Lai. Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein tyrosine phosphatase (PTP)-PEST. J. Biol. Chem. 281, 38405-38417 (2006).

  21. Yuan-Chii Gladys Lee, Yu-Chyi Hwang, Kuang-Chi Chen, Yong-Shiang Lin, Dah-Yeou Huang, Tao-Wei Huang, Cheng-Yan Kao, Han-Chung Wu, Chin-Tarng Lin, Chi-Ying F. Huang. Effect of Epstein-Barr Virus Infection on Global Gene Expression in Nasopharyngeal Carcinoma. Functional and Integrative Genomics 7, 79-93 (2007).

  22. Kuan-Yu Chen, Yuan-Chii Gladys Lee, Jin-Mei Lai, Yih-Leong Chang, Yung-Chie Lee, Chong-Jen Yu, Chi-Ying F. Huang*, Pan-Chyr Yang*. Identification of Trophinin as an Enhancer for Cell Invasion and a Prognostic Factor for Early Stage Lung Cancer. European Journal of Cancer 43, 782-90 (2007). (*corresponding author)

  23. Tai-Shan Cheng, Yun-Ling Hsiao, Ching-Chih Lin, Ching-Mei Hsu, Mau-Sun Chang, Chu-I Lee, Ricky Chang-Tze Yu, Chi-Ying F. Huang, Shen-Long Howng, and Yi-Ren Hong. hNinein is required for targeting spindle-associated protein Astrin to the centrosome during the S and G2 phases. Exp. Cell. Res. 313, 1710-1721 (2007).

  24. Chun-Nan Hsu, Jin-Mei Lai, Chia-Hung Liu, Huei-Hun Tseng, Chih-Yun Lin, Kuan-Ting Lin, Hsu-Hua Yeh, Ting-Yi Sung, Wen-Lian Hsu, Li-Jen Su, Sheng-An Lee, Chan-Han Chen, Gen-Cher Lee, Der-Tsai Lee, Yow-Ling Shiue, Chang-Wei Yeh, Chao-Hui Chang, Cheng-Yan Kao, Chi-Ying F. Huang. Detection of the inferred interaction network in hepatocellular carcinoma from EHCO (Encyclopedia of Hepatocellular Carcinoma genes Online). BMC Bioinformatics 8, 66 (2007).

  25. Chang-Han Chen, Pei-Jung Lu, Yu-Chia Chen, Shu-Ling Fu, Kou-Juey Wu, Ann-Ping Tsou, Yuan-Chii Gladys Lee, Tsu-Chun Emma Lin, Shih-Lan Hsu, Wey-Jinq Lin, Chi-Ying F. Huang* and Chen-Kung Chou*. FLJ10540-elicited cell transformation is through the activation of PI3-kinase/AKT pathway. Oncogene 26, 4272-4283 (2007) (*corresponding author)

  26. Li-Jen Su, Ching-Wei Chang, Yu-Chung Wu, Kuang-Chi Chen, Chien-Ju Lin, Shu-Ching Liang, Chi-Hung Lin, Jacqueline Whang-Peng, Shih-Lan Hsu, Chen-Hsin Chen and Chi-Ying F. Huang. Selection of DDX5 as a Novel Internal Control for Q-RT-PCR from microarray data: Using a Block Bootstrap Re-sampling scheme. BMC Genomics 8(1),140 (2007).

  27. Chueh-Chuan Yen, Shu-Ching Liang, Yiin-Jeng Jong, Yann-Jang Chen, Chi-Hung Lin, Yuh-Min Chen, Yu-Chung Wu, Wu-Chou Su, Chi-Ying F. Huang, Szu-Wen Tseng and Jacqueline Whang-Peng. Chromosomal aberrations of malignant pleural effusions of lung adenocarcinoma: Different cytogenetic changes are correlated with genders and smoking habits. Lung Cancer Sep;57(3):292-301 (2007).

  28. Wei-Li Wang, Sheau-Farn Yeh, Eagle Yi-Kung Huang, Yu-Ling Lu, Chun-Fa Wang, Chi-Ying F. Huang and Wey-Jinq Lin. Mitochondrial anchoring of PKC by PICK1 confers resistance to etoposide-induced apoptosis. Apoptosis Oct. 12(10):1857-71 (2007).

  29. Chang-Tze Ricky Yu, Jiunn-Chyi Wu, Mei-Chih Liao, Shih-Lan Hsu and Chi-Ying F. Huang. Identification of c-Fos as a mitotic phosphoprotein: regulation of c-Fos by Aurora-A. J. Biomedical Sci. 15:79-87 (2008).

  30. Pao-Ling Torng, Yuan-Chii G. Lee, Chi-Ying F. Huang, Y. H. Ye, Yong-Shiang Lin, Yi-Wen Chu, Su-Cheng Huang, Pinchas Cohen, Cheng-Wen Wu, Chin-Tarng Lin. Insulin-like grow factor binding protein-3 (IGFBP-3) acts as an invasion-metastasis suppressor in ovarian endometrioid carcinoma. Oncogene 3:2137-2147 (2008).

  31. Tai-Shan Cheng, Yun-Ling Hsiao, Ching-Chih Lin, Ricky Chang-Tze Yu, Ching-Mei Hsu, Mau-Sun Chang, Chu-I Lee, Chi-Ying F. Huang, Shen-Long Howng, and Yi-Ren Hong. Glycogen synthase kinase 3beta interacts with and phosphorylates the spindle-associated protein astrin. J. Biol. Chem 283(4):2454-2464 (2008).

  32. Dah-Yeou Huang, Yi-Ting Lin, Pey-Shynan Jan, Yu-Chyi Hwang, Sung-Tzu Liang, Yeh Peng, Chi-Ying F. Huang, Han-Chung Wu and Chin-Tang Lin. Transcription factor SOX-5 enhances nasopharyngeal carcinoma progression by downregulating SPARC gene expression. J. Pathology 214(4): 445-455 (2008).

  33. Chia-Ying Yang, Chao-Hui Chang, Tsu-Chun Emma Lin, Ya-Ling Yu, Sheng-An Lee, Chueh-Chuan Yen, Jinn-Moon Yang, Jin-Mei Lai, Yi-Ren Hong, Tzu-Ling Tseng, Kun-Mao Chao and Chi-Ying F. Huang. PhosphoPOINT: a comprehensive human kinase interactome and phospho-protein database. Bioinformatics 24, i14-i20 (2008).

  34. Sheng-An Lee, Cheng-hsiung Chan, Chi-Hung Tsai, Jin-Mei Lai, Feng-Sheng Wang, Cheng-Yan Kao and Chi-Ying F. Huang. Ortholog-based protein-protein interaction prediction and its application to inter-species interactions. BMC Bioinformatics 9(Suppl 12):S11 (2008).

  35. Fen-Hwa Wong#, Chi-Ying F. Huang#, Li-Jen Su, Yu-Chung Wu, Yong-Shiang Lin, Jiun-Yi Hsia, Hsin-Ting Tsai, Sheng-An Lee, Chi-Hung Lin, Cheng-Hwai Tzeng, Po-Min Chen, Yann-Jan Chen, Shu-Ching Liang, Jin-Mei Lai, and Chueh-Chuan Yen. Combination of microarray profiling and protein-protein interaction databases delineates the minimal discriminators as a metastasis network for esophageal squamous cell carcinoma. Int J Oncology 34: 117-128 (2009). (#contributed equally)

  36. Zhong-Zhe Lin, Hey-Chi Hsu, Chih-Hung Hsu, Pei-Yen Yeh, Chi-Ying F. Huang, Yung-Feng Huang, Te-Jung Chen, Sung-Hsin Kuo, Chiun Hsu, Fu-Chang Hu, Yung-Ming Jeng, Ying Chung, and Ann-Lii Cheng. The Aurora kinase inhibitor VE-465 has anticancer effects in pre-clinical studies of human hepatocellular carcinoma. J. Hepatology 50(3): 518-527 (2009).

  37. Chang-Han Chen, Jin-Mei Lai, Teh-Ying Chou, Cheng-Yu Chen, Li-Jen Su, Yuan-Chii Lee, Tai-Shan Cheng, Yi-Ren Hong, Jacqueline Whang-Peng, Chen-Kung Chou, Yu-Chung Wu, and Chi-Ying F. Huang. VEGFA upregulates FLJ10540 and modulates migration and invasion of lung cancer via PI3K/AKT pathway. PLoS ONE 4(4): e5052 (2009).

  38. Sheng-An Lee, Chen-Hsiung Chan, Tzu-Chi Chen, Chia-Ying Yang, Kuo-Chuan Huang, Chi-Hung Tsai, Jin-Mei Lai, Feng-Sheng Wang, Cheng-Yan Kao, Chi-Ying F. Huang. POINeT: Protein Interactome with Sub-network Analysis and Hub Prioritization. BMC Bioinformatics 10:114 (2009).

  39. Chang-Han Chen, Chih-Yen Chien, Chao-Cheng Huang, Hui-Ching Chuang, Fu-Min Fang, Hsuan-Ying Huang, Ching-Mei Chen, Hsin-Ling Liu and Chi-Ying F. Huang. Expression of FLJ10540 is correlated with aggressiveness of oral cavity squamous cell carcinoma by stimulating cell migration and invasion via increased FOXM1 and MMP-2 activity. Oncogene 28, 2723-2737 (2009).

  40. Tzu-Chi Chen, Sheng-An Lee, Chen-Hsiung Chan, Yue-Li Juang, Yi-Ren Hong, Yi-Shann Huang, Jin-Mei Lai, Cheng-Yan Kao, and Chi-Ying F. Huang. Cliques in mitotic spindle network bring kinetochore-associated complexes to form dependence pathway. Proteomics 9, 4048-4062 (2009) (with a figure selected as journal cover.)

  41. Shun-Fu Chen, Yue-Li Juang, Wei-Kang Chou, Jin-Mei Lai, Chi-Ying F Huang*, Cheng-Yan Kao, and Feng-Sheng Wang*. Inferring a transcriptional regulatory network of the cytokinesis-related genes by network component analysis. BMC Systems Biology 3:110 (2009). (*corresponding author)

  42. Tzu-Chi Chen, Sheng-An Lee, Tse-Ming Hong, Jin-Yuan Shih, Jin-Mei Lai, Hsin-Ying Chiou, Shuenn-Chen Yang, Chen-Hsiung Chan, Cheng-Yan Kao, Pan-Chyr Yang and Chi-Ying F. Huang. From midbody protein-protein interaction network construction to novel regulators in cytokinesis. Journal of Proteome Research 8, 4943-4953 (2009).

  43. Ya-Shih Tseng, Jheng-Chang Lee, Chi-Ying F. Huang and Hsiao-Sheng Liu. Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway. BMC Cancer 9:435 (2009).

  44. Ferrell JE, Pomerening JR, Kim SY, Trunnell NB, Xiong W, Huang CY, Machleder EM. Simple, realistic models of complex biological processes: positive feedback and bistability in a cell fate switch and a cell cycle oscillator. FEBS Lett. 583 (24): 3999-4005 (2009)

  45. Huang CW, Lin CY, Huang HY, Liu HW, Chen YJ, Shih DF, Chen HY, Juan CC, Ker CG, Huang CY, Li CF, Shiue YL. CKS1B overexpression implicates clinical aggressiveness of hepatocellular carcinomas but not p27(Kip1) protein turnover: an independent prognosticator with potential p27 (Kip1)-independent oncogenic attributes? Ann Surg Oncol. 17(3):907-22 (2010).

  46. Ann-Shung Lieu, Tai-Shan Cheng, Chia-Hua Chou, Chia-Hung Wu, Chia-Yi Hsu, Chi-Ying F. Huang, Li-Kwan Chang, Joon-Khim Loh, Chung-Shing Chang,Ching-Mei Hsu, Shen-Long Howng And Yi-Ren Hong. Functional characterization of AIBp, a novel Aurora-A binding protein in centrosome structure and spindle formation. International Journal Of Oncology (37): 429-436 (2010)

  47. Yu-Chung Wu, Li-Jen Su, Hao-Wei Wang, Chien-Fu Jeff Lin, Wen-Hu Hsu, Teh-Ying Chou, Chi-Ying F. Huang, Chia-Li Lu, and Chung-Tsen Hsueh. Cooverexpression of Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Adversely Affects the Postoperative Survival in Non-small Cell Lung Cancer. Journal of Thoracic Oncology 5(8):1167-74 (2010).

  48. Yun-Chih Hsieh, Yerra Koteswara Rao, Chun-Chi Wu, Chi-Ying F. Huang, Madamanchi Geethangili, Shih-Lan Hsu, and Yew-Min Tzeng. Methyl Antcinate A from Antrodia camphorata Induces Apoptosis in Human Liver Cancer Cells through Oxidant-Mediated Cofilin- and Bax-Triggered Mitochondrial Pathway. Chem Res Toxicol. 23(7):1256-67 (2010).

  49. Yin-Ju Chen, Yu-Hsuan Chen, Lu-Ping Chow, Ya-Hui Tsai, Pei-Hong Chen, Chi-Ying F. Huang, Wei-Tzu Chen, and Lih-Hwa Hwang. Heat shock protein 72 is associated with the hepatitis C virus replicase complex and enhances viral RNA replication. J Biol Chem 285, 28183-28190 (2010).

  50. Ming-Ying Lan, Chi-Long Chen, Kuan-Ting Lin, Sheng-An Lee, Wu-Lung R. Yang, Chun-Nan Hsu, Jaw-Ching Wu, Ching-Yin Ho, Jin-Ching Lin, Chi-Ying F. Huang. From NPC Therapeutic Target Identification to Potential Treatment Strategy. Molecular Cancer Therapeutics 9(9):2511-23 (2010).

  51. Chia-Hung Liu#, Kuan-Ting Lin#, Chi-Ying F. Huang#, Yih-Jyh Shann, Yu-Shi Lin, Cheng-Yan Kao, Chun-Nan Hsu. Genome-Wide Detection of Putative Oncofetal Genes in Human Hepatocellular Carcinoma by Splicing Pattern Comparison. iConcept Transaction on Computational Intelligence in Bioinformatics, 2:1, iConcept Press (2010) (#contributed equally)

  52. Sheng-Da Hsu, Feng-Mao Lin, Wei-Yun Wu, Chao Liang, Wei-Chih Huang, Wen-Ling Chan, Wen-Ting Tsai, Goun-Zhou Chen, Chia-Jung Lee, Chih-Min Chiu, Chia-Hung Chien, Ming-Chia Wu, Chi-Ying Huang, Ann-Ping Tsou and Hsien-Da Huang. miRTarBase: a database curates experimentally validated microRNA-target interactions. Nucleic Acids Research 39:D163–D169 (2011).

  53. Yuan-I Chang, Sheng-Chieh Hsu, Gar-Yang Chau, Chi-Ying F. Huang, Jung-Sung Sung, Wei-Kai Hua, Wey-Jinq Lin. Identification of the methylation preference region in heterogeneous nuclear ribonucleoprotein K by protein arginine methyltransferase 1 and its implication in regulating nuclear/cytoplasmic distribution. Biochemical and Biophysical Research Communications 404:865–869 (2011).

  54. Hsien-Chia Juan, Hsin-Ting Tsai, Po-Hao Chang, Chi-Ying F. Huang, Cheng-Po Hu and Fen-Hwa Wong. Insulin-like growth factor 1 mediates 5-fluorouracil chemoresistance in esophageal carcinoma cells through increasing survivin stability. Apoptosis 16:174-183 (2011).

  55. Chien-Chung Lin, Lien-Chin Chen, Vincent S. Tseng, Jing-Jou Yan, Wu-Wei Lai, Wen-Pin Su, Chi-Hung Lin, Chi-Ying F. Huang, and Wu-Chou Su. Malignant pleural effusion cells show aberrant glucose metabolism gene expression. European Respiratory Journal 37: 1453–1465 (2011).

  56. Yu-Ying Lin, Chun-Hung Yang, Gwo-Tarng Sheu, Chi-Ying F. Huang, Yu-Chung Wu, Shu-Ming Chuang, Ming-Ji Fann, Han Chang, Huei Lee, Jinghua Tsai Chang. A novel exon 15-deleted, splicing variant of slit2 shows potential for growth inhibition in addition to invasion inhibition in lung cancer. Cancer 117(15): 3404-15 (2011).

  57. Jiz-Yuh Wang, Chi-Ling Yeh, Hsiao-Chin Chou, Chi-Hwa Yang, Yu-Ning Fu, Ya-Ting Chen, Hui-Wen Cheng, Chi-Ying F. Huang, Hui-Ping Liu, Shiu-Feng Huang and Yi-Rong Chen. Vaccinia H1-related phosphatase (VHR) is a phosphatase of ErbB receptors and is down-regulated in non-small cell lung cancer. The Journal of Biological Chemistry 286(12): 10177–10184 (2011).

  58. Yei-Hsuan Huang, Chun-Chi Wu, Chen-Kung Chou, and Chi-Ying F. Huang. A Translational Regulator, PUM2, Promotes both Protein Stability and Kinase Activity of Aurora-A. PLoS ONE 6(5): e19718 (2011)

  59. Kai-Wei Hsueh, Shu-Ling Fu, Chi-Ying F. Huang, Chao-Hsiung Lin. Aurora-A phosphorylates hnRNPK and disrupts its interaction with p53. FEBS Letters 585, 2671–2675 (2011).

  60. Hsiao-Sheng Liu, Ching-Shiun Ke, Hung-Chi Cheng, Chi-Ying F. Huang, and Chun-Li Su. Curcumin-induced Mitotic Spindle Defect and Cell Cycle Arrest in Human Bladder Cancer Cells is partly through Inhibition of Aurora-A. Mol. Pharmacol. 80: 638-646 (2011).



Book Chapter

  1. Jin-Mei Lai, Chi-Ying F. Huang, and Chang-Han Chen. Using siRNA to uncover novel oncogenic signaling pathways. RNA interference, Methods in Molecular Biology 623, 231-242 (2010).



Patents

1. 謝惠珠(Hui-Chu Hsieh), 曾錙翎 (Tzu-Ling Tseng), 蘇立仁 (Li-Jen Su), 黃奇英 (Chi-Ying Huang), 徐士蘭 (Shih-Lan Hsu), “肝纖維化及/或肝硬化之生物標誌及其檢驗方法” (Biomarkers for liver fibrotic injury) (日本發明第4297942號專利權)。(Date of Grant: 24 April, 2009)



2. 謝惠珠(Hui-Chu Hsieh), 曾錙翎 (Tzu-Ling Tseng), 蘇立仁 (Li-Jen Su), 黃奇英 (Chi-Ying Huang), 徐士蘭 (Shih-Lan Hsu), “Biomarkers for liver fibrotic injury” (新加坡發明第134283號專利權)。(Date of Grant: 30 Nov., 2009)






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